MX2018011217A - Formulacion de fosfomicina para administracion parenteral. - Google Patents

Formulacion de fosfomicina para administracion parenteral.

Info

Publication number
MX2018011217A
MX2018011217A MX2018011217A MX2018011217A MX2018011217A MX 2018011217 A MX2018011217 A MX 2018011217A MX 2018011217 A MX2018011217 A MX 2018011217A MX 2018011217 A MX2018011217 A MX 2018011217A MX 2018011217 A MX2018011217 A MX 2018011217A
Authority
MX
Mexico
Prior art keywords
fosfomycin
parenteral administration
administration
formulations
pharmaceutically acceptable
Prior art date
Application number
MX2018011217A
Other languages
English (en)
Inventor
Georgopoulos Apostolos
Schifer Albert
ROUS Wolfgang
Original Assignee
Georgopoulos Apostolos
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgopoulos Apostolos filed Critical Georgopoulos Apostolos
Publication of MX2018011217A publication Critical patent/MX2018011217A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1468—Containers characterised by specific material properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/002—Compounding apparatus specially for enteral or parenteral nutritive solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0029—Parenteral nutrition; Parenteral nutrition compositions as drug carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

El campo de la presente invención es el de las formulaciones de fosfomicina para administración parenteral, en particular para administración intravenosa. Las formulaciones de la técnica anterior proveen fosfomicina como un polvo para ser diluido directamente antes de la administración. La finalidad de la invención es proveer una formulación de fosfomicina para administración parenteral que es más fácil de producir y administrar o que reduce el riesgo de lesiones por pinchazo para los profesionales de atención de la salud y los riesgos de salud para los pacientes (p. ej., debido a contaminación o dosis incorrectas) al impedir pasos de procesamiento adicionales. Durante el curso de la invención se observó sorprendentemente que la fosfomicina es mucho más estable en una solución acuosa de lo que se suponía comúnmente. Por lo tanto, la invención provee un contenedor cerrado que contiene una solución acuosa para administración parenteral, en donde por lo menos una sal de fosfomicina farmacéuticamente aceptable, en particular la sal disódica de fosfomicina, y un ácido farmacéuticamente aceptable, en particular ácido succínico, están disueltos en la solución. Los contenedores preferidos son ampolletas rompibles hechas de plástico o vidrio, viales perforables, bolsas para infusión o jeringas listas para inyección.
MX2018011217A 2016-03-16 2017-03-16 Formulacion de fosfomicina para administracion parenteral. MX2018011217A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16160698.3A EP3219305A1 (de) 2016-03-16 2016-03-16 Fosfomycin-formulierung zur parenteralen verabreichung
PCT/EP2017/056252 WO2017158099A1 (de) 2016-03-16 2017-03-16 Fosfomycin-formulierung zur parenteralen verabreichung

Publications (1)

Publication Number Publication Date
MX2018011217A true MX2018011217A (es) 2019-03-28

Family

ID=55637175

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018011217A MX2018011217A (es) 2016-03-16 2017-03-16 Formulacion de fosfomicina para administracion parenteral.

Country Status (21)

Country Link
US (2) US10675291B2 (es)
EP (3) EP3219305A1 (es)
JP (1) JP2019511573A (es)
KR (1) KR20180122346A (es)
CN (1) CN108883062A (es)
AU (1) AU2017235463A1 (es)
BR (1) BR112018068510A2 (es)
CA (1) CA3014503A1 (es)
CY (1) CY1123109T1 (es)
DK (1) DK3419598T3 (es)
ES (1) ES2771486T3 (es)
HR (1) HRP20200039T1 (es)
HU (1) HUE047900T2 (es)
LT (1) LT3419598T (es)
MX (1) MX2018011217A (es)
PL (1) PL3419598T3 (es)
PT (1) PT3419598T (es)
RS (1) RS59873B1 (es)
RU (1) RU2018134749A (es)
SI (1) SI3419598T1 (es)
WO (1) WO2017158099A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3219305A1 (de) * 2016-03-16 2017-09-20 Apostolos Georgopoulos Fosfomycin-formulierung zur parenteralen verabreichung
KR20210148496A (ko) * 2020-05-28 2021-12-08 제주대학교 산학협력단 포스포마이신을 이용한 멜라닌 저색소증 개선제 조성물
TWI796597B (zh) * 2020-09-21 2023-03-21 長庚大學 使用紫蘇之經水萃取的產物來對抗冠狀病毒感染的方法
EP4268805A1 (de) * 2022-04-29 2023-11-01 Apostolos Georgopoulos Fosfomycin-formulierung zur parenteralen verabreichung und herstellungsverfahren

Family Cites Families (19)

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DE3602145C1 (de) 1986-01-24 1993-04-15 Buender Glas Gmbh Ampulle auf Glas
DE3823428A1 (de) 1988-07-11 1990-01-18 Hansen Bernd Ampulle aus kunststoff
PL377761A1 (pl) 2003-01-09 2006-02-20 Baxter Healthcare S.A. Bezpieczny pojemnik do substancji biologicznie czynnych i sposób jego wytwarzania
JP2007502329A (ja) * 2003-05-23 2007-02-08 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド セルトラリン組成物
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CH697917B1 (de) 2007-09-21 2012-03-30 Franz Dr Marschall Verpackungseinheit zur Bereitstellung einer parenteral verabreichbaren, pharmakologisch akzeptablen pharmazeutischen Formulierung.
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AU2009307875A1 (en) 2008-10-21 2010-04-29 Gilead Sciences, Inc. Fosfomycin/tobramycin combinations for the treatment and prevention of ophthalmic, otological and dermatological infections
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EA021876B1 (ru) 2010-09-20 2015-09-30 ЛИМОНОВ, Виктор Львович Фармацевтическая композиция антимикробного и противовоспалительного действия для парентерального введения, способ ее получения
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TWI571259B (zh) * 2013-03-15 2017-02-21 卡帝俄斯製藥公司 胺基糖苷及磷黴素組合之改良調配物及用於治療呼吸器相關性肺炎（ｖａｐ）與呼吸器相關性氣管（ｖａｔ）支氣管炎之方法及系統
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EP3219305A1 (de) * 2016-03-16 2017-09-20 Apostolos Georgopoulos Fosfomycin-formulierung zur parenteralen verabreichung

Also Published As

Publication number Publication date
EP3603618A1 (de) 2020-02-05
PL3419598T3 (pl) 2020-05-18
ES2771486T3 (es) 2020-07-06
EP3219305A1 (de) 2017-09-20
US20190070202A1 (en) 2019-03-07
CA3014503A1 (en) 2017-09-21
RU2018134749A (ru) 2020-04-16
SI3419598T1 (sl) 2020-03-31
LT3419598T (lt) 2020-02-10
PT3419598T (pt) 2020-02-18
EP3419598A1 (de) 2019-01-02
KR20180122346A (ko) 2018-11-12
HUE047900T2 (hu) 2020-05-28
HRP20200039T1 (hr) 2020-05-29
BR112018068510A2 (pt) 2021-04-13
AU2017235463A1 (en) 2018-09-27
DK3419598T3 (da) 2020-02-10
US20200261478A1 (en) 2020-08-20
JP2019511573A (ja) 2019-04-25
US10993951B2 (en) 2021-05-04
RS59873B1 (sr) 2020-03-31
US10675291B2 (en) 2020-06-09
RU2018134749A3 (es) 2020-05-21
WO2017158099A1 (de) 2017-09-21
CN108883062A (zh) 2018-11-23
EP3419598B1 (de) 2019-11-06
CY1123109T1 (el) 2021-10-29

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