MX2016002655A - Metodo para reducir la muerte de celulas neuronales con haloalquilaminas. - Google Patents

Metodo para reducir la muerte de celulas neuronales con haloalquilaminas.

Info

Publication number
MX2016002655A
MX2016002655A MX2016002655A MX2016002655A MX2016002655A MX 2016002655 A MX2016002655 A MX 2016002655A MX 2016002655 A MX2016002655 A MX 2016002655A MX 2016002655 A MX2016002655 A MX 2016002655A MX 2016002655 A MX2016002655 A MX 2016002655A
Authority
MX
Mexico
Prior art keywords
cell death
haloalkylamines
directed
methods
pharmaceutical compositions
Prior art date
Application number
MX2016002655A
Other languages
English (en)
Inventor
David J Poulsen
Thomas Frederick Rau
Original Assignee
Univ Montana
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Montana filed Critical Univ Montana
Publication of MX2016002655A publication Critical patent/MX2016002655A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/131—Amines acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

La presente invención se dirige a composiciones farmacéuticas y métodos para tratar la lesión cerebral traumática (TBI). La invención también se dirige a composiciones farmacéuticas y métodos para tratar una condición transiente hipóxica y/o isquémica en el sistema nervioso central. Más específicamente, la presente invención se dirige a composiciones farmacéuticas y métodos para reducir la ocurrencia de la muerte de células neuronales en el sistema nervioso central, tal como, la reducción de la ocurrencia de la muerte de células del cerebro en el hipocampo y/o la corteza.
MX2016002655A 2013-09-06 2014-09-08 Metodo para reducir la muerte de celulas neuronales con haloalquilaminas. MX2016002655A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361874865P 2013-09-06 2013-09-06
PCT/US2014/054569 WO2015035308A2 (en) 2013-09-06 2014-09-08 Method of reducing neuronal cell death with haloalkylamines

Publications (1)

Publication Number Publication Date
MX2016002655A true MX2016002655A (es) 2016-06-06

Family

ID=52629091

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016002655A MX2016002655A (es) 2013-09-06 2014-09-08 Metodo para reducir la muerte de celulas neuronales con haloalquilaminas.

Country Status (7)

Country Link
US (3) US20160220515A1 (es)
EP (1) EP3041465B1 (es)
JP (3) JP6475733B2 (es)
CN (2) CN110251496A (es)
CA (1) CA2923476C (es)
MX (1) MX2016002655A (es)
WO (1) WO2015035308A2 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6475733B2 (ja) 2013-09-06 2019-02-27 ザ ユニバーシティー オブ モンタナ ハロアルキルアミンを用いた神経細胞死の低減方法

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US6009875A (en) 1993-10-14 2000-01-04 Berlex Laboratories, Inc. Use of sympathetic antagonists for treatment of chronic muscle pain
US5513661A (en) 1993-10-14 1996-05-07 Hubbard; David R. Use of sympathetic blockade for treatment of chronic muscle pain
US5898035A (en) 1995-08-29 1999-04-27 New York Medical College Formulations of haloalkylamines and local anesthetic and methods for the treatment of reflex sympathetic dystrophy (RSD)
US6284763B1 (en) 1998-08-26 2001-09-04 Queen's University At Kingston Methods for remodeling neuronal and cardiovascular pathways
WO2002005849A2 (en) 2000-07-19 2002-01-24 Pitmy International N.V. Transportation of nucleic acid substances
US6730667B2 (en) 2001-11-26 2004-05-04 William R. Deagle Iontophoresis disc pain blocker
US7172614B2 (en) * 2002-06-27 2007-02-06 Advanced Cardiovascular Systems, Inc. Support structures for embolic filtering devices
WO2004028548A2 (en) * 2002-09-26 2004-04-08 Carbomer, Inc. Inhibitors of the nitrix oxide synthase iii (nos iii) as neuroprotective agents
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WO2006065555A2 (en) * 2004-12-13 2006-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. Use of alpha-adrenergic blockers for the treatment of dysmenorrhea
WO2007057508A2 (en) 2005-11-18 2007-05-24 Orion Corporation Treatment of pain with a combination of an alpha2 -adrenoceptor antagonist such as atipemezole or fipamezoiie and an opioid receptor agonist, such as tramadol
WO2007062862A2 (en) 2005-12-02 2007-06-07 Ludwig Maximilians Universität München Use of calmodulin inhibitors for the treatment of neurodegenerative disorders
US20070249725A1 (en) 2006-02-17 2007-10-25 Hubbard David R Pharmaceutical formulations of sympathetic antagonist for the treatment of chronic muscle pain
US20110105621A1 (en) * 2006-08-23 2011-05-05 The University Of Montana Method of reducing brain cell damage, inflammation or death
CN103479603B (zh) 2006-08-23 2016-06-22 蒙大拿大学 减轻神经元细胞损害的方法
US20090197969A1 (en) * 2006-08-23 2009-08-06 Poulsen David J Method of reducing brain cell damage or death
CN101641013B (zh) 2007-01-22 2014-07-30 Gtx公司 核受体结合剂
US8292830B2 (en) 2007-05-22 2012-10-23 University Of Louisville Research Foundation, Inc. Soft tissue impact assessment device and system
US20110053913A1 (en) 2009-06-25 2011-03-03 Khem Jhamandas Methods and Therapies for Alleviating Pain
WO2011134075A1 (en) * 2010-04-30 2011-11-03 The University Of Western Ontario Sox9 inhibitors
WO2012074561A2 (en) 2010-11-30 2012-06-07 Columbia Northwest Pharmaceuticals Llc Methods and compositions for the treatment of anxiety disorders, including post traumatic stress disorder (ptsd) and related central nervous system (cns) disorders
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JP6475733B2 (ja) 2013-09-06 2019-02-27 ザ ユニバーシティー オブ モンタナ ハロアルキルアミンを用いた神経細胞死の低減方法

Also Published As

Publication number Publication date
EP3041465A4 (en) 2017-03-08
US20190083423A1 (en) 2019-03-21
JP2020059746A (ja) 2020-04-16
EP3041465A2 (en) 2016-07-13
JP2019077718A (ja) 2019-05-23
CA2923476A1 (en) 2015-03-12
JP6475733B2 (ja) 2019-02-27
WO2015035308A3 (en) 2015-10-29
EP3041465B1 (en) 2020-11-11
JP6865806B2 (ja) 2021-04-28
CN105530924A (zh) 2016-04-27
JP2016529320A (ja) 2016-09-23
US20210093586A1 (en) 2021-04-01
JP6636660B2 (ja) 2020-01-29
WO2015035308A2 (en) 2015-03-12
CA2923476C (en) 2021-03-16
US20160220515A1 (en) 2016-08-04
US10849865B2 (en) 2020-12-01
CN110251496A (zh) 2019-09-20

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