MX2019003569A - Metodos para tratar el cancer con bavituximab en funcion de niveles de b2 glucoproteina 1 y ensayos de estos. - Google Patents

Metodos para tratar el cancer con bavituximab en funcion de niveles de b2 glucoproteina 1 y ensayos de estos.

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Publication number
MX2019003569A
MX2019003569A MX2019003569A MX2019003569A MX2019003569A MX 2019003569 A MX2019003569 A MX 2019003569A MX 2019003569 A MX2019003569 A MX 2019003569A MX 2019003569 A MX2019003569 A MX 2019003569A MX 2019003569 A MX2019003569 A MX 2019003569A
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MX
Mexico
Prior art keywords
bavituximab
methods
glycoprotein
treating cancer
levels
Prior art date
Application number
MX2019003569A
Other languages
English (en)
Inventor
Min Tang
Joseph S Shan
Steven W King
Connie Chang
Michael A Brown
Original Assignee
Oncologie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncologie Inc filed Critical Oncologie Inc
Publication of MX2019003569A publication Critical patent/MX2019003569A/es

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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
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  • Organic Chemistry (AREA)
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  • Veterinary Medicine (AREA)
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  • Hematology (AREA)
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  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
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  • Oncology (AREA)
  • Food Science & Technology (AREA)
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  • Peptides Or Proteins (AREA)
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Abstract

Se describen nuevos y sorprendentes métodos y kits para la identificación y el tratamiento de pacientes que pueden tratarse con anticuerpos dirigidos a PS, en particular para la identificación y el tratamiento del cáncer en pacientes con bavituximab y tratamientos conjuntos con bavituximab. Los métodos y kits se basan en el sorprendente hallazgo de que los rangos definidos de concentraciones en sangre previas al tratamiento de ß2-glucoproteína 1 (ß2GPI), particularmente ß2GPl funcional, actúan como un indicador para predecir con precisión pacientes con mejores resultados del tratamiento.
MX2019003569A 2016-09-27 2017-09-26 Metodos para tratar el cancer con bavituximab en funcion de niveles de b2 glucoproteina 1 y ensayos de estos. MX2019003569A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662400589P 2016-09-27 2016-09-27
US201662406727P 2016-10-11 2016-10-11
US201762480994P 2017-04-03 2017-04-03
US201762507580P 2017-05-17 2017-05-17
PCT/US2017/053370 WO2018064013A1 (en) 2016-09-27 2017-09-26 METHODS FOR TREATING CANCER WITH BAVITUXIMAB BASED ON LEVELS OF β2-GLYCOPROTEIN 1, AND ASSAYS THEREFOR

Publications (1)

Publication Number Publication Date
MX2019003569A true MX2019003569A (es) 2020-07-22

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Family Applications (1)

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MX2019003569A MX2019003569A (es) 2016-09-27 2017-09-26 Metodos para tratar el cancer con bavituximab en funcion de niveles de b2 glucoproteina 1 y ensayos de estos.

Country Status (8)

Country Link
EP (1) EP3519827A1 (es)
JP (1) JP2019537619A (es)
KR (1) KR20190057303A (es)
CN (1) CN109863402A (es)
AU (1) AU2017334698A1 (es)
CA (1) CA3037008A1 (es)
MX (1) MX2019003569A (es)
WO (1) WO2018064013A1 (es)

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CN112698033A (zh) * 2020-12-09 2021-04-23 复旦大学附属中山医院 一种血源性外泌体her2的检测方法及其应用
CN114716547B (zh) * 2022-05-18 2023-11-21 珠海丽禾医疗诊断产品有限公司 一种包括抗原结合结构域的结合蛋白及其生产方法和应用
WO2024065243A1 (en) * 2022-09-28 2024-04-04 University Of Macau Drug for treatment of breast cancer and application thereof

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Publication number Publication date
WO2018064013A9 (en) 2018-07-05
WO2018064013A1 (en) 2018-04-05
CA3037008A1 (en) 2018-04-05
WO2018064013A8 (en) 2019-05-23
AU2017334698A1 (en) 2019-03-21
JP2019537619A (ja) 2019-12-26
EP3519827A1 (en) 2019-08-07
KR20190057303A (ko) 2019-05-28
CN109863402A (zh) 2019-06-07

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