MX2016014647A - Proteinas de fusion del ligando de ox40 (ox40l) y sus usos. - Google Patents

Proteinas de fusion del ligando de ox40 (ox40l) y sus usos.

Info

Publication number
MX2016014647A
MX2016014647A MX2016014647A MX2016014647A MX2016014647A MX 2016014647 A MX2016014647 A MX 2016014647A MX 2016014647 A MX2016014647 A MX 2016014647A MX 2016014647 A MX2016014647 A MX 2016014647A MX 2016014647 A MX2016014647 A MX 2016014647A
Authority
MX
Mexico
Prior art keywords
fusion polypeptide
fusion proteins
polypeptide subunits
domain
ox40l fusion
Prior art date
Application number
MX2016014647A
Other languages
English (en)
Other versions
MX360295B (es
Inventor
Damschroder Melissa
Hammond Scott
Oberst Michael
Feng Hui
Original Assignee
Medimmune Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Llc filed Critical Medimmune Llc
Publication of MX2016014647A publication Critical patent/MX2016014647A/es
Publication of MX360295B publication Critical patent/MX360295B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6056—Antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La descripción proporciona subunidades polipeptídicas de fusión OX40L huIgG4 que comprenden un dominio Fc de IgG4 humana; un dominio de trimerización, y un dominio de unión al receptor del ligando OX40, en donde las subunidades polipeptídicas de fusión pueden autoensamblarse en proteínas hexaméricas. También se proporcionan métodos para fabricar subunidades polipeptídicas de fusión y proteínas hexaméricas, y métodos para usar, por ejemplo, en el tratamiento del cáncer.
MX2016014647A 2014-05-29 2015-05-27 Proteinas de fusion del ligando de ox40 (ox40l) y sus usos. MX360295B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462004555P 2014-05-29 2014-05-29
US201562111796P 2015-02-04 2015-02-04
PCT/US2015/032598 WO2015183902A1 (en) 2014-05-29 2015-05-27 Ox40l fusion proteins and uses thereof

Publications (2)

Publication Number Publication Date
MX2016014647A true MX2016014647A (es) 2017-05-30
MX360295B MX360295B (es) 2018-10-29

Family

ID=53540957

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016014647A MX360295B (es) 2014-05-29 2015-05-27 Proteinas de fusion del ligando de ox40 (ox40l) y sus usos.

Country Status (10)

Country Link
US (1) US9718870B2 (es)
EP (1) EP3148573A4 (es)
JP (1) JP6666267B2 (es)
CN (1) CN106456734A (es)
BR (1) BR112016027845A2 (es)
GB (1) GB2532817A (es)
MX (1) MX360295B (es)
RU (1) RU2016150096A (es)
TW (1) TW201623327A (es)
WO (1) WO2015183902A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2016150096A (ru) * 2014-05-29 2018-07-02 МЕДИММЬЮН, ЭлЭлСи Белки слияния на основе ox40l и пути их применения
SI3489256T1 (sl) 2014-11-14 2021-08-31 F. Hoffmann-La Roche Ag Molekule, ki vežejo antigen in vsebujejo trimer ligandov iz družine TNF
EP3253876B1 (en) 2015-02-06 2020-11-04 Heat Biologics, Inc. Vector co-expressing vaccine and costimulatory molecules
CN107207579B (zh) 2015-03-31 2022-02-25 豪夫迈·罗氏有限公司 包含三聚体tnf家族配体的抗原结合分子
US11536716B2 (en) * 2015-06-25 2022-12-27 Hoffmann-La Roche Inc. Cell based assay for determining antibody or ligand binding and function
RU2018108236A (ru) 2015-08-12 2019-09-12 Медиммьюн Лимитед Слитые белки на основе gitrl и пути их применения
AR106188A1 (es) 2015-10-01 2017-12-20 Hoffmann La Roche Anticuerpos anti-cd19 humano humanizados y métodos de utilización
EP4183451A1 (en) 2015-10-01 2023-05-24 Heat Biologics, Inc. Compositions and methods for adjoining type i and type ii extracellular domains as heterologous chimeric proteins
EP3231813A1 (en) * 2016-03-29 2017-10-18 F. Hoffmann-La Roche AG Trimeric costimulatory tnf family ligand-containing antigen binding molecules
EP3243836A1 (en) * 2016-05-11 2017-11-15 F. Hoffmann-La Roche AG C-terminally fused tnf family ligand trimer-containing antigen binding molecules
WO2018071405A1 (en) 2016-10-11 2018-04-19 University Of Miami Vectors and vaccine cells for immunity against zika virus
US10331233B2 (en) * 2016-10-27 2019-06-25 Fluidity Technologies, Inc. Camera and sensor controls for remotely operated vehicles and virtual environments
US10331232B2 (en) * 2016-10-27 2019-06-25 Fluidity Technologies, Inc. Controller with situational awareness display
MX2019006624A (es) * 2016-12-09 2019-08-01 Seattle Genetics Inc Anticuerpos bivalentes enmascarados por helices superenrolladas.
US20200347143A1 (en) * 2016-12-19 2020-11-05 Glenmark Pharmaceuticals S.A. Novel tnfr agonists and uses thereof
AU2018223821B2 (en) 2017-02-27 2022-05-19 Shattuck Labs, Inc. TIGIT- and LIGHT-based chimeric proteins
EP3585409A4 (en) 2017-02-27 2020-12-02 Shattuck Labs, Inc. CHEMERICAL PROTEINS BASED ON CSF1R
US11192933B2 (en) 2017-02-27 2021-12-07 Shattuck Labs, Inc. VSIG8-based chimeric proteins
WO2018178074A1 (en) 2017-03-29 2018-10-04 F. Hoffmann-La Roche Ag Trimeric antigen binding molecules specific for a costimulatory tnf receptor
US11548930B2 (en) 2017-04-04 2023-01-10 Heat Biologics, Inc. Intratumoral vaccination
US11789010B2 (en) * 2017-04-28 2023-10-17 Five Prime Therapeutics, Inc. Methods of treatment with CD80 extracellular domain polypeptides
US10780121B2 (en) 2018-08-29 2020-09-22 Shattuck Labs, Inc. FLT3L-based chimeric proteins
CN109839509A (zh) * 2019-02-15 2019-06-04 浠思（上海）生物技术有限公司 利用ox40/ox40l的htrf结合分析实验技术筛选潜在激动剂的方法
JP2023525140A (ja) * 2020-05-13 2023-06-14 アンセルム（アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル） Ｏｘ４０活性化特性を有する組換えタンパク質
EP4277639A2 (en) * 2021-01-15 2023-11-22 Seattle Children's Hospital d/b/a Seattle Children's Research Institute Hybrid and truncated immune cell proteins
CN118234851A (zh) * 2021-11-19 2024-06-21 南开大学 重组武装溶瘤病毒组合物及其在til过继治疗中的用途
CN114966061B (zh) * 2022-07-28 2022-10-21 中国食品药品检定研究院 一种抗ox40抗体的生物活性检测方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681718A (en) 1986-03-14 1997-10-28 Celltech Limited Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof
US5892019A (en) 1987-07-15 1999-04-06 The United States Of America, As Represented By The Department Of Health And Human Services Production of a single-gene-encoded immunoglobulin
US5457035A (en) 1993-07-23 1995-10-10 Immunex Corporation Cytokine which is a ligand for OX40
US6242566B1 (en) 1994-02-10 2001-06-05 Board Of Trustees Of The Leland Stanford Junior University Ligand (ACT-4-L) to a receptor on the surface of activated CD4+ T-cells
US6312700B1 (en) 1998-02-24 2001-11-06 Andrew D. Weinberg Method for enhancing an antigen specific immune response with OX-40L
US7056695B2 (en) * 2000-03-02 2006-06-06 Xencor TNF-α variants
EP1366067B1 (en) * 2001-03-07 2012-09-26 Merck Patent GmbH Expression technology for proteins containing a hybrid isotype antibody moiety
EP1572936A2 (en) * 2002-03-05 2005-09-14 Eli Lilly And Company Heterologous g-csf fusion proteins
GB0216648D0 (en) 2002-07-18 2002-08-28 Lonza Biologics Plc Method of expressing recombinant protein in CHO cells
US20080187954A1 (en) 2004-03-10 2008-08-07 Lonza Ltd. Method For Producing Antibodies
CA2580981C (en) * 2004-09-22 2013-10-22 Kirin Beer Kabushiki Kaisha Stabilized human igg4 antibodies
EP1877090B1 (en) 2005-05-06 2014-01-15 Providence Health System Trimeric ox40-immunoglobulin fusion protein and methods of use
AU2013263717B2 (en) * 2005-05-06 2016-05-19 Providence Health & Services - Oregon Trimeric OX40L-immunoglobulin fusion protein and methods of use
TWI461436B (zh) * 2005-11-25 2014-11-21 Kyowa Hakko Kirin Co Ltd 人類ｃｄ１３４（ｏｘ４０）之人類單株抗體及其製造及使用方法
KR20080090412A (ko) * 2005-12-08 2008-10-08 유니버시티 오브 루이빌 리서치 파운데이션, 인코포레이티드 생체내 세포 표면 엔지니어링
CN101802197A (zh) * 2007-05-14 2010-08-11 比奥根艾迪克Ma公司 单链FC（ScFc）区、包含其的结合多肽及与其相关的方法
WO2008145142A1 (en) * 2007-05-31 2008-12-04 Genmab A/S Stable igg4 antibodies
US8637637B2 (en) * 2010-01-12 2014-01-28 Bill Nai-Chau Sun Fc fusion proteins of human growth hormone
GB201014033D0 (en) * 2010-08-20 2010-10-06 Ucb Pharma Sa Biological products
AU2012371610A1 (en) * 2012-03-02 2014-10-02 Providence Health & Services - Oregon Dual OX40 agonist/IL-2 cancer therapy methods
RU2016150096A (ru) * 2014-05-29 2018-07-02 МЕДИММЬЮН, ЭлЭлСи Белки слияния на основе ox40l и пути их применения
KR20170072928A (ko) * 2014-10-24 2017-06-27 아스트라제네카 아베 조합물

Also Published As

Publication number Publication date
EP3148573A1 (en) 2017-04-05
MX360295B (es) 2018-10-29
RU2016150096A (ru) 2018-07-02
WO2015183902A1 (en) 2015-12-03
US20160024176A1 (en) 2016-01-28
CN106456734A (zh) 2017-02-22
EP3148573A4 (en) 2017-11-15
RU2016150096A3 (es) 2019-01-24
TW201623327A (zh) 2016-07-01
GB201509062D0 (en) 2015-07-08
US9718870B2 (en) 2017-08-01
BR112016027845A2 (pt) 2017-10-31
JP2017519494A (ja) 2017-07-20
GB2532817A (en) 2016-06-01
JP6666267B2 (ja) 2020-03-13

Similar Documents

Publication Publication Date Title
MX360295B (es) Proteinas de fusion del ligando de ox40 (ox40l) y sus usos.
MX2018001787A (es) Proteinas de fusion del ligando de la proteina relacionada con el receptor de factor de necrosis tumoral inducido por glucorticoides (gitrl) y usos de las mismas.
PH12017501372A1 (en) Tnfrsf-binding agents and uses thereof
EP3733716A4 (en) DIMERAL FUSION PROTEIN USING ANTIBODY FC REGION AS A SKELETON AND ASSOCIATED USE
HK1254755A1 (zh) 抗-肌肉生長抑制因子抗體、包含變體fc區的多肽及使用方法
PH12016501644B1 (en) Binding proteins and methods of use thereof
GEP20217326B (en) Constructs having a sirp-alpha domain or variant thereof
IL251319B1 (en) Anti-myostatin antibodies, polypeptides containing variable fc regions and methods of use
NZ738008A (en) Tigit-binding agents and uses thereof
PH12018501882A1 (en) Binding proteins and methods of use thereof
GB2564823A (en) Compositions and methods for T-cell receptors reprogramming using fusion proteins
MX2017014822A (es) Composiciones y métodos para la reprogramación del tcr con proteínas de fusión.
MX2017012965A (es) Anticuerpo anti-c-met y conjugado de farmaco citotoxico de anticuerpo anti-c-met y uso farmaceutico del mismo.
EA201791884A1 (ru) Химерные антигенные рецепторы против dll3 и способы применения
GEP20227343B (en) Anti-lag3 antibodies and antigen-binding fragments
MX2017004311A (es) Anticuerpos del receptor del factor de necrosis tumoral inducido por glucocorticoide (gitr) y metodos de uso de los mismos.
WO2016100985A3 (en) Chimeric antigen receptors and methods of use thereof
MX2022014695A (es) Anticuerpos anti-gitr y sus usos.
MX2018010672A (es) Anticuerpos para cumulo de diferenciación 40 (cd40) con actividad agonista mejorada.
PH12019501605A1 (en) Glucagon receptor binding proteins and methods of use thereof
SG10201805646WA (en) Angiopoietin-like 4 antibodies and methods of use
TW201613977A (en) Angiopoetin-like 4 (ANGPTL4) antibodies and methods of use
MX2019014090A (es) Métodos para el tratamiento de la reservoritis crónica.
WO2015175599A3 (en) Immunotherapy with binding agents
EP3535282A4 (en) OPTOGENETIC MODULATION BY OPSINE WITH SEVERAL PROPERTIES FOR THE RESTORATION OF SIGHT AND OTHER APPLICATIONS THEREOF

Legal Events

Date Code Title Description
FG Grant or registration