MX2020009617A - Determinación espectrométrica de masa de testosterona en muestra multplexada de un paciente. - Google Patents

Determinación espectrométrica de masa de testosterona en muestra multplexada de un paciente.

Info

Publication number
MX2020009617A
MX2020009617A MX2020009617A MX2020009617A MX2020009617A MX 2020009617 A MX2020009617 A MX 2020009617A MX 2020009617 A MX2020009617 A MX 2020009617A MX 2020009617 A MX2020009617 A MX 2020009617A MX 2020009617 A MX2020009617 A MX 2020009617A
Authority
MX
Mexico
Prior art keywords
testosterone
mass spectrometric
samples
multiplexed
patient samples
Prior art date
Application number
MX2020009617A
Other languages
English (en)
Inventor
Scott Goldman
Nigel Clarke
Mildred M Goldman
Juliet Coletti
Original Assignee
Quest Diagnostics Invest Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quest Diagnostics Invest Llc filed Critical Quest Diagnostics Invest Llc
Publication of MX2020009617A publication Critical patent/MX2020009617A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Endocrinology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

En la presente se proporcionan métodos para la alta cuantificación de producción de testosterona, utilizando al menos dos diferentes agentes de derivación de diferentes masas. En otro aspecto, en la presente se proporcionan métodos para determinar la cantidad de testosterona en cada pluralidad de muestras humanas con un solo ensayo espectrométrico de masa al someter a cada pluralidad de muestras humanas a diferentes agentes de derivación para generar una testosterona derivada de manera diferente en cada pluralidad de las muestras; al combinar la pluralidad de las muestras para formar una muestras multiplexada; y cuantificar la cantidad de testosterona en cada muestra por medio de espectrometría de masa.
MX2020009617A 2018-03-16 2019-03-15 Determinación espectrométrica de masa de testosterona en muestra multplexada de un paciente. MX2020009617A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862644351P 2018-03-16 2018-03-16
PCT/US2019/022618 WO2019178565A1 (en) 2018-03-16 2019-03-15 Mass spectrometric determination of testosterone in multiplexed patient samples

Publications (1)

Publication Number Publication Date
MX2020009617A true MX2020009617A (es) 2020-12-07

Family

ID=67905411

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020009617A MX2020009617A (es) 2018-03-16 2019-03-15 Determinación espectrométrica de masa de testosterona en muestra multplexada de un paciente.

Country Status (8)

Country Link
US (2) US11674969B2 (es)
EP (1) EP3765841A4 (es)
JP (2) JP7326356B2 (es)
CN (1) CN112189137A (es)
BR (1) BR112020018817A2 (es)
CA (1) CA3094088A1 (es)
MX (1) MX2020009617A (es)
WO (1) WO2019178565A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112379009A (zh) * 2020-10-15 2021-02-19 生物岛实验室 生物样本中类固醇激素的检测方法及该方法所用试剂盒

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU695111B2 (en) * 1994-02-18 1998-08-06 Merck Serono Sa Methods for altering fertility
US7045296B2 (en) * 2001-05-08 2006-05-16 Applera Corporation Process for analyzing protein samples
WO2003089921A1 (en) * 2002-04-15 2003-10-30 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods for separation and detection of ketosteroids and other carbonyl-containing compounds
US6977143B1 (en) * 2003-09-08 2005-12-20 Quest Diagnostics Investments Incorporated Determination of testosterone by mass spectrometry
JP2005300430A (ja) * 2004-04-14 2005-10-27 Shimadzu Corp ラベル化ペプチドの特異的検出法、および片在ピークの特異的検出法
US7834313B2 (en) * 2008-08-08 2010-11-16 Quest Diagnostics Investments Incorporated Mass spectrometry assay for plasma-renin
WO2010099108A2 (en) * 2009-02-24 2010-09-02 Mayo Foundation For Medical Education And Research Multiplexing derivatized anayltes using mass spectroscopy
DE102009028237A1 (de) * 2009-08-05 2011-02-17 Robert Bosch Gmbh Verfahren und Vorrichtung zur Regeneration eines Partikelfilters mit einer im Abgaskanal nachgeordneten Abgassonde
CA2783708C (en) * 2009-12-11 2018-09-18 Quest Diagnostics Investments Incorporated Mass spectrometry of steroidal compounds in multiplex samples
US9834578B2 (en) 2010-05-27 2017-12-05 University Of Utah Research Foundation Enhanced sensitivity for analysis of ketosteroid compounds using mass spectrometry
US10837972B2 (en) 2010-06-09 2020-11-17 Quest Diagnostics Investments Incorporated Mass spectrometric determination of derivatized methylmalonic acid
CN107064330B (zh) 2010-12-28 2022-02-25 探索诊断投资公司 通过质谱法定量胰岛素
WO2012109275A1 (en) * 2011-02-07 2012-08-16 Laboratory Corporation Of America Holdings Methods and systems for determining the presence or amount of delta 5 steroid compounds in a sample
JP2015121406A (ja) * 2013-12-20 2015-07-02 株式会社島津製作所 液体クロマトグラフ質量分析装置用イオン化プローブ及び液体クロマトグラフ質量分析装置
WO2015126595A1 (en) * 2014-02-21 2015-08-27 Purdue Research Foundation Analyzing an extracted sample using an immiscible extraction solvent
US10267775B2 (en) 2014-05-30 2019-04-23 Tecan Sp, Inc. Extraction, derivatization, and quantification of analytes
CN107850568A (zh) * 2015-05-27 2018-03-27 奎斯特诊断投资有限公司 用于质谱定量由微量取样装置提取的分析物的方法
CN106645373B (zh) * 2016-09-29 2019-03-08 中国农业科学院油料作物研究所 一种磷脂的精确定量分析方法

Also Published As

Publication number Publication date
JP7326356B2 (ja) 2023-08-15
EP3765841A4 (en) 2022-06-08
JP2021518567A (ja) 2021-08-02
US11674969B2 (en) 2023-06-13
US20190285654A1 (en) 2019-09-19
JP2023164797A (ja) 2023-11-14
US20230273226A1 (en) 2023-08-31
EP3765841A1 (en) 2021-01-20
WO2019178565A1 (en) 2019-09-19
BR112020018817A2 (pt) 2021-02-09
CN112189137A (zh) 2021-01-05
CA3094088A1 (en) 2019-09-19

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