MX2018003985A - Proteina lisosomal modificada y produccion de la misma. - Google Patents
Proteina lisosomal modificada y produccion de la misma.Info
- Publication number
- MX2018003985A MX2018003985A MX2018003985A MX2018003985A MX2018003985A MX 2018003985 A MX2018003985 A MX 2018003985A MX 2018003985 A MX2018003985 A MX 2018003985A MX 2018003985 A MX2018003985 A MX 2018003985A MX 2018003985 A MX2018003985 A MX 2018003985A
- Authority
- MX
- Mexico
- Prior art keywords
- lysosomal protein
- modified
- protein
- lysosomal
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/06—Sulfuric ester hydrolases (3.1.6)
- C12Y301/06013—Iduronate-2-sulfatase (3.1.6.13)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y310/00—Hydrolases acting on sulfur-nitrogen bonds (3.10)
- C12Y310/01—Hydrolases acting on sulfur-nitrogen bonds (3.10) acting on sulfur-nitrogen bonds (3.10.1)
- C12Y310/01001—N-Sulfoglucosamine sulfohydrolase (3.10.1.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01076—L-Iduronidase (3.2.1.76)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
Abstract
Se desvela en el presente documento una proteína lisosomal modificada, métodos de preparación de una proteína lisosomal modificada y uso terapéutico de una proteína modificada tal. Además, se desvela en el presente documento un método de tratamiento de un mamífero afectado con una enfermedad de almacenamiento lisosomal. En particular, la presente divulgación se refiere a un método de preparación de una proteína lisosomal modificada, comprendiendo dicho método hacer reaccionar una proteína lisosomal glucosilada con un peryodato de metal alcalino y hacer reaccionar dicha proteína lisosomal con un borohidruro de metal alcalino durante un periodo de tiempo de no más de 2 h, modificándose así los restos de glucano de la proteína lisosomal y reduciéndose la actividad de la proteína lisosomal con respecto a los receptores de reconocimiento de glucanos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15187877 | 2015-10-01 | ||
| PCT/EP2016/073452 WO2017055570A1 (en) | 2015-10-01 | 2016-09-30 | Modified lysosomal protein and production thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018003985A true MX2018003985A (es) | 2018-12-10 |
Family
ID=54252124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018003985A MX2018003985A (es) | 2015-10-01 | 2016-09-30 | Proteina lisosomal modificada y produccion de la misma. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20180258408A1 (es) |
| EP (1) | EP3356542A1 (es) |
| JP (1) | JP2018535654A (es) |
| KR (1) | KR20180055888A (es) |
| CN (1) | CN108291246A (es) |
| AU (1) | AU2016329442A1 (es) |
| BR (1) | BR112018006278A2 (es) |
| CA (1) | CA3000289A1 (es) |
| IL (1) | IL258369A (es) |
| MX (1) | MX2018003985A (es) |
| PH (1) | PH12018500604A1 (es) |
| WO (1) | WO2017055570A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA50746A (fr) | 2017-10-02 | 2020-08-12 | Denali Therapeutics Inc | Protéines de fusion comprenant des enzymes d'enzymothérapie substitutive |
| WO2020047282A1 (en) * | 2018-08-29 | 2020-03-05 | University Of Copenhagen | Lysosomal enzymes modified by cell based glycoengineering |
| WO2023196807A1 (en) * | 2022-04-06 | 2023-10-12 | Rutgers, The State University Of New Jersey | Methods for treating lysosomal storage diseases |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8008252B2 (en) * | 2001-10-10 | 2011-08-30 | Novo Nordisk A/S | Factor VII: remodeling and glycoconjugation of Factor VII |
| WO2008109677A2 (en) * | 2007-03-06 | 2008-09-12 | Saint Louis University | Modified enzyme and treatment method |
| PT2970413T (pt) * | 2014-04-01 | 2018-10-23 | Swedish Orphan Biovitrum Ab Publ | Sulfamidase modificada e sua produção |
-
2016
- 2016-09-30 CA CA3000289A patent/CA3000289A1/en not_active Abandoned
- 2016-09-30 BR BR112018006278A patent/BR112018006278A2/pt not_active Application Discontinuation
- 2016-09-30 KR KR1020187011617A patent/KR20180055888A/ko unknown
- 2016-09-30 AU AU2016329442A patent/AU2016329442A1/en not_active Abandoned
- 2016-09-30 MX MX2018003985A patent/MX2018003985A/es unknown
- 2016-09-30 JP JP2018515835A patent/JP2018535654A/ja not_active Withdrawn
- 2016-09-30 CN CN201680066788.3A patent/CN108291246A/zh active Pending
- 2016-09-30 EP EP16775701.2A patent/EP3356542A1/en not_active Withdrawn
- 2016-09-30 WO PCT/EP2016/073452 patent/WO2017055570A1/en active Application Filing
- 2016-09-30 US US15/764,175 patent/US20180258408A1/en not_active Abandoned
-
2018
- 2018-03-20 PH PH12018500604A patent/PH12018500604A1/en unknown
- 2018-03-26 IL IL258369A patent/IL258369A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL258369A (en) | 2018-05-31 |
| PH12018500604A1 (en) | 2018-10-01 |
| BR112018006278A2 (pt) | 2018-10-16 |
| EP3356542A1 (en) | 2018-08-08 |
| AU2016329442A1 (en) | 2018-05-10 |
| US20180258408A1 (en) | 2018-09-13 |
| KR20180055888A (ko) | 2018-05-25 |
| CN108291246A (zh) | 2018-07-17 |
| JP2018535654A (ja) | 2018-12-06 |
| WO2017055570A1 (en) | 2017-04-06 |
| CA3000289A1 (en) | 2017-04-06 |
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