MX2019011023A - Diarilureas como moduladores alostéricos de cannabinoide cb1. - Google Patents

Diarilureas como moduladores alostéricos de cannabinoide cb1.

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Publication number
MX2019011023A
MX2019011023A MX2019011023A MX2019011023A MX2019011023A MX 2019011023 A MX2019011023 A MX 2019011023A MX 2019011023 A MX2019011023 A MX 2019011023A MX 2019011023 A MX2019011023 A MX 2019011023A MX 2019011023 A MX2019011023 A MX 2019011023A
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MX
Mexico
Prior art keywords
allosteric modulators
diarylureas
compounds
present
receptor
Prior art date
Application number
MX2019011023A
Other languages
English (en)
Inventor
Zhang Yanan
NGUYEN Thuy
German Nadezhda
Original Assignee
Rti Int
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Publication date
Application filed by Rti Int filed Critical Rti Int
Publication of MX2019011023A publication Critical patent/MX2019011023A/es

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    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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Abstract

La presente invención proporciona nuevos derivados de diarilurea (compuestos de la fórmula (I)) y sus usos. Los compuestos de la presente invención se demuestra que son moduladores alostéricos del receptor de CB1 y, por lo tanto, son útiles para el tratamiento de enfermedades y condiciones mediadas por CB1.
MX2019011023A 2017-05-12 2018-05-10 Diarilureas como moduladores alostéricos de cannabinoide cb1. MX2019011023A (es)

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US201762505383P 2017-05-12 2017-05-12
PCT/US2018/031977 WO2018209030A1 (en) 2017-05-12 2018-05-10 Diarylureas as cb1 allosteric modulators

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JP (1) JP7455581B2 (es)
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AU (2) AU2018265148A1 (es)
CA (1) CA3056305A1 (es)
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CA3140660A1 (en) * 2019-06-28 2020-12-30 Yanan Zhang Urea derivatives as cb1 allosteric modulators

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US6093742A (en) * 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38
DE1042305T1 (de) * 1997-12-22 2001-04-19 Bayer Ag HEMMUNG DER p38 KINASE UNTER VERWENDUNG VON SYMMETRISCHEN UND ASYMMETRISCHEN DIPHENYLHARNSTOFFEN
WO2003055848A2 (en) * 2001-12-26 2003-07-10 Bayer Healthcare Ag Urea derivatives as vr1- antagonists
JP2003192659A (ja) * 2001-12-26 2003-07-09 Bayer Ag フェニル尿素誘導体
SV2005001973A (es) * 2003-12-12 2005-11-04 Wyeth Corp Quinolinas utiles en el tratamiento de enfermedades cardiovasculares ref. wyth0090-504 (am101500)
WO2006018662A2 (en) * 2004-08-16 2006-02-23 Prosidion Limited Aryl urea derivatives for treating obesity
AU2005302669A1 (en) * 2004-10-27 2006-05-11 Neurogen Corporation Diaryl ureas as CB1 antagonists
AU2008345225A1 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
AU2009244504A1 (en) * 2008-05-05 2009-11-12 Amgen Inc. Urea compounds as gamma secretase modulators
KR101332830B1 (ko) * 2012-07-05 2013-11-27 한국화학연구원 페닐우레아 유도체 또는 이의 약학적으로 허용가능한 염을 포함하는 항암감작제
US9926275B2 (en) * 2013-08-22 2018-03-27 Northeastern University Allosteric modulators of the cannabinoid 1 receptor
CN104744350A (zh) * 2015-03-11 2015-07-01 西安交通大学 一种吡啶取代的二芳基脲化合物及其制备方法和应用

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AU2022205221A1 (en) 2022-08-04
EP3621951A4 (en) 2021-01-27
MX2023001906A (es) 2023-03-13
US20210332007A1 (en) 2021-10-28
CN110621656A (zh) 2019-12-27
JP7455581B2 (ja) 2024-03-26
US20200062699A1 (en) 2020-02-27
CA3056305A1 (en) 2018-11-15
US11084781B2 (en) 2021-08-10
AU2018265148A1 (en) 2019-10-03
JP2020519566A (ja) 2020-07-02
WO2018209030A1 (en) 2018-11-15
EP3621951A1 (en) 2020-03-18
CN116283668A (zh) 2023-06-23

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