MX2019002526A - Agente terapeutico para trastornos de queratoconjuntivitis. - Google Patents
Agente terapeutico para trastornos de queratoconjuntivitis.Info
- Publication number
- MX2019002526A MX2019002526A MX2019002526A MX2019002526A MX2019002526A MX 2019002526 A MX2019002526 A MX 2019002526A MX 2019002526 A MX2019002526 A MX 2019002526A MX 2019002526 A MX2019002526 A MX 2019002526A MX 2019002526 A MX2019002526 A MX 2019002526A
- Authority
- MX
- Mexico
- Prior art keywords
- therapeutic agent
- corneal
- disorders
- keratoconjunctive
- keratitis
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 7
- 229940124597 therapeutic agent Drugs 0.000 title abstract 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 5
- 208000035475 disorder Diseases 0.000 abstract 5
- 206010023332 keratitis Diseases 0.000 abstract 4
- 206010010741 Conjunctivitis Diseases 0.000 abstract 3
- 208000003556 Dry Eye Syndromes Diseases 0.000 abstract 2
- 206010013774 Dry eye Diseases 0.000 abstract 2
- 230000007547 defect Effects 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 230000002458 infectious effect Effects 0.000 abstract 2
- 230000037390 scarring Effects 0.000 abstract 2
- 206010011013 Corneal erosion Diseases 0.000 abstract 1
- 208000035874 Excoriation Diseases 0.000 abstract 1
- 208000009319 Keratoconjunctivitis Sicca Diseases 0.000 abstract 1
- 206010037508 Punctate keratitis Diseases 0.000 abstract 1
- 206010064996 Ulcerative keratitis Diseases 0.000 abstract 1
- 238000005299 abrasion Methods 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 208000021921 corneal disease Diseases 0.000 abstract 1
- 201000007717 corneal ulcer Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 201000010666 keratoconjunctivitis Diseases 0.000 abstract 1
- 230000002085 persistent effect Effects 0.000 abstract 1
- 201000003826 superficial keratitis Diseases 0.000 abstract 1
- 208000024205 superior limbic keratoconjunctivitis Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Dermatology (AREA)
Abstract
La invención actual aborda el problema de proporcionar un agente terapéutico novedoso para trastornos de queratoconjuntivitis. Como un medio para solucionar el problema, se proporciona un agente terapéutico para trastornos de queratoconjuntivitis que contiene un agonista RAR? como un ingrediente activo. El agente terapéutico exhibe un efecto de aminoración excelente en un modelo de trastorno de queratoconjuntivitis, y por lo tanto es útil como un agente terapéutico para trastornos de queratoconjuntivitis tales como úlcera de córnea, abrasión epitelial de córnea, queratitis, ojo seco, conjuntivitis, queratitis superficial crónica, erosión de córnea, trastornos persistentes de córnea, queratopatía punteada superficial, defectos epiteliales de la córnea, defectos epiteliales conjuntivales, queratoconjuntivitis seca, queratoconjuntivitis límbica superior, queratoconjuntivitis filamentosa, queratitis infecciosa, queratitis no infecciosa, conjuntivitis infecciosa y conjuntivitis no infecciosa. El agente terapéutico también es útil como un agente terapéutico para cicatrizado de córnea y cicatrizado conjuntival, ambos asociados con trastornos de queratoconjuntivitis.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012246373 | 2012-11-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019002526A true MX2019002526A (es) | 2019-07-15 |
Family
ID=50684334
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015005842A MX363111B (es) | 2012-11-08 | 2013-11-07 | Agente terapeutico para trastornos de queratoconjuntivitis. |
MX2019002526A MX2019002526A (es) | 2012-11-08 | 2015-05-08 | Agente terapeutico para trastornos de queratoconjuntivitis. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015005842A MX363111B (es) | 2012-11-08 | 2013-11-07 | Agente terapeutico para trastornos de queratoconjuntivitis. |
Country Status (17)
Country | Link |
---|---|
US (6) | US9492431B2 (es) |
EP (1) | EP2918290B1 (es) |
JP (3) | JP6254529B2 (es) |
KR (1) | KR102173932B1 (es) |
CN (2) | CN105188753B (es) |
AU (2) | AU2013342882B2 (es) |
BR (1) | BR112015010428B1 (es) |
CA (1) | CA2890424C (es) |
CL (2) | CL2015001225A1 (es) |
ES (1) | ES2834111T3 (es) |
HK (1) | HK1219224A1 (es) |
MX (2) | MX363111B (es) |
NZ (1) | NZ708756A (es) |
RU (1) | RU2659203C2 (es) |
SG (2) | SG10201704687YA (es) |
WO (1) | WO2014073209A1 (es) |
ZA (1) | ZA201504065B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014073209A1 (ja) | 2012-11-08 | 2014-05-15 | 国立大学法人山口大学 | 角結膜障害の治療剤 |
EP2740485B1 (en) * | 2012-12-07 | 2018-10-31 | Brightpulse Holding LTD. | Protein slurp-1 for use in the treatment of ocular diseases |
MX362239B (es) | 2013-05-22 | 2019-01-09 | Univ Yamaguchi | Uso del a´cido (e)-4-(2-{3-[ (1h-pirazol-1-il)metil]-5,5,8,8- tetrametil-5,6,7,8-tetrahidronaftalen-2-il}vinil)benzoico en el tratamiento de trastornos retinocoroidales. |
IL295440A (en) | 2016-06-08 | 2022-10-01 | Clementia Pharmaceuticals Inc | Methods for the treatment of heterotopic aggravation |
EA039050B1 (ru) | 2016-11-16 | 2021-11-26 | Клементиа Фармасьютикалс Инк. | Способы лечения множественного остеохондроматоза (мо) |
Family Cites Families (34)
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WO1994015902A1 (en) | 1993-01-11 | 1994-07-21 | Ligand Pharmaceuticals Inc. | Compounds having selectivity for retinoid x receptors |
US5824685A (en) | 1995-02-01 | 1998-10-20 | The Johns Hopkins University School Of Medicine | Method of preventing proliferation of retinal pigment epithelium by retinoic acid receptor agonists |
US5624957A (en) * | 1995-06-06 | 1997-04-29 | Bristol-Myers Squibb Company | Rary-specific retinobenzoic acid derivatives |
US5919970A (en) | 1997-04-24 | 1999-07-06 | Allergan Sales, Inc. | Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity |
US7514074B2 (en) | 1997-07-14 | 2009-04-07 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
US6204288B1 (en) * | 1999-03-08 | 2001-03-20 | The University Of Mississippi | 1,2-dithiolane derivatives |
US20030114482A1 (en) | 1999-12-15 | 2003-06-19 | Maurizio Pacifici | Use of retinoid receptor antagonists or agonists in the treatment of cartilage and bone pathologies |
US6313168B1 (en) | 1999-12-15 | 2001-11-06 | Allergan Sales, Inc. | Use of retinoid receptor antagonists in the treatment of cartilage and bone pathologies |
EP1265637A2 (en) | 2000-03-14 | 2002-12-18 | The University Of Western Ontario | Compositions and methods for affecting osteogenesis |
DK1324970T3 (da) * | 2000-10-02 | 2009-01-05 | Hoffmann La Roche | Retinoider til behandling af emfysem |
CN1283621C (zh) | 2001-09-18 | 2006-11-08 | 霍夫曼-拉罗奇有限公司 | 烷基脲的类维生素a激动剂ⅰ |
CN1301968C (zh) | 2001-09-18 | 2007-02-28 | 霍夫曼-拉罗奇有限公司 | 取代的脲的类维生素a激动剂ⅱ |
AUPR892501A0 (en) | 2001-11-16 | 2001-12-13 | Peter Maccallum Cancer Institute, The | Method of enhancing self renewal of stem cells and uses thereof |
US20050101581A1 (en) | 2002-08-28 | 2005-05-12 | Reading Christopher L. | Therapeutic treatment methods 2 |
JP2005206544A (ja) | 2004-01-23 | 2005-08-04 | Yasuyoshi Uchida | 筋肉再生剤 |
AU2005240078A1 (en) * | 2004-04-30 | 2005-11-17 | Allergan, Inc. | Retinoid-containing sustained release intraocular drug delivery systems and related methods of manufacturing |
AU2006227623B2 (en) | 2005-03-17 | 2011-10-20 | Elan Pharma International Limited | Injectable compositions of nanoparticulate immunosuppressive compounds |
US7345931B2 (en) | 2005-08-01 | 2008-03-18 | Infineon Technologies Ag | Maintaining internal voltages of an integrated circuit in response to a clocked standby mode |
US20090281184A1 (en) | 2005-09-27 | 2009-11-12 | Sapporo Medical University | Pharmaceutical for prevention and treatment of ophthalmic disease induced by in-crease in vasopermeability |
AU2007233868A1 (en) | 2006-03-31 | 2007-10-11 | F. Hoffmann-La Roche Ag | Process for preparing retinoid compounds |
TR201819157T4 (tr) | 2006-05-16 | 2019-01-21 | Io Therapeutics Llc | Kemoterapi Ve Veya Radyasyon Terapisinin Yan Etkilerinin Tedavisinde Kullanıma Yönelik Rar Antagonisti Veya Ters Agonisti |
US8444970B2 (en) * | 2006-10-27 | 2013-05-21 | Lpath, Inc. | Compositions and methods for treating ocular diseases and conditions |
US20100222304A1 (en) | 2006-11-02 | 2010-09-02 | Lillian W Chiang | Methods of Treating Neuropathic Pain by Modulation of Glycogenolysis or Glycolysis |
US9119777B2 (en) | 2008-05-30 | 2015-09-01 | Microdose Therapeutx, Inc. | Methods and compositions for administration of oxybutynin |
JP2009235031A (ja) * | 2008-03-28 | 2009-10-15 | Nano Egg:Kk | 角膜組織の再生促進剤 |
EP2379174A4 (en) | 2008-12-18 | 2012-11-14 | Astrazeneca Ab | PHARMACEUTICAL PRODUCT USING A P38 KINASE INHIBITOR AND A SECOND ACTIVE SUBSTANCE |
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DK2613776T3 (da) | 2010-09-01 | 2020-10-19 | Univ Jefferson | Sammensætning og fremgangsmåde til muskelreparation og -regenerering |
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WO2012125724A1 (en) | 2011-03-14 | 2012-09-20 | Beth Israel Deaconess Medical Center | Methods and compositions for the treatment of proliferative disorders |
WO2012129562A2 (en) | 2011-03-24 | 2012-09-27 | The Scripps Research Institute | Compounds and methods for inducing chondrogenesis |
US8772273B2 (en) * | 2011-10-04 | 2014-07-08 | Quretino Therapeutics, Inc. | Formulations and uses of retinoic acid receptor selective agonists |
WO2014073209A1 (ja) * | 2012-11-08 | 2014-05-15 | 国立大学法人山口大学 | 角結膜障害の治療剤 |
MX362239B (es) | 2013-05-22 | 2019-01-09 | Univ Yamaguchi | Uso del a´cido (e)-4-(2-{3-[ (1h-pirazol-1-il)metil]-5,5,8,8- tetrametil-5,6,7,8-tetrahidronaftalen-2-il}vinil)benzoico en el tratamiento de trastornos retinocoroidales. |
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2013
- 2013-11-07 WO PCT/JP2013/006563 patent/WO2014073209A1/ja active Application Filing
- 2013-11-07 AU AU2013342882A patent/AU2013342882B2/en active Active
- 2013-11-07 CN CN201380069723.0A patent/CN105188753B/zh active Active
- 2013-11-07 JP JP2014545578A patent/JP6254529B2/ja active Active
- 2013-11-07 KR KR1020157013042A patent/KR102173932B1/ko active IP Right Grant
- 2013-11-07 US US14/440,832 patent/US9492431B2/en active Active
- 2013-11-07 CN CN201811479227.3A patent/CN109589324B/zh active Active
- 2013-11-07 BR BR112015010428A patent/BR112015010428B1/pt active IP Right Grant
- 2013-11-07 ES ES13854101T patent/ES2834111T3/es active Active
- 2013-11-07 MX MX2015005842A patent/MX363111B/es unknown
- 2013-11-07 SG SG10201704687YA patent/SG10201704687YA/en unknown
- 2013-11-07 SG SG11201503612QA patent/SG11201503612QA/en unknown
- 2013-11-07 NZ NZ708756A patent/NZ708756A/en unknown
- 2013-11-07 RU RU2015121628A patent/RU2659203C2/ru active
- 2013-11-07 CA CA2890424A patent/CA2890424C/en active Active
- 2013-11-07 EP EP13854101.6A patent/EP2918290B1/en active Active
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2015
- 2015-05-07 CL CL2015001225A patent/CL2015001225A1/es unknown
- 2015-05-08 MX MX2019002526A patent/MX2019002526A/es active IP Right Grant
- 2015-06-05 ZA ZA2015/04065A patent/ZA201504065B/en unknown
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2016
- 2016-06-22 HK HK16107218.3A patent/HK1219224A1/zh unknown
- 2016-10-14 US US15/293,548 patent/US9750721B2/en active Active
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2017
- 2017-07-20 US US15/655,418 patent/US10016395B2/en active Active
- 2017-11-30 JP JP2017230426A patent/JP6462836B2/ja active Active
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2018
- 2018-06-14 US US16/008,730 patent/US10537556B2/en active Active
- 2018-07-13 CL CL2018001915A patent/CL2018001915A1/es unknown
- 2018-08-13 AU AU2018217197A patent/AU2018217197B2/en active Active
- 2018-12-27 JP JP2018244364A patent/JP6744389B2/ja active Active
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2019
- 2019-12-02 US US16/700,866 patent/US11471440B2/en active Active
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2022
- 2022-09-07 US US17/939,198 patent/US20230255937A1/en active Pending
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