MX2019002020A - Agonistas y composiciones del receptor 5-ht2c y métodos de uso. - Google Patents
Agonistas y composiciones del receptor 5-ht2c y métodos de uso.Info
- Publication number
- MX2019002020A MX2019002020A MX2019002020A MX2019002020A MX2019002020A MX 2019002020 A MX2019002020 A MX 2019002020A MX 2019002020 A MX2019002020 A MX 2019002020A MX 2019002020 A MX2019002020 A MX 2019002020A MX 2019002020 A MX2019002020 A MX 2019002020A
- Authority
- MX
- Mexico
- Prior art keywords
- disorders
- ht2c receptor
- compositions
- antipsychotic
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Addiction (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención se refiere a los compuestos de la Fórmula A y composiciones farmacéuticas de estos que modulan la actividad del receptor 5-HT2C. Los compuestos de la presente invención y composiciones farmacéuticas de estos se refieren a métodos útiles en el tratamiento de un trastorno mediado por el receptor 5-HT2C, tal como, el control del peso, la inducción de la saciedad y la disminución de la ingesta de alimentos, y para la prevención y el tratamiento de la obesidad, el aumento de peso inducido por antipsicóticos, la diabetes tipo 2, el síndrome de Prader-Willi, la dependencia al tabaco/nicotina, la adicción a las drogas, la adicción al alcohol y similares, trastornos del espectro obsesivo-compulsivo y trastornos del control de impulsos (que incluye morderse las uñas y onicofagia), trastornos del sueño, incontinencia urinaria, trastornos psiquiátricos (que incluyen esquizofrenia, anorexia nerviosa y bulimia nerviosa), enfermedad de Alzheimer, disfunción eréctil, epilepsia, trastornos motores (que incluyen parkinsonismo y trastornos motores inducidos por antipsicóticos), hipertensión, dislipidemia, enfermedad del hígado graso no alcohólico, enfermedad renal asociada a la obesidad y apnea del sueño. También se proporcionan composiciones que comprenden un compuesto de la presente, opcionalmente combinado con un agente complementario.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662377119P | 2016-08-19 | 2016-08-19 | |
| PCT/US2017/047644 WO2018035477A1 (en) | 2016-08-19 | 2017-08-18 | 5-ht2c receptor agonists and compositions and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019002020A true MX2019002020A (es) | 2019-11-25 |
Family
ID=59799461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019002020A MX2019002020A (es) | 2016-08-19 | 2017-08-18 | Agonistas y composiciones del receptor 5-ht2c y métodos de uso. |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10836764B2 (es) |
| EP (1) | EP3500570B1 (es) |
| JP (1) | JP6977024B2 (es) |
| KR (1) | KR20190049732A (es) |
| CN (1) | CN109952301B (es) |
| AU (1) | AU2017313908C1 (es) |
| BR (1) | BR112019003142A2 (es) |
| CA (1) | CA3033142A1 (es) |
| EA (1) | EA038219B1 (es) |
| IL (1) | IL264682B (es) |
| MA (1) | MA45987A (es) |
| MX (1) | MX2019002020A (es) |
| NZ (1) | NZ750469A (es) |
| WO (1) | WO2018035477A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109952301B (zh) * | 2016-08-19 | 2022-03-25 | 艾尼纳制药公司 | 5-ht2c受体激动剂和组合物及使用方法 |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| WO2019131902A1 (ja) | 2017-12-27 | 2019-07-04 | 武田薬品工業株式会社 | 腹圧性尿失禁および便失禁の治療薬 |
| EP3860996A4 (en) | 2018-10-02 | 2022-08-31 | Northwestern University | BETA-CARBOLINES AS POSITIVE ALLOSTERIC MODULATORS OF HUMAN SEROTONIN RECEPTOR 2C (5-HT2C) |
| CN114206349A (zh) | 2019-04-17 | 2022-03-18 | 指南针探路者有限公司 | 治疗神经认知障碍、慢性疼痛及减轻炎症的方法 |
| US20230277568A1 (en) * | 2020-07-10 | 2023-09-07 | Eleusis Therapeutics Us, Inc. | Method of treatment for psilocybin or psilocin infusion |
| US11312684B1 (en) | 2021-02-10 | 2022-04-26 | Eleusis Therapeutics Us, Inc. | Pharmaceutically acceptable salts of psilocin and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4597961A (en) | 1985-01-23 | 1986-07-01 | Etscorn Frank T | Transcutaneous application of nicotine |
| US4920989A (en) | 1985-04-25 | 1990-05-01 | Regents Of The University Of California | Method and apparatus for aiding in the reduction of incidence of tobacco smoking |
| IL86170A (en) | 1987-05-01 | 1992-12-01 | Elan Transdermal Ltd | Preparations and compositions comprising nicotine for percutaneous administration |
| US5004610A (en) | 1988-06-14 | 1991-04-02 | Alza Corporation | Subsaturated nicotine transdermal therapeutic system |
| WO1992001029A1 (en) | 1990-07-03 | 1992-01-23 | Quaker Chemical Corporation | Aqueous coolant |
| WO1992018005A1 (en) | 1991-04-16 | 1992-10-29 | National Institutes Of Health | Method of treating trichotillomania and onychophagia |
| WO2003086303A2 (en) | 2002-04-12 | 2003-10-23 | The University Of Chicago | Farnesoid x-activated receptor agonists |
| US20100266504A1 (en) * | 2007-11-15 | 2010-10-21 | Takahiro Matsumoto | Condensed pyridine derivative and use thereof |
| US8518933B2 (en) * | 2009-04-23 | 2013-08-27 | Abbvie Inc. | Modulators of 5-HT receptors and methods of use thereof |
| KR20180118801A (ko) * | 2010-09-01 | 2018-10-31 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 체중 관리에 유용한 5-ｈｔ2ｃ 작동제의 변형-방출 투여 형태 |
| WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
| WO2015161287A1 (en) * | 2014-04-17 | 2015-10-22 | G1 Therapeutics, Inc. | Tricyclic lactams for use in the protection of normal cells during chemotherapy |
| CN109952301B (zh) * | 2016-08-19 | 2022-03-25 | 艾尼纳制药公司 | 5-ht2c受体激动剂和组合物及使用方法 |
-
2017
- 2017-08-18 CN CN201780062933.5A patent/CN109952301B/zh active Active
- 2017-08-18 MX MX2019002020A patent/MX2019002020A/es unknown
- 2017-08-18 CA CA3033142A patent/CA3033142A1/en active Pending
- 2017-08-18 BR BR112019003142-1A patent/BR112019003142A2/pt active Search and Examination
- 2017-08-18 US US16/326,522 patent/US10836764B2/en active Active
- 2017-08-18 WO PCT/US2017/047644 patent/WO2018035477A1/en unknown
- 2017-08-18 AU AU2017313908A patent/AU2017313908C1/en not_active Ceased
- 2017-08-18 JP JP2019509528A patent/JP6977024B2/ja active Active
- 2017-08-18 NZ NZ750469A patent/NZ750469A/en not_active IP Right Cessation
- 2017-08-18 MA MA045987A patent/MA45987A/fr unknown
- 2017-08-18 KR KR1020197007503A patent/KR20190049732A/ko not_active Application Discontinuation
- 2017-08-18 EA EA201990527A patent/EA038219B1/ru not_active IP Right Cessation
- 2017-08-18 EP EP17762266.9A patent/EP3500570B1/en active Active
-
2019
- 2019-02-06 IL IL264682A patent/IL264682B/en unknown
-
2020
- 2020-10-19 US US17/073,458 patent/US11608339B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN109952301B (zh) | 2022-03-25 |
| AU2017313908B2 (en) | 2021-10-21 |
| NZ750469A (en) | 2023-03-31 |
| WO2018035477A1 (en) | 2018-02-22 |
| AU2017313908C1 (en) | 2022-06-09 |
| EP3500570B1 (en) | 2022-10-05 |
| EP3500570A1 (en) | 2019-06-26 |
| AU2017313908A1 (en) | 2019-02-28 |
| JP2019524844A (ja) | 2019-09-05 |
| EA201990527A1 (ru) | 2019-07-31 |
| CA3033142A1 (en) | 2018-02-22 |
| US20190225612A1 (en) | 2019-07-25 |
| US20210214355A1 (en) | 2021-07-15 |
| US11608339B2 (en) | 2023-03-21 |
| EA038219B1 (ru) | 2021-07-26 |
| CN109952301A (zh) | 2019-06-28 |
| JP6977024B2 (ja) | 2021-12-08 |
| MA45987A (fr) | 2019-06-26 |
| US10836764B2 (en) | 2020-11-17 |
| KR20190049732A (ko) | 2019-05-09 |
| BR112019003142A2 (pt) | 2019-05-21 |
| IL264682B (en) | 2021-08-31 |
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