MX2020011610A - Composiciones y métodos de células t receptoras de autoanticuerpo quimérico del receptor de fosfolipasa a2. - Google Patents

Composiciones y métodos de células t receptoras de autoanticuerpo quimérico del receptor de fosfolipasa a2.

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Publication number
MX2020011610A
MX2020011610A MX2020011610A MX2020011610A MX2020011610A MX 2020011610 A MX2020011610 A MX 2020011610A MX 2020011610 A MX2020011610 A MX 2020011610A MX 2020011610 A MX2020011610 A MX 2020011610A MX 2020011610 A MX2020011610 A MX 2020011610A
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MX
Mexico
Prior art keywords
receptor
caar
phospholipase
cells
compositions
Prior art date
Application number
MX2020011610A
Other languages
English (en)
Spanish (es)
Inventor
Saar Gill
Aimee S Payne
Jonathan Hogan
Baomei Wang
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of MX2020011610A publication Critical patent/MX2020011610A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
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    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/32—T-cell receptors [TCR]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K2121/00—Preparations for use in therapy
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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MX2020011610A 2018-05-02 2019-05-02 Composiciones y métodos de células t receptoras de autoanticuerpo quimérico del receptor de fosfolipasa a2. MX2020011610A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862665863P 2018-05-02 2018-05-02
PCT/US2019/030459 WO2019213434A1 (en) 2018-05-02 2019-05-02 Compositions and methods of phospholipase a2 receptor chimeric autoantibody receptor t cells

Publications (1)

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MX2020011610A true MX2020011610A (es) 2021-02-09

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US (3) US20210095001A1 (enExample)
EP (1) EP3813885A4 (enExample)
JP (2) JP7519906B2 (enExample)
KR (1) KR20210007998A (enExample)
CN (1) CN112312930A (enExample)
AU (1) AU2019262131A1 (enExample)
CA (1) CA3098865A1 (enExample)
MX (1) MX2020011610A (enExample)
WO (1) WO2019213434A1 (enExample)

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JP7519906B2 (ja) 2024-07-22
JP2021522790A (ja) 2021-09-02
WO2019213434A1 (en) 2019-11-07
US20210095001A1 (en) 2021-04-01
KR20210007998A (ko) 2021-01-20
EP3813885A1 (en) 2021-05-05
EP3813885A4 (en) 2022-01-12
JP2024059867A (ja) 2024-05-01
CN112312930A (zh) 2021-02-02
US20220098271A1 (en) 2022-03-31
CA3098865A1 (en) 2019-11-07
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AU2019262131A1 (en) 2020-11-19

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