BR112017004584A2 - sistema microfluídico para processar fluidos contendo partículas magnéticas, método para alcançar dispersão de um conjunto de partículas magnéticas em uma câmara de um sistema microfluídico, e método para acumular um conjunto de partículas magnéticas em uma câmara do sistema microfluídico - Google Patents

sistema microfluídico para processar fluidos contendo partículas magnéticas, método para alcançar dispersão de um conjunto de partículas magnéticas em uma câmara de um sistema microfluídico, e método para acumular um conjunto de partículas magnéticas em uma câmara do sistema microfluídico

Info

Publication number
BR112017004584A2
BR112017004584A2 BR112017004584A BR112017004584A BR112017004584A2 BR 112017004584 A2 BR112017004584 A2 BR 112017004584A2 BR 112017004584 A BR112017004584 A BR 112017004584A BR 112017004584 A BR112017004584 A BR 112017004584A BR 112017004584 A2 BR112017004584 A2 BR 112017004584A2
Authority
BR
Brazil
Prior art keywords
magnetic particles
microfluidic system
chamber
magnetic
chambers
Prior art date
Application number
BR112017004584A
Other languages
English (en)
Inventor
Irmscher Matthias
Original Assignee
Koninklijke Philips Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Nv filed Critical Koninklijke Philips Nv
Publication of BR112017004584A2 publication Critical patent/BR112017004584A2/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Soft Magnetic Materials (AREA)
  • Micromachines (AREA)

Abstract

a presente invenção refere-se a um sistema microfluídico que compreende uma fonte magnética (150) e duas câmaras (110) que são conectadas por um canal. de acordo com uma modalidade preferencial, as câmaras e o canal são preenchidos com fluidos diferentes de modo que uma tensão superficial diferente de zero seja criada nas interfaces fluídicas associadas. além disso, a fonte magnética (150) é disposta para fornecer ao menos duas regiões de gradiente magnético separadas (gr) e para permitir a atração de partículas magnéticas (mp) presentes em uma das câmaras nessas regiões diferentes, sendo que, adicionalmente, as forças de atração magnéticas (f) geradas por ao menos uma das regiões de gradiente (gr) é forte o suficiente para permitir empurrar ou puxar as partículas magnéticas através das ditas interfaces fluídicas. em uma modalidade preferencial, a fonte magnética pode ser concebida com um ímã permanente (150) de formato hexaédrico. a invenção refere-se adicionalmente a um método para alcançar dispersão e um método para alcançar acúmulo de um conjunto de partículas magnéticas no dito sistema microfluídico.
BR112017004584A 2014-12-02 2015-12-01 sistema microfluídico para processar fluidos contendo partículas magnéticas, método para alcançar dispersão de um conjunto de partículas magnéticas em uma câmara de um sistema microfluídico, e método para acumular um conjunto de partículas magnéticas em uma câmara do sistema microfluídico BR112017004584A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14195888 2014-12-02
US201562102757P 2015-01-13 2015-01-13
PCT/EP2015/078118 WO2016087397A1 (en) 2014-12-02 2015-12-01 Dispersion and accumulation of magnetic particles in a microfluidic system

Publications (1)

Publication Number Publication Date
BR112017004584A2 true BR112017004584A2 (pt) 2018-01-23

Family

ID=52002796

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017004584A BR112017004584A2 (pt) 2014-12-02 2015-12-01 sistema microfluídico para processar fluidos contendo partículas magnéticas, método para alcançar dispersão de um conjunto de partículas magnéticas em uma câmara de um sistema microfluídico, e método para acumular um conjunto de partículas magnéticas em uma câmara do sistema microfluídico

Country Status (8)

Country Link
US (1) US9931632B2 (pt)
EP (1) EP3227024A1 (pt)
JP (1) JP6353155B2 (pt)
CN (1) CN106660044B (pt)
BR (1) BR112017004584A2 (pt)
MX (1) MX2017002359A (pt)
RU (1) RU2632460C1 (pt)
WO (1) WO2016087397A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2632460C1 (ru) * 2014-12-02 2017-10-04 Конинклейке Филипс Н.В. Диспергирование и накопление магнитных частиц в микрофлюидной системе
US10156658B1 (en) 2017-06-06 2018-12-18 Saudi Arabian Oil Company Detecting a tracer in a hydrocarbon reservoir
GB201711804D0 (en) * 2017-07-21 2017-09-06 Mast Group Ltd Apparatus for conducting an assay
CN111215159A (zh) * 2018-11-26 2020-06-02 南京怡天生物科技有限公司 微流控芯片及基于该芯片融合样本的方法
CN109746064B (zh) * 2019-01-28 2021-10-15 武汉纺织大学 一种梯度磁场微流控芯片
WO2020190746A1 (en) 2019-03-15 2020-09-24 Saudi Arabian Oil Company Bulk synthesis of janus nanomaterials
JP7462043B2 (ja) * 2019-11-22 2024-04-04 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド 凝集体を含む液体を移送する装置、システム、および方法
US11422285B2 (en) 2020-06-17 2022-08-23 Saudi Arabian Oil Company Nanofluidic chips as micromodels for carbonate reservoirs
WO2022051628A1 (en) 2020-09-03 2022-03-10 Saudi Arabian Oil Company Injecting multiple tracer tag fluids into a wellbore
US11660595B2 (en) 2021-01-04 2023-05-30 Saudi Arabian Oil Company Microfluidic chip with multiple porosity regions for reservoir modeling
US12019038B2 (en) 2021-01-21 2024-06-25 Saudi Arabian Oil Company Evaluation of source rock samples from subterranean reservoirs
US11534759B2 (en) 2021-01-22 2022-12-27 Saudi Arabian Oil Company Microfluidic chip with mixed porosities for reservoir modeling
US11796517B2 (en) 2021-11-09 2023-10-24 Saudi Arabian Oil Company Multifunctional magnetic tags for mud logging
US11725139B2 (en) 2021-12-13 2023-08-15 Saudi Arabian Oil Company Manipulating hydrophilicity of conventional dye molecules for water tracer applications
US11999855B2 (en) 2021-12-13 2024-06-04 Saudi Arabian Oil Company Fluorescent dye molecules having hydrophilicity and hydrophobicity for tracer applications
US11885790B2 (en) 2021-12-13 2024-01-30 Saudi Arabian Oil Company Source productivity assay integrating pyrolysis data and X-ray diffraction data
US12000278B2 (en) 2021-12-16 2024-06-04 Saudi Arabian Oil Company Determining oil and water production rates in multiple production zones from a single production well

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020098097A1 (en) 2001-01-22 2002-07-25 Angad Singh Magnetically-actuated micropump
BR0313618A (pt) * 2002-08-21 2005-06-21 Shell Int Research Método para análise quìmica de fluidos de poço
WO2004078316A1 (en) * 2003-03-08 2004-09-16 Ecole Polytechnique Federale De Lausanne (Epfl) Magnetic bead manipulation and transport device
JP2008546542A (ja) * 2005-05-18 2008-12-25 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ マイクロ流体ネットワークにおける伝導通路、マイクロ回路、マイクロ構造の製造
JP4726135B2 (ja) * 2005-07-14 2011-07-20 株式会社エンプラス 流体取扱装置
EP1929269A2 (en) * 2005-09-30 2008-06-11 Caliper Life Sciences, Inc. Microfluidic device for purifying a biological component using magnetic beads
JP4844263B2 (ja) * 2006-07-07 2011-12-28 株式会社島津製作所 微量化学反応方法及び装置
KR101431778B1 (ko) * 2007-02-09 2014-08-20 어드밴스드 리퀴드 로직, 아이엔씨. 자성 비즈를 이용하는 액적 작동기 장치 및 방법
US20080302732A1 (en) 2007-05-24 2008-12-11 Hyongsok Soh Integrated fluidics devices with magnetic sorting
JP2010536565A (ja) * 2007-08-23 2010-12-02 シンベニオ・バイオシステムズ・インコーポレーテッド 目標種用のトラップ用磁気選別システム
EP2234916A4 (en) 2008-01-22 2016-08-10 Integenx Inc UNIVERSAL SPECIMEN PREPARATION SYSTEM AND ITS USE IN AN INTEGRATED ANALYSIS SYSTEM
WO2009132151A2 (en) 2008-04-23 2009-10-29 The Regents Of The University Of California Microfluidic devices and methods of using same
DE502008001596D1 (de) * 2008-06-02 2010-12-02 Boehringer Ingelheim Micropart Mikrofluidische Folienstruktur zum Dosierren von Flüssigkeiten
EP2379212B1 (en) * 2008-12-16 2020-05-27 Koninklijke Philips N.V. Hydrophobic valve
WO2010140128A1 (en) * 2009-06-03 2010-12-09 Koninklijke Philips Electronics N.V. Valve with material having modifiable degree of penetrability
DE102009035941B8 (de) * 2009-08-03 2017-04-27 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Diagnostiksystem
BR112012005142A2 (pt) * 2009-09-11 2019-09-24 Koninl Philips Electronics Nv dispositivo para o transporte de ésferas magnéticas ou magnetizáveis sobre uma superfície de transporte, método para o transporte de esferas magnéticas ou magnetizáveis sogre um superfície de transporte ou aparelho microfluídico
WO2011042828A1 (en) 2009-10-06 2011-04-14 Koninklijke Philips Electronics N.V. Magnetic sample purification
US9517472B2 (en) * 2010-12-21 2016-12-13 Shimadzu Corporation Device and method for processing target component in tube
US9527078B2 (en) * 2011-07-20 2016-12-27 Enplas Corporation Fluid handling device, fluid handling method, and fluid handling system
JP5807542B2 (ja) * 2011-12-22 2015-11-10 株式会社島津製作所 対象成分を操作するためのチップデバイス及びそれを用いた方法
RU2510509C1 (ru) * 2012-07-16 2014-03-27 Федеральное государственное бюджетное учреждение науки Институт цитологии и генетики Сибирского отделения Российской академии наук Микрофлюидная система для проведения иммуноанализа
RU2632460C1 (ru) * 2014-12-02 2017-10-04 Конинклейке Филипс Н.В. Диспергирование и накопление магнитных частиц в микрофлюидной системе

Also Published As

Publication number Publication date
JP2017523907A (ja) 2017-08-24
MX2017002359A (es) 2017-05-17
US20170259264A1 (en) 2017-09-14
EP3227024A1 (en) 2017-10-11
JP6353155B2 (ja) 2018-07-04
RU2632460C1 (ru) 2017-10-04
WO2016087397A1 (en) 2016-06-09
CN106660044B (zh) 2019-04-23
CN106660044A (zh) 2017-05-10
US9931632B2 (en) 2018-04-03

Similar Documents

Publication Publication Date Title
BR112017004584A2 (pt) sistema microfluídico para processar fluidos contendo partículas magnéticas, método para alcançar dispersão de um conjunto de partículas magnéticas em uma câmara de um sistema microfluídico, e método para acumular um conjunto de partículas magnéticas em uma câmara do sistema microfluídico
CL2021001179A1 (es) Anticuerpos específicos para tl1a y ácidos nucleicos que los codifican (divisional de la solicitud no. 201801596).
BR112017016965A2 (pt) dispositivo para formação de espuma
MX2016013156A (es) Dispositivos, sistemas y metodos fluidicos, para encapsular y dividir reactivos, y aplicaciones de los mismos.
AR099172A1 (es) Sistemas y métodos de fracturación
DK3660264T3 (da) Olie-, vand-, gas- og faststofpartikelseparering inden for olie- og/eller gasproduktion
BR112017014049A2 (pt) método para reduzir a perda de circulação em uma formação subterrânea, fluido de tratamento e sistema para obstrução de uma zona de perda de circulação
BR112017011989B8 (pt) Separar impurezas de uma corrente de fluido usando contatores em co-corrente múltiplos
BR112017006167A2 (pt) estrutura de liberação de ligação de sistema microeletromecânico (mems) e método de transferência de wafer para integração de circuito integrado tridimensional (ci em 3d)
BR112017020845A2 (pt) ?dispositivo para capturar e remover material magnético de um fluxo de material?
MX2016013216A (es) Dispositivos mejorados para la separacion de materiales biologicos.
BR112017007654A2 (pt) sistemas e métodos para o imageamento de amostras de fluido
CL2018000544A1 (es) Sistema, método y aparato para flotación por espuma
BR112016021678A2 (pt) método e sistema para determinar uma janela de peso de lama em um poço, e, meio legível por computador.
BR112017012817A2 (pt) agente de clivagem de película líquida
BR112017025705A2 (pt) método de liberação de glicosídeos de esteviol de uma célula hospedeira, método de recuperação de glicosídeos de esteviol de uma composição e composição
BR112017009554A2 (pt) dispositivo de inspeção para utilização em um contentor de fluido e dispositivo de inspeção para utilização dentro de um fluido
BR112017010881A2 (pt) sistema e método para monitorar um indivíduo e mídia legível por computador
BR112018012447A2 (pt) ?método para transferência de calor entre um item metálico ou não metálico e um fluido de transferência de calor e fluido de transferência de calor?
AR105783A1 (es) Concentrados en suspensión aceitosa de baja separación gravimétrica y baja viscosidad
PE20170282A1 (es) Recuperacion de minerales usando superficies polimericas hidrofobicas
BR112016023754A2 (pt) ?uso de lactobacillus paracasei para promover recuperação da diversidade da microbiota intestinal após disbiose?
BR112014027739A2 (pt) aparelho para separar partículas magnéticas de uma dispersão, processo para separação de pelo menos uma partícula magnética de uma dispersão, e, uso de um aparelho
BR112018012499A2 (pt) método de tratamento térmico de um item não metálico ou metálico
WO2015196141A8 (en) Nucleic acid sample preparation

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired