MX2019002572A - Compuestos para reducir el contenido de melanina celular. - Google Patents

Compuestos para reducir el contenido de melanina celular.

Info

Publication number
MX2019002572A
MX2019002572A MX2019002572A MX2019002572A MX2019002572A MX 2019002572 A MX2019002572 A MX 2019002572A MX 2019002572 A MX2019002572 A MX 2019002572A MX 2019002572 A MX2019002572 A MX 2019002572A MX 2019002572 A MX2019002572 A MX 2019002572A
Authority
MX
Mexico
Prior art keywords
melanin content
reducing cellular
compounds
reducing
alkoxy
Prior art date
Application number
MX2019002572A
Other languages
English (en)
Inventor
Peter Stott Ian
Thimmaiah Sreenivasa
Chandramowli Ganesh
Original Assignee
Unilever Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Nv filed Critical Unilever Nv
Publication of MX2019002572A publication Critical patent/MX2019002572A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

La presente invención se refiere a moléculas capaces de reducir contenido de melanina celular; en particular a reducir el contenido de melanina para aplicaciones en campos tales como aclaramiento de la piel. Existe una necesidad continua para nuevos agentes cosméticos aclaradores de la piel, con efectividad general mejorada. Por lo tanto, un objetivo de la presente invención es proporcionar un compuesto que actúa como un reducir de contenido de melanina. Se encuentra que compuestos de indolilo específicos pueden reducir el contenido de melanina en los melanocitos. Se describe el uso de un compuesto de fórmula (I) o una sal del mismo, para reducir el contenido de melanina celular de piel humana, donde (i) R es: (a) - (CH2)n - A, donde n = 1 hasta 6 y A es -OH o -NH2; o (b)- O - (CH2)n - X, donde n = 1 hasta 5 y X es un halógeno; (ii) R2 es grupo -H, alquilo, n-hexilo, arilo, alcoxi o ariloxi; y (iii) R3 es grupo -H, alquilo, arilo, alcoxi o ariloxi. (ver Fórmula).
MX2019002572A 2016-09-06 2017-08-14 Compuestos para reducir el contenido de melanina celular. MX2019002572A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16187446 2016-09-06
PCT/EP2017/070550 WO2018046243A1 (en) 2016-09-06 2017-08-14 Compounds for reducing cellular melanin content

Publications (1)

Publication Number Publication Date
MX2019002572A true MX2019002572A (es) 2019-06-06

Family

ID=56920514

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019002572A MX2019002572A (es) 2016-09-06 2017-08-14 Compuestos para reducir el contenido de melanina celular.

Country Status (4)

Country Link
EP (1) EP3509566B1 (es)
CN (1) CN109661224B (es)
MX (1) MX2019002572A (es)
WO (1) WO2018046243A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021037759A1 (en) * 2019-08-28 2021-03-04 Unilever Global Ip Limited Novel compounds for skin lightening
WO2023191901A1 (en) * 2022-03-31 2023-10-05 Agarwal Neeru Topical compositions for tanscreen comprising ecamsule and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5578159A (en) 1978-12-06 1980-06-12 Sadahatsu Araki Intake air cleaner for engine
FR2751535B1 (fr) * 1996-07-25 1998-11-27 Oreal Utilisation de derives de la melatonine pour la la depigmentation de la peau et compositions les comprenant
WO1998006695A1 (fr) * 1996-08-09 1998-02-19 Sederma S.A. Derives de la melatonine et leur utilisation dans les compositions cosmetiques ou dermopharmaceutiques
EP1267868B1 (en) 2000-02-29 2007-07-18 MediQuest Therapeutics, Inc. Inhibitors of melanocyte tyrosinase as topical skin lighteners
FR2845599B1 (fr) 2002-10-11 2005-01-07 Lmd Medicament comprenant une thiouree pour son utilisation en tant que depigmentant
CN1903203A (zh) 2005-07-26 2007-01-31 复旦大学 多取代酰基硫脲嘧啶衍生物在制备抗病毒药物中的用途
EP2196190A1 (en) * 2008-12-09 2010-06-16 Cognis IP Management GmbH Skin whitening
JP5737176B2 (ja) * 2009-03-25 2015-06-17 味の素株式会社 新規アミド誘導体および美白剤
FI121484B (fi) 2009-03-30 2010-11-30 Waertsilae Finland Oy Sovitelma ja menetelmä mäntämoottorin värähtelyn vaimentamiseksi sekä mäntämoottori
DE102013204070A1 (de) * 2013-03-11 2014-09-11 Beiersdorf Ag Verwendung kosmetisch oder dermatologisch unbedenklicher substituierter Michael-Akzeptoren zur Verhinderung, Verminderung oder Prophylaxe der Tyrosinaseaktivität der menschlichen Haut und/oder deren Aufhellung
EA032573B1 (ru) * 2014-12-30 2019-06-28 Юнилевер Н.В. Композиция для осветления кожи, содержащая 4-гексилрезорцин и иломастат

Also Published As

Publication number Publication date
EP3509566B1 (en) 2020-11-04
CN109661224B (zh) 2022-05-24
CN109661224A (zh) 2019-04-19
WO2018046243A1 (en) 2018-03-15
EP3509566A1 (en) 2019-07-17

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