MX2017009643A - Composiciones y métodos de uso de inhibidores de tirosina quinasa. - Google Patents

Composiciones y métodos de uso de inhibidores de tirosina quinasa.

Info

Publication number
MX2017009643A
MX2017009643A MX2017009643A MX2017009643A MX2017009643A MX 2017009643 A MX2017009643 A MX 2017009643A MX 2017009643 A MX2017009643 A MX 2017009643A MX 2017009643 A MX2017009643 A MX 2017009643A MX 2017009643 A MX2017009643 A MX 2017009643A
Authority
MX
Mexico
Prior art keywords
methods
phosphorylation
tyrosine
compositions
kinase inhibitors
Prior art date
Application number
MX2017009643A
Other languages
English (en)
Spanish (es)
Inventor
Bennett Anton
Sung YI Jae-
Original Assignee
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yale filed Critical Univ Yale
Publication of MX2017009643A publication Critical patent/MX2017009643A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
MX2017009643A 2015-01-26 2016-01-26 Composiciones y métodos de uso de inhibidores de tirosina quinasa. MX2017009643A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562107553P 2015-01-26 2015-01-26
US201562250052P 2015-11-03 2015-11-03
PCT/US2016/014882 WO2016123086A1 (en) 2015-01-26 2016-01-26 Compositions and methods of using tyrosine kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2017009643A true MX2017009643A (es) 2018-05-04

Family

ID=56544226

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017009643A MX2017009643A (es) 2015-01-26 2016-01-26 Composiciones y métodos de uso de inhibidores de tirosina quinasa.
MX2022012505A MX2022012505A (es) 2015-01-26 2017-07-25 Composiciones y metodos de uso de inhibidores de tirosina quinasa.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022012505A MX2022012505A (es) 2015-01-26 2017-07-25 Composiciones y metodos de uso de inhibidores de tirosina quinasa.

Country Status (6)

Country Link
US (4) US10471059B2 (enExample)
EP (2) EP4653015A3 (enExample)
JP (4) JP6854766B2 (enExample)
CN (2) CN107530298B (enExample)
MX (2) MX2017009643A (enExample)
WO (1) WO2016123086A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2928773T3 (es) 2017-01-17 2022-11-22 Heparegenix Gmbh Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos
CN106943595A (zh) * 2017-03-30 2017-07-14 福州大学 Src/Abl抑制剂作为预防或治疗辐射损伤药物的应用
ES3053674T3 (en) 2018-03-22 2026-01-23 Viking Therapeutics Inc Crystalline forms and methods of producing crystalline forms of a compound
WO2019246121A1 (en) * 2018-06-18 2019-12-26 Duke University Compositions and methods for treating disorders characterized with aberrant ras/mapk signaling
WO2020117962A1 (en) * 2018-12-05 2020-06-11 Viking Therapeutics, Inc. Compositions for the treatment of fibrosis and inflammation
EP3930715B1 (en) * 2019-02-27 2024-05-08 Astrazeneca AB Saracatinib for use in the treatment of idiopathic pulmonary fibrosis
WO2021119525A1 (en) * 2019-12-11 2021-06-17 Tiaki Therapeutics Inc. Shp1 and shp2 inhibitors and their methods of use
US12441707B2 (en) 2019-12-30 2025-10-14 Tyra Biosciences, Inc. Indazole compounds
US20240075031A1 (en) * 2020-12-07 2024-03-07 Hht Foundation International, Inc. Method of treating hereditary hemorrhagic telangiectasia using pazopanib
WO2023127012A1 (ja) * 2021-12-27 2023-07-06 国立研究開発法人理化学研究所 動脈瘤の治療及び／又は予防のための医薬組成物、動脈瘤の診断補助方法、並びに動脈瘤治療薬の評価方法
WO2023175136A1 (en) * 2022-03-18 2023-09-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Combination of dasatinib and lovastatin for use in methods for the treatment of cardiac fibrosis
CN116832040B (zh) * 2023-06-12 2026-01-13 北京市心肺血管疾病研究所 细胞周期蛋白依赖性激酶抑制剂在治疗射血分数保留型心力衰竭中的应用
WO2025031474A1 (en) * 2023-08-10 2025-02-13 Insilico Medicine Ip Limited Method and medicament for treating endometriosis
WO2025111752A1 (zh) * 2023-11-27 2025-06-05 中山大学 以Lck/Fyn介导STAT3磷酸化为靶点的阻断剂和生物材料的用途
WO2025170008A1 (ja) * 2024-02-07 2025-08-14 国立大学法人京都大学 成熟心筋細胞の製造方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6355786B1 (en) * 1998-10-30 2002-03-12 Vanderbilt University Purified and isolated protein zero related (PZR) and therapeutic and screening methods using same
WO2001034201A2 (en) 1999-11-12 2001-05-17 Advanced Research And Technology Institute, Inc. Methods for inhibiting neurofibromatosis type 1 (nf1)
CN1897950A (zh) 2003-10-14 2007-01-17 惠氏公司 稠合芳基和杂芳基衍生物及其使用方法
CN101056539B (zh) * 2004-09-09 2012-12-12 综合医院公司 调节心脏细胞中的磷酸酶活性
WO2007011757A1 (en) * 2005-07-14 2007-01-25 Myogen, Inc. Use of inhibitors of the ubiquitin proteasome pathway for increasing contractility of the heart
WO2007047919A2 (en) * 2005-10-20 2007-04-26 University Of South Florida Treatment of restenosis and stenosis with dasatinib
GB0609962D0 (en) * 2006-05-19 2006-06-28 Biotica Tech Ltd Novel compounds
WO2008054792A2 (en) 2006-10-31 2008-05-08 University Of Toledo Na+/k+-atpase-specific peptide inhibitors/activators of src and src family kinases
US8865692B2 (en) 2007-11-13 2014-10-21 Meritage Pharma, Inc Compositions for the treatment of gastrointestinal inflammation
EP2359813A1 (en) * 2010-02-04 2011-08-24 Ratiopharm GmbH Pharmaceutical composition comprising N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamid
EP2988738A4 (en) * 2013-01-10 2016-11-09 Pulmokine Inc THERAPEUTIC INDICATIONS OF KINASE INHIBITORS
US9783504B2 (en) * 2013-07-09 2017-10-10 Dana-Farber Cancer Institute, Inc. Kinase inhibitors for the treatment of disease

Also Published As

Publication number Publication date
US20230036788A1 (en) 2023-02-02
EP4653015A2 (en) 2025-11-26
CN113244399A (zh) 2021-08-13
JP2025061369A (ja) 2025-04-10
EP3250192A4 (en) 2018-09-26
JP2018504416A (ja) 2018-02-15
MX2022012505A (es) 2022-11-07
EP4653015A3 (en) 2025-12-31
JP7840031B2 (ja) 2026-04-03
EP3250192A1 (en) 2017-12-06
CN107530298B (zh) 2021-06-04
JP6854766B2 (ja) 2021-04-07
US11458137B2 (en) 2022-10-04
JP2023052878A (ja) 2023-04-12
HK1245678A1 (en) 2018-08-31
US10471059B2 (en) 2019-11-12
JP2021050218A (ja) 2021-04-01
CN107530298A (zh) 2018-01-02
US20200009142A1 (en) 2020-01-09
US20250360129A1 (en) 2025-11-27
WO2016123086A1 (en) 2016-08-04
EP3250192B1 (en) 2025-10-08
US20180271864A1 (en) 2018-09-27
CA2974958A1 (en) 2016-08-04

Similar Documents

Publication Publication Date Title
MX2017009643A (es) Composiciones y métodos de uso de inhibidores de tirosina quinasa.
CO2022015638A2 (es) Compuestos, composiciones farmacéuticas y métodos para la preparación de compuestos y para su uso
ECSP21038390A (es) Compuestos, composiciones farmacéuticas y métodos de preparación de compuestos y de su uso como inhibidores de la cinasa atr
MX2020001103A (es) Inhibidores de tirosina cinasa 2 (tyk2) y usos de los mismos.
CO2021001472A2 (es) Inhibidores de transglutaminasa 2 (tg2)
BR112022003543A2 (pt) Inibidores de kras g12
CL2019000821A1 (es) Composiciones, métodos y usos para inhibir la actividad arginasa. (divisional solicitud 201801134)
MX2022001940A (es) Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2.
BR112016015449A8 (pt) compostos inibidores terapêuticos, composição farmacêutica os compreendendo e uso dos mesmos
CL2018001899A1 (es) Salicilamidas de espiroheptanos y compuestos relacionados como inhibidores de cinasa rho (rock)
UY38403A (es) Moduladores de la alfa-1 antitripsina
MX2022013081A (es) Compuestos para el tratamiento de sars.
CL2022001743A1 (es) Dosis de gamma-hidroxibutirato (ghb)
BR112017007460A2 (pt) inibidores de di-hidropirrolopiridina de ror-gama
ECSP109957A (es) Derivados de pirimidinil-piridazinona.
CL2016001889A1 (es) (2s)-n-[(1s)-1-ciano-2-feniletil]-1,4-oxazepan-2-carboxamidas como inhibidores de dipeptidil peptidasa 1.
BR112016028288A2 (pt) ?composto, composição farmacêutica, métodos para tratamento de um indivíduo com uma doença ou condição e para inibir a quinase, e, uso de um composto?
CL2008001743A1 (es) Uso de un compuesto derivado de quinazolina para tratar el cancer; uso del compuesto y de otro compuesto antineoplasico; compuestos derivados de quinazolina; y composicion farmaceutica que los comprende.
ECSP23057264A (es) Inhibidores de cdk2 y métodos de uso de los mismos
MX2022005563A (es) Ligandos de la pseudoquinasa tyk2.
BR112018074238A2 (pt) combinação de anticorpo anti-cd20, inibidor de p13 quinase-delta seletivo e inibidor de btk para tratar desordens proliferativas de células b
BR112017023225A2 (pt) inibidor de proteína cinase
CL2020003010A1 (es) Moduladores de la expresión de apol1
MX2021012749A (es) Inhibidor selectivo de la jak1 cinasa.
CO2022000270A2 (es) Inhibidores de enzimas