MX2015004436A - Tratamientos conjuntos y usos para tratar trastornos desmielinizantes. - Google Patents

Info

Publication number

MX2015004436A

MX2015004436A MX2015004436A MX2015004436A MX2015004436A MX 2015004436 A MX2015004436 A MX 2015004436A MX 2015004436 A MX2015004436 A MX 2015004436A MX 2015004436 A MX2015004436 A MX 2015004436A MX 2015004436 A MX2015004436 A MX 2015004436A

Authority

MX

Mexico

Prior art keywords

lingo

seq

antibody

antibody molecule

subject

Prior art date

2012-10-09

Links

• Espacenet
• Global Dossier
• Discuss

• 208000016192 Demyelinating disease Diseases 0.000 title claims abstract description 37
• 238000011282 treatment Methods 0.000 title claims description 116
• 238000002648 combination therapy Methods 0.000 title 1
• 239000003795 chemical substances by application Substances 0.000 claims abstract description 163
• 238000000034 method Methods 0.000 claims abstract description 151
• 241000282414 Homo sapiens Species 0.000 claims abstract description 58
• 210000004248 oligodendroglia Anatomy 0.000 claims abstract description 41
• 239000000203 mixture Substances 0.000 claims abstract description 33
• 230000004968 inflammatory condition Effects 0.000 claims abstract description 12
• 230000002708 enhancing effect Effects 0.000 claims abstract 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 192
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 189
• 229920001184 polypeptide Polymers 0.000 claims description 180
• 201000006417 multiple sclerosis Diseases 0.000 claims description 167
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 143
• 238000012360 testing method Methods 0.000 claims description 91
• 239000012634 fragment Substances 0.000 claims description 90
• 230000006870 function Effects 0.000 claims description 85
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 76
• 201000010099 disease Diseases 0.000 claims description 59
• 210000001328 optic nerve Anatomy 0.000 claims description 52
• 230000006378 damage Effects 0.000 claims description 41
• 230000003902 lesion Effects 0.000 claims description 38
• 208000024891 symptom Diseases 0.000 claims description 35
• 208000003435 Optic Neuritis Diseases 0.000 claims description 34
• 230000006872 improvement Effects 0.000 claims description 34
• 238000002595 magnetic resonance imaging Methods 0.000 claims description 30
• 238000005259 measurement Methods 0.000 claims description 30
• 108090000467 Interferon-beta Proteins 0.000 claims description 27
• 208000007400 Relapsing-Remitting Multiple Sclerosis Diseases 0.000 claims description 24
• 102000005962 receptors Human genes 0.000 claims description 24
• 108020003175 receptors Proteins 0.000 claims description 24
• 230000000295 complement effect Effects 0.000 claims description 22
• 230000007423 decrease Effects 0.000 claims description 22
• 230000001154 acute effect Effects 0.000 claims description 21
• 101000981680 Homo sapiens Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 Proteins 0.000 claims description 20
• 210000001364 upper extremity Anatomy 0.000 claims description 20
• 201000008628 secondary progressive multiple sclerosis Diseases 0.000 claims description 19
• 239000003246 corticosteroid Substances 0.000 claims description 18
• 230000001965 increasing effect Effects 0.000 claims description 18
• LDCRTTXIJACKKU-ONEGZZNKSA-N dimethyl fumarate Chemical compound COC(=O)\C=C\C(=O)OC LDCRTTXIJACKKU-ONEGZZNKSA-N 0.000 claims description 17
• 229960000556 fingolimod Drugs 0.000 claims description 17
• KKGQTZUTZRNORY-UHFFFAOYSA-N fingolimod Chemical compound CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1 KKGQTZUTZRNORY-UHFFFAOYSA-N 0.000 claims description 17
• 102000052739 human LINGO1 Human genes 0.000 claims description 17
• 230000003920 cognitive function Effects 0.000 claims description 16
• 210000003141 lower extremity Anatomy 0.000 claims description 16
• 239000004472 Lysine Substances 0.000 claims description 15
• 239000012636 effector Substances 0.000 claims description 15
• 108010072051 Glatiramer Acetate Proteins 0.000 claims description 14
• 108010005714 Interferon beta-1b Proteins 0.000 claims description 14
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 14
• 210000001744 T-lymphocyte Anatomy 0.000 claims description 14
• 230000004069 differentiation Effects 0.000 claims description 14
• 229960004419 dimethyl fumarate Drugs 0.000 claims description 14
• 239000003018 immunosuppressive agent Substances 0.000 claims description 14
• 235000018977 lysine Nutrition 0.000 claims description 14
• 229960005027 natalizumab Drugs 0.000 claims description 14
• 238000009792 diffusion process Methods 0.000 claims description 13
• 238000011156 evaluation Methods 0.000 claims description 13
• 230000013016 learning Effects 0.000 claims description 13
• KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims description 13
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 12
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 12
• 230000015654 memory Effects 0.000 claims description 12
• UTNUDOFZCWSZMS-YFHOEESVSA-N teriflunomide Chemical compound C\C(O)=C(/C#N)C(=O)NC1=CC=C(C(F)(F)F)C=C1 UTNUDOFZCWSZMS-YFHOEESVSA-N 0.000 claims description 12
• 102100026720 Interferon beta Human genes 0.000 claims description 10
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 10
• 229960002806 daclizumab Drugs 0.000 claims description 10
• 238000000338 in vitro Methods 0.000 claims description 10
• 239000007927 intramuscular injection Substances 0.000 claims description 10
• 229960001156 mitoxantrone Drugs 0.000 claims description 10
• 230000004083 survival effect Effects 0.000 claims description 10
• 229960000331 teriflunomide Drugs 0.000 claims description 10
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 10
• 235000002374 tyrosine Nutrition 0.000 claims description 10
• 230000000007 visual effect Effects 0.000 claims description 10
• 208000027418 Wounds and injury Diseases 0.000 claims description 9
• 239000002131 composite material Substances 0.000 claims description 9
• 229940125721 immunosuppressive agent Drugs 0.000 claims description 9
• 208000014674 injury Diseases 0.000 claims description 9
• 206010063401 primary progressive multiple sclerosis Diseases 0.000 claims description 9
• 238000012545 processing Methods 0.000 claims description 9
• 238000010254 subcutaneous injection Methods 0.000 claims description 9
• 239000007929 subcutaneous injection Substances 0.000 claims description 9
• 102000013135 CD52 Antigen Human genes 0.000 claims description 8
• 108010065524 CD52 Antigen Proteins 0.000 claims description 8
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 8
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 8
• 101100202644 Parasynechococcus marenigrum (strain WH8102) bsmB gene Proteins 0.000 claims description 8
• 229960000548 alemtuzumab Drugs 0.000 claims description 8
• 235000013922 glutamic acid Nutrition 0.000 claims description 8
• 239000004220 glutamic acid Substances 0.000 claims description 8
• 238000001802 infusion Methods 0.000 claims description 8
• YLOCGHYTXIINAI-XKUOMLDTSA-N (2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 YLOCGHYTXIINAI-XKUOMLDTSA-N 0.000 claims description 7
• 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims description 7
• 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims description 7
• 235000004279 alanine Nutrition 0.000 claims description 7
• RGHILYZRVFRRNK-UHFFFAOYSA-N anthracene-1,2-dione Chemical compound C1=CC=C2C=C(C(C(=O)C=C3)=O)C3=CC2=C1 RGHILYZRVFRRNK-UHFFFAOYSA-N 0.000 claims description 7
• 230000003915 cell function Effects 0.000 claims description 7
• 230000001149 cognitive effect Effects 0.000 claims description 7
• 229940042385 glatiramer Drugs 0.000 claims description 7
• 230000001976 improved effect Effects 0.000 claims description 7
• 238000010255 intramuscular injection Methods 0.000 claims description 7
• 238000010984 neurological examination Methods 0.000 claims description 7
• 229920000642 polymer Polymers 0.000 claims description 7
• 230000001755 vocal effect Effects 0.000 claims description 7
• 206010071068 Clinically isolated syndrome Diseases 0.000 claims description 6
• 108010052167 Dihydroorotate Dehydrogenase Proteins 0.000 claims description 6
• 102100032823 Dihydroorotate dehydrogenase (quinone), mitochondrial Human genes 0.000 claims description 6
• 108010041012 Integrin alpha4 Proteins 0.000 claims description 6
• 229940021459 betaseron Drugs 0.000 claims description 6
• 230000003111 delayed effect Effects 0.000 claims description 6
• 210000003414 extremity Anatomy 0.000 claims description 6
• 239000003112 inhibitor Substances 0.000 claims description 6
• 206010061818 Disease progression Diseases 0.000 claims description 5
• 230000006735 deficit Effects 0.000 claims description 5
• 230000005750 disease progression Effects 0.000 claims description 5
• 238000012546 transfer Methods 0.000 claims description 5
• 230000004382 visual function Effects 0.000 claims description 5
• 230000010330 visuo-spatial memory Effects 0.000 claims description 5
• 208000010934 demyelinating disease of central nervous system Diseases 0.000 claims description 4
• 229940077362 extavia Drugs 0.000 claims description 4
• 230000000977 initiatory effect Effects 0.000 claims description 4
• 210000000225 synapse Anatomy 0.000 claims description 4
• 238000001514 detection method Methods 0.000 claims description 3
• 230000007497 verbal memory Effects 0.000 claims description 3
• 238000011952 auditory verbal learning test Methods 0.000 claims description 2
• 229940027941 immunoglobulin g Drugs 0.000 claims description 2
• 230000001737 promoting effect Effects 0.000 claims description 2
• 230000006886 spatial memory Effects 0.000 claims description 2
• 229960003444 immunosuppressant agent Drugs 0.000 claims 5
• VKZRWSNIWNFCIQ-WDSKDSINSA-N (2s)-2-[2-[[(1s)-1,2-dicarboxyethyl]amino]ethylamino]butanedioic acid Chemical compound OC(=O)C[C@@H](C(O)=O)NCCN[C@H](C(O)=O)CC(O)=O VKZRWSNIWNFCIQ-WDSKDSINSA-N 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• KZMAWJRXKGLWGS-UHFFFAOYSA-N 2-chloro-n-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-n-(3-methoxypropyl)acetamide Chemical compound S1C(N(C(=O)CCl)CCCOC)=NC(C=2C=CC(OC)=CC=2)=C1 KZMAWJRXKGLWGS-UHFFFAOYSA-N 0.000 claims 1
• 101000926140 Homo sapiens Gem-associated protein 2 Proteins 0.000 claims 1
• 101000716750 Homo sapiens Protein SCAF11 Proteins 0.000 claims 1
• 101000723833 Homo sapiens Zinc finger E-box-binding homeobox 2 Proteins 0.000 claims 1
• 108010002350 Interleukin-2 Proteins 0.000 claims 1
• 102100020876 Protein SCAF11 Human genes 0.000 claims 1
• WCIDIJQCEUODDY-UHFFFAOYSA-N chloro(dimethyl)sulfanium Chemical compound C[S+](C)Cl WCIDIJQCEUODDY-UHFFFAOYSA-N 0.000 claims 1
• 230000019771 cognition Effects 0.000 claims 1
• 238000011990 functional testing Methods 0.000 claims 1
• 230000002519 immonomodulatory effect Effects 0.000 abstract description 56
• 239000005557 antagonist Substances 0.000 abstract description 50
• 230000023105 myelination Effects 0.000 abstract description 18
• 235000001014 amino acid Nutrition 0.000 description 98
• 229940024606 amino acid Drugs 0.000 description 95
• 150000001413 amino acids Chemical class 0.000 description 92
• 210000004027 cell Anatomy 0.000 description 70
• 108090000623 proteins and genes Proteins 0.000 description 68
• 210000003169 central nervous system Anatomy 0.000 description 59
• 101100112922 Candida albicans CDR3 gene Proteins 0.000 description 50
• 230000003376 axonal effect Effects 0.000 description 45
• 230000027455 binding Effects 0.000 description 44
• 102000004169 proteins and genes Human genes 0.000 description 40
• 230000014509 gene expression Effects 0.000 description 35
• 235000018102 proteins Nutrition 0.000 description 35
• 201000002491 encephalomyelitis Diseases 0.000 description 34
• 150000007523 nucleic acids Chemical class 0.000 description 32
• 102000014150 Interferons Human genes 0.000 description 30
• 108010050904 Interferons Proteins 0.000 description 30
• 241000699670 Mus sp. Species 0.000 description 30
• 239000000427 antigen Substances 0.000 description 28
• 108091007433 antigens Proteins 0.000 description 28
• 102000036639 antigens Human genes 0.000 description 28
• 102000039446 nucleic acids Human genes 0.000 description 28
• 108020004707 nucleic acids Proteins 0.000 description 28
• 230000008859 change Effects 0.000 description 27
• 108060003951 Immunoglobulin Proteins 0.000 description 26
• 230000000694 effects Effects 0.000 description 26
• 102000018358 immunoglobulin Human genes 0.000 description 26
• 239000013598 vector Substances 0.000 description 24
• 241000700159 Rattus Species 0.000 description 23
• 210000003050 axon Anatomy 0.000 description 23
• 238000004458 analytical method Methods 0.000 description 22
• 210000004556 brain Anatomy 0.000 description 22
• 238000001990 intravenous administration Methods 0.000 description 21
• 108091033319 polynucleotide Proteins 0.000 description 21
• 102000040430 polynucleotide Human genes 0.000 description 21
• 239000002157 polynucleotide Substances 0.000 description 21
• 208000015114 central nervous system disease Diseases 0.000 description 20
• 238000006467 substitution reaction Methods 0.000 description 20
• VHRSUDSXCMQTMA-PJHHCJLFSA-N 6alpha-methylprednisolone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)CO)CC[C@H]21 VHRSUDSXCMQTMA-PJHHCJLFSA-N 0.000 description 19
• 239000013604 expression vector Substances 0.000 description 19
• 125000003729 nucleotide group Chemical group 0.000 description 19
• 230000008439 repair process Effects 0.000 description 19
• 229960004584 methylprednisolone Drugs 0.000 description 18
• 239000002773 nucleotide Substances 0.000 description 18
• 102000003996 Interferon-beta Human genes 0.000 description 17
• 241000699666 Mus <mouse, genus> Species 0.000 description 17
• 230000002757 inflammatory effect Effects 0.000 description 17
• 101710117290 Aldo-keto reductase family 1 member C4 Proteins 0.000 description 16
• 229940079322 interferon Drugs 0.000 description 16
• 229960001388 interferon-beta Drugs 0.000 description 16
• 210000002569 neuron Anatomy 0.000 description 16
• 208000035475 disorder Diseases 0.000 description 15
• 210000000278 spinal cord Anatomy 0.000 description 15
• 101150092843 SEC1 gene Proteins 0.000 description 14
• 108010003723 Single-Domain Antibodies Proteins 0.000 description 14
• 230000005713 exacerbation Effects 0.000 description 14
• 229960003646 lysine Drugs 0.000 description 14
• 230000002829 reductive effect Effects 0.000 description 14
• 238000000926 separation method Methods 0.000 description 14
• 206010012305 Demyelination Diseases 0.000 description 13
• 108091028043 Nucleic acid sequence Proteins 0.000 description 13
• 230000018109 developmental process Effects 0.000 description 13
• 108020001507 fusion proteins Proteins 0.000 description 13
• 102000037865 fusion proteins Human genes 0.000 description 13
• 229940047124 interferons Drugs 0.000 description 13
• 230000008485 antagonism Effects 0.000 description 12
• 150000001875 compounds Chemical class 0.000 description 12
• 238000011161 development Methods 0.000 description 12
• 239000003814 drug Substances 0.000 description 12
• 108020004414 DNA Proteins 0.000 description 11
• 108010005716 Interferon beta-1a Proteins 0.000 description 11
• 229940003504 avonex Drugs 0.000 description 11
• 230000015572 biosynthetic process Effects 0.000 description 10
• 238000012217 deletion Methods 0.000 description 10
• 230000037430 deletion Effects 0.000 description 10
• 239000013612 plasmid Substances 0.000 description 10
• 230000004044 response Effects 0.000 description 10
• 210000002966 serum Anatomy 0.000 description 10
• 230000002459 sustained effect Effects 0.000 description 10
• 229960004441 tyrosine Drugs 0.000 description 10
• 206010061218 Inflammation Diseases 0.000 description 9
• 108010083674 Myelin Proteins Proteins 0.000 description 9
• 102000006386 Myelin Proteins Human genes 0.000 description 9
• 108010076504 Protein Sorting Signals Proteins 0.000 description 9
• 125000000539 amino acid group Chemical group 0.000 description 9
• 238000010171 animal model Methods 0.000 description 9
• 230000000692 anti-sense effect Effects 0.000 description 9
• 229960001334 corticosteroids Drugs 0.000 description 9
• 238000005516 engineering process Methods 0.000 description 9
• 229960002885 histidine Drugs 0.000 description 9
• 230000004054 inflammatory process Effects 0.000 description 9
• 108020004999 messenger RNA Proteins 0.000 description 9
• 210000005012 myelin Anatomy 0.000 description 9
• 230000003557 neuropsychological effect Effects 0.000 description 9
• 230000000750 progressive effect Effects 0.000 description 9
• 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 description 8
• 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 description 8
• 102000010789 Interleukin-2 Receptors Human genes 0.000 description 8
• 108010038453 Interleukin-2 Receptors Proteins 0.000 description 8
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 8
• 102000000343 Nogo Receptor 1 Human genes 0.000 description 8
• 108010041199 Nogo Receptor 1 Proteins 0.000 description 8
• 108091034117 Oligonucleotide Proteins 0.000 description 8
• 230000034994 death Effects 0.000 description 8
• 230000004927 fusion Effects 0.000 description 8
• 229960002989 glutamic acid Drugs 0.000 description 8
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 8
• 235000014304 histidine Nutrition 0.000 description 8
• 230000004048 modification Effects 0.000 description 8
• 238000012986 modification Methods 0.000 description 8
• 210000005036 nerve Anatomy 0.000 description 8
• 230000000926 neurological effect Effects 0.000 description 8
• 229950005751 ocrelizumab Drugs 0.000 description 8
• 230000002093 peripheral effect Effects 0.000 description 8
• 230000011664 signaling Effects 0.000 description 8
• 229910052720 vanadium Inorganic materials 0.000 description 8
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 7
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 7
• 108020004511 Recombinant DNA Proteins 0.000 description 7
• 229960003767 alanine Drugs 0.000 description 7
• VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 7
• BCGWQEUPMDMJNV-UHFFFAOYSA-N imipramine Chemical compound C1CC2=CC=CC=C2N(CCCN(C)C)C2=CC=CC=C21 BCGWQEUPMDMJNV-UHFFFAOYSA-N 0.000 description 7
• 230000005764 inhibitory process Effects 0.000 description 7
• 210000003007 myelin sheath Anatomy 0.000 description 7
• 230000001537 neural effect Effects 0.000 description 7
• 210000000535 oligodendrocyte precursor cell Anatomy 0.000 description 7
• 229940124597 therapeutic agent Drugs 0.000 description 7
• 239000004475 Arginine Substances 0.000 description 6
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 6
• 101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 description 6
• 101001047628 Homo sapiens Immunoglobulin kappa variable 2-29 Proteins 0.000 description 6
• 101001008321 Homo sapiens Immunoglobulin kappa variable 2D-26 Proteins 0.000 description 6
• 101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 description 6
• 101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 description 6
• 102100022949 Immunoglobulin kappa variable 2-29 Human genes 0.000 description 6
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 6
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 6
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 6
• 206010028980 Neoplasm Diseases 0.000 description 6
• 206010030113 Oedema Diseases 0.000 description 6
• 208000017493 Pelizaeus-Merzbacher disease Diseases 0.000 description 6
• 208000006011 Stroke Diseases 0.000 description 6
• 241000700605 Viruses Species 0.000 description 6
• 230000002159 abnormal effect Effects 0.000 description 6
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 6
• 235000009697 arginine Nutrition 0.000 description 6
• 229960003121 arginine Drugs 0.000 description 6
• 235000009582 asparagine Nutrition 0.000 description 6
• 229960001230 asparagine Drugs 0.000 description 6
• FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 description 6
• 238000002598 diffusion tensor imaging Methods 0.000 description 6
• 229910052731 fluorine Inorganic materials 0.000 description 6
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 6
• 235000004554 glutamine Nutrition 0.000 description 6
• 230000013595 glycosylation Effects 0.000 description 6
• 238000006206 glycosylation reaction Methods 0.000 description 6
• 230000036541 health Effects 0.000 description 6
• 230000006698 induction Effects 0.000 description 6
• 238000003780 insertion Methods 0.000 description 6
• 230000037431 insertion Effects 0.000 description 6
• 238000004519 manufacturing process Methods 0.000 description 6
• 239000011159 matrix material Substances 0.000 description 6
• 210000002241 neurite Anatomy 0.000 description 6
• 208000008795 neuromyelitis optica Diseases 0.000 description 6
• 239000008194 pharmaceutical composition Substances 0.000 description 6
• 206010036807 progressive multifocal leukoencephalopathy Diseases 0.000 description 6
• 238000011160 research Methods 0.000 description 6
• 241000894007 species Species 0.000 description 6
• 208000011580 syndromic disease Diseases 0.000 description 6
• 230000001225 therapeutic effect Effects 0.000 description 6
• 231100000331 toxic Toxicity 0.000 description 6
• 230000002588 toxic effect Effects 0.000 description 6
• 108090000994 Catalytic RNA Proteins 0.000 description 5
• 102000053642 Catalytic RNA Human genes 0.000 description 5
• 206010051290 Central nervous system lesion Diseases 0.000 description 5
• 241000282412 Homo Species 0.000 description 5
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 5
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 5
• 241001529936 Murinae Species 0.000 description 5
• 229930040373 Paraformaldehyde Natural products 0.000 description 5
• 108020004459 Small interfering RNA Proteins 0.000 description 5
• 208000002552 acute disseminated encephalomyelitis Diseases 0.000 description 5
• 230000009286 beneficial effect Effects 0.000 description 5
• 230000004071 biological effect Effects 0.000 description 5
• 210000004899 c-terminal region Anatomy 0.000 description 5
• 230000002490 cerebral effect Effects 0.000 description 5
• 210000004978 chinese hamster ovary cell Anatomy 0.000 description 5
• 230000003247 decreasing effect Effects 0.000 description 5
• 230000006866 deterioration Effects 0.000 description 5
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 5
• 238000010494 dissociation reaction Methods 0.000 description 5
• 230000005593 dissociations Effects 0.000 description 5
• ODQWQRRAPPTVAG-GZTJUZNOSA-N doxepin Chemical compound C1OC2=CC=CC=C2C(=C/CCN(C)C)/C2=CC=CC=C21 ODQWQRRAPPTVAG-GZTJUZNOSA-N 0.000 description 5
• 229940079593 drug Drugs 0.000 description 5
• -1 for example Chemical compound 0.000 description 5
• 229960002743 glutamine Drugs 0.000 description 5
• 210000004408 hybridoma Anatomy 0.000 description 5
• 238000001727 in vivo Methods 0.000 description 5
• 238000007477 logistic regression Methods 0.000 description 5
• 239000003550 marker Substances 0.000 description 5
• 230000001404 mediated effect Effects 0.000 description 5
• 230000007658 neurological function Effects 0.000 description 5
• 229920002866 paraformaldehyde Polymers 0.000 description 5
• 239000002953 phosphate buffered saline Substances 0.000 description 5
• 239000000902 placebo Substances 0.000 description 5
• 229940068196 placebo Drugs 0.000 description 5
• 108091092562 ribozyme Proteins 0.000 description 5
• 238000011947 six minute walk test Methods 0.000 description 5
• 229910052717 sulfur Inorganic materials 0.000 description 5
• 238000003786 synthesis reaction Methods 0.000 description 5
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 4
• 208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 description 4
• 241000283690 Bos taurus Species 0.000 description 4
• 241000282836 Camelus dromedarius Species 0.000 description 4
• 229910052688 Gadolinium Inorganic materials 0.000 description 4
• 208000010055 Globoid Cell Leukodystrophy Diseases 0.000 description 4
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 4
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 4
• 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 description 4
• 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 description 4
• 108010008212 Integrin alpha4beta1 Proteins 0.000 description 4
• 208000028226 Krabbe disease Diseases 0.000 description 4
• 241000124008 Mammalia Species 0.000 description 4
• 241001465754 Metazoa Species 0.000 description 4
• 206010067063 Progressive relapsing multiple sclerosis Diseases 0.000 description 4
• 208000034189 Sclerosis Diseases 0.000 description 4
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 4
• 239000002253 acid Substances 0.000 description 4
• 238000007792 addition Methods 0.000 description 4
• 230000008901 benefit Effects 0.000 description 4
• 230000000903 blocking effect Effects 0.000 description 4
• 229960000623 carbamazepine Drugs 0.000 description 4
• 230000001684 chronic effect Effects 0.000 description 4
• DGBIGWXXNGSACT-UHFFFAOYSA-N clonazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1Cl DGBIGWXXNGSACT-UHFFFAOYSA-N 0.000 description 4
• 230000024203 complement activation Effects 0.000 description 4
• 229940038717 copaxone Drugs 0.000 description 4
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 4
• 230000001086 cytosolic effect Effects 0.000 description 4
• 238000003745 diagnosis Methods 0.000 description 4
• 229960005426 doxepin Drugs 0.000 description 4
• 239000003623 enhancer Substances 0.000 description 4
• 208000012997 experimental autoimmune encephalomyelitis Diseases 0.000 description 4
• UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 description 4
• 229960004801 imipramine Drugs 0.000 description 4
• 208000027866 inflammatory disease Diseases 0.000 description 4
• 238000007918 intramuscular administration Methods 0.000 description 4
• QRXWMOHMRWLFEY-UHFFFAOYSA-N isoniazide Chemical compound NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 description 4
• 210000003734 kidney Anatomy 0.000 description 4
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 4
• 210000004962 mammalian cell Anatomy 0.000 description 4
• 238000013507 mapping Methods 0.000 description 4
• 239000000463 material Substances 0.000 description 4
• 239000002609 medium Substances 0.000 description 4
• YHXISWVBGDMDLQ-UHFFFAOYSA-N moclobemide Chemical compound C1=CC(Cl)=CC=C1C(=O)NCCN1CCOCC1 YHXISWVBGDMDLQ-UHFFFAOYSA-N 0.000 description 4
• 210000004126 nerve fiber Anatomy 0.000 description 4
• 229910052757 nitrogen Inorganic materials 0.000 description 4
• 238000002360 preparation method Methods 0.000 description 4
• 230000008569 process Effects 0.000 description 4
• 230000035755 proliferation Effects 0.000 description 4
• 238000000746 purification Methods 0.000 description 4
• 230000001105 regulatory effect Effects 0.000 description 4
• 238000012216 screening Methods 0.000 description 4
• 238000013517 stratification Methods 0.000 description 4
• 238000002560 therapeutic procedure Methods 0.000 description 4
• XFYDIVBRZNQMJC-UHFFFAOYSA-N tizanidine Chemical compound ClC=1C=CC2=NSN=C2C=1NC1=NCCN1 XFYDIVBRZNQMJC-UHFFFAOYSA-N 0.000 description 4
• 208000009174 transverse myelitis Diseases 0.000 description 4
• PHLBKPHSAVXXEF-UHFFFAOYSA-N trazodone Chemical compound ClC1=CC=CC(N2CCN(CCCN3C(N4C=CC=CC4=N3)=O)CC2)=C1 PHLBKPHSAVXXEF-UHFFFAOYSA-N 0.000 description 4
• 102000040650 (ribonucleotides)n+m Human genes 0.000 description 3
• PLRACCBDVIHHLZ-UHFFFAOYSA-N 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Chemical compound C1N(C)CCC(C=2C=CC=CC=2)=C1 PLRACCBDVIHHLZ-UHFFFAOYSA-N 0.000 description 3
• 201000011452 Adrenoleukodystrophy Diseases 0.000 description 3
• 208000011403 Alexander disease Diseases 0.000 description 3
• KHOITXIGCFIULA-UHFFFAOYSA-N Alophen Chemical compound C1=CC(OC(=O)C)=CC=C1C(C=1N=CC=CC=1)C1=CC=C(OC(C)=O)C=C1 KHOITXIGCFIULA-UHFFFAOYSA-N 0.000 description 3
• 206010003591 Ataxia Diseases 0.000 description 3
• 241000283707 Capra Species 0.000 description 3
• 241000282693 Cercopithecidae Species 0.000 description 3
• 108091033380 Coding strand Proteins 0.000 description 3
• 241000699802 Cricetulus griseus Species 0.000 description 3
• UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 description 3
• 102000003886 Glycoproteins Human genes 0.000 description 3
• 108090000288 Glycoproteins Proteins 0.000 description 3
• 208000023105 Huntington disease Diseases 0.000 description 3
• 108020004684 Internal Ribosome Entry Sites Proteins 0.000 description 3
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 3
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 3
• 102100024102 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 Human genes 0.000 description 3
• OCJYIGYOJCODJL-UHFFFAOYSA-N Meclizine Chemical compound CC1=CC=CC(CN2CCN(CC2)C(C=2C=CC=CC=2)C=2C=CC(Cl)=CC=2)=C1 OCJYIGYOJCODJL-UHFFFAOYSA-N 0.000 description 3
• 102000009030 Member 1 Subfamily D ATP Binding Cassette Transporter Human genes 0.000 description 3
• 108010049137 Member 1 Subfamily D ATP Binding Cassette Transporter Proteins 0.000 description 3
• 108700011259 MicroRNAs Proteins 0.000 description 3
• 208000008238 Muscle Spasticity Diseases 0.000 description 3
• PHVGLTMQBUFIQQ-UHFFFAOYSA-N Nortryptiline Chemical compound C1CC2=CC=CC=C2C(=CCCNC)C2=CC=CC=C21 PHVGLTMQBUFIQQ-UHFFFAOYSA-N 0.000 description 3
• 206010033892 Paraplegia Diseases 0.000 description 3
• 208000007542 Paresis Diseases 0.000 description 3
• 208000018737 Parkinson disease Diseases 0.000 description 3
• 241000283984 Rodentia Species 0.000 description 3
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 3
• 206010073696 Wallerian degeneration Diseases 0.000 description 3
• 238000009825 accumulation Methods 0.000 description 3
• FHEAIOHRHQGZPC-KIWGSFCNSA-N acetic acid;(2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound CC(O)=O.C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 FHEAIOHRHQGZPC-KIWGSFCNSA-N 0.000 description 3
• 230000009471 action Effects 0.000 description 3
• 239000002246 antineoplastic agent Substances 0.000 description 3
• 238000004166 bioassay Methods 0.000 description 3
• SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 description 3
• 238000004422 calculation algorithm Methods 0.000 description 3
• 238000012412 chemical coupling Methods 0.000 description 3
• 238000006243 chemical reaction Methods 0.000 description 3
• 208000037516 chromosome inversion disease Diseases 0.000 description 3
• 208000007118 chronic progressive multiple sclerosis Diseases 0.000 description 3
• 238000009826 distribution Methods 0.000 description 3
• 230000004064 dysfunction Effects 0.000 description 3
• 210000002889 endothelial cell Anatomy 0.000 description 3
• 210000003527 eukaryotic cell Anatomy 0.000 description 3
• 210000002950 fibroblast Anatomy 0.000 description 3
• 230000002068 genetic effect Effects 0.000 description 3
• 229960003776 glatiramer acetate Drugs 0.000 description 3
• 238000003384 imaging method Methods 0.000 description 3
• 229940124622 immune-modulator drug Drugs 0.000 description 3
• 230000006749 inflammatory damage Effects 0.000 description 3
• 238000002347 injection Methods 0.000 description 3
• 239000007924 injection Substances 0.000 description 3
• 238000011835 investigation Methods 0.000 description 3
• 230000002427 irreversible effect Effects 0.000 description 3
• 238000002955 isolation Methods 0.000 description 3
• 201000010901 lateral sclerosis Diseases 0.000 description 3
• 230000000670 limiting effect Effects 0.000 description 3
• 239000007788 liquid Substances 0.000 description 3
• 210000004698 lymphocyte Anatomy 0.000 description 3
• 239000002679 microRNA Substances 0.000 description 3
• 229960004644 moclobemide Drugs 0.000 description 3
• 238000012544 monitoring process Methods 0.000 description 3
• 208000005264 motor neuron disease Diseases 0.000 description 3
• 208000035824 paresthesia Diseases 0.000 description 3
• 230000037361 pathway Effects 0.000 description 3
• 229910052698 phosphorus Inorganic materials 0.000 description 3
• 230000000069 prophylactic effect Effects 0.000 description 3
• 238000003259 recombinant expression Methods 0.000 description 3
• 230000009467 reduction Effects 0.000 description 3
• 230000008929 regeneration Effects 0.000 description 3
• 238000011069 regeneration method Methods 0.000 description 3
• 230000002207 retinal effect Effects 0.000 description 3
• 210000003994 retinal ganglion cell Anatomy 0.000 description 3
• 230000028327 secretion Effects 0.000 description 3
• VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 description 3
• 239000011734 sodium Substances 0.000 description 3
• 239000011780 sodium chloride Substances 0.000 description 3
• 208000018198 spasticity Diseases 0.000 description 3
• DUYSYHSSBDVJSM-KRWOKUGFSA-N sphingosine 1-phosphate Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O DUYSYHSSBDVJSM-KRWOKUGFSA-N 0.000 description 3
• 238000007920 subcutaneous administration Methods 0.000 description 3
• 230000001360 synchronised effect Effects 0.000 description 3
• 229940121136 tecfidera Drugs 0.000 description 3
• 210000001519 tissue Anatomy 0.000 description 3
• 230000002103 transcriptional effect Effects 0.000 description 3
• 230000000472 traumatic effect Effects 0.000 description 3
• 201000006397 traumatic glaucoma Diseases 0.000 description 3
• 206010044652 trigeminal neuralgia Diseases 0.000 description 3
• 229910052721 tungsten Inorganic materials 0.000 description 3
• 230000004393 visual impairment Effects 0.000 description 3
• 208000002670 vitamin B12 deficiency Diseases 0.000 description 3
• 230000008734 wallerian degeneration Effects 0.000 description 3
• AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 description 2
• RKUNBYITZUJHSG-FXUDXRNXSA-N (S)-atropine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@H]3CC[C@@H](C2)N3C)=CC=CC=C1 RKUNBYITZUJHSG-FXUDXRNXSA-N 0.000 description 2
• RYCNUMLMNKHWPZ-SNVBAGLBSA-N 1-acetyl-sn-glycero-3-phosphocholine Chemical compound CC(=O)OC[C@@H](O)COP([O-])(=O)OCC[N+](C)(C)C RYCNUMLMNKHWPZ-SNVBAGLBSA-N 0.000 description 2
• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 2
• YFGHCGITMMYXAQ-UHFFFAOYSA-N 2-[(diphenylmethyl)sulfinyl]acetamide Chemical compound C=1C=CC=CC=1C(S(=O)CC(=O)N)C1=CC=CC=C1 YFGHCGITMMYXAQ-UHFFFAOYSA-N 0.000 description 2
• FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 description 2
• NUKYPUAOHBNCPY-UHFFFAOYSA-N 4-aminopyridine Chemical compound NC1=CC=NC=C1 NUKYPUAOHBNCPY-UHFFFAOYSA-N 0.000 description 2
• RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
• 241000251468 Actinopterygii Species 0.000 description 2
• 208000024827 Alzheimer disease Diseases 0.000 description 2
• 244000303258 Annona diversifolia Species 0.000 description 2
• 235000002198 Annona diversifolia Nutrition 0.000 description 2
• 208000001827 Ataxia with vitamin E deficiency Diseases 0.000 description 2
• 241000894006 Bacteria Species 0.000 description 2
• 208000006373 Bell palsy Diseases 0.000 description 2
• 206010069632 Bladder dysfunction Diseases 0.000 description 2
• 102100028726 Bone morphogenetic protein 10 Human genes 0.000 description 2
• 101710118482 Bone morphogenetic protein 10 Proteins 0.000 description 2
• 108030001720 Bontoxilysin Proteins 0.000 description 2
• 206010008190 Cerebrovascular accident Diseases 0.000 description 2
• 241000251730 Chondrichthyes Species 0.000 description 2
• GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 2
• 108010047041 Complementarity Determining Regions Proteins 0.000 description 2
• 241000699800 Cricetinae Species 0.000 description 2
• DSRJIHMZAQEUJV-UHFFFAOYSA-N Cuprizon Chemical compound C1CCCCC1=NNC(=O)C(=O)NN=C1CCCCC1 DSRJIHMZAQEUJV-UHFFFAOYSA-N 0.000 description 2
• 102000004127 Cytokines Human genes 0.000 description 2
• 108090000695 Cytokines Proteins 0.000 description 2
• 208000003164 Diplopia Diseases 0.000 description 2
• XIQVNETUBQGFHX-UHFFFAOYSA-N Ditropan Chemical compound C=1C=CC=CC=1C(O)(C(=O)OCC#CCN(CC)CC)C1CCCCC1 XIQVNETUBQGFHX-UHFFFAOYSA-N 0.000 description 2
• 238000002965 ELISA Methods 0.000 description 2
• 241000588724 Escherichia coli Species 0.000 description 2
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
• 101000690301 Homo sapiens Aldo-keto reductase family 1 member C4 Proteins 0.000 description 2
• 101001054334 Homo sapiens Interferon beta Proteins 0.000 description 2
• 101001116548 Homo sapiens Protein CBFA2T1 Proteins 0.000 description 2
• RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 2
• 206010020751 Hypersensitivity Diseases 0.000 description 2
• 206010020772 Hypertension Diseases 0.000 description 2
• 208000004044 Hypesthesia Diseases 0.000 description 2
• 206010021036 Hyponatraemia Diseases 0.000 description 2
• 102000013463 Immunoglobulin Light Chains Human genes 0.000 description 2
• 108010065825 Immunoglobulin Light Chains Proteins 0.000 description 2
• 108010078049 Interferon alpha-2 Proteins 0.000 description 2
• 208000010038 Ischemic Optic Neuropathy Diseases 0.000 description 2
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 2
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 2
• AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 2
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 2
• 108010006444 Leucine-Rich Repeat Proteins Proteins 0.000 description 2
• 208000030136 Marchiafava-Bignami Disease Diseases 0.000 description 2
• 102000012750 Membrane Glycoproteins Human genes 0.000 description 2
• 108010090054 Membrane Glycoproteins Proteins 0.000 description 2
• 201000011442 Metachromatic leukodystrophy Diseases 0.000 description 2
• 241000699660 Mus musculus Species 0.000 description 2
• 101001135571 Mus musculus Tyrosine-protein phosphatase non-receptor type 2 Proteins 0.000 description 2
• 208000007101 Muscle Cramp Diseases 0.000 description 2
• 208000010428 Muscle Weakness Diseases 0.000 description 2
• 206010028372 Muscular weakness Diseases 0.000 description 2
• 208000012902 Nervous system disease Diseases 0.000 description 2
• 206010029240 Neuritis Diseases 0.000 description 2
• 238000000636 Northern blotting Methods 0.000 description 2
• 206010030924 Optic ischaemic neuropathy Diseases 0.000 description 2
• 206010069350 Osmotic demyelination syndrome Diseases 0.000 description 2
• 206010033799 Paralysis Diseases 0.000 description 2
• BYPFEZZEUUWMEJ-UHFFFAOYSA-N Pentoxifylline Chemical compound O=C1N(CCCCC(=O)C)C(=O)N(C)C2=C1N(C)C=N2 BYPFEZZEUUWMEJ-UHFFFAOYSA-N 0.000 description 2
• QPFYXYFORQJZEC-FOCLMDBBSA-N Phenazopyridine Chemical compound NC1=NC(N)=CC=C1\N=N\C1=CC=CC=C1 QPFYXYFORQJZEC-FOCLMDBBSA-N 0.000 description 2
• CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 description 2
• 206010035226 Plasma cell myeloma Diseases 0.000 description 2
• 241000288906 Primates Species 0.000 description 2
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 2
• 206010037714 Quadriplegia Diseases 0.000 description 2
• 108091030071 RNAI Proteins 0.000 description 2
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
• 102000007562 Serum Albumin Human genes 0.000 description 2
• 108010071390 Serum Albumin Proteins 0.000 description 2
• 108091027967 Small hairpin RNA Proteins 0.000 description 2
• SEQDDYPDSLOBDC-UHFFFAOYSA-N Temazepam Chemical compound N=1C(O)C(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 SEQDDYPDSLOBDC-UHFFFAOYSA-N 0.000 description 2
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 2
• 239000004473 Threonine Substances 0.000 description 2
• 241000723873 Tobacco mosaic virus Species 0.000 description 2
• KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical compound C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 description 2
• 208000030886 Traumatic Brain injury Diseases 0.000 description 2
• 206010044565 Tremor Diseases 0.000 description 2
• 208000036826 VIIth nerve paralysis Diseases 0.000 description 2
• 241000700618 Vaccinia virus Species 0.000 description 2
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 2
• 230000005856 abnormality Effects 0.000 description 2
• 239000002671 adjuvant Substances 0.000 description 2
• KRMDCWKBEZIMAB-UHFFFAOYSA-N amitriptyline Chemical compound C1CC2=CC=CC=C2C(=CCCN(C)C)C2=CC=CC=C21 KRMDCWKBEZIMAB-UHFFFAOYSA-N 0.000 description 2
• 230000003321 amplification Effects 0.000 description 2
• 229940035676 analgesics Drugs 0.000 description 2
• 239000000730 antalgic agent Substances 0.000 description 2
• 201000007058 anterior ischemic optic neuropathy Diseases 0.000 description 2
• 230000001410 anti-tremor Effects 0.000 description 2
• 239000000935 antidepressant agent Substances 0.000 description 2
• 229940005513 antidepressants Drugs 0.000 description 2
• 229940041181 antineoplastic drug Drugs 0.000 description 2
• 201000007201 aphasia Diseases 0.000 description 2
• 238000003556 assay Methods 0.000 description 2
• 230000001363 autoimmune Effects 0.000 description 2
• 230000007844 axonal damage Effects 0.000 description 2
• 230000002146 bilateral effect Effects 0.000 description 2
• 229960000503 bisacodyl Drugs 0.000 description 2
• 229940053031 botulinum toxin Drugs 0.000 description 2
• 210000000133 brain stem Anatomy 0.000 description 2
• 229960001058 bupropion Drugs 0.000 description 2
• 238000004364 calculation method Methods 0.000 description 2
• 201000011510 cancer Diseases 0.000 description 2
• 230000003197 catalytic effect Effects 0.000 description 2
• 238000004113 cell culture Methods 0.000 description 2
• 230000001413 cellular effect Effects 0.000 description 2
• 210000001175 cerebrospinal fluid Anatomy 0.000 description 2
• 238000002512 chemotherapy Methods 0.000 description 2
• 210000000349 chromosome Anatomy 0.000 description 2
• MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 2
• 238000003776 cleavage reaction Methods 0.000 description 2
• 229960003120 clonazepam Drugs 0.000 description 2
• 238000011284 combination treatment Methods 0.000 description 2
• 239000002299 complementary DNA Substances 0.000 description 2
• 238000007796 conventional method Methods 0.000 description 2
• IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 description 2
• 238000005520 cutting process Methods 0.000 description 2
• 230000009089 cytolysis Effects 0.000 description 2
• LTWQNYPDAUSXBC-CDJGKPBYSA-L dantrolene sodium hemiheptahydrate Chemical compound O.O.O.O.O.O.O.[Na+].[Na+].C1=CC([N+](=O)[O-])=CC=C1C(O1)=CC=C1\C=N\N1C(=O)[N-]C(=O)C1.C1=CC([N+](=O)[O-])=CC=C1C(O1)=CC=C1\C=N\N1C(=O)[N-]C(=O)C1 LTWQNYPDAUSXBC-CDJGKPBYSA-L 0.000 description 2
• 230000003210 demyelinating effect Effects 0.000 description 2
• JXSJBGJIGXNWCI-UHFFFAOYSA-N diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate Chemical compound CCOC(=O)CC(SP(=S)(OC)OC)C(=O)OCC JXSJBGJIGXNWCI-UHFFFAOYSA-N 0.000 description 2
• 230000003292 diminished effect Effects 0.000 description 2
• ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 2
• 238000004520 electroporation Methods 0.000 description 2
• 201000006517 essential tremor Diseases 0.000 description 2
• 201000003264 familial isolated deficiency of vitamin E Diseases 0.000 description 2
• 229960004979 fampridine Drugs 0.000 description 2
• 206010016256 fatigue Diseases 0.000 description 2
• 230000005714 functional activity Effects 0.000 description 2
• 230000009368 gene silencing by RNA Effects 0.000 description 2
• 230000012010 growth Effects 0.000 description 2
• 210000002443 helper t lymphocyte Anatomy 0.000 description 2
• 102000054751 human RUNX1T1 Human genes 0.000 description 2
• ZQDWXGKKHFNSQK-UHFFFAOYSA-N hydroxyzine Chemical compound C1CN(CCOCCO)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZQDWXGKKHFNSQK-UHFFFAOYSA-N 0.000 description 2
• 229930005342 hyoscyamine Natural products 0.000 description 2
• 229960003210 hyoscyamine Drugs 0.000 description 2
• 230000001631 hypertensive effect Effects 0.000 description 2
• 208000034783 hypoesthesia Diseases 0.000 description 2
• 230000001900 immune effect Effects 0.000 description 2
• 230000028709 inflammatory response Effects 0.000 description 2
• 230000002401 inhibitory effect Effects 0.000 description 2
• 229960000310 isoleucine Drugs 0.000 description 2
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 2
• 229960003350 isoniazid Drugs 0.000 description 2
• VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 description 2
• 210000004901 leucine-rich repeat Anatomy 0.000 description 2
• 210000000265 leukocyte Anatomy 0.000 description 2
• 230000004807 localization Effects 0.000 description 2
• SAPNXPWPAUFAJU-UHFFFAOYSA-N lofepramine Chemical compound C12=CC=CC=C2CCC2=CC=CC=C2N1CCCN(C)CC(=O)C1=CC=C(Cl)C=C1 SAPNXPWPAUFAJU-UHFFFAOYSA-N 0.000 description 2
• 210000002540 macrophage Anatomy 0.000 description 2
• 229960001474 meclozine Drugs 0.000 description 2
• 230000004630 mental health Effects 0.000 description 2
• 229960000485 methotrexate Drugs 0.000 description 2
• 230000005012 migration Effects 0.000 description 2
• 238000013508 migration Methods 0.000 description 2
• 210000002433 mononuclear leukocyte Anatomy 0.000 description 2
• 238000010172 mouse model Methods 0.000 description 2
• 238000002703 mutagenesis Methods 0.000 description 2
• 231100000350 mutagenesis Toxicity 0.000 description 2
• 201000000050 myeloid neoplasm Diseases 0.000 description 2
• 210000000653 nervous system Anatomy 0.000 description 2
• 208000004296 neuralgia Diseases 0.000 description 2
• 208000015122 neurodegenerative disease Diseases 0.000 description 2
• 230000014511 neuron projection development Effects 0.000 description 2
• 230000003961 neuronal insult Effects 0.000 description 2
• 230000006576 neuronal survival Effects 0.000 description 2
• 230000000324 neuroprotective effect Effects 0.000 description 2
• 238000010855 neuropsychological testing Methods 0.000 description 2
• 238000003199 nucleic acid amplification method Methods 0.000 description 2
• 231100000862 numbness Toxicity 0.000 description 2
• 206010029864 nystagmus Diseases 0.000 description 2
• 238000012014 optical coherence tomography Methods 0.000 description 2
• 230000003287 optical effect Effects 0.000 description 2
• 230000003204 osmotic effect Effects 0.000 description 2
• 210000001672 ovary Anatomy 0.000 description 2
• 230000036961 partial effect Effects 0.000 description 2
• 230000006320 pegylation Effects 0.000 description 2
• 230000035515 penetration Effects 0.000 description 2
• WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 2
• 238000002823 phage display Methods 0.000 description 2
• 230000000144 pharmacologic effect Effects 0.000 description 2
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 2
• 230000026731 phosphorylation Effects 0.000 description 2
• 238000006366 phosphorylation reaction Methods 0.000 description 2
• 230000008488 polyadenylation Effects 0.000 description 2
• DQMZLTXERSFNPB-UHFFFAOYSA-N primidone Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NCNC1=O DQMZLTXERSFNPB-UHFFFAOYSA-N 0.000 description 2
• 230000002797 proteolythic effect Effects 0.000 description 2
• BWPIARFWQZKAIA-UHFFFAOYSA-N protriptyline Chemical compound C1=CC2=CC=CC=C2C(CCCNC)C2=CC=CC=C21 BWPIARFWQZKAIA-UHFFFAOYSA-N 0.000 description 2
• 238000012797 qualification Methods 0.000 description 2
• 238000011002 quantification Methods 0.000 description 2
• 238000003127 radioimmunoassay Methods 0.000 description 2
• 108700020894 rat LINGO1 Proteins 0.000 description 2
• 238000011084 recovery Methods 0.000 description 2
• 230000000306 recurrent effect Effects 0.000 description 2
• 230000011514 reflex Effects 0.000 description 2
• 230000010076 replication Effects 0.000 description 2
• 229960004641 rituximab Drugs 0.000 description 2
• 230000007017 scission Effects 0.000 description 2
• 230000001953 sensory effect Effects 0.000 description 2
• 229960002073 sertraline Drugs 0.000 description 2
• 238000009097 single-agent therapy Methods 0.000 description 2
• 239000000243 solution Substances 0.000 description 2
• 238000010186 staining Methods 0.000 description 2
• 239000000126 substance Substances 0.000 description 2
• 230000009747 swallowing Effects 0.000 description 2
• 238000007910 systemic administration Methods 0.000 description 2
• 238000012422 test repetition Methods 0.000 description 2
• 230000000451 tissue damage Effects 0.000 description 2
• 231100000827 tissue damage Toxicity 0.000 description 2
• 229960000488 tizanidine Drugs 0.000 description 2
• 238000013518 transcription Methods 0.000 description 2
• 230000035897 transcription Effects 0.000 description 2
• 238000001890 transfection Methods 0.000 description 2
• 238000011830 transgenic mouse model Methods 0.000 description 2
• 230000014616 translation Effects 0.000 description 2
• 230000009529 traumatic brain injury Effects 0.000 description 2
• 229960003991 trazodone Drugs 0.000 description 2
• 241000701161 unidentified adenovirus Species 0.000 description 2
• 241000701447 unidentified baculovirus Species 0.000 description 2
• 241001430294 unidentified retrovirus Species 0.000 description 2
• 239000004474 valine Substances 0.000 description 2
• PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 description 2
• 230000004304 visual acuity Effects 0.000 description 2
• 239000002699 waste material Substances 0.000 description 2
• 210000004885 white matter Anatomy 0.000 description 2
• 229910052727 yttrium Inorganic materials 0.000 description 2
• UBQNRHZMVUUOMG-UHFFFAOYSA-N zonisamide Chemical compound C1=CC=C2C(CS(=O)(=O)N)=NOC2=C1 UBQNRHZMVUUOMG-UHFFFAOYSA-N 0.000 description 2
• WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 description 1
• IGLYMJRIWWIQQE-QUOODJBBSA-N (1S,2R)-2-phenylcyclopropan-1-amine (1R,2S)-2-phenylcyclopropan-1-amine Chemical compound N[C@H]1C[C@@H]1C1=CC=CC=C1.N[C@@H]1C[C@H]1C1=CC=CC=C1 IGLYMJRIWWIQQE-QUOODJBBSA-N 0.000 description 1
• DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 description 1
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
• TWHNMSJGYKMTRB-KXYUELECSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;2-[(1r)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-methylphenol Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.C1([C@@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(C)C=2)O)=CC=CC=C1 TWHNMSJGYKMTRB-KXYUELECSA-N 0.000 description 1
• ASWBNKHCZGQVJV-UHFFFAOYSA-N (3-hexadecanoyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C ASWBNKHCZGQVJV-UHFFFAOYSA-N 0.000 description 1
• MHNSPTUQQIYJOT-CULRIWENSA-N (3z)-3-(6h-benzo[c][1]benzoxepin-11-ylidene)-n,n-dimethylpropan-1-amine;hydrochloride Chemical compound Cl.C1OC2=CC=CC=C2C(=C/CCN(C)C)\C2=CC=CC=C21 MHNSPTUQQIYJOT-CULRIWENSA-N 0.000 description 1
• WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 description 1
• RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 description 1
• UKAUYVFTDYCKQA-UHFFFAOYSA-N -2-Amino-4-hydroxybutanoic acid Natural products OC(=O)C(N)CCO UKAUYVFTDYCKQA-UHFFFAOYSA-N 0.000 description 1
• HNSDLXPSAYFUHK-UHFFFAOYSA-N 1,4-bis(2-ethylhexyl) sulfosuccinate Chemical compound CCCCC(CC)COC(=O)CC(S(O)(=O)=O)C(=O)OCC(CC)CCCC HNSDLXPSAYFUHK-UHFFFAOYSA-N 0.000 description 1
• WSEQXVZVJXJVFP-UHFFFAOYSA-N 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile Chemical compound O1CC2=CC(C#N)=CC=C2C1(CCCN(C)C)C1=CC=C(F)C=C1 WSEQXVZVJXJVFP-UHFFFAOYSA-N 0.000 description 1
• BDKLKNJTMLIAFE-UHFFFAOYSA-N 2-(3-fluorophenyl)-1,3-oxazole-4-carbaldehyde Chemical compound FC1=CC=CC(C=2OC=C(C=O)N=2)=C1 BDKLKNJTMLIAFE-UHFFFAOYSA-N 0.000 description 1
• KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 description 1
• KWTQSFXGGICVPE-UHFFFAOYSA-N 2-amino-5-(diaminomethylideneamino)pentanoic acid;hydron;chloride Chemical compound Cl.OC(=O)C(N)CCCN=C(N)N KWTQSFXGGICVPE-UHFFFAOYSA-N 0.000 description 1
• BRMWTNUJHUMWMS-UHFFFAOYSA-N 3-Methylhistidine Natural products CN1C=NC(CC(N)C(O)=O)=C1 BRMWTNUJHUMWMS-UHFFFAOYSA-N 0.000 description 1
• 229940117976 5-hydroxylysine Drugs 0.000 description 1
• 229930000680 A04AD01 - Scopolamine Natural products 0.000 description 1
• 208000030507 AIDS Diseases 0.000 description 1
• 208000035657 Abasia Diseases 0.000 description 1
• 206010065051 Acute hepatitis C Diseases 0.000 description 1
• 102100029457 Adenine phosphoribosyltransferase Human genes 0.000 description 1
• 108010024223 Adenine phosphoribosyltransferase Proteins 0.000 description 1
• 208000000044 Amnesia Diseases 0.000 description 1
• 208000031091 Amnestic disease Diseases 0.000 description 1
• 206010002091 Anaesthesia Diseases 0.000 description 1
• 206010002652 Anorgasmia Diseases 0.000 description 1
• 108010083359 Antigen Receptors Proteins 0.000 description 1
• 102000006306 Antigen Receptors Human genes 0.000 description 1
• 108020004491 Antisense DNA Proteins 0.000 description 1
• 108020005544 Antisense RNA Proteins 0.000 description 1
• 208000019901 Anxiety disease Diseases 0.000 description 1
• 241000272478 Aquila Species 0.000 description 1
• KWTQSFXGGICVPE-WCCKRBBISA-N Arginine hydrochloride Chemical compound Cl.OC(=O)[C@@H](N)CCCN=C(N)N KWTQSFXGGICVPE-WCCKRBBISA-N 0.000 description 1
• BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
• 206010003840 Autonomic nervous system imbalance Diseases 0.000 description 1
• 235000014469 Bacillus subtilis Nutrition 0.000 description 1
• KPYSYYIEGFHWSV-UHFFFAOYSA-N Baclofen Chemical compound OC(=O)CC(CN)C1=CC=C(Cl)C=C1 KPYSYYIEGFHWSV-UHFFFAOYSA-N 0.000 description 1
• 241000701822 Bovine papillomavirus Species 0.000 description 1
• 206010063292 Brain stem syndrome Diseases 0.000 description 1
• 125000001433 C-terminal amino-acid group Chemical group 0.000 description 1
• 241000282472 Canis lupus familiaris Species 0.000 description 1
• 201000009030 Carcinoma Diseases 0.000 description 1
• 241000701489 Cauliflower mosaic virus Species 0.000 description 1
• 231100000023 Cell-mediated cytotoxicity Toxicity 0.000 description 1
• 206010057250 Cell-mediated cytotoxicity Diseases 0.000 description 1
• 206010008025 Cerebellar ataxia Diseases 0.000 description 1
• 206010008072 Cerebellar syndrome Diseases 0.000 description 1
• 206010010774 Constipation Diseases 0.000 description 1
• 208000034656 Contusions Diseases 0.000 description 1
• 206010010947 Coordination abnormal Diseases 0.000 description 1
• RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
• 239000000055 Corticotropin-Releasing Hormone Substances 0.000 description 1
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
• 241000701022 Cytomegalovirus Species 0.000 description 1
• 101710112752 Cytotoxin Proteins 0.000 description 1
• QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 description 1
• 238000000116 DAPI staining Methods 0.000 description 1
• 101150074155 DHFR gene Proteins 0.000 description 1
• 108010000437 Deamino Arginine Vasopressin Proteins 0.000 description 1
• 206010012289 Dementia Diseases 0.000 description 1
• HCYAFALTSJYZDH-UHFFFAOYSA-N Desimpramine Chemical compound C1CC2=CC=CC=C2N(CCCNC)C2=CC=CC=C21 HCYAFALTSJYZDH-UHFFFAOYSA-N 0.000 description 1
• 208000032131 Diabetic Neuropathies Diseases 0.000 description 1
• 102100024746 Dihydrofolate reductase Human genes 0.000 description 1
• 229940083266 Dihydroorotate dehydrogenase inhibitor Drugs 0.000 description 1
• 102100022263 Disks large homolog 3 Human genes 0.000 description 1
• 206010013887 Dysarthria Diseases 0.000 description 1
• 208000014094 Dystonic disease Diseases 0.000 description 1
• 241000196324 Embryophyta Species 0.000 description 1
• 208000027534 Emotional disease Diseases 0.000 description 1
• YQYJSBFKSSDGFO-UHFFFAOYSA-N Epihygromycin Natural products OC1C(O)C(C(=O)C)OC1OC(C(=C1)O)=CC=C1C=C(C)C(=O)NC1C(O)C(O)C2OCOC2C1O YQYJSBFKSSDGFO-UHFFFAOYSA-N 0.000 description 1
• 241000283086 Equidae Species 0.000 description 1
• 208000010228 Erectile Dysfunction Diseases 0.000 description 1
• 241001539473 Euphoria Species 0.000 description 1
• 206010015535 Euphoric mood Diseases 0.000 description 1
• 208000034347 Faecal incontinence Diseases 0.000 description 1
• 241000282326 Felis catus Species 0.000 description 1
• 208000021663 Female sexual arousal disease Diseases 0.000 description 1
• VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Natural products OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
• 235000018958 Gardenia augusta Nutrition 0.000 description 1
• SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
• 239000004471 Glycine Substances 0.000 description 1
• 206010019468 Hemiplegia Diseases 0.000 description 1
• 102100021519 Hemoglobin subunit beta Human genes 0.000 description 1
• 108091005904 Hemoglobin subunit beta Proteins 0.000 description 1
• 208000005176 Hepatitis C Diseases 0.000 description 1
• 101000902100 Homo sapiens Disks large homolog 3 Proteins 0.000 description 1
• 101001002508 Homo sapiens Immunoglobulin-binding protein 1 Proteins 0.000 description 1
• 101000588302 Homo sapiens Nuclear factor erythroid 2-related factor 2 Proteins 0.000 description 1
• 102000003839 Human Proteins Human genes 0.000 description 1
• 108090000144 Human Proteins Proteins 0.000 description 1
• 241000701024 Human betaherpesvirus 5 Species 0.000 description 1
• 101100321817 Human parvovirus B19 (strain HV) 7.5K gene Proteins 0.000 description 1
• PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
• STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 1
• 206010021118 Hypotonia Diseases 0.000 description 1
• 108010091358 Hypoxanthine Phosphoribosyltransferase Proteins 0.000 description 1
• 102100029098 Hypoxanthine-guanine phosphoribosyltransferase Human genes 0.000 description 1
• HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• 108700005091 Immunoglobulin Genes Proteins 0.000 description 1
• 102000012745 Immunoglobulin Subunits Human genes 0.000 description 1
• 108010079585 Immunoglobulin Subunits Proteins 0.000 description 1
• 102100021042 Immunoglobulin-binding protein 1 Human genes 0.000 description 1
• 102100032818 Integrin alpha-4 Human genes 0.000 description 1
• 108010047761 Interferon-alpha Proteins 0.000 description 1
• 102000006992 Interferon-alpha Human genes 0.000 description 1
• 102000008070 Interferon-gamma Human genes 0.000 description 1
• 108010074328 Interferon-gamma Proteins 0.000 description 1
• PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 description 1
• 108010025815 Kanamycin Kinase Proteins 0.000 description 1
• 208000007766 Kaposi sarcoma Diseases 0.000 description 1
• QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 description 1
• WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 1
• WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 1
• 235000019766 L-Lysine Nutrition 0.000 description 1
• AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
• ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
• UKAUYVFTDYCKQA-VKHMYHEASA-N L-homoserine Chemical compound OC(=O)[C@@H](N)CCO UKAUYVFTDYCKQA-VKHMYHEASA-N 0.000 description 1
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
• 241000282852 Lama guanicoe Species 0.000 description 1
• 108091026898 Leader sequence (mRNA) Proteins 0.000 description 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
• 241000282560 Macaca mulatta Species 0.000 description 1
• 238000000585 Mann–Whitney U test Methods 0.000 description 1
• 102000003792 Metallothionein Human genes 0.000 description 1
• 108090000157 Metallothionein Proteins 0.000 description 1
• FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 description 1
• 206010027925 Monoparesis Diseases 0.000 description 1
• 206010027951 Mood swings Diseases 0.000 description 1
• 241000713333 Mouse mammary tumor virus Species 0.000 description 1
• 208000007379 Muscle Hypotonia Diseases 0.000 description 1
• 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
• 102000047918 Myelin Basic Human genes 0.000 description 1
• 101710107068 Myelin basic protein Proteins 0.000 description 1
• 208000002033 Myoclonus Diseases 0.000 description 1
• 206010028632 Myokymia Diseases 0.000 description 1
• JDHILDINMRGULE-LURJTMIESA-N N(pros)-methyl-L-histidine Chemical compound CN1C=NC=C1C[C@H](N)C(O)=O JDHILDINMRGULE-LURJTMIESA-N 0.000 description 1
• QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 1
• STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 1
• RTHCYVBBDHJXIQ-UHFFFAOYSA-N N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine Chemical compound C=1C=CC=CC=1C(CCNC)OC1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-UHFFFAOYSA-N 0.000 description 1
• 208000025966 Neurological disease Diseases 0.000 description 1
• 102000010410 Nogo Proteins Human genes 0.000 description 1
• 108010077641 Nogo Proteins Proteins 0.000 description 1
• 102000005781 Nogo Receptor Human genes 0.000 description 1
• 108020003872 Nogo receptor Proteins 0.000 description 1
• 108091092724 Noncoding DNA Proteins 0.000 description 1
• 102100031701 Nuclear factor erythroid 2-related factor 2 Human genes 0.000 description 1
• 108091005461 Nucleic proteins Chemical group 0.000 description 1
• BHPOSOPTQVNCFN-UHFFFAOYSA-N OC1=CC=C(C=2C(C3=C(C=CC(=C3C(C12)=O)NCCNCCO)NCCNCCO)=O)O.C1(C(C=CC2=CC3=CC=CC=C3C=C12)=O)=O Chemical compound OC1=CC=C(C=2C(C3=C(C=CC(=C3C(C12)=O)NCCNCCO)NCCNCCO)=O)O.C1(C(C=CC2=CC3=CC=CC=C3C=C12)=O)=O BHPOSOPTQVNCFN-UHFFFAOYSA-N 0.000 description 1
• 206010063534 Ocular dysmetria Diseases 0.000 description 1
• AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
• UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
• 229910019142 PO4 Inorganic materials 0.000 description 1
• 208000002193 Pain Diseases 0.000 description 1
• 206010033885 Paraparesis Diseases 0.000 description 1
• 241001494479 Pecora Species 0.000 description 1
• 102000007079 Peptide Fragments Human genes 0.000 description 1
• 108010033276 Peptide Fragments Proteins 0.000 description 1
• 206010034701 Peroneal nerve palsy Diseases 0.000 description 1
• 108010081690 Pertussis Toxin Proteins 0.000 description 1
• QZVCTJOXCFMACW-UHFFFAOYSA-N Phenoxybenzamine Chemical compound C=1C=CC=CC=1CN(CCCl)C(C)COC1=CC=CC=C1 QZVCTJOXCFMACW-UHFFFAOYSA-N 0.000 description 1
• 206010034962 Photopsia Diseases 0.000 description 1
• 241000235648 Pichia Species 0.000 description 1
• 241000407193 Pindis Species 0.000 description 1
• 244000134552 Plantago ovata Species 0.000 description 1
• 235000003421 Plantago ovata Nutrition 0.000 description 1
• 241000276498 Pollachius virens Species 0.000 description 1
• 241001505332 Polyomavirus sp. Species 0.000 description 1
• 229920001213 Polysorbate 20 Polymers 0.000 description 1
• VVWYOYDLCMFIEM-UHFFFAOYSA-N Propantheline Chemical compound C1=CC=C2C(C(=O)OCC[N+](C)(C(C)C)C(C)C)C3=CC=CC=C3OC2=C1 VVWYOYDLCMFIEM-UHFFFAOYSA-N 0.000 description 1
• KNAHARQHSZJURB-UHFFFAOYSA-N Propylthiouracile Chemical compound CCCC1=CC(=O)NC(=S)N1 KNAHARQHSZJURB-UHFFFAOYSA-N 0.000 description 1
• 108010067787 Proteoglycans Proteins 0.000 description 1
• 102000016611 Proteoglycans Human genes 0.000 description 1
• 208000006262 Psychological Sexual Dysfunctions Diseases 0.000 description 1
• 239000009223 Psyllium Substances 0.000 description 1
• CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
• 208000019155 Radiation injury Diseases 0.000 description 1
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
• 208000005793 Restless legs syndrome Diseases 0.000 description 1
• 241000235070 Saccharomyces Species 0.000 description 1
• 206010070834 Sensitisation Diseases 0.000 description 1
• 201000001880 Sexual dysfunction Diseases 0.000 description 1
• 241000700584 Simplexvirus Species 0.000 description 1
• 208000005392 Spasm Diseases 0.000 description 1
• 208000014604 Specific Language disease Diseases 0.000 description 1
• 102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 description 1
• 108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 description 1
• 108091081024 Start codon Proteins 0.000 description 1
• 241000282887 Suidae Species 0.000 description 1
• 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 description 1
• 244000247617 Teramnus labialis var. labialis Species 0.000 description 1
• 108091036066 Three prime untranslated region Proteins 0.000 description 1
• 108010022394 Threonine synthase Proteins 0.000 description 1
• 102000006601 Thymidine Kinase Human genes 0.000 description 1
• 108020004440 Thymidine kinase Proteins 0.000 description 1
• 108010057266 Type A Botulinum Toxins Proteins 0.000 description 1
• GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 description 1
• 108010004977 Vasopressins Proteins 0.000 description 1
• 102000002852 Vasopressins Human genes 0.000 description 1
• 208000012886 Vertigo Diseases 0.000 description 1
• 241001416177 Vicugna pacos Species 0.000 description 1
• 206010047513 Vision blurred Diseases 0.000 description 1
• BKPRVQDIOGQWTG-ICOOEGOYSA-N [(1s,2r)-2-phenylcyclopropyl]azanium;[(1r,2s)-2-phenylcyclopropyl]azanium;sulfate Chemical compound [O-]S([O-])(=O)=O.[NH3+][C@H]1C[C@@H]1C1=CC=CC=C1.[NH3+][C@@H]1C[C@H]1C1=CC=CC=C1 BKPRVQDIOGQWTG-ICOOEGOYSA-N 0.000 description 1
• 159000000021 acetate salts Chemical class 0.000 description 1
• BZKPWHYZMXOIDC-UHFFFAOYSA-N acetazolamide Chemical compound CC(=O)NC1=NN=C(S(N)(=O)=O)S1 BZKPWHYZMXOIDC-UHFFFAOYSA-N 0.000 description 1
• 229960000583 acetic acid Drugs 0.000 description 1
• 229960001138 acetylsalicylic acid Drugs 0.000 description 1
• 229940036707 acthar Drugs 0.000 description 1
• 230000003213 activating effect Effects 0.000 description 1
• 230000004913 activation Effects 0.000 description 1
• 239000013543 active substance Substances 0.000 description 1
• 208000037621 acute hepatitis C virus infection Diseases 0.000 description 1
• 230000002411 adverse Effects 0.000 description 1
• 208000026935 allergic disease Diseases 0.000 description 1
• 150000001371 alpha-amino acids Chemical class 0.000 description 1
• 235000008206 alpha-amino acids Nutrition 0.000 description 1
• 229960004538 alprazolam Drugs 0.000 description 1
• 230000004075 alteration Effects 0.000 description 1
• DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 description 1
• 229960003805 amantadine Drugs 0.000 description 1
• 150000003862 amino acid derivatives Chemical class 0.000 description 1
• 229940126575 aminoglycoside Drugs 0.000 description 1
• 229960000836 amitriptyline Drugs 0.000 description 1
• 230000006986 amnesia Effects 0.000 description 1
• 230000037005 anaesthesia Effects 0.000 description 1
• 238000000137 annealing Methods 0.000 description 1
• 239000003242 anti bacterial agent Substances 0.000 description 1
• 230000003110 anti-inflammatory effect Effects 0.000 description 1
• 230000000340 anti-metabolite Effects 0.000 description 1
• 229940088710 antibiotic agent Drugs 0.000 description 1
• 230000005875 antibody response Effects 0.000 description 1
• 229940100197 antimetabolite Drugs 0.000 description 1
• 239000002256 antimetabolite Substances 0.000 description 1
• 239000003963 antioxidant agent Substances 0.000 description 1
• 230000003078 antioxidant effect Effects 0.000 description 1
• 235000006708 antioxidants Nutrition 0.000 description 1
• 239000003816 antisense DNA Substances 0.000 description 1
• 230000036506 anxiety Effects 0.000 description 1
• 229960003589 arginine hydrochloride Drugs 0.000 description 1
• KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 description 1
• 235000003704 aspartic acid Nutrition 0.000 description 1
• 229940065779 atarax Drugs 0.000 description 1
• 229940057415 aubagio Drugs 0.000 description 1
• 230000006472 autoimmune response Effects 0.000 description 1
• 210000003719 b-lymphocyte Anatomy 0.000 description 1
• 229960000794 baclofen Drugs 0.000 description 1
• 230000001580 bacterial effect Effects 0.000 description 1
• 229940088007 benadryl Drugs 0.000 description 1
• 208000032257 benign familial neonatal 1 seizures Diseases 0.000 description 1
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
• 230000003115 biocidal effect Effects 0.000 description 1
• 239000003139 biocide Substances 0.000 description 1
• 230000008512 biological response Effects 0.000 description 1
• 238000001815 biotherapy Methods 0.000 description 1
• 210000004369 blood Anatomy 0.000 description 1
• 239000008280 blood Substances 0.000 description 1
• 230000008499 blood brain barrier function Effects 0.000 description 1
• 210000001218 blood-brain barrier Anatomy 0.000 description 1
• 229940089093 botox Drugs 0.000 description 1
• 108010006025 bovine growth hormone Proteins 0.000 description 1
• 208000029028 brain injury Diseases 0.000 description 1
• QWCRAEMEVRGPNT-UHFFFAOYSA-N buspirone Chemical compound C1C(=O)N(CCCCN2CCN(CC2)C=2N=CC=CN=2)C(=O)CC21CCCC2 QWCRAEMEVRGPNT-UHFFFAOYSA-N 0.000 description 1
• 229960002495 buspirone Drugs 0.000 description 1
• 239000007978 cacodylate buffer Substances 0.000 description 1
• 239000001506 calcium phosphate Substances 0.000 description 1
• 229910000389 calcium phosphate Inorganic materials 0.000 description 1
• 235000011010 calcium phosphates Nutrition 0.000 description 1
• 229940112129 campath Drugs 0.000 description 1
• 229930003827 cannabinoid Natural products 0.000 description 1
• 239000003557 cannabinoid Substances 0.000 description 1
• 229940065144 cannabinoids Drugs 0.000 description 1
• 229940057922 carbatrol Drugs 0.000 description 1
• 229960004205 carbidopa Drugs 0.000 description 1
• TZFNLOMSOLWIDK-JTQLQIEISA-N carbidopa (anhydrous) Chemical compound NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 TZFNLOMSOLWIDK-JTQLQIEISA-N 0.000 description 1
• 125000000837 carbohydrate group Chemical group 0.000 description 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
• 230000015556 catabolic process Effects 0.000 description 1
• 229940063628 catapres Drugs 0.000 description 1
• 229940047493 celexa Drugs 0.000 description 1
• 230000007910 cell fusion Effects 0.000 description 1
• 230000005890 cell-mediated cytotoxicity Effects 0.000 description 1
• 208000009885 central pontine myelinolysis Diseases 0.000 description 1
• 238000005119 centrifugation Methods 0.000 description 1
• 208000019065 cervical carcinoma Diseases 0.000 description 1
• 229960003405 ciprofloxacin Drugs 0.000 description 1
• 229960001653 citalopram Drugs 0.000 description 1
• 229960002896 clonidine Drugs 0.000 description 1
• 238000010367 cloning Methods 0.000 description 1
• 238000011278 co-treatment Methods 0.000 description 1
• 208000010877 cognitive disease Diseases 0.000 description 1
• 230000036648 cognitive speed Effects 0.000 description 1
• 229940088505 compazine Drugs 0.000 description 1
• 230000002860 competitive effect Effects 0.000 description 1
• 230000004154 complement system Effects 0.000 description 1
• 239000003184 complementary RNA Substances 0.000 description 1
• 238000010276 construction Methods 0.000 description 1
• 230000009519 contusion Effects 0.000 description 1
• 229910052802 copper Inorganic materials 0.000 description 1
• 239000010949 copper Substances 0.000 description 1
• 230000001054 cortical effect Effects 0.000 description 1
• 229960000258 corticotropin Drugs 0.000 description 1
• 210000003792 cranial nerve Anatomy 0.000 description 1
• 201000007241 cutaneous T cell lymphoma Diseases 0.000 description 1
• 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 1
• 229960004397 cyclophosphamide Drugs 0.000 description 1
• 235000018417 cysteine Nutrition 0.000 description 1
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
• 230000001461 cytolytic effect Effects 0.000 description 1
• 230000001120 cytoprotective effect Effects 0.000 description 1
• 229940127089 cytotoxic agent Drugs 0.000 description 1
• 231100000599 cytotoxic agent Toxicity 0.000 description 1
• 239000002619 cytotoxin Substances 0.000 description 1
• 229940119321 dantrium Drugs 0.000 description 1
• 229940026692 decadron Drugs 0.000 description 1
• 238000006731 degradation reaction Methods 0.000 description 1
• YSMODUONRAFBET-UHFFFAOYSA-N delta-DL-hydroxylysine Natural products NCC(O)CCC(N)C(O)=O YSMODUONRAFBET-UHFFFAOYSA-N 0.000 description 1
• CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 description 1
• 229940027008 deltasone Drugs 0.000 description 1
• 238000013461 design Methods 0.000 description 1
• 229960004281 desmopressin Drugs 0.000 description 1
• NFLWUMRGJYTJIN-NXBWRCJVSA-N desmopressin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSCCC(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)=O)CCC(=O)N)C1=CC=CC=C1 NFLWUMRGJYTJIN-NXBWRCJVSA-N 0.000 description 1
• 230000025009 detection of wounding Effects 0.000 description 1
• 229940076405 detrol Drugs 0.000 description 1
• UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
• 229940099238 diamox Drugs 0.000 description 1
• 229960003529 diazepam Drugs 0.000 description 1
• AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
• 102000004419 dihydrofolate reductase Human genes 0.000 description 1
• 108020001096 dihydrofolate reductase Proteins 0.000 description 1
• 239000003363 dihydroorotate dehydrogenase inhibitor Substances 0.000 description 1
• 229940064790 dilantin Drugs 0.000 description 1
• 238000010790 dilution Methods 0.000 description 1
• 239000012895 dilution Substances 0.000 description 1
• 229960004993 dimenhydrinate Drugs 0.000 description 1
• MZDOIJOUFRQXHC-UHFFFAOYSA-N dimenhydrinate Chemical compound O=C1N(C)C(=O)N(C)C2=NC(Cl)=N[C]21.C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 MZDOIJOUFRQXHC-UHFFFAOYSA-N 0.000 description 1
• 229960000520 diphenhydramine Drugs 0.000 description 1
• 230000009266 disease activity Effects 0.000 description 1
• 230000006806 disease prevention Effects 0.000 description 1
• BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
• 238000006073 displacement reaction Methods 0.000 description 1
• 229940099170 ditropan Drugs 0.000 description 1
• 208000002173 dizziness Diseases 0.000 description 1
• PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
• 239000003534 dna topoisomerase inhibitor Substances 0.000 description 1
• 229940018602 docusate Drugs 0.000 description 1
• VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 1
• 229960001393 dosulepin Drugs 0.000 description 1
• 208000029444 double vision Diseases 0.000 description 1
• ODQWQRRAPPTVAG-UHFFFAOYSA-N doxepin Chemical compound C1OC2=CC=CC=C2C(=CCCN(C)C)C2=CC=CC=C21 ODQWQRRAPPTVAG-UHFFFAOYSA-N 0.000 description 1
• 238000009510 drug design Methods 0.000 description 1
• 238000009509 drug development Methods 0.000 description 1
• 229940126534 drug product Drugs 0.000 description 1
• 238000002651 drug therapy Methods 0.000 description 1
• 229940099198 dulcolax Drugs 0.000 description 1
• 208000010118 dystonia Diseases 0.000 description 1
• 229940098766 effexor Drugs 0.000 description 1
• 229940011681 elavil Drugs 0.000 description 1
• 238000001493 electron microscopy Methods 0.000 description 1
• 238000001962 electrophoresis Methods 0.000 description 1
• 230000002996 emotional effect Effects 0.000 description 1
• 210000002472 endoplasmic reticulum Anatomy 0.000 description 1
• 210000003038 endothelium Anatomy 0.000 description 1
• 229940089063 epitol Drugs 0.000 description 1
• 108010002591 epsilon receptor Proteins 0.000 description 1
• YSMODUONRAFBET-UHNVWZDZSA-N erythro-5-hydroxy-L-lysine Chemical compound NC[C@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-UHNVWZDZSA-N 0.000 description 1
• 238000002474 experimental method Methods 0.000 description 1
• 230000004424 eye movement Effects 0.000 description 1
• 230000004438 eyesight Effects 0.000 description 1
• 230000002550 fecal effect Effects 0.000 description 1
• 239000002268 fleet enema Substances 0.000 description 1
• 229940042555 fleet enema Drugs 0.000 description 1
• 238000000799 fluorescence microscopy Methods 0.000 description 1
• 229960002464 fluoxetine Drugs 0.000 description 1
• 239000001530 fumaric acid Substances 0.000 description 1
• 229960002870 gabapentin Drugs 0.000 description 1
• 230000005021 gait Effects 0.000 description 1
• 229940044627 gamma-interferon Drugs 0.000 description 1
• 229940009600 gammagard Drugs 0.000 description 1
• 208000021302 gastroesophageal reflux disease Diseases 0.000 description 1
• 238000007429 general method Methods 0.000 description 1
• 239000012362 glacial acetic acid Substances 0.000 description 1
• 239000011521 glass Substances 0.000 description 1
• 235000011187 glycerol Nutrition 0.000 description 1
• 230000035876 healing Effects 0.000 description 1
• 229910001385 heavy metal Inorganic materials 0.000 description 1
• 206010019465 hemiparesis Diseases 0.000 description 1
• 235000010299 hexamethylene tetramine Nutrition 0.000 description 1
• VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 description 1
• 102000056549 human Fv Human genes 0.000 description 1
• 108700005872 human Fv Proteins 0.000 description 1
• 210000005260 human cell Anatomy 0.000 description 1
• 238000009396 hybridization Methods 0.000 description 1
• 229960002591 hydroxyproline Drugs 0.000 description 1
• 229960000930 hydroxyzine Drugs 0.000 description 1
• 230000009610 hypersensitivity Effects 0.000 description 1
• 229960001680 ibuprofen Drugs 0.000 description 1
• 210000000987 immune system Anatomy 0.000 description 1
• 230000005847 immunogenicity Effects 0.000 description 1
• 230000016784 immunoglobulin production Effects 0.000 description 1
• 238000011532 immunohistochemical staining Methods 0.000 description 1
• 238000003364 immunohistochemistry Methods 0.000 description 1
• 239000002955 immunomodulating agent Substances 0.000 description 1
• 229940121354 immunomodulator Drugs 0.000 description 1
• 230000002584 immunomodulator Effects 0.000 description 1
• 230000001771 impaired effect Effects 0.000 description 1
• 201000001881 impotence Diseases 0.000 description 1
• 230000002779 inactivation Effects 0.000 description 1
• 238000010348 incorporation Methods 0.000 description 1
• 230000001939 inductive effect Effects 0.000 description 1
• 208000015181 infectious disease Diseases 0.000 description 1
• 230000008595 infiltration Effects 0.000 description 1
• 238000001764 infiltration Methods 0.000 description 1
• 210000004969 inflammatory cell Anatomy 0.000 description 1
• 230000010365 information processing Effects 0.000 description 1
• 239000004615 ingredient Substances 0.000 description 1
• 108010044426 integrins Proteins 0.000 description 1
• 102000006495 integrins Human genes 0.000 description 1
• 229950000038 interferon alfa Drugs 0.000 description 1
• 229960003521 interferon alfa-2a Drugs 0.000 description 1
• 229960003507 interferon alfa-2b Drugs 0.000 description 1
• 108010010648 interferon alfacon-1 Proteins 0.000 description 1
• 229960003358 interferon alfacon-1 Drugs 0.000 description 1
• 201000001801 internuclear ophthalmoplegia Diseases 0.000 description 1
• 210000000936 intestine Anatomy 0.000 description 1
• 238000007912 intraperitoneal administration Methods 0.000 description 1
• 239000007928 intraperitoneal injection Substances 0.000 description 1
• 238000007913 intrathecal administration Methods 0.000 description 1
• 238000010253 intravenous injection Methods 0.000 description 1
• 229960002725 isoflurane Drugs 0.000 description 1
• 229940010484 iveegam Drugs 0.000 description 1
• 210000003292 kidney cell Anatomy 0.000 description 1
• 229940073092 klonopin Drugs 0.000 description 1
• 208000028756 lack of coordination Diseases 0.000 description 1
• 229960000681 leflunomide Drugs 0.000 description 1
• 229940047834 lemtrada Drugs 0.000 description 1
• 208000036546 leukodystrophy Diseases 0.000 description 1
• 229960004502 levodopa Drugs 0.000 description 1
• 230000033001 locomotion Effects 0.000 description 1
• 229960002813 lofepramine Drugs 0.000 description 1
• 230000007774 longterm Effects 0.000 description 1
• 208000018883 loss of balance Diseases 0.000 description 1
• 210000001165 lymph node Anatomy 0.000 description 1
• 230000005415 magnetization Effects 0.000 description 1
• 230000003211 malignant effect Effects 0.000 description 1
• 229940099262 marinol Drugs 0.000 description 1
• 210000003519 mature b lymphocyte Anatomy 0.000 description 1
• 230000007246 mechanism Effects 0.000 description 1
• 229940064748 medrol Drugs 0.000 description 1
• 201000001441 melanoma Diseases 0.000 description 1
• 230000003340 mental effect Effects 0.000 description 1
• 239000002207 metabolite Substances 0.000 description 1
• 229940042003 metamucil Drugs 0.000 description 1
• 230000001394 metastastic effect Effects 0.000 description 1
• 206010061289 metastatic neoplasm Diseases 0.000 description 1
• 229960004011 methenamine Drugs 0.000 description 1
• 229930182817 methionine Natural products 0.000 description 1
• HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 description 1
• 244000005700 microbiome Species 0.000 description 1
• 238000000520 microinjection Methods 0.000 description 1
• 229960001785 mirtazapine Drugs 0.000 description 1
• RONZAEMNMFQXRA-UHFFFAOYSA-N mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 description 1
• 229960001165 modafinil Drugs 0.000 description 1
• 230000036651 mood Effects 0.000 description 1
• 230000007659 motor function Effects 0.000 description 1
• 201000000585 muscular atrophy Diseases 0.000 description 1
• 230000035772 mutation Effects 0.000 description 1
• 229960000951 mycophenolic acid Drugs 0.000 description 1
• HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 description 1
• 201000005962 mycosis fungoides Diseases 0.000 description 1
• 229940090010 mysoline Drugs 0.000 description 1
• 210000000822 natural killer cell Anatomy 0.000 description 1
• 229960001800 nefazodone Drugs 0.000 description 1
• VRBKIVRKKCLPHA-UHFFFAOYSA-N nefazodone Chemical compound O=C1N(CCOC=2C=CC=CC=2)C(CC)=NN1CCCN(CC1)CCN1C1=CC=CC(Cl)=C1 VRBKIVRKKCLPHA-UHFFFAOYSA-N 0.000 description 1
• 230000017066 negative regulation of growth Effects 0.000 description 1
• 230000004770 neurodegeneration Effects 0.000 description 1
• 210000004498 neuroglial cell Anatomy 0.000 description 1
• 230000007514 neuronal growth Effects 0.000 description 1
• 229940072228 neurontin Drugs 0.000 description 1
• 230000002981 neuropathic effect Effects 0.000 description 1
• 208000021722 neuropathic pain Diseases 0.000 description 1
• 201000001119 neuropathy Diseases 0.000 description 1
• 230000007823 neuropathy Effects 0.000 description 1
• 230000003472 neutralizing effect Effects 0.000 description 1
• 229960000564 nitrofurantoin Drugs 0.000 description 1
• NXFQHRVNIOXGAQ-YCRREMRBSA-N nitrofurantoin Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)NC(=O)C1 NXFQHRVNIOXGAQ-YCRREMRBSA-N 0.000 description 1
• 230000009871 nonspecific binding Effects 0.000 description 1
• 229940087480 norpramin Drugs 0.000 description 1
• 229960001158 nortriptyline Drugs 0.000 description 1
• 208000028780 ocular motility disease Diseases 0.000 description 1
• 229960002450 ofatumumab Drugs 0.000 description 1
• 229920001542 oligosaccharide Polymers 0.000 description 1
• 150000002482 oligosaccharides Chemical class 0.000 description 1
• 206010030875 ophthalmoplegia Diseases 0.000 description 1
• 230000014207 opsonization Effects 0.000 description 1
• 229960003104 ornithine Drugs 0.000 description 1
• 210000000963 osteoblast Anatomy 0.000 description 1
• 230000036542 oxidative stress Effects 0.000 description 1
• 229960005434 oxybutynin Drugs 0.000 description 1
• 230000036407 pain Effects 0.000 description 1
• 229940055692 pamelor Drugs 0.000 description 1
• 229960005489 paracetamol Drugs 0.000 description 1
• 244000045947 parasite Species 0.000 description 1
• 229940087824 parnate Drugs 0.000 description 1
• 229960002296 paroxetine Drugs 0.000 description 1
• 239000002245 particle Substances 0.000 description 1
• 244000052769 pathogen Species 0.000 description 1
• 230000008506 pathogenesis Effects 0.000 description 1
• 230000007170 pathology Effects 0.000 description 1
• 230000007310 pathophysiology Effects 0.000 description 1
• 229960000761 pemoline Drugs 0.000 description 1
• NRNCYVBFPDDJNE-UHFFFAOYSA-N pemoline Chemical compound O1C(N)=NC(=O)C1C1=CC=CC=C1 NRNCYVBFPDDJNE-UHFFFAOYSA-N 0.000 description 1
• 229960001412 pentobarbital Drugs 0.000 description 1
• 229960001476 pentoxifylline Drugs 0.000 description 1
• 230000008447 perception Effects 0.000 description 1
• 230000010412 perfusion Effects 0.000 description 1
• 208000033808 peripheral neuropathy Diseases 0.000 description 1
• 239000000825 pharmaceutical preparation Substances 0.000 description 1
• 229960001181 phenazopyridine Drugs 0.000 description 1
• 229960003418 phenoxybenzamine Drugs 0.000 description 1
• 229960002036 phenytoin Drugs 0.000 description 1
• 239000010452 phosphate Substances 0.000 description 1
• 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
• 229910000065 phosphene Inorganic materials 0.000 description 1
• 230000004962 physiological condition Effects 0.000 description 1
• 230000003169 placental effect Effects 0.000 description 1
• 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
• 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
• 229940068977 polysorbate 20 Drugs 0.000 description 1
• 229920000053 polysorbate 80 Polymers 0.000 description 1
• 229940068968 polysorbate 80 Drugs 0.000 description 1
• 230000001323 posttranslational effect Effects 0.000 description 1
• 239000000843 powder Substances 0.000 description 1
• 238000001556 precipitation Methods 0.000 description 1
• 239000002243 precursor Substances 0.000 description 1
• OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
• XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
• 229940071643 prefilled syringe Drugs 0.000 description 1
• 229960001233 pregabalin Drugs 0.000 description 1
• AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 description 1
• 238000004321 preservation Methods 0.000 description 1
• 230000002265 prevention Effects 0.000 description 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
• 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 description 1
• 229960002393 primidone Drugs 0.000 description 1
• WIKYUJGCLQQFNW-UHFFFAOYSA-N prochlorperazine Chemical compound C1CN(C)CCN1CCCN1C2=CC(Cl)=CC=C2SC2=CC=CC=C21 WIKYUJGCLQQFNW-UHFFFAOYSA-N 0.000 description 1
• 229960003111 prochlorperazine Drugs 0.000 description 1
• DSKIOWHQLUWFLG-SPIKMXEPSA-N prochlorperazine maleate Chemical compound [H+].[H+].[H+].[H+].[O-]C(=O)\C=C/C([O-])=O.[O-]C(=O)\C=C/C([O-])=O.C1CN(C)CCN1CCCN1C2=CC(Cl)=CC=C2SC2=CC=CC=C21 DSKIOWHQLUWFLG-SPIKMXEPSA-N 0.000 description 1
• 238000004393 prognosis Methods 0.000 description 1
• 230000000770 proinflammatory effect Effects 0.000 description 1
• 210000001236 prokaryotic cell Anatomy 0.000 description 1
• 229960000697 propantheline Drugs 0.000 description 1
• 238000011321 prophylaxis Methods 0.000 description 1
• 230000000272 proprioceptive effect Effects 0.000 description 1
• 230000009145 protein modification Effects 0.000 description 1
• 238000001243 protein synthesis Methods 0.000 description 1
• 210000001938 protoplast Anatomy 0.000 description 1
• 229960002601 protriptyline Drugs 0.000 description 1
• 229940117394 provigil Drugs 0.000 description 1
• 229940035613 prozac Drugs 0.000 description 1
• 229940070687 psyllium Drugs 0.000 description 1
• 208000022749 pupil disease Diseases 0.000 description 1
• 229940070891 pyridium Drugs 0.000 description 1
• 238000011552 rat model Methods 0.000 description 1
• 229940075993 receptor modulator Drugs 0.000 description 1
• 238000010188 recombinant method Methods 0.000 description 1
• 230000006798 recombination Effects 0.000 description 1
• 230000012121 regulation of immune response Effects 0.000 description 1
• 230000020284 regulation of myelination Effects 0.000 description 1
• 230000004043 responsiveness Effects 0.000 description 1
• 229940116246 restoril Drugs 0.000 description 1
• 108091008146 restriction endonucleases Proteins 0.000 description 1
• 238000003757 reverse transcription PCR Methods 0.000 description 1
• 238000012552 review Methods 0.000 description 1
• 238000003118 sandwich ELISA Methods 0.000 description 1
• 229940060641 sani-supp Drugs 0.000 description 1
• 230000002784 sclerotic effect Effects 0.000 description 1
• STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 1
• 229960002646 scopolamine Drugs 0.000 description 1
• 239000006152 selective media Substances 0.000 description 1
• 230000035945 sensitivity Effects 0.000 description 1
• 230000008313 sensitization Effects 0.000 description 1
• 230000037152 sensory function Effects 0.000 description 1
• 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
• BLFQGGGGFNSJKA-XHXSRVRCSA-N sertraline hydrochloride Chemical compound Cl.C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 BLFQGGGGFNSJKA-XHXSRVRCSA-N 0.000 description 1
• 231100000872 sexual dysfunction Toxicity 0.000 description 1
• 229940001089 sinemet Drugs 0.000 description 1
• 208000019116 sleep disease Diseases 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 235000017281 sodium acetate Nutrition 0.000 description 1
• 229940087562 sodium acetate trihydrate Drugs 0.000 description 1
• 239000001509 sodium citrate Substances 0.000 description 1
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
• IHQKEDIOMGYHEB-UHFFFAOYSA-M sodium dimethylarsinate Chemical compound [Na+].C[As](C)([O-])=O IHQKEDIOMGYHEB-UHFFFAOYSA-M 0.000 description 1
• 239000001488 sodium phosphate Substances 0.000 description 1
• 229910000162 sodium phosphate Inorganic materials 0.000 description 1
• MIXCUJKCXRNYFM-UHFFFAOYSA-M sodium;diiodomethanesulfonate;n-propyl-n-[2-(2,4,6-trichlorophenoxy)ethyl]imidazole-1-carboxamide Chemical compound [Na+].[O-]S(=O)(=O)C(I)I.C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl MIXCUJKCXRNYFM-UHFFFAOYSA-M 0.000 description 1
• 229940087854 solu-medrol Drugs 0.000 description 1
• 230000009870 specific binding Effects 0.000 description 1
• 230000009295 sperm incapacitation Effects 0.000 description 1
• WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 description 1
• 210000003594 spinal ganglia Anatomy 0.000 description 1
• 210000004988 splenocyte Anatomy 0.000 description 1
• 230000010473 stable expression Effects 0.000 description 1
• 238000010561 standard procedure Methods 0.000 description 1
• 238000007619 statistical method Methods 0.000 description 1
• 150000003431 steroids Chemical class 0.000 description 1
• 230000001629 suppression Effects 0.000 description 1
• 238000002636 symptomatic treatment Methods 0.000 description 1
• 230000002195 synergetic effect Effects 0.000 description 1
• 230000008685 targeting Effects 0.000 description 1
• 229940090016 tegretol Drugs 0.000 description 1
• 229960003188 temazepam Drugs 0.000 description 1
• 210000002435 tendon Anatomy 0.000 description 1
• VCKUSRYTPJJLNI-UHFFFAOYSA-N terazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 VCKUSRYTPJJLNI-UHFFFAOYSA-N 0.000 description 1
• 229960001693 terazosin Drugs 0.000 description 1
• 230000000542 thalamic effect Effects 0.000 description 1
• 238000011285 therapeutic regimen Methods 0.000 description 1
• 238000004448 titration Methods 0.000 description 1
• 229940041597 tofranil Drugs 0.000 description 1
• OOGJQPCLVADCPB-HXUWFJFHSA-N tolterodine Chemical compound C1([C@@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(C)C=2)O)=CC=CC=C1 OOGJQPCLVADCPB-HXUWFJFHSA-N 0.000 description 1
• 229960004045 tolterodine Drugs 0.000 description 1
• 229940035305 topamax Drugs 0.000 description 1
• 229960004394 topiramate Drugs 0.000 description 1
• 229940044693 topoisomerase inhibitor Drugs 0.000 description 1
• 239000003053 toxin Substances 0.000 description 1
• 231100000765 toxin Toxicity 0.000 description 1
• VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
• XUPZAARQDNSRJB-SJDTYFKWSA-N trans-dothiepin hydrochloride Chemical compound [Cl-].C1SC2=CC=CC=C2C(=C/CC[NH+](C)C)/C2=CC=CC=C21 XUPZAARQDNSRJB-SJDTYFKWSA-N 0.000 description 1
• 238000013519 translation Methods 0.000 description 1
• 229960003741 tranylcypromine Drugs 0.000 description 1
• 238000011269 treatment regimen Methods 0.000 description 1
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
• RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
• 230000001228 trophic effect Effects 0.000 description 1
• 210000004881 tumor cell Anatomy 0.000 description 1
• 108010087967 type I signal peptidase Proteins 0.000 description 1
• 241001515965 unidentified phage Species 0.000 description 1
• BDIAUFOIMFAIPU-UHFFFAOYSA-N valepotriate Natural products CC(C)CC(=O)OC1C=C(C(=COC2OC(=O)CC(C)C)COC(C)=O)C2C11CO1 BDIAUFOIMFAIPU-UHFFFAOYSA-N 0.000 description 1
• 229960003726 vasopressin Drugs 0.000 description 1
• 229960004688 venlafaxine Drugs 0.000 description 1
• 230000002861 ventricular Effects 0.000 description 1
• 231100000889 vertigo Toxicity 0.000 description 1
• 206010047385 vestibular ataxia Diseases 0.000 description 1
• 230000003612 virological effect Effects 0.000 description 1
• 229940045977 vivactil Drugs 0.000 description 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
• 239000008215 water for injection Substances 0.000 description 1
• 230000003442 weekly effect Effects 0.000 description 1
• 238000005303 weighing Methods 0.000 description 1
• 229940009065 wellbutrin Drugs 0.000 description 1
• 230000003936 working memory Effects 0.000 description 1
• 229940000119 zanaflex Drugs 0.000 description 1
• 229960002811 ziconotide Drugs 0.000 description 1
• BPKIMPVREBSLAJ-QTBYCLKRSA-N ziconotide Chemical compound C([C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]2C(=O)N[C@@H]3C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@H](C(N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CSSC2)C(N)=O)=O)CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC3)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(N1)=O)CCSC)[C@@H](C)O)C1=CC=C(O)C=C1 BPKIMPVREBSLAJ-QTBYCLKRSA-N 0.000 description 1
• 229940020965 zoloft Drugs 0.000 description 1
• ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 description 1
• 229960001475 zolpidem Drugs 0.000 description 1
• 229940083488 zonalon Drugs 0.000 description 1
• 229940061639 zonegran Drugs 0.000 description 1
• 229960002911 zonisamide Drugs 0.000 description 1