MX2019000501A - Vetiver. - Google Patents

Vetiver.

Info

Publication number
MX2019000501A
MX2019000501A MX2019000501A MX2019000501A MX2019000501A MX 2019000501 A MX2019000501 A MX 2019000501A MX 2019000501 A MX2019000501 A MX 2019000501A MX 2019000501 A MX2019000501 A MX 2019000501A MX 2019000501 A MX2019000501 A MX 2019000501A
Authority
MX
Mexico
Prior art keywords
polypeptide
isovalencene
spirovetiva
valencene
sesquiterpenes
Prior art date
Application number
MX2019000501A
Other languages
English (en)
Inventor
Schalk Michel
Rocci Letizia
Original Assignee
Firmenich & Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1612609.6A external-priority patent/GB201612609D0/en
Application filed by Firmenich & Cie filed Critical Firmenich & Cie
Publication of MX2019000501A publication Critical patent/MX2019000501A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
    • C12Y106/02—Oxidoreductases acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C12Y106/02004—NADPH-hemoprotein reductase (1.6.2.4), i.e. NADP-cytochrome P450-reductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03073—Valencene synthase (4.2.3.73)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03113—Terpinolene synthase (4.2.3.113)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se proporciona un método para producir uno o más compuestos de sesquiterpeno que comprende: poner en contacto un precursor de FPP acíclico con un polipéptido que tiene una actividad de terpeno sintasa, en donde el polipéptido comprende una secuencia de los aminoácidos que tiene al menos 55 % de identidad de la secuencia con la SEC ID NO:1, para producir uno o más terpenos seleccionados del grupo que consiste de isovalenceno, espirovetiva-1(10),7(11)-dieno y valenceno o derivados de los mismos, o una mezcla de sesquiterpenos que comprende uno o más del isovalenceno, espirovetiva-1(10),7(11)-dieno y/o valenceno; y aislar opcionalmente uno o más terpenos de la mezcla. También se describe un ácido nucleico derivado de Vetiveria zizanoides que codifica un polipéptido que tiene una actividad de sesquiterpeno sintasa, un polipéptido que se puede usar para producir uno o más sesquiterpenos o una mezcla de sesquiterpenos que comprende uno o más del isovalenceno, espirovetiva-1(10),7(11)-dieno y/o valenceno, y una célula u organismo no humano que comprende el ácido nucleico o que comprende un vector de expresión que comprende el ácido nucleico.
MX2019000501A 2016-07-20 2017-07-19 Vetiver. MX2019000501A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1612609.6A GB201612609D0 (en) 2016-07-20 2016-07-20 Vetivier
EP17159264 2017-03-03
PCT/EP2017/068268 WO2018015453A2 (en) 2016-07-20 2017-07-19 Vetiver

Publications (1)

Publication Number Publication Date
MX2019000501A true MX2019000501A (es) 2019-03-28

Family

ID=59523078

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019000501A MX2019000501A (es) 2016-07-20 2017-07-19 Vetiver.

Country Status (7)

Country Link
US (1) US11293040B2 (es)
EP (1) EP3488008A2 (es)
JP (1) JP7026671B2 (es)
CN (1) CN109477120B (es)
BR (1) BR112019000892A2 (es)
MX (1) MX2019000501A (es)
WO (1) WO2018015453A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019141739A1 (en) * 2018-01-18 2019-07-25 Firmenich Sa Cytochrome p450 monooxygenase catalyzed oxidation of sesquiterpenes
CN110305855B (zh) * 2019-06-26 2022-03-22 昆明理工大学 天麻GeCPR基因及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2954889A1 (en) * 2001-03-09 2002-09-19 University Of Kentucky Research Foundation Cytochrome p450s and uses thereof
EP2311940B1 (en) * 2005-06-17 2017-08-09 Firmenich SA Novel sesquiterpene synthases and methods of their use
HUE033564T2 (hu) * 2009-05-20 2017-12-28 Firmenich & Cie Eljárás (+)-zizaen elõállítására
EP2537926A1 (en) * 2011-06-21 2012-12-26 Isobionics B.V. Valencene synthase
MX2016003431A (es) * 2013-09-19 2016-06-30 Firmenich & Cie Metodo para producir alcoholes fragantes.
US10934564B2 (en) * 2014-08-21 2021-03-02 Manus Bio Inc. Methods for production of oxygenated terpenes

Also Published As

Publication number Publication date
CN109477120A (zh) 2019-03-15
JP7026671B2 (ja) 2022-02-28
JP2019524104A (ja) 2019-09-05
US11293040B2 (en) 2022-04-05
EP3488008A2 (en) 2019-05-29
WO2018015453A2 (en) 2018-01-25
BR112019000892A2 (pt) 2019-04-30
CN109477120B (zh) 2023-06-30
WO2018015453A3 (en) 2018-03-08
US20200308612A1 (en) 2020-10-01

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