MX2018011877A - Proceso mejorado para la preparacion de tartrato de butorfanol. - Google Patents

Proceso mejorado para la preparacion de tartrato de butorfanol.

Info

Publication number
MX2018011877A
MX2018011877A MX2018011877A MX2018011877A MX2018011877A MX 2018011877 A MX2018011877 A MX 2018011877A MX 2018011877 A MX2018011877 A MX 2018011877A MX 2018011877 A MX2018011877 A MX 2018011877A MX 2018011877 A MX2018011877 A MX 2018011877A
Authority
MX
Mexico
Prior art keywords
preparation
improved process
butorphanol tartrate
butorphanol
tartrate
Prior art date
Application number
MX2018011877A
Other languages
English (en)
Inventor
Bhalerao Rahul
Sridharan R
Sadashiv Kandre Shivaji
Suryakant Deore Ganesh
Shivajirao Kadam Kishorkumar
Mundhe Dharnidhar
Original Assignee
Hikal Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hikal Ltd filed Critical Hikal Ltd
Publication of MX2018011877A publication Critical patent/MX2018011877A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Abstract

La presente invención se refiere a un proceso mejorado para la preparación de Tartrato de butorfanol de fórmula (I),.
MX2018011877A 2016-03-29 2017-03-27 Proceso mejorado para la preparacion de tartrato de butorfanol. MX2018011877A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201621010777 2016-03-29
PCT/IN2017/050112 WO2017168444A1 (en) 2016-03-29 2017-03-27 An improved process for the preparation of butorphanol tartrate

Publications (1)

Publication Number Publication Date
MX2018011877A true MX2018011877A (es) 2019-03-06

Family

ID=59963601

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018011877A MX2018011877A (es) 2016-03-29 2017-03-27 Proceso mejorado para la preparacion de tartrato de butorfanol.

Country Status (12)

Country Link
US (1) US10544101B2 (es)
EP (1) EP3436425B1 (es)
JP (1) JP6980687B2 (es)
KR (1) KR20180129854A (es)
CN (1) CN109071414B (es)
AU (1) AU2017242268A1 (es)
CA (1) CA3019491A1 (es)
CL (1) CL2018002756A1 (es)
IL (1) IL261986B (es)
MX (1) MX2018011877A (es)
PH (1) PH12018550165A1 (es)
WO (1) WO2017168444A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109694348B (zh) * 2018-11-12 2022-07-05 江苏宝众宝达药业股份有限公司 一种右美沙芬中间体拆分母液中回收物料的消旋回收方法
CN112142668B (zh) * 2019-06-28 2022-06-21 苏州盛迪亚生物医药有限公司 一种酒石酸布托啡诺及其中间体的制备方法
CN112159356A (zh) * 2020-10-09 2021-01-01 赤峰艾克制药科技股份有限公司 一种氢溴酸右美沙芬中间体副产物的消旋回收方法
CN114685370A (zh) * 2020-12-25 2022-07-01 成都苑东生物制药股份有限公司 一种酒石酸布托啡诺晶型i及其制备方法和用途
CN116818928B (zh) * 2023-04-28 2024-04-19 杭州沐源生物医药科技有限公司 一种酒石酸布托啡诺注射液中杂质的分离检测方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH301668A (de) * 1949-07-29 1954-09-15 Hoffmann La Roche Verfahren zur Herstellung eines Morphinanabkömmlings.
US3775414A (en) * 1972-05-10 1973-11-27 Bristol Myers Co Process for the preparation of 14-hydroxymorphinan derivatives
US3980641A (en) * 1975-07-31 1976-09-14 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinans
US4058531A (en) * 1976-03-23 1977-11-15 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
US4139534A (en) * 1977-02-17 1979-02-13 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
CN102977021A (zh) * 2012-11-29 2013-03-20 威海迪之雅医药化工开发有限公司 一种氢溴酸右美沙芬的制备方法

Also Published As

Publication number Publication date
CL2018002756A1 (es) 2019-02-01
EP3436425A1 (en) 2019-02-06
EP3436425B1 (en) 2021-01-06
EP3436425A4 (en) 2019-09-04
US10544101B2 (en) 2020-01-28
IL261986A (en) 2018-10-31
KR20180129854A (ko) 2018-12-05
CA3019491A1 (en) 2017-10-05
JP6980687B2 (ja) 2021-12-15
US20190112273A1 (en) 2019-04-18
IL261986B (en) 2021-03-25
CN109071414B (zh) 2021-11-05
AU2017242268A1 (en) 2018-10-25
WO2017168444A1 (en) 2017-10-05
PH12018550165A1 (en) 2019-05-15
CN109071414A (zh) 2018-12-21
JP2019511508A (ja) 2019-04-25

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