MX2015002961A - Metodo para producir el compuesto sulfonilamidina. - Google Patents

Metodo para producir el compuesto sulfonilamidina.

Info

Publication number
MX2015002961A
MX2015002961A MX2015002961A MX2015002961A MX2015002961A MX 2015002961 A MX2015002961 A MX 2015002961A MX 2015002961 A MX2015002961 A MX 2015002961A MX 2015002961 A MX2015002961 A MX 2015002961A MX 2015002961 A MX2015002961 A MX 2015002961A
Authority
MX
Mexico
Prior art keywords
amidine compound
product
target compound
producing
production method
Prior art date
Application number
MX2015002961A
Other languages
English (en)
Other versions
MX351307B (es
Inventor
Toshitaka Yoshino
Takashi Kikuchi
Shinya Yoshida
Atsushi Nakamura
Takahiro Akiba
Kiichi Sato
Shuichi Nakagawa
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of MX2015002961A publication Critical patent/MX2015002961A/es
Publication of MX351307B publication Critical patent/MX351307B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D309/06—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Se proporcionan: un método para producir un compuesto sulfonilamidina, que tiene un excelente antagonismo del receptor de hormona liberadora de gonadotropina y es útil como un agente terapéutico para enfermedades dependientes de gonadotropina (por ejemplo, cáncer de próstata, cáncer de mama, endometriosis, fibroides uterinos, hiperplasia prostática, o similares) o una sal del mismo, y un intermediario de síntesis útil en el método de producción. El método de producción de acuerdo con la presente invención, mediante el cual se inhibe la formación de un subproducto, donde dicho subproducto difícilmente se elimina a menos que se conduzca la purificación de columna, y se inhibe la racemización de un compuesto objetivo y por lo tanto se obtiene el compuesto objetivo a una alta pureza, es adecuado para la producción industrial.
MX2015002961A 2012-09-07 2013-09-06 Método para producir el compuesto sulfonilamidina. MX351307B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012197914 2012-09-07
PCT/JP2013/074076 WO2014038663A1 (ja) 2012-09-07 2013-09-06 スルホニルアミジン化合物の製造法

Publications (2)

Publication Number Publication Date
MX2015002961A true MX2015002961A (es) 2015-09-24
MX351307B MX351307B (es) 2017-10-10

Family

ID=50237268

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015002961A MX351307B (es) 2012-09-07 2013-09-06 Método para producir el compuesto sulfonilamidina.

Country Status (8)

Country Link
US (1) US9527818B2 (es)
EP (1) EP2894152A4 (es)
JP (1) JP6222094B2 (es)
KR (1) KR20150048762A (es)
CN (1) CN104603114B (es)
CA (1) CA2883126A1 (es)
MX (1) MX351307B (es)
WO (1) WO2014038663A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201613579A (en) 2014-06-24 2016-04-16 Astellas Pharma Inc Pharmaceutical composition for oral administration
MX2019014483A (es) 2017-06-05 2020-08-17 ObsEva SA Regimenes de dosificación de antagonistas de hormona liberadora de gonadotropina para el tratamiento de endometriosis.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0511796A (pt) 2004-06-04 2008-01-15 Astellas Pharma Inc derivado de propano-1, 3-diona ou seu sal
CN101142193B (zh) * 2005-03-31 2010-12-29 安斯泰来制药株式会社 1,3-丙二酮衍生物或其盐
DK1864976T3 (da) * 2005-03-31 2012-10-22 Astellas Pharma Inc Propan-1,3-dion-derivat eller salt deraf
JP2014051470A (ja) * 2012-09-07 2014-03-20 Astellas Pharma Inc スルホニルアミジン化合物の結晶

Also Published As

Publication number Publication date
CA2883126A1 (en) 2014-03-13
US9527818B2 (en) 2016-12-27
KR20150048762A (ko) 2015-05-07
JPWO2014038663A1 (ja) 2016-08-12
MX351307B (es) 2017-10-10
US20150259299A1 (en) 2015-09-17
CN104603114B (zh) 2017-06-20
WO2014038663A1 (ja) 2014-03-13
JP6222094B2 (ja) 2017-11-01
EP2894152A1 (en) 2015-07-15
CN104603114A (zh) 2015-05-06
EP2894152A4 (en) 2016-03-09

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