JP6854766B2 - チロシンキナーゼ阻害剤を用いる組成物および方法 - Google Patents

チロシンキナーゼ阻害剤を用いる組成物および方法 Download PDF

Info

Publication number
JP6854766B2
JP6854766B2 JP2017539224A JP2017539224A JP6854766B2 JP 6854766 B2 JP6854766 B2 JP 6854766B2 JP 2017539224 A JP2017539224 A JP 2017539224A JP 2017539224 A JP2017539224 A JP 2017539224A JP 6854766 B2 JP6854766 B2 JP 6854766B2
Authority
JP
Japan
Prior art keywords
dasatinib
mice
pzr
antibody
shp2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2017539224A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018504416A (ja
JP2018504416A5 (enExample
Inventor
アントン ベネット
アントン ベネット
ジェ−スン イ
ジェ−スン イ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Original Assignee
Yale University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yale University filed Critical Yale University
Publication of JP2018504416A publication Critical patent/JP2018504416A/ja
Publication of JP2018504416A5 publication Critical patent/JP2018504416A5/ja
Application granted granted Critical
Publication of JP6854766B2 publication Critical patent/JP6854766B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2017539224A 2015-01-26 2016-01-26 チロシンキナーゼ阻害剤を用いる組成物および方法 Active JP6854766B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562107553P 2015-01-26 2015-01-26
US62/107,553 2015-01-26
US201562250052P 2015-11-03 2015-11-03
US62/250,052 2015-11-03
PCT/US2016/014882 WO2016123086A1 (en) 2015-01-26 2016-01-26 Compositions and methods of using tyrosine kinase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020200158A Division JP2021050218A (ja) 2015-01-26 2020-12-02 チロシンキナーゼ阻害剤を用いる組成物および方法

Publications (3)

Publication Number Publication Date
JP2018504416A JP2018504416A (ja) 2018-02-15
JP2018504416A5 JP2018504416A5 (enExample) 2019-02-21
JP6854766B2 true JP6854766B2 (ja) 2021-04-07

Family

ID=56544226

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2017539224A Active JP6854766B2 (ja) 2015-01-26 2016-01-26 チロシンキナーゼ阻害剤を用いる組成物および方法
JP2020200158A Pending JP2021050218A (ja) 2015-01-26 2020-12-02 チロシンキナーゼ阻害剤を用いる組成物および方法
JP2023015070A Pending JP2023052878A (ja) 2015-01-26 2023-02-03 チロシンキナーゼ阻害剤を用いる組成物および方法
JP2025005945A Pending JP2025061369A (ja) 2015-01-26 2025-01-16 チロシンキナーゼ阻害剤を用いる組成物および方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2020200158A Pending JP2021050218A (ja) 2015-01-26 2020-12-02 チロシンキナーゼ阻害剤を用いる組成物および方法
JP2023015070A Pending JP2023052878A (ja) 2015-01-26 2023-02-03 チロシンキナーゼ阻害剤を用いる組成物および方法
JP2025005945A Pending JP2025061369A (ja) 2015-01-26 2025-01-16 チロシンキナーゼ阻害剤を用いる組成物および方法

Country Status (8)

Country Link
US (4) US10471059B2 (enExample)
EP (2) EP3250192B1 (enExample)
JP (4) JP6854766B2 (enExample)
CN (2) CN107530298B (enExample)
CA (1) CA2974958A1 (enExample)
HK (1) HK1245678A1 (enExample)
MX (2) MX2017009643A (enExample)
WO (1) WO2016123086A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018209164B2 (en) 2017-01-17 2021-11-04 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
CN106943595A (zh) * 2017-03-30 2017-07-14 福州大学 Src/Abl抑制剂作为预防或治疗辐射损伤药物的应用
KR20200138283A (ko) 2018-03-22 2020-12-09 바이킹 테라퓨틱스 인코포레이티드 결정질 형태, 및 결정질 형태의 화합물을 제조하는 방법
WO2019246121A1 (en) * 2018-06-18 2019-12-26 Duke University Compositions and methods for treating disorders characterized with aberrant ras/mapk signaling
US12102646B2 (en) 2018-12-05 2024-10-01 Viking Therapeutics, Inc. Compositions for the treatment of fibrosis and inflammation
DK3930715T3 (da) * 2019-02-27 2024-08-05 Astrazeneca Ab Saracatinib til anvendelse til behandling af idiopatisk lungefibrose
WO2021119525A1 (en) * 2019-12-11 2021-06-17 Tiaki Therapeutics Inc. Shp1 and shp2 inhibitors and their methods of use
US12441707B2 (en) 2019-12-30 2025-10-14 Tyra Biosciences, Inc. Indazole compounds
WO2022125551A1 (en) * 2020-12-07 2022-06-16 Hht Foundation International, Inc. Method of treating hereditary hemorrhagic telangiectasia using pazopanib
WO2023127012A1 (ja) * 2021-12-27 2023-07-06 国立研究開発法人理化学研究所 動脈瘤の治療及び／又は予防のための医薬組成物、動脈瘤の診断補助方法、並びに動脈瘤治療薬の評価方法
WO2023175136A1 (en) * 2022-03-18 2023-09-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Combination of dasatinib and lovastatin for use in methods for the treatment of cardiac fibrosis
CN116832040A (zh) * 2023-06-12 2023-10-03 北京市心肺血管疾病研究所 细胞周期蛋白依赖性激酶抑制剂在治疗射血分数保留型心力衰竭中的应用
WO2025031474A1 (en) * 2023-08-10 2025-02-13 Insilico Medicine Ip Limited Method and medicament for treating endometriosis
WO2025111752A1 (zh) * 2023-11-27 2025-06-05 中山大学 以Lck/Fyn介导STAT3磷酸化为靶点的阻断剂和生物材料的用途
WO2025170008A1 (ja) * 2024-02-07 2025-08-14 国立大学法人京都大学 成熟心筋細胞の製造方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6355786B1 (en) * 1998-10-30 2002-03-12 Vanderbilt University Purified and isolated protein zero related (PZR) and therapeutic and screening methods using same
JP2003513939A (ja) 1999-11-12 2003-04-15 アドバンスト リサーチ アンド テクノロジー インスティテュート，インコーポレイティド 神経繊維腫症タイプ１（ｎｆ１）の阻害方法
CN1897950A (zh) * 2003-10-14 2007-01-17 惠氏公司 稠合芳基和杂芳基衍生物及其使用方法
JP2008512484A (ja) 2004-09-09 2008-04-24 ザ ジェネラル ホスピタル コーポレーション 心臓細胞におけるホスファターゼ活性の調節
WO2007011757A1 (en) * 2005-07-14 2007-01-25 Myogen, Inc. Use of inhibitors of the ubiquitin proteasome pathway for increasing contractility of the heart
US20070123539A1 (en) * 2005-10-20 2007-05-31 University Of South Florida Treatment of Restenosis and Stenosis with Dasatinib
GB0609962D0 (en) * 2006-05-19 2006-06-28 Biotica Tech Ltd Novel compounds
US8283441B2 (en) * 2006-10-31 2012-10-09 University Of Toledo Na+K+-ATPase-specific peptide inhibitors/activators of SRC and SRC family kinases
US20090143343A1 (en) * 2007-11-13 2009-06-04 Meritage Pharma, Inc. Compositions for the treatment of inflammation of the gastrointestinal tract
EP2359813A1 (en) 2010-02-04 2011-08-24 Ratiopharm GmbH Pharmaceutical composition comprising N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamid
WO2014110198A2 (en) * 2013-01-10 2014-07-17 Zisman Lawrence S Therapeutic indications of kinase inhibitors
EP3019491A4 (en) * 2013-07-09 2016-12-21 Dana Farber Cancer Inst Inc KINASEHEMMER FOR THE TREATMENT OF DISEASES

Also Published As

Publication number Publication date
EP4653015A2 (en) 2025-11-26
US20180271864A1 (en) 2018-09-27
HK1245678A1 (zh) 2018-08-31
CN107530298B (zh) 2021-06-04
CA2974958A1 (en) 2016-08-04
US20250360129A1 (en) 2025-11-27
JP2025061369A (ja) 2025-04-10
JP2018504416A (ja) 2018-02-15
US10471059B2 (en) 2019-11-12
WO2016123086A1 (en) 2016-08-04
MX2022012505A (es) 2022-11-07
EP3250192A1 (en) 2017-12-06
JP2021050218A (ja) 2021-04-01
US20200009142A1 (en) 2020-01-09
US20230036788A1 (en) 2023-02-02
JP2023052878A (ja) 2023-04-12
EP3250192B1 (en) 2025-10-08
US11458137B2 (en) 2022-10-04
CN113244399A (zh) 2021-08-13
EP3250192A4 (en) 2018-09-26
MX2017009643A (es) 2018-05-04
CN107530298A (zh) 2018-01-02

Similar Documents

Publication Publication Date Title
JP6854766B2 (ja) チロシンキナーゼ阻害剤を用いる組成物および方法
Zhao et al. An essential role for Wnt/β-catenin signaling in mediating hypertensive heart disease
Li et al. Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy
US12138284B2 (en) Dominant active yap, a hippo effector, induces chromatin accessibility and cardiomyocyte renewal
Pérez López et al. A-kinase anchoring protein Lbc coordinates a p38 activating signaling complex controlling compensatory cardiac hypertrophy
Wu et al. Pharmacological inhibition of c-Jun N-terminal kinase signaling prevents cardiomyopathy caused by mutation in LMNA gene
JP7570100B2 (ja) 老化細胞を除去する方法、および老化細胞の調製方法
Ranek et al. Muscarinic 2 receptors modulate cardiac proteasome function in a protein kinase G-dependent manner
US20130109738A1 (en) Control of Cardiac Growth, Differentiation and Hypertrophy
Choi et al. Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival
Xu et al. Ghrelin ameliorates hypoxia-induced pulmonary hypertension via phospho-GSK3 b/b-catenin signaling in neonatal rats
HK40057503A (en) Compositions and methods of using tyrosine kinase inhibitors
WO2022045074A1 (ja) 肥満症を予防又は治療するための医薬組成物
JP7525591B2 (ja) 心機能不全を予測及び処置するための方法
Wang et al. Kielin/chordin-like protein (KCP) deficiency exacerbates doxorubicin-induced myocardial injury by promoting macrophage M1 polarization through autophagy inhibition.
Yang SER14-RPN6 Phosphorylation Mediates the Activation of 26S Proteasomes by Cyclic AMP and Protects Against Cardiac Proteotoxic Stress in Mice
JP2023081768A (ja) 脂肪肝治療剤、医薬組成物、治療方法、及びスクリーニング方法
TW201217341A (en) Receptor-type kinase modulator and methods of treating polycystic kidney disease
JP2014141472A (ja) １，３，５−トリアジン誘導体を有する線維化予防又は治療剤

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171106

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190107

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190107

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20191017

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20200109

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20200313

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200416

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20200803

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20201202

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20201202

C11 Written invitation by the commissioner to file amendments

Free format text: JAPANESE INTERMEDIATE CODE: C11

Effective date: 20201214

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210105

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20210106

C21 Notice of transfer of a case for reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C21

Effective date: 20210107

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20210119

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20210222

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20210316

R150 Certificate of patent or registration of utility model

Ref document number: 6854766

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250