MX2017009723A - Uso de prg4 como agente antiinflamatorio. - Google Patents
Uso de prg4 como agente antiinflamatorio.Info
- Publication number
- MX2017009723A MX2017009723A MX2017009723A MX2017009723A MX2017009723A MX 2017009723 A MX2017009723 A MX 2017009723A MX 2017009723 A MX2017009723 A MX 2017009723A MX 2017009723 A MX2017009723 A MX 2017009723A MX 2017009723 A MX2017009723 A MX 2017009723A
- Authority
- MX
- Mexico
- Prior art keywords
- prg4
- inflammatory
- inflammatory agent
- pro
- lubricin
- Prior art date
Links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Marine Sciences & Fisheries (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
Abstract
En el presente documento se divulgan métodos de uso de glicoproteína PRG4, también conocida como lubricina, para reducir, inhibir o regular a la baja las vías proinflamatorias en pacientes con riesgo de sufrir o que sufren de una respuesta inflamatoria o síntoma de alergia a través de la antagonización de CD44, la regulación de la producción de citoquinas proinflamatorias, la inhibición de la translocación de NF-kB y/o facilitando la eliminación de alérgenos o restos de la matriz o restos celulares inductores de inflamación.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562107799P | 2015-01-26 | 2015-01-26 | |
US201562273059P | 2015-12-30 | 2015-12-30 | |
PCT/US2016/014952 WO2016123123A1 (en) | 2015-01-26 | 2016-01-26 | Use of prg4 as an anti-inflammatory agent |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017009723A true MX2017009723A (es) | 2018-08-15 |
Family
ID=55361962
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017009723A MX2017009723A (es) | 2015-01-26 | 2016-01-26 | Uso de prg4 como agente antiinflamatorio. |
Country Status (21)
Country | Link |
---|---|
US (2) | US10967048B2 (es) |
EP (2) | EP3718559A1 (es) |
JP (2) | JP6758299B2 (es) |
KR (1) | KR20170123619A (es) |
CN (2) | CN113908257A (es) |
AU (2) | AU2016211694B2 (es) |
BR (1) | BR112017015310A8 (es) |
CA (1) | CA2972817A1 (es) |
CL (2) | CL2017001893A1 (es) |
EA (1) | EA036291B1 (es) |
ES (1) | ES2808199T3 (es) |
HK (1) | HK1247834A1 (es) |
IL (2) | IL253596B (es) |
MA (1) | MA53108A (es) |
MX (1) | MX2017009723A (es) |
PH (1) | PH12017501323A1 (es) |
RU (1) | RU2017129880A (es) |
SG (2) | SG10201809947UA (es) |
TN (1) | TN2017000270A1 (es) |
WO (1) | WO2016123123A1 (es) |
ZA (1) | ZA201705378B (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9982027B2 (en) | 2013-10-22 | 2018-05-29 | Lubris Llc | Control of rheological properties of mixed hyaluronate/lubricin solutions |
AU2014354859B2 (en) | 2013-11-26 | 2020-04-09 | Lubris Llc | Compositions and methods for inhibiting intercellular interactions |
ES2808199T3 (es) | 2015-01-26 | 2021-02-25 | Lubris Llc | Uso de PRG4 como un agente antiinflamatorio |
US11089832B2 (en) | 2015-05-01 | 2021-08-17 | Gentex Corporation | Helmet impact attenuation article |
PT3300482T (pt) | 2015-05-19 | 2021-10-15 | Lubris Llc | Uso de prg4 para melhorar a acuidade visual dinâmica e as aberrações de ordem superior |
CN106215170A (zh) * | 2016-08-23 | 2016-12-14 | 重庆医科大学 | 白细胞介素36α在制备治疗、诊断或预防脓毒症药物中的用途 |
WO2018217919A1 (en) | 2017-05-23 | 2018-11-29 | Harmony Development Group, Inc. | Tethered implantable device having an apical base plate with a hydraulic intracardiac adjusting mechanism |
WO2019006152A1 (en) | 2017-06-28 | 2019-01-03 | Harmony Development Group, Inc. | INFLATABLE TRANSDUCTION IMPLANT SYSTEM COMPRISING AN ANNULAR DOUBLE FORCE TRANSDUCTION IMPLANT |
WO2019173385A1 (en) | 2018-03-05 | 2019-09-12 | Harmony Development Group, Inc. | A force transducting implant system for the mitigation of atrioventricular pressure gradient loss and the restoration of healthy ventricular geometry |
CN108795867A (zh) * | 2018-06-05 | 2018-11-13 | 华东理工大学 | 用于构建结肠癌细胞腹膜转移体外三维模型的方法 |
EP3810181A4 (en) * | 2018-06-21 | 2022-03-30 | Lubris LLC | LUBRICINE FOR WOUND HEALING |
CN109125709B (zh) * | 2018-08-23 | 2021-10-22 | 成都华创生物技术有限公司 | Trail突变体在制备治疗痤疮药物中的应用及一种制剂 |
CN109620952A (zh) * | 2019-01-04 | 2019-04-16 | 北京中台恒基生物技术有限公司 | 一种肿瘤疫苗及其制备方法 |
WO2020232148A1 (en) * | 2019-05-13 | 2020-11-19 | The Johns Hopkins University | Macrophage diversity in regenerative, fibrotic biomaterial environments |
US20220332839A1 (en) * | 2019-06-03 | 2022-10-20 | Lubris Llc | Use of prg4 to treat cancer |
US20230256052A1 (en) * | 2020-07-07 | 2023-08-17 | University Of Connecticut | Method and composition for reducing or preventing bone resorption |
IT202000022636A1 (it) * | 2020-09-25 | 2022-03-25 | Ente Ospedaliero Specializzato In Gastroenterologia Istituto Nazionale Di Ricovero E Cura A Caratter | “terapia di combinazione di sorafenib e/o regorafenib con la proteina ricombinante umana proteoglicano-4 per il trattamento dell'epatocarcinoma” |
CN114184792B (zh) * | 2021-11-17 | 2024-05-28 | 中国人民解放军总医院第二医学中心 | 冠心病标志物il-29及其应用 |
Family Cites Families (32)
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US6433142B1 (en) | 1989-08-08 | 2002-08-13 | Genetics Institute, Llc | Megakaryocyte stimulating factors |
US6743774B1 (en) | 1999-04-23 | 2004-06-01 | Rhode Island Hospital | Tribonectins |
US6960562B2 (en) | 1999-04-23 | 2005-11-01 | Rhode Island Hospital, A Lifespan Partner | Tribonectin polypeptides and uses thereof |
US7001881B1 (en) | 1999-04-23 | 2006-02-21 | Rhode Island Hospital | Tribonectins |
AU2001251342A1 (en) | 2000-04-05 | 2001-10-23 | Archer-Daniels-Midland Company | Ketogulonigenium endogenous plasmids |
US7415381B2 (en) | 2003-01-09 | 2008-08-19 | Rhode Island Hospital, A Lifespan Partner | Joint friction sensing |
WO2005000331A2 (en) | 2003-06-04 | 2005-01-06 | Mucosal Therapeutics, Inc. | Compositions for the treatment and prevention of degenerative joint disorders |
DK1663291T3 (da) * | 2003-08-14 | 2012-07-02 | Wyeth Llc | Rekombinante lubricinmolekyler og anvendelser deraf |
US20090155200A1 (en) | 2004-04-20 | 2009-06-18 | Jay Gregory D | Methods of promoting cartilage healing or cartilage integration |
AU2005267012A1 (en) * | 2004-07-23 | 2006-02-02 | Mucosal Therapeutics Llc | Compositions and methods for viscosupplementation |
EP1827478A4 (en) | 2004-12-03 | 2009-08-05 | Mucosal Therapeutics Llc | METHODS OF TREATING JOINED OR SICK JOINTS |
US20070111327A1 (en) | 2005-05-05 | 2007-05-17 | Jay Gregory D | Methods of detecting lubricin |
CN101077887A (zh) * | 2006-05-23 | 2007-11-28 | 中国医学科学院血液学研究所 | 人促造血细胞增殖的细胞因子及其制备方法和用途 |
UY30776A1 (es) | 2006-12-21 | 2008-07-03 | Medarex Inc | Anticuerpos cd44 |
WO2008143816A1 (en) | 2007-05-15 | 2008-11-27 | Mucosal Therapeutics | Compositions and methods for reducing friction between the surface of tendons or other soft tissues |
US20090068247A1 (en) | 2007-09-12 | 2009-03-12 | Mucosal Therapeutics | Biocompatible devices coated with a tribonectin and methods for their production |
US20090104148A1 (en) | 2007-09-18 | 2009-04-23 | Jay Gregory D | Treatment and prevention of joint disease |
US20090191287A1 (en) | 2008-01-29 | 2009-07-30 | Johnson W Dudley | Mitigation of Inflammation-Related Injuries |
US8506944B2 (en) * | 2008-05-07 | 2013-08-13 | The Regents Of The University Of California | Replenishment and enrichment of ocular surface lubrication |
SI2285364T1 (sl) | 2008-05-07 | 2015-03-31 | The Regents Of The University Of California | Terapevtska regeneracija in obogatitev lubrikacije okularne površine |
WO2010083239A2 (en) * | 2009-01-13 | 2010-07-22 | Truitt Edward R Iii | Therapeutic modulation of vaginal epithelium boundary lubrication |
CA2762989C (en) | 2009-05-22 | 2021-04-13 | Benjamin Sullivan | Prg4 for treatment of oral cavity boundary lubrication disorders |
ES2634505T3 (es) | 2009-08-13 | 2017-09-28 | Lubris Llc | Tratamiento de PRG4 para la cistitis intersticial |
WO2011091000A2 (en) | 2010-01-19 | 2011-07-28 | Singularis, Inc. | Oral care compositions and methods |
US20130116186A1 (en) | 2011-10-04 | 2013-05-09 | Rhode Island Hospital, A Lifespan Partner | Lubricin injections to maintain cartilage health |
PL2948553T3 (pl) * | 2013-01-25 | 2020-11-16 | Baylor College Of Medicine | Adenowirusowy system dostarczania i ekspresji terapii genowej zależny od pomocnika |
US9982027B2 (en) | 2013-10-22 | 2018-05-29 | Lubris Llc | Control of rheological properties of mixed hyaluronate/lubricin solutions |
AU2014354859B2 (en) | 2013-11-26 | 2020-04-09 | Lubris Llc | Compositions and methods for inhibiting intercellular interactions |
US20180161393A1 (en) | 2015-01-26 | 2018-06-14 | Lubris Llc | Prg4 for treating gout and its symptoms |
ES2808199T3 (es) | 2015-01-26 | 2021-02-25 | Lubris Llc | Uso de PRG4 como un agente antiinflamatorio |
PT3300482T (pt) | 2015-05-19 | 2021-10-15 | Lubris Llc | Uso de prg4 para melhorar a acuidade visual dinâmica e as aberrações de ordem superior |
US20170312335A1 (en) | 2015-12-30 | 2017-11-02 | Lubris Llc | Topical use of prg4 for treatment of allergy and symptoms of inflammation |
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2016
- 2016-01-26 ES ES16704975T patent/ES2808199T3/es active Active
- 2016-01-26 MX MX2017009723A patent/MX2017009723A/es unknown
- 2016-01-26 CN CN202111044599.5A patent/CN113908257A/zh active Pending
- 2016-01-26 CN CN201680007369.2A patent/CN107847556B/zh active Active
- 2016-01-26 EA EA201791688A patent/EA036291B1/ru unknown
- 2016-01-26 SG SG10201809947UA patent/SG10201809947UA/en unknown
- 2016-01-26 TN TN2017000270A patent/TN2017000270A1/en unknown
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