MX2015014354A - Poliplexos. - Google Patents
Poliplexos.Info
- Publication number
- MX2015014354A MX2015014354A MX2015014354A MX2015014354A MX2015014354A MX 2015014354 A MX2015014354 A MX 2015014354A MX 2015014354 A MX2015014354 A MX 2015014354A MX 2015014354 A MX2015014354 A MX 2015014354A MX 2015014354 A MX2015014354 A MX 2015014354A
- Authority
- MX
- Mexico
- Prior art keywords
- peptide
- active agent
- predetermined
- polymer
- present disclosure
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/005—Enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
Abstract
La presente descripción se refiere a los compuestos que comprenden (i) un agente activo, en donde el agente activo incluye una carga a un pH predeterminado, (ii) un polímero, en donde el polímero incluye una carga opuesta a la del agente activo al pH predeterminado; y (iii) un poliplexo que comprende el péptido y el polímero electrostáticamente enlazados entre sí al pH predeterminado. En algunas modalidades, el agente activo es un péptido, tal como un péptido que comprende el péptido inhibitorio de la cinasa II MAPKCAP, y en algunas modalidades el péptido incluye un péptido penetrador de las células. En modalidades adicionales, la descripción proporciona los métodos para tratar un trastorno o condición mediante la administración de una composición de acuerdo a la presente descripción a un sujeto en necesidad de la misma.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361811078P | 2013-04-11 | 2013-04-11 | |
PCT/US2014/033873 WO2014169256A2 (en) | 2013-04-11 | 2014-04-11 | Polyplexes |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2015014354A true MX2015014354A (es) | 2016-06-07 |
Family
ID=51690135
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015014354A MX2015014354A (es) | 2013-04-11 | 2014-04-11 | Poliplexos. |
Country Status (12)
Country | Link |
---|---|
US (1) | US10835549B2 (es) |
EP (1) | EP2991616A4 (es) |
JP (1) | JP2016518358A (es) |
KR (1) | KR20150143639A (es) |
CN (1) | CN105431134A (es) |
AU (1) | AU2014250830A1 (es) |
BR (1) | BR112015025968A2 (es) |
CA (1) | CA2911315A1 (es) |
HK (1) | HK1216152A1 (es) |
MX (1) | MX2015014354A (es) |
RU (1) | RU2015148055A (es) |
WO (1) | WO2014169256A2 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107406489A (zh) | 2015-01-08 | 2017-11-28 | 莫伊莱麦屈克斯公司 | Mk2抑制剂肽的制剂 |
CN104815333B (zh) * | 2015-04-05 | 2017-10-31 | 北京工业大学 | 一种聚离子胶束纳米粒子的制备方法及其应用 |
US11147827B2 (en) | 2016-08-05 | 2021-10-19 | Vanderbilt University | Conjugation of lipophilic albumin-binding moiety to RNA for improved carrier-free in vivo pharmacokinetics and gene silencing |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2445947A1 (en) * | 2001-04-30 | 2002-11-07 | Targeted Genetics Corporation | Lipid-comprising drug delivery complexes and methods for their production |
DE60329126D1 (de) | 2002-02-20 | 2009-10-15 | Beth Israel Hospital | Konjugate mit biologisch abbaubarem polymer und verwendung dafür |
WO2004063342A2 (en) * | 2003-01-09 | 2004-07-29 | Invitrogen Corporation | Cellular delivery and activation polypeptide-nucleic acid complexes |
WO2007001448A2 (en) | 2004-11-04 | 2007-01-04 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
WO2009021137A2 (en) | 2007-08-07 | 2009-02-12 | Purdue Research Foundation | Kinase inhibitors and uses thereof |
US9271933B2 (en) | 2007-11-27 | 2016-03-01 | Rutgers, The State University Of New Jersey | Graft copolymer polyelectrolyte complexes for drug delivery |
US20110060123A1 (en) | 2008-04-30 | 2011-03-10 | Kazunori Kataoka | Charge conversional ternary polyplex |
US20100150952A1 (en) * | 2008-11-07 | 2010-06-17 | University Of Washington | pH-RESPONSIVE POLYMER CARRIER COMPOSITIONS FOR CYTOSOLIC PROTEIN DELIVERY |
US9327008B2 (en) * | 2008-12-10 | 2016-05-03 | Purdue Research Foundation | Cell-permeant peptide-based inhibitor of kinases |
WO2011149964A2 (en) | 2010-05-24 | 2011-12-01 | Moerae Matrix, Inc., | Methods for treating or preventing vascular graft failure |
DK2970389T3 (da) * | 2013-03-15 | 2020-10-26 | Rhythm Pharmaceuticals Inc | Farmaceutiske forbindelser |
-
2014
- 2014-04-11 CA CA2911315A patent/CA2911315A1/en not_active Abandoned
- 2014-04-11 KR KR1020157032241A patent/KR20150143639A/ko not_active Application Discontinuation
- 2014-04-11 RU RU2015148055A patent/RU2015148055A/ru not_active Application Discontinuation
- 2014-04-11 MX MX2015014354A patent/MX2015014354A/es unknown
- 2014-04-11 US US14/784,017 patent/US10835549B2/en active Active
- 2014-04-11 BR BR112015025968A patent/BR112015025968A2/pt not_active Application Discontinuation
- 2014-04-11 CN CN201480033617.1A patent/CN105431134A/zh active Pending
- 2014-04-11 WO PCT/US2014/033873 patent/WO2014169256A2/en active Application Filing
- 2014-04-11 JP JP2016507694A patent/JP2016518358A/ja active Pending
- 2014-04-11 AU AU2014250830A patent/AU2014250830A1/en not_active Abandoned
- 2014-04-11 EP EP14783124.2A patent/EP2991616A4/en not_active Withdrawn
-
2016
- 2016-04-13 HK HK16104189.5A patent/HK1216152A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
US10835549B2 (en) | 2020-11-17 |
WO2014169256A3 (en) | 2014-12-11 |
AU2014250830A1 (en) | 2015-11-12 |
KR20150143639A (ko) | 2015-12-23 |
RU2015148055A (ru) | 2017-05-16 |
HK1216152A1 (zh) | 2016-10-21 |
JP2016518358A (ja) | 2016-06-23 |
BR112015025968A2 (pt) | 2018-01-09 |
EP2991616A2 (en) | 2016-03-09 |
WO2014169256A2 (en) | 2014-10-16 |
CN105431134A (zh) | 2016-03-23 |
CA2911315A1 (en) | 2014-10-16 |
US20160058876A1 (en) | 2016-03-03 |
EP2991616A4 (en) | 2016-11-09 |
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