MX2018004338A - Proceso para sintesis de pirfenidona. - Google Patents

Proceso para sintesis de pirfenidona.

Info

Publication number
MX2018004338A
MX2018004338A MX2018004338A MX2018004338A MX2018004338A MX 2018004338 A MX2018004338 A MX 2018004338A MX 2018004338 A MX2018004338 A MX 2018004338A MX 2018004338 A MX2018004338 A MX 2018004338A MX 2018004338 A MX2018004338 A MX 2018004338A
Authority
MX
Mexico
Prior art keywords
pirfenidone
synthesis
reaction
chlorobenzene
system consisting
Prior art date
Application number
MX2018004338A
Other languages
English (en)
Inventor
Mossotti Matteo
Barozza Alessandro
Roletto Jacopo
Paissoni Paolo
Original Assignee
Procos Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procos Spa filed Critical Procos Spa
Publication of MX2018004338A publication Critical patent/MX2018004338A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Se describe un proceso para la síntesis de pirfenidona (1) a partir de 5-metil-2 (1H) piridinona y clorobenceno en presencia de un sistema catalítico que consiste de una sal de cobre y un ligando orgánico, en presencia de una base. El proceso aprovecha la alta eficiencia del sistema catalítico que consiste de sal de cobre (I) y una ligandina orgánica en presencia de una base inorgánica en la reacción de N-amidación de clorobenceno, un reactivo barato también usable como solvente en este caso; las condiciones de reacción a altas temperaturas, a presión atmosférica o superior producen una reacción con buenos rendimientos.
MX2018004338A 2015-10-29 2016-10-27 Proceso para sintesis de pirfenidona. MX2018004338A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITUB2015A004832A ITUB20154832A1 (it) 2015-10-29 2015-10-29 Processo per la sintesi di pirfenidone
PCT/EP2016/075899 WO2017072216A1 (en) 2015-10-29 2016-10-27 Process for the synthesis of pirfenidone

Publications (1)

Publication Number Publication Date
MX2018004338A true MX2018004338A (es) 2018-05-22

Family

ID=55409972

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018004338A MX2018004338A (es) 2015-10-29 2016-10-27 Proceso para sintesis de pirfenidona.

Country Status (7)

Country Link
US (1) US10472325B2 (es)
EP (1) EP3368513B1 (es)
ES (1) ES2875126T3 (es)
IT (1) ITUB20154832A1 (es)
MX (1) MX2018004338A (es)
PT (1) PT3368513T (es)
WO (1) WO2017072216A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111848503B (zh) * 2020-09-10 2022-11-11 苏州富德兆丰生化科技有限公司 吡非尼酮的合成方法
US20220251042A1 (en) * 2020-09-10 2022-08-11 Suzhou Fude Zhaofeng Biochemical Technology Co., Ltd Total synthesis of pirfenidone

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3839346A (en) * 1972-12-18 1974-10-01 Affiliated Med Res N-substituted pyridone and general method for preparing pyridones
GB1458049A (en) * 1972-12-18 1976-12-08 Affiliated Med Res Process for preparing aryl-substituted pyridones
JP4342940B2 (ja) * 2001-08-06 2009-10-14 塩野義製薬株式会社 ５−メチル−１−フェニル−２（１ｈ）ピリジノンの製造方法
CN1218942C (zh) 2002-06-11 2005-09-14 中南大学湘雅医学院 抗纤维化吡啶酮化合物及其生产工艺方法
CN100396669C (zh) 2006-03-15 2008-06-25 浙江省医学科学院 一种抗纤维化药物吡非尼酮的制备方法
MX2007006349A (es) 2007-05-29 2009-02-18 Cell Therapy And Technology S Nuevo proceso de sintesis para la obtencion de 5-metil-1-fenil-2-(ih)-piridona, composicion y uso de la misma.
WO2009035598A1 (en) * 2007-09-10 2009-03-19 Concert Pharmaceuticals, Inc. Deuterated pirfenidone
TWI434833B (zh) * 2009-06-03 2014-04-21 Intermune Inc 用於合成吡非尼酮（ｐｉｒｆｅｎｉｄｏｎｅ）的改良方法
CN101891676A (zh) 2010-08-03 2010-11-24 陕西合成药业有限公司 一种新的5-甲基-1-苯基-2-(1h)-吡啶酮的制备方法
CN102558040A (zh) 2011-12-28 2012-07-11 辰欣药业股份有限公司 一种吡非尼酮的制备方法

Also Published As

Publication number Publication date
US20180319747A1 (en) 2018-11-08
ES2875126T3 (es) 2021-11-08
PT3368513T (pt) 2021-06-18
WO2017072216A1 (en) 2017-05-04
US10472325B2 (en) 2019-11-12
ITUB20154832A1 (it) 2017-04-29
EP3368513B1 (en) 2021-04-14
EP3368513A1 (en) 2018-09-05

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