MX2019014738A - Oblea de espuma que se desintegra rapidamente con alta masa por unidad de area. - Google Patents

Oblea de espuma que se desintegra rapidamente con alta masa por unidad de area.

Info

Publication number
MX2019014738A
MX2019014738A MX2019014738A MX2019014738A MX2019014738A MX 2019014738 A MX2019014738 A MX 2019014738A MX 2019014738 A MX2019014738 A MX 2019014738A MX 2019014738 A MX2019014738 A MX 2019014738A MX 2019014738 A MX2019014738 A MX 2019014738A
Authority
MX
Mexico
Prior art keywords
per unit
unit area
mass per
high mass
active ingredient
Prior art date
Application number
MX2019014738A
Other languages
English (en)
Inventor
Müller Markus
Bauer Marius
Linn Michael
Original Assignee
Lts Lohmann Therapie Systeme Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lts Lohmann Therapie Systeme Ag filed Critical Lts Lohmann Therapie Systeme Ag
Publication of MX2019014738A publication Critical patent/MX2019014738A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/122—Foams; Dry foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Nutrition Science (AREA)
  • Dispersion Chemistry (AREA)
  • Physiology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención se refiere a formas de dosificación planas que se desintegran o disuelven en un entorno acuoso para liberar por lo menos un ingrediente activo en un orificio del cuerpo o cavidad del cuerpo y que se forman a partir de una matriz de polímero en la forma de una espuma solidificada que tiene cavidades, y por lo menos un ingrediente activo farmacéutico y que tiene una alta masa por unidad de área en la región de 50 a 350 g/m2; a pesar de su alta masa por unidad de área y la carga del ingrediente activo elevado resultante durante la administración, estas formas de dosificación se caracterizan por una sensación en la boca sustancialmente mejorada en comparación con las formas de dosificación de película convencionales; la invención también se refiere a métodos para producir una forma de dosificación de este tipo.
MX2019014738A 2017-06-07 2018-06-07 Oblea de espuma que se desintegra rapidamente con alta masa por unidad de area. MX2019014738A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102017112527.2A DE102017112527B4 (de) 2017-06-07 2017-06-07 Schnell zerfallende Schaumwafer mit hohem Flächengewicht
PCT/EP2018/065008 WO2018224591A1 (de) 2017-06-07 2018-06-07 Schnell zerfallende schaumwafer mit hohem flächengewicht

Publications (1)

Publication Number Publication Date
MX2019014738A true MX2019014738A (es) 2020-02-07

Family

ID=62599569

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019014738A MX2019014738A (es) 2017-06-07 2018-06-07 Oblea de espuma que se desintegra rapidamente con alta masa por unidad de area.

Country Status (12)

Country Link
US (1) US20200138714A1 (es)
EP (1) EP3634379A1 (es)
JP (3) JP7471823B2 (es)
KR (1) KR102398857B1 (es)
CN (1) CN110709064A (es)
AU (1) AU2018281944B2 (es)
BR (1) BR112019024798A2 (es)
CA (1) CA3064168C (es)
DE (1) DE102017112527B4 (es)
MX (1) MX2019014738A (es)
RU (1) RU2019144316A (es)
WO (1) WO2018224591A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017129012A1 (de) * 2017-12-06 2019-06-06 Lts Lohmann Therapie-Systeme Ag Oraler Dünnfilm mit hoher Wirkstoffbeladung
EP4157244A1 (en) * 2020-06-02 2023-04-05 IX Biopharma Limited Methods for treating major depressive disorder and treatment-resistant depression
DE102021120937A1 (de) 2021-08-11 2023-02-16 Lts Lohmann Therapie-Systeme Ag. Oraler Dünnfilm
JP2023548215A (ja) * 2020-11-09 2023-11-15 エルテーエス ローマン テラピー－ジステーメ アーゲー 経口薄フィルム
DE102021106491A1 (de) 2021-03-17 2022-09-22 Lts Lohmann Therapie-Systeme Ag. Gerollte oral thin films mit hoher wirkstoffbeladung
EP4151204A1 (de) * 2021-09-17 2023-03-22 LTS Lohmann Therapie-Systeme AG Schnell zerfallende orale dünne filme/schäume mit hoher wirkstoffbeladung auf basis eines gemisches von polyvinylalkoholen mit unterschiedlichen molekulargewichten
EP4302750A1 (en) 2022-07-07 2024-01-10 LTS Lohmann Therapie-Systeme AG Oral thin films comprising adrenaline

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ATE212235T1 (de) * 1991-04-08 2002-02-15 Sumitomo Pharma Poröse feste zubereitung, die eine physiologische aktive proteinverbindung enthält
US5393528A (en) 1992-05-07 1995-02-28 Staab; Robert J. Dissolvable device for contraception or delivery of medication
US5458884A (en) * 1992-09-10 1995-10-17 Britton; Peter Bioerodible device for administering active ingredients
US5352683A (en) * 1993-03-05 1994-10-04 Virginia Commonwealth University Medical College Of Virginia Method for the treatment of chronic pain
US20010006677A1 (en) 1996-10-29 2001-07-05 Mcginity James W. Effervescence polymeric film drug delivery system
DE19652257A1 (de) 1996-12-16 1998-06-18 Lohmann Therapie Syst Lts Einzeln dosierte, bei Kontakt mit Flüssigkeit schnell zerfallende, wirkstoff- und insbesondere aromastoffhaltige, folienförmige Darreichnungsform
US6596298B2 (en) 1998-09-25 2003-07-22 Warner-Lambert Company Fast dissolving orally comsumable films
US6552024B1 (en) * 1999-01-21 2003-04-22 Lavipharm Laboratories Inc. Compositions and methods for mucosal delivery
US6090401A (en) * 1999-03-31 2000-07-18 Mcneil-Ppc, Inc. Stable foam composition
US7067116B1 (en) * 2000-03-23 2006-06-27 Warner-Lambert Company Llc Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1
DE10032456A1 (de) * 2000-07-04 2002-01-31 Lohmann Therapie Syst Lts Schnell zerfallende Darreichungsform zur Freisetzung von Wirkstoffen im Mundraum oder in Körperhöhlen
DE10107659B4 (de) * 2001-02-19 2008-03-13 Lts Lohmann Therapie-Systeme Ag Mucoadhäsive zerfallsfähige Arzneizubereitung zur Wirkstoffverabreichung in der Veterinär- und Humanmedizin
DE10207394B4 (de) * 2002-02-21 2007-03-29 Lts Lohmann Therapie-Systeme Ag Geschmacksmaskierte oblatenförmige Arzneizubereitung
CA2493881C (en) * 2002-05-16 2011-07-12 Kyukyu Pharmaceutical Co., Ltd. Rapidly soluble film-shaped preparation
JP4795962B2 (ja) * 2003-05-28 2011-10-19 モノソル・アールエックス・エルエルシー ポリエチレンオキシドフィルムおよびそれからなる薬物送達系
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US9265779B2 (en) * 2008-05-13 2016-02-23 Lts Lohmann Therapie-Systeme Ag Method of using a film-shaped preparation comprising oily substances for oral administration
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JP6067687B2 (ja) * 2011-06-08 2017-01-25 エルテーエス ローマン テラピー−ジステーメ アーゲー 味覚マスキングのためのイオン交換樹脂を含有する可食性経口ストリップ又はウエハース剤形
US11207316B2 (en) * 2014-05-30 2021-12-28 West Virginia University Ketamine or dextromethorphan formulations and methods of use

Also Published As

Publication number Publication date
EP3634379A1 (de) 2020-04-15
KR102398857B1 (ko) 2022-05-16
AU2018281944B2 (en) 2021-09-23
KR20200013762A (ko) 2020-02-07
JP2020530433A (ja) 2020-10-22
CN110709064A (zh) 2020-01-17
CA3064168C (en) 2023-02-28
US20200138714A1 (en) 2020-05-07
DE102017112527A1 (de) 2018-12-13
JP2024069308A (ja) 2024-05-21
JP2022095893A (ja) 2022-06-28
RU2019144316A (ru) 2021-07-09
RU2019144316A3 (es) 2021-07-09
WO2018224591A1 (de) 2018-12-13
JP7471823B2 (ja) 2024-04-22
DE102017112527B4 (de) 2019-01-03
BR112019024798A2 (pt) 2020-06-09
CA3064168A1 (en) 2018-12-13
AU2018281944A1 (en) 2020-01-02

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