MX2019000384A - Metodo para producir una forma polimorfica de 3-[5-amino-4-(3-cianobenzoilo)-pirazol-1-il]-n-ciclopropil-4-meti lbenzamida. - Google Patents

Metodo para producir una forma polimorfica de 3-[5-amino-4-(3-cianobenzoilo)-pirazol-1-il]-n-ciclopropil-4-meti lbenzamida.

Info

Publication number
MX2019000384A
MX2019000384A MX2019000384A MX2019000384A MX2019000384A MX 2019000384 A MX2019000384 A MX 2019000384A MX 2019000384 A MX2019000384 A MX 2019000384A MX 2019000384 A MX2019000384 A MX 2019000384A MX 2019000384 A MX2019000384 A MX 2019000384A
Authority
MX
Mexico
Prior art keywords
methylbenzamide
pyrazol
cyclopropyl
amino
cyanob
Prior art date
Application number
MX2019000384A
Other languages
English (en)
Inventor
Suleiman Osama
Romero Perez Lucia
Stephan Harlacher Cornelius
Jones Stewart
Original Assignee
Mereo Biopharma 1 Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mereo Biopharma 1 Ltd filed Critical Mereo Biopharma 1 Ltd
Publication of MX2019000384A publication Critical patent/MX2019000384A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Esta invención se refiere a un proceso para la preparación de la Forma B de 3-[5-amino-4-(3-cianobenzoil)pirazol-1-iI]-N-ciclopropi l-4-metilbenzamida. En la presente también se describe la Forma B de 3-[5-amino-4-(3-cianobenzoil)-pirazol-1-il]-N-ciclopropil-4-met ilbenzamida, o composiciones farmacéuticas de la misma, que se pueden obtener mediante el procedimiento descrito en la presente.
MX2019000384A 2016-07-14 2017-07-13 Metodo para producir una forma polimorfica de 3-[5-amino-4-(3-cianobenzoilo)-pirazol-1-il]-n-ciclopropil-4-meti lbenzamida. MX2019000384A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1612238.4A GB201612238D0 (en) 2016-07-14 2016-07-14 Method for producing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-Yl]-n-cyclopropyl-4-methylbenzamide
PCT/GB2017/052055 WO2018011578A1 (en) 2016-07-14 2017-07-13 Method for producing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide

Publications (1)

Publication Number Publication Date
MX2019000384A true MX2019000384A (es) 2019-05-23

Family

ID=56890595

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019000384A MX2019000384A (es) 2016-07-14 2017-07-13 Metodo para producir una forma polimorfica de 3-[5-amino-4-(3-cianobenzoilo)-pirazol-1-il]-n-ciclopropil-4-meti lbenzamida.

Country Status (19)

Country Link
US (1) US10995071B2 (es)
EP (1) EP3484853B9 (es)
JP (1) JP7094020B2 (es)
KR (1) KR102460533B1 (es)
CN (1) CN109415325B (es)
AU (1) AU2017294642B2 (es)
BR (1) BR112019000540A2 (es)
CA (1) CA3030617C (es)
DK (1) DK3484853T5 (es)
ES (1) ES2879608T3 (es)
GB (1) GB201612238D0 (es)
HU (1) HUE054686T2 (es)
IL (1) IL263900B (es)
MX (1) MX2019000384A (es)
PL (1) PL3484853T3 (es)
PT (1) PT3484853T (es)
RU (1) RU2765719C2 (es)
SG (1) SG11201811517SA (es)
WO (1) WO2018011578A1 (es)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL139169A0 (en) * 1998-05-05 2001-11-25 Hoffmann La Roche Pyrazole derivatives as p-38 map kinase inhibitors
ATE517872T1 (de) 2003-06-26 2011-08-15 Novartis Ag Fünfgliedrige p38-kinaseinhibitoren auf heterocyclusbasis
DK2827860T3 (en) 2012-03-20 2016-12-12 Mereo Biopharma 1 Ltd USE OF A pyrazole derivative in the treatment of acute exacerbations of chronic obstructive pulmonary disease
RU2713203C1 (ru) 2016-03-08 2020-02-04 Мерео Байофарма 1 Лимитед Режим дозирования при лечении острых обострений хронической обструктивной болезни легких
WO2017153701A1 (en) 2016-03-08 2017-09-14 Mereo Biopharma 1 Limited Dosage regimen for the treatment of acute exacerbations of inflammatory conditions

Also Published As

Publication number Publication date
GB201612238D0 (en) 2016-08-31
HUE054686T2 (hu) 2021-09-28
KR20190027819A (ko) 2019-03-15
US10995071B2 (en) 2021-05-04
ES2879608T3 (es) 2021-11-22
US20190315694A1 (en) 2019-10-17
CA3030617A1 (en) 2018-01-18
RU2765719C2 (ru) 2022-02-02
CN109415325B (zh) 2022-04-01
AU2017294642A1 (en) 2019-01-17
SG11201811517SA (en) 2019-01-30
DK3484853T5 (da) 2021-09-06
IL263900A (en) 2019-01-31
EP3484853A1 (en) 2019-05-22
CA3030617C (en) 2024-02-20
DK3484853T3 (da) 2021-05-25
JP2019521133A (ja) 2019-07-25
PT3484853T (pt) 2021-05-25
IL263900B (en) 2022-04-01
BR112019000540A2 (pt) 2019-04-24
PL3484853T3 (pl) 2021-11-02
EP3484853B1 (en) 2021-04-21
JP7094020B2 (ja) 2022-07-01
CN109415325A (zh) 2019-03-01
EP3484853B9 (en) 2021-07-28
RU2019103879A (ru) 2020-08-14
WO2018011578A1 (en) 2018-01-18
RU2019103879A3 (es) 2020-08-14
AU2017294642B2 (en) 2021-03-04
KR102460533B1 (ko) 2022-10-31

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