MX2020003758A - Metodos para separar diastereoisomeros de gemcitabina-fosfato. - Google Patents

Metodos para separar diastereoisomeros de gemcitabina-fosfato.

Info

Publication number
MX2020003758A
MX2020003758A MX2020003758A MX2020003758A MX2020003758A MX 2020003758 A MX2020003758 A MX 2020003758A MX 2020003758 A MX2020003758 A MX 2020003758A MX 2020003758 A MX2020003758 A MX 2020003758A MX 2020003758 A MX2020003758 A MX 2020003758A
Authority
MX
Mexico
Prior art keywords
gemcitabine
phosphate
separating
methods
alaninyl
Prior art date
Application number
MX2020003758A
Other languages
English (en)
Inventor
Hugh Griffith
Original Assignee
NuCana plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NuCana plc filed Critical NuCana plc
Publication of MX2020003758A publication Critical patent/MX2020003758A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Esta solicitud está relacionada a un metodo para separar los diastereoisomeros de fosfato de gemcitabina-[fenil-benzoxi-L-anani nil)]-fosfato (NUC-1031) usando cristalizacion; en particular, la cristalizacion de alcohol isopropilico proporciona gemcitabina-[fenil-benzoxi-L-alaninil)]- (S)-fosfato en forma altamente diastereoisomericamente pura; esta solicitud tambien esta relacionada a una forma cristalina de gemcitabina-[fenil-benz oxi-L-alaninil)]-(S)-fosfato.
MX2020003758A 2014-10-06 2015-09-29 Metodos para separar diastereoisomeros de gemcitabina-fosfato. MX2020003758A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1417644.0A GB201417644D0 (en) 2014-10-06 2014-10-06 Method of separating phosphate diastereoisomers
PCT/GB2015/052839 WO2016055769A1 (en) 2014-10-06 2015-09-29 Methods of separating gemcitabine-phosphate diastereoisomers

Publications (1)

Publication Number Publication Date
MX2020003758A true MX2020003758A (es) 2021-10-26

Family

ID=51946917

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017004446A MX2017004446A (es) 2014-10-06 2015-09-29 Metodos para separar diastereoisomeros de gemcitabina-fosfato.
MX2020003758A MX2020003758A (es) 2014-10-06 2015-09-29 Metodos para separar diastereoisomeros de gemcitabina-fosfato.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2017004446A MX2017004446A (es) 2014-10-06 2015-09-29 Metodos para separar diastereoisomeros de gemcitabina-fosfato.

Country Status (29)

Country Link
US (1) US10669300B2 (es)
EP (2) EP3725794A1 (es)
JP (2) JP6893172B2 (es)
KR (1) KR102532498B1 (es)
CN (2) CN107108682B (es)
AU (2) AU2015329767B2 (es)
CA (1) CA2959977C (es)
CL (1) CL2017000819A1 (es)
CY (1) CY1123061T1 (es)
DK (1) DK3204398T3 (es)
EA (1) EA033118B1 (es)
ES (1) ES2793957T3 (es)
GB (1) GB201417644D0 (es)
HR (1) HRP20200849T1 (es)
HU (1) HUE050882T2 (es)
IL (1) IL251125B (es)
LT (1) LT3204398T (es)
MA (1) MA41039B1 (es)
ME (1) ME03730B (es)
MX (2) MX2017004446A (es)
MY (1) MY183302A (es)
PH (1) PH12017500586A1 (es)
PL (1) PL3204398T3 (es)
PT (1) PT3204398T (es)
RS (1) RS60634B1 (es)
SG (2) SG10201902952SA (es)
SI (1) SI3204398T1 (es)
WO (1) WO2016055769A1 (es)
ZA (1) ZA201701723B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0317009D0 (en) * 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
US10005810B2 (en) 2012-11-16 2018-06-26 University College Cardiff Consultants Limited Process for preparing nucleoside prodrugs
CN106459129B (zh) 2014-06-25 2020-03-31 努卡那有限公司 吉西他滨前药
SI3119794T1 (en) 2014-06-25 2018-02-28 NuCana plc FORMULATION, COMPOSITION OF GEMCITABIN PREPARED
GB201417644D0 (en) 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
CN106543220A (zh) * 2015-09-16 2017-03-29 博瑞生物医药（苏州）股份有限公司 氨基磷酸酯化合物及其制备方法和晶体
CN112156102B (zh) * 2015-09-16 2023-10-03 济南高合医疗科技有限公司 一种nuc-1031单一异构体的晶型及其制备方法
CN106543252A (zh) * 2015-09-16 2017-03-29 博瑞生物医药（苏州）股份有限公司 核苷氨基磷酸酯类前药的制备方法及其中间体
US10660912B2 (en) 2015-10-05 2020-05-26 NuCana plc Combination therapy for cancer
PT3386998T (pt) 2015-12-11 2021-11-30 NuCana plc Síntese diastereosseletiva de derivados fosfato e do pró-fármaco gemcitabina nuc-10311
GB201522771D0 (en) * 2015-12-23 2016-02-03 Nucana Biomed Ltd Crystalline form of a phosphate derivative
WO2018019188A1 (zh) * 2016-07-23 2018-02-01 博瑞生物医药（苏州）股份有限公司 核苷氨基磷酸酯类前药的多晶型及其制备方法
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
CN107400156B (zh) * 2017-09-19 2020-01-31 北京大学 一种分离麦角甾烷型三萜25r-与25s-差向异构体的方法
CN115028594A (zh) * 2020-06-03 2022-09-09 吴卫东 恩替他滨药用前体化合物及其制备方法和医学用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE258154T1 (de) * 2000-02-11 2004-02-15 Degussa Trennung von dl-racemischen mischungen
GB0317009D0 (en) * 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
FR2954310B1 (fr) * 2009-12-18 2014-07-25 Univ Rouen Procede de dedoublement d'enantiomeres par evapocristallisation preferentielle
US10005810B2 (en) * 2012-11-16 2018-06-26 University College Cardiff Consultants Limited Process for preparing nucleoside prodrugs
WO2014204856A1 (en) 2013-06-17 2014-12-24 Catabasis Pharmaceuticals, Inc. Fatty acid anticancer derivatives and their uses
JP2017504572A (ja) * 2013-11-27 2017-02-09 アイデニクス・ファーマシューティカルズ・エルエルシー 肝臓癌治療のためのヌクレオチド類
SI3119794T1 (en) * 2014-06-25 2018-02-28 NuCana plc FORMULATION, COMPOSITION OF GEMCITABIN PREPARED
CN106459129B (zh) 2014-06-25 2020-03-31 努卡那有限公司 吉西他滨前药
EP3172218B1 (en) 2014-07-22 2020-10-21 NuCana plc Process for the preparation of gemcitabine-[phenyl(benzoxy-l-alaninyl)] phosphate
GB201417644D0 (en) 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
KR20180021697A (ko) 2015-05-14 2018-03-05 뉴카나 피엘씨 암 치료
US10660912B2 (en) 2015-10-05 2020-05-26 NuCana plc Combination therapy for cancer
PT3386998T (pt) 2015-12-11 2021-11-30 NuCana plc Síntese diastereosseletiva de derivados fosfato e do pró-fármaco gemcitabina nuc-10311
KR102566461B1 (ko) 2015-12-23 2023-08-14 뉴카나 피엘씨 조합 요법
HUE050290T2 (hu) 2015-12-23 2020-11-30 NuCana plc Kombinált terápia
GB201522771D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Crystalline form of a phosphate derivative

Also Published As

Publication number Publication date
CA2959977A1 (en) 2016-04-14
CY1123061T1 (el) 2021-10-29
EA033118B1 (ru) 2019-08-30
US20170226147A1 (en) 2017-08-10
ES2793957T3 (es) 2020-11-17
KR102532498B1 (ko) 2023-05-12
PT3204398T (pt) 2020-05-28
AU2015329767A1 (en) 2017-04-13
IL251125B (en) 2020-07-30
JP2017530172A (ja) 2017-10-12
DK3204398T3 (da) 2020-06-02
AU2020203714B2 (en) 2021-07-22
BR112017006855A2 (pt) 2017-12-12
EP3204398B1 (en) 2020-05-13
LT3204398T (lt) 2020-09-10
PL3204398T3 (pl) 2020-11-16
MA41039B1 (fr) 2020-08-31
HUE050882T2 (hu) 2021-01-28
US10669300B2 (en) 2020-06-02
WO2016055769A1 (en) 2016-04-14
SG11201701885UA (en) 2017-04-27
MY183302A (en) 2021-02-18
AU2020203714A1 (en) 2020-06-25
CN112552362A (zh) 2021-03-26
KR20170090413A (ko) 2017-08-07
GB201417644D0 (en) 2014-11-19
EP3204398A1 (en) 2017-08-16
SG10201902952SA (en) 2019-05-30
ME03730B (me) 2021-01-20
CN107108682B (zh) 2020-12-18
EP3725794A1 (en) 2020-10-21
ZA201701723B (en) 2023-11-29
AU2015329767B2 (en) 2020-03-12
IL251125A0 (en) 2017-04-30
CN107108682A (zh) 2017-08-29
EA201790794A1 (ru) 2017-07-31
RS60634B1 (sr) 2020-09-30
HRP20200849T1 (hr) 2020-10-30
MX2017004446A (es) 2017-06-19
JP2020128392A (ja) 2020-08-27
CA2959977C (en) 2024-01-02
SI3204398T1 (sl) 2020-09-30
JP6893172B2 (ja) 2021-06-23
JP6967625B2 (ja) 2021-11-17
CL2017000819A1 (es) 2017-11-03
PH12017500586A1 (en) 2017-08-30

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