MX2017003516A - Derivados de pirazol como estimuladores de guanilato ciclasa soluble (sgc). - Google Patents
Derivados de pirazol como estimuladores de guanilato ciclasa soluble (sgc).Info
- Publication number
- MX2017003516A MX2017003516A MX2017003516A MX2017003516A MX2017003516A MX 2017003516 A MX2017003516 A MX 2017003516A MX 2017003516 A MX2017003516 A MX 2017003516A MX 2017003516 A MX2017003516 A MX 2017003516A MX 2017003516 A MX2017003516 A MX 2017003516A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrazole derivatives
- sgc stimulators
- stimulators
- sgc
- useful
- Prior art date
Links
- 150000003217 pyrazoles Chemical class 0.000 title abstract 2
- 229940127296 soluble guanylate cyclase stimulator Drugs 0.000 title 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 150000003278 haem Chemical class 0.000 abstract 1
Classifications
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C—CHEMISTRY; METALLURGY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462051557P | 2014-09-17 | 2014-09-17 | |
| US201562204710P | 2015-08-13 | 2015-08-13 | |
| PCT/US2015/050468 WO2016044447A1 (en) | 2014-09-17 | 2015-09-16 | Pyrazole derivatives as sgc stimulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2017003516A true MX2017003516A (es) | 2017-07-28 |
Family
ID=54200121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017003516A MX2017003516A (es) | 2014-09-17 | 2015-09-16 | Derivados de pirazol como estimuladores de guanilato ciclasa soluble (sgc). |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US20170291889A1 (enExample) |
| EP (1) | EP3194382B1 (enExample) |
| JP (1) | JP6624616B2 (enExample) |
| CN (1) | CN107406422B (enExample) |
| AU (2) | AU2015317824A1 (enExample) |
| CA (1) | CA2959757A1 (enExample) |
| MX (1) | MX2017003516A (enExample) |
| WO (1) | WO2016044447A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10844064B2 (en) * | 2014-09-17 | 2020-11-24 | Cyclerion Therapeutics, Inc. | sGC stimulators |
| BR112018011154B1 (pt) * | 2015-11-30 | 2023-09-26 | Cyclerion Therapeutics, Inc | Dispersões sólidas compreendendo um estimulador de sgc |
| KR20180094965A (ko) | 2015-12-14 | 2018-08-24 | 아이언우드 파마슈티컬스, 인코포레이티드 | 위장 괄약근 기능장애의 치료를 위한 sGC 자극제의 용도 |
| CN105859726B (zh) * | 2016-05-18 | 2018-07-13 | 南京富润凯德生物医药有限公司 | 一种嘧啶并环中选择性脱卤素的方法 |
| EA201990236A1 (ru) | 2016-07-07 | 2019-08-30 | Сайклерион Терапьютикс, Инк. | Новые способы получения стимуляторов растворимой гуанилатциклазы |
| KR102487872B1 (ko) * | 2016-07-07 | 2023-01-12 | 사이클리온 테라퓨틱스, 인크. | 가용성 구아닐레이트 시클라제 자극제의 신규 제조 방법 |
| EA039753B1 (ru) * | 2016-07-07 | 2022-03-10 | Сайклерион Терапьютикс, Инк. | ТВЕРДЫЕ ФОРМЫ СТИМУЛЯТОРА sGC |
| US11331308B2 (en) | 2016-10-11 | 2022-05-17 | Bayer Pharma Aktiengesellschaft | Combination containing sGC activators and mineralocorticoid receptor antagonists |
| ES2985316T3 (es) | 2016-10-11 | 2024-11-05 | Bayer Pharma AG | Combinación que contiene el estimulador sGC vericuguat y el antagonista de los receptores de corticoides minerales finerenona |
| WO2018111795A2 (en) | 2016-12-13 | 2018-06-21 | Ironwood Pharmaceuticals, Inc. | Use of sgc stimulators for the treatment of esophageal motility disorders |
| WO2019081456A1 (en) | 2017-10-24 | 2019-05-02 | Bayer Aktiengesellschaft | USE OF SGC ACTIVATORS AND STIMULATORS COMPRISING A BETA2 SUBUNIT |
| EP3498298A1 (en) | 2017-12-15 | 2019-06-19 | Bayer AG | The use of sgc stimulators and sgc activators alone or in combination with pde5 inhibitors for the treatment of bone disorders including osteogenesis imperfecta (oi) |
| JP7337067B2 (ja) * | 2017-12-19 | 2023-09-01 | サイクレリオン・セラピューティクス，インコーポレーテッド | ｓＧＣ刺激薬 |
| WO2019161534A1 (en) * | 2018-02-22 | 2019-08-29 | Ironwood Pharmaceuticals, Inc. | Novel processes and intermediates for preparation of soluble guanylate cyclase stimulators |
| CN111902410B (zh) * | 2018-01-10 | 2024-04-19 | 赛克里翁治疗有限公司 | 用于制备可溶性鸟苷酸环化酶刺激剂的方法及中间物 |
| CN112055584A (zh) | 2018-04-30 | 2020-12-08 | 拜耳公司 | sGC活化剂和sGC刺激剂用于治疗认知障碍的用途 |
| MA52616A (fr) | 2018-05-15 | 2021-03-24 | Bayer Ag | Benzamides à substitution 1,3-thiazol-2-yl pour le traitement de maladies associées à la sensibilisation de fibres nerveuses |
| US11508483B2 (en) | 2018-05-30 | 2022-11-22 | Adverio Pharma Gmbh | Method of identifying a subgroup of patients suffering from dcSSc which benefits from a treatment with sGC stimulators and sGC activators in a higher degree than a control group |
| US12220414B2 (en) | 2018-07-11 | 2025-02-11 | Tisento Therapeutics Inc. | Use of sGC stimulators for the treatment of mitochondrial disorders |
| WO2020148379A1 (en) | 2019-01-17 | 2020-07-23 | Bayer Aktiengesellschaft | Methods to determine whether a subject is suitable of being treated with an agonist of soluble guanylyl cyclase (sgc) |
| CN110577467A (zh) * | 2019-09-18 | 2019-12-17 | 重庆医药高等专科学校 | 一种3-羟基丙酸的合成方法 |
| CN110498740A (zh) * | 2019-09-18 | 2019-11-26 | 重庆医药高等专科学校 | 一种生产3-羟基丙酸的方法 |
| US12569470B2 (en) * | 2019-12-18 | 2026-03-10 | Bioradical Research Institute Corp. | Vasodilator and use thereof |
| CN112007027B (zh) * | 2020-09-14 | 2022-07-15 | 长春金赛药业有限责任公司 | 含酯基芳香丙酰胺类化合物及其代谢产物在制备治疗心衰药物中的应用 |
| CN112169717B (zh) * | 2020-09-30 | 2022-06-03 | 深圳大学 | 一种微胶囊化氯化血红素及其制备方法与应用 |
| US20230372317A1 (en) * | 2020-10-27 | 2023-11-23 | Pts Consulting, Llc | A liquid injectable composition of donepezil |
| EP4376843A1 (en) * | 2021-07-28 | 2024-06-05 | Cyclerion Therapeutics, Inc. | Treatment of hfpef in post-menopausal women with an sgc stimulator |
| WO2025106494A1 (en) * | 2023-11-15 | 2025-05-22 | Yanping Kong | Compositions and methods for treating erectile dysfunction and male hypogonadism |
| WO2025189097A1 (en) * | 2024-03-07 | 2025-09-12 | Yale University | Artificial intelligence-guided screening of under-recognized cardiomyopathies adapted for point-of-care cardiac ultrasound |
| DE202024103267U1 (de) | 2024-06-18 | 2024-07-09 | Ashutosh Aggarwal | Ein System zur Herstellung einer antihypertensiven Formulierung mit verlängerter Freisetzung |
| CN119185590B (zh) * | 2024-11-28 | 2025-02-25 | 华润双鹤利民药业（济南）有限公司 | 羟丙基-β-环糊精在制备维立西呱固体制剂中的应用、固体制剂及制备方法 |
| CN119909007B (zh) * | 2025-04-02 | 2025-06-03 | 四川大学 | 一种具有氧化还原活性和电活性的可注射水凝胶及其制备方法与应用 |
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| US4627850A (en) | 1983-11-02 | 1986-12-09 | Alza Corporation | Osmotic capsule |
| DE3660408D1 (en) | 1985-02-27 | 1988-08-25 | Oerlikon Buehrle Ag | Apparatus for measuring the vibrations of a spiral bevel gear transmission in a gear-testing machine |
| IL92966A (en) | 1989-01-12 | 1995-07-31 | Pfizer | Dispensing devices powered by hydrogel |
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-
2015
- 2015-09-16 EP EP15771410.6A patent/EP3194382B1/en active Active
- 2015-09-16 JP JP2017515199A patent/JP6624616B2/ja not_active Expired - Fee Related
- 2015-09-16 MX MX2017003516A patent/MX2017003516A/es unknown
- 2015-09-16 WO PCT/US2015/050468 patent/WO2016044447A1/en not_active Ceased
- 2015-09-16 US US15/511,900 patent/US20170291889A1/en not_active Abandoned
- 2015-09-16 CA CA2959757A patent/CA2959757A1/en not_active Abandoned
- 2015-09-16 AU AU2015317824A patent/AU2015317824A1/en not_active Abandoned
- 2015-09-16 CN CN201580062199.3A patent/CN107406422B/zh not_active Expired - Fee Related
-
2018
- 2018-02-22 US US15/902,708 patent/US20190031641A1/en not_active Abandoned
- 2018-10-19 US US16/165,192 patent/US20190284168A1/en not_active Abandoned
-
2020
- 2020-07-09 AU AU2020204571A patent/AU2020204571A1/en not_active Abandoned
-
2021
- 2021-01-07 US US17/143,933 patent/US20210221793A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20210221793A1 (en) | 2021-07-22 |
| WO2016044447A1 (en) | 2016-03-24 |
| CA2959757A1 (en) | 2016-03-24 |
| EP3194382B1 (en) | 2021-09-08 |
| AU2020204571A1 (en) | 2020-07-30 |
| CN107406422A (zh) | 2017-11-28 |
| US20190284168A1 (en) | 2019-09-19 |
| US20190031641A1 (en) | 2019-01-31 |
| US20170291889A1 (en) | 2017-10-12 |
| AU2015317824A1 (en) | 2017-03-23 |
| CN107406422B (zh) | 2022-02-01 |
| EP3194382A1 (en) | 2017-07-26 |
| JP2017528494A (ja) | 2017-09-28 |
| JP6624616B2 (ja) | 2019-12-25 |
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