MX2017002359A - Dispersion y acumulacion de particulas magneticas en un sistema de microfluido. - Google Patents

Dispersion y acumulacion de particulas magneticas en un sistema de microfluido.

Info

Publication number
MX2017002359A
MX2017002359A MX2017002359A MX2017002359A MX2017002359A MX 2017002359 A MX2017002359 A MX 2017002359A MX 2017002359 A MX2017002359 A MX 2017002359A MX 2017002359 A MX2017002359 A MX 2017002359A MX 2017002359 A MX2017002359 A MX 2017002359A
Authority
MX
Mexico
Prior art keywords
magnetic
magnetic particles
microfluidic system
chambers
accumulation
Prior art date
Application number
MX2017002359A
Other languages
English (en)
Inventor
Irmscher Matthias
Original Assignee
Koninklijke Philips Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP14195888 priority Critical
Priority to US201562102757P priority
Application filed by Koninklijke Philips Nv filed Critical Koninklijke Philips Nv
Priority to PCT/EP2015/078118 priority patent/WO2016087397A1/en
Publication of MX2017002359A publication Critical patent/MX2017002359A/es

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/026Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0673Handling of plugs of fluid surrounded by immiscible fluid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043Moving fluids with specific forces or mechanical means specific forces magnetic forces

Abstract

La invención se refiere a un sistema de microfluido que comprende una fuente magnética (150) y dos cámaras (110) que se conectan por un canal. De acuerdo con una modalidad preferida, las cámaras y el canal se rellenan con diferentes fluidos de tal forma que se crea una tensión de superficie no de cero en las interfases de fluido asociadas. Además, la fuente magnética (150) se dispone para proporcionar al menos dos regiones gradientes magnéticas separadas (GR) y para permitir la atracción de las partículas magnéticas (MP) presentes en una de las cámaras dentro de estas diferentes regiones, en donde además la fuerza de atracción magnética (F) generada por al menos una de las regiones gradientes (GR) en lo suficientemente fuerte para permitir el impulsor o la fracción de las partículas magnéticas a través de tales interfases de fluido. En una modalidad preferida, la fuente magnética puede realizarse a través de un imán permanente (150) con forma hexaédrica. La invención además se refiere a un método para obtener la dispersión y un método para obtener acumulación de un ensamble de partículas magnéticas en tal sistema de microfluido.
MX2017002359A 2014-12-02 2015-12-01 Dispersion y acumulacion de particulas magneticas en un sistema de microfluido. MX2017002359A (es)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP14195888 2014-12-02
US201562102757P true 2015-01-13 2015-01-13
PCT/EP2015/078118 WO2016087397A1 (en) 2014-12-02 2015-12-01 Dispersion and accumulation of magnetic particles in a microfluidic system

Publications (1)

Publication Number Publication Date
MX2017002359A true MX2017002359A (es) 2017-05-17

Family

ID=52002796

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017002359A MX2017002359A (es) 2014-12-02 2015-12-01 Dispersion y acumulacion de particulas magneticas en un sistema de microfluido.

Country Status (8)

Country Link
US (1) US9931632B2 (es)
EP (1) EP3227024A1 (es)
JP (1) JP6353155B2 (es)
CN (1) CN106660044B (es)
BR (1) BR112017004584A2 (es)
MX (1) MX2017002359A (es)
RU (1) RU2632460C1 (es)
WO (1) WO2016087397A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106660044B (zh) * 2014-12-02 2019-04-23 皇家飞利浦有限公司 微流体系统和微流体系统中的磁性粒子的弥散和积聚方法
US10156658B1 (en) 2017-06-06 2018-12-18 Saudi Arabian Oil Company Detecting a tracer in a hydrocarbon reservoir
GB201711804D0 (en) * 2017-07-21 2017-09-06 Mast Group Ltd Apparatus for conducting an assay

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US20020098097A1 (en) 2001-01-22 2002-07-25 Angad Singh Magnetically-actuated micropump
RU2315180C2 (ru) * 2002-08-21 2008-01-20 Шелл Интернэшнл Рисерч Маатсхаппий Б.В. Способ определения химического состава флюида в процессе бурения и добычи
EP1601438B1 (en) * 2003-03-08 2009-10-07 Ecole Polytechnique Federale de Lausanne EPFL-SRI Magnetic bead manipulation and transport device
KR20080023303A (ko) * 2005-05-18 2008-03-13 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 마이크로유체 그물구조 내 전도성 경로, 마이크로회로 및마이크로구조물의 제작
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JP5986996B2 (ja) * 2011-07-20 2016-09-06 株式会社エンプラス 流体取扱装置、流体取扱方法および流体取扱システム
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Also Published As

Publication number Publication date
JP6353155B2 (ja) 2018-07-04
JP2017523907A (ja) 2017-08-24
US9931632B2 (en) 2018-04-03
RU2632460C1 (ru) 2017-10-04
EP3227024A1 (en) 2017-10-11
BR112017004584A2 (pt) 2018-01-23
WO2016087397A1 (en) 2016-06-09
CN106660044B (zh) 2019-04-23
CN106660044A (zh) 2017-05-10
US20170259264A1 (en) 2017-09-14

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