MX2021001595A - Uso de ligandos agonistas del receptor igf-2 para el tratamiento del sindrome de angelman y autismo. - Google Patents
Uso de ligandos agonistas del receptor igf-2 para el tratamiento del sindrome de angelman y autismo.Info
- Publication number
- MX2021001595A MX2021001595A MX2021001595A MX2021001595A MX2021001595A MX 2021001595 A MX2021001595 A MX 2021001595A MX 2021001595 A MX2021001595 A MX 2021001595A MX 2021001595 A MX2021001595 A MX 2021001595A MX 2021001595 A MX2021001595 A MX 2021001595A
- Authority
- MX
- Mexico
- Prior art keywords
- igf
- autism
- treatment
- angelman syndrome
- receptor agonist
- Prior art date
Links
- 102000038460 IGF Type 2 Receptor Human genes 0.000 title abstract 3
- 108010031792 IGF Type 2 Receptor Proteins 0.000 title abstract 3
- 239000003446 ligand Substances 0.000 title abstract 3
- 208000009575 Angelman syndrome Diseases 0.000 title abstract 2
- 206010003805 Autism Diseases 0.000 title abstract 2
- 208000020706 Autistic disease Diseases 0.000 title abstract 2
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
- NBSCHQHZLSJFNQ-QTVWNMPRSA-N D-Mannose-6-phosphate Chemical compound OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]1O NBSCHQHZLSJFNQ-QTVWNMPRSA-N 0.000 abstract 2
- 239000000556 agonist Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 101150002416 Igf2 gene Proteins 0.000 abstract 1
- 208000029726 Neurodevelopmental disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se proporcionan métodos para el tratamiento de trastornos del neurodesarrollo, tales como el síndrome de Angelman y el autismo, que comprenden administrar a un individuo una composición que comprende un ligando agonista del receptor IGF 2 El ligando agonista del receptor IGF-2 puede ser IGF-2, manosa-6- fosfato o un derivado de la misma. También se describen composiciones que comprenden derivados de manosa-6-fosfato.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862717372P | 2018-08-10 | 2018-08-10 | |
PCT/US2019/046227 WO2020033971A1 (en) | 2018-08-10 | 2019-08-12 | Use of igf-2 receptor agonist ligands for treatment of angelman syndrome and autism |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021001595A true MX2021001595A (es) | 2021-06-08 |
Family
ID=69415274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021001595A MX2021001595A (es) | 2018-08-10 | 2019-08-12 | Uso de ligandos agonistas del receptor igf-2 para el tratamiento del sindrome de angelman y autismo. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20210315914A1 (es) |
EP (2) | EP4356964A2 (es) |
JP (1) | JP7466927B2 (es) |
KR (1) | KR20210075068A (es) |
CN (1) | CN113164501A (es) |
AU (1) | AU2019319296A1 (es) |
BR (1) | BR112021002456A2 (es) |
CA (1) | CA3109137A1 (es) |
ES (1) | ES2966930T3 (es) |
MX (1) | MX2021001595A (es) |
PL (1) | PL3833358T3 (es) |
WO (1) | WO2020033971A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4138880A2 (en) * | 2020-04-24 | 2023-03-01 | New York University | Use of igf-2 for treatment of epileptic seizures |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9516012D0 (en) | 1995-08-04 | 1995-10-04 | Univ Manchester | Pharmaceutical composition |
US6093388A (en) * | 1996-08-12 | 2000-07-25 | Btg International Limited | Mannose-6-phosphate composition and its use in treating fibrotic disorders |
AUPO309896A0 (en) * | 1996-10-18 | 1996-11-14 | Australian National University, The | Novel phosphosugars and phosphosugar-containing compounds having anti-inflammatory activity |
US7560424B2 (en) * | 2001-04-30 | 2009-07-14 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
GB0516722D0 (en) * | 2005-08-15 | 2005-09-21 | Cancer Rec Tech Ltd | Methods and materials |
AR064464A1 (es) * | 2006-12-22 | 2009-04-01 | Genentech Inc | Anticuerpos anti - receptor del factor de crecimiento insulinico |
FR2930942B1 (fr) * | 2008-05-07 | 2011-03-04 | Centre Nat Rech Scient | Nouvelles utilisations de derives de d-mannopyranose activateurs de l'angiogenese |
JP2012525369A (ja) * | 2009-04-28 | 2012-10-22 | ファーマキシス リミテッド | 創傷および線維性障害の治療のためのホスホテトラヒドロピラン化合物 |
WO2011000958A1 (en) * | 2009-07-03 | 2011-01-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compounds targeting the cation-independent mannose 6-phosphate receptor |
EP2558622A4 (en) * | 2010-04-06 | 2013-07-24 | Univ George Washington | COMPOSITIONS AND METHODS FOR IDENTIFYING INTERFERENCE FROM THE AUTISM SPECTRUM |
WO2013119964A2 (en) * | 2012-02-08 | 2013-08-15 | Stem Centrx, Inc. | Identification and enrichment of cell subpopulations |
BR112015012506A2 (pt) * | 2012-11-28 | 2017-07-11 | Neuren Pharmaceuticals Ltd | tratamento de transtornos do espectro do autismo usando ácido glicil-l-2-metilprolil-l-glutâmico |
US20150224164A1 (en) * | 2013-11-26 | 2015-08-13 | Neuren Pharmaceuticals Limited | Treatment of autism spectrum disorders using glycyl-l-2-methylprolyl-l-glumatic acid |
WO2017087256A1 (en) | 2015-11-17 | 2017-05-26 | Merck Sharp & Dohme Corp. | Spirocyclic pyridotriazine derivatives useful as hiv integrase inhibitors |
-
2019
- 2019-08-12 EP EP23212830.6A patent/EP4356964A2/en active Pending
- 2019-08-12 JP JP2021506933A patent/JP7466927B2/ja active Active
- 2019-08-12 PL PL19846073.5T patent/PL3833358T3/pl unknown
- 2019-08-12 CN CN201980066500.6A patent/CN113164501A/zh active Pending
- 2019-08-12 KR KR1020217007050A patent/KR20210075068A/ko unknown
- 2019-08-12 EP EP19846073.5A patent/EP3833358B1/en active Active
- 2019-08-12 WO PCT/US2019/046227 patent/WO2020033971A1/en unknown
- 2019-08-12 AU AU2019319296A patent/AU2019319296A1/en active Pending
- 2019-08-12 MX MX2021001595A patent/MX2021001595A/es unknown
- 2019-08-12 CA CA3109137A patent/CA3109137A1/en active Pending
- 2019-08-12 US US17/267,715 patent/US20210315914A1/en active Pending
- 2019-08-12 ES ES19846073T patent/ES2966930T3/es active Active
- 2019-08-12 BR BR112021002456-5A patent/BR112021002456A2/pt unknown
Also Published As
Publication number | Publication date |
---|---|
ES2966930T3 (es) | 2024-04-25 |
EP3833358A1 (en) | 2021-06-16 |
CN113164501A (zh) | 2021-07-23 |
JP2021534125A (ja) | 2021-12-09 |
US20210315914A1 (en) | 2021-10-14 |
JP7466927B2 (ja) | 2024-04-15 |
AU2019319296A1 (en) | 2021-03-25 |
BR112021002456A2 (pt) | 2021-05-04 |
EP3833358A4 (en) | 2022-04-13 |
CA3109137A1 (en) | 2020-02-13 |
EP3833358B1 (en) | 2023-12-06 |
PL3833358T3 (pl) | 2024-03-04 |
WO2020033971A1 (en) | 2020-02-13 |
KR20210075068A (ko) | 2021-06-22 |
EP4356964A2 (en) | 2024-04-24 |
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