MX2014004394A - Metodo para la sintesis de biomoleculas marcadas con 18f. - Google Patents

Metodo para la sintesis de biomoleculas marcadas con 18f.

Info

Publication number
MX2014004394A
MX2014004394A MX2014004394A MX2014004394A MX2014004394A MX 2014004394 A MX2014004394 A MX 2014004394A MX 2014004394 A MX2014004394 A MX 2014004394A MX 2014004394 A MX2014004394 A MX 2014004394A MX 2014004394 A MX2014004394 A MX 2014004394A
Authority
MX
Mexico
Prior art keywords
present
synthesis
provides
labelled biomolecules
reagent
Prior art date
Application number
MX2014004394A
Other languages
English (en)
Other versions
MX353304B (es
Inventor
Imtiaz Khan
Rajiv Bhalla
Anthony Wilson
Jane Brown
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Publication of MX2014004394A publication Critical patent/MX2014004394A/es
Publication of MX353304B publication Critical patent/MX353304B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K51/0448—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil tropane or nortropane groups, e.g. cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/30—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reactions not involving the formation of esterified sulfo groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/10—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente invención proporciona un método para la síntesis de biomoléculas marcadas con 18F, la cual es manejable para automatización. La presente invención también proporciona un casete para la automatización del método de la invención. El método de la presente invención proporciona numerosas ventajas sobre los métodos de la técnica anterior. Se requiere de un paso de menos purificación según comparado con métodos conocidos. También se requiere de menos reactivo ya que un reactivo particular es empleado en dos diferentes pasos. El procedimiento químico de esta manera es simplificado, el costo de artículos se reduce y la carga de validación y documentación de reactivos requeridos para la producción clínica de GMP se reduce al mínimo.
MX2014004394A 2011-10-14 2012-10-15 Metodo para la sintesis de biomoleculas marcadas con 18f. MX353304B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161547088P 2011-10-14 2011-10-14
GB201117786A GB201117786D0 (en) 2011-10-14 2011-10-14 Eluent vial
PCT/EP2012/070400 WO2013053940A1 (en) 2011-10-14 2012-10-15 Method for the synthesis of 18f-labelled biomolecules

Publications (2)

Publication Number Publication Date
MX2014004394A true MX2014004394A (es) 2014-05-27
MX353304B MX353304B (es) 2018-01-08

Family

ID=45219737

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014004394A MX353304B (es) 2011-10-14 2012-10-15 Metodo para la sintesis de biomoleculas marcadas con 18f.

Country Status (12)

Country Link
US (1) US9125954B2 (es)
EP (1) EP2766325B1 (es)
JP (1) JP6154815B2 (es)
KR (1) KR102007053B1 (es)
CN (1) CN103874672B (es)
AU (1) AU2012322748B2 (es)
BR (1) BR112014002400A2 (es)
CA (1) CA2851595C (es)
GB (1) GB201117786D0 (es)
MX (1) MX353304B (es)
RU (1) RU2620598C2 (es)
WO (1) WO2013053940A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3068747A1 (en) * 2013-11-13 2016-09-21 GE Healthcare Limited Dual run cassette for the synthesis of 18f-labelled compounds
GB201607572D0 (en) * 2016-04-29 2016-06-15 Ge Healthcare Ltd Ip And Kings College London Alyklation method
US10596276B2 (en) 2018-07-25 2020-03-24 Advanced Accelerator Applications (Italy) S.R.L. Stable, concentrated radionuclide complex solutions
GB201919016D0 (en) * 2019-12-20 2020-02-05 Ge Healthcare Ltd Apparatus and method for solid phase extraction
CN111153840A (zh) * 2020-01-09 2020-05-15 复旦大学附属华山医院 [18f]-ge-179的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE245977T1 (de) 1993-05-27 2003-08-15 Cenes Ltd Therapeutische substituierte guanidine
GB0216621D0 (en) 2002-07-17 2002-08-28 Imaging Res Solutions Ltd Imaging compounds
CA2538520C (en) * 2003-07-24 2015-02-10 The Queen's Medical Center Preparation and use of alkylating agents
KR100789847B1 (ko) 2004-12-15 2007-12-28 (주)퓨쳐켐 알코올 용매하에서 유기플루오로 화합물의 제조방법
GB0512770D0 (en) * 2005-06-23 2005-07-27 Hammersmith Imanet Ltd Imaging compounds
KR101009712B1 (ko) * 2007-02-22 2011-01-19 재단법인 아산사회복지재단 양성자성 용매와 이에 녹는 염들을 이용한 음이온 교환고분자 지지체로부터의 플루오린-18 플루오라이드 용리와이를 이용한 플루오린-18의 표지방법
GB0917612D0 (en) * 2009-10-08 2009-11-25 Ge Healthcare Ltd In vivo imaging agents

Also Published As

Publication number Publication date
AU2012322748B2 (en) 2017-04-27
CN103874672A (zh) 2014-06-18
US9125954B2 (en) 2015-09-08
KR102007053B1 (ko) 2019-08-02
KR20140076574A (ko) 2014-06-20
EP2766325A1 (en) 2014-08-20
AU2012322748A1 (en) 2014-04-24
CA2851595A1 (en) 2013-04-18
JP6154815B2 (ja) 2017-06-28
CA2851595C (en) 2020-11-10
GB201117786D0 (en) 2011-11-30
CN103874672B (zh) 2017-03-08
JP2014534190A (ja) 2014-12-18
US20140235861A1 (en) 2014-08-21
BR112014002400A2 (pt) 2017-02-21
EP2766325B1 (en) 2020-03-18
RU2620598C2 (ru) 2017-05-29
WO2013053940A1 (en) 2013-04-18
RU2014111249A (ru) 2015-11-20
MX353304B (es) 2018-01-08

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