MX2014004383A - Metodo para reducir el enrojecimiento facial asociado con el uso sistemico de inhibidores de fosfodiesterasa tipo 5. - Google Patents
Metodo para reducir el enrojecimiento facial asociado con el uso sistemico de inhibidores de fosfodiesterasa tipo 5.Info
- Publication number
- MX2014004383A MX2014004383A MX2014004383A MX2014004383A MX2014004383A MX 2014004383 A MX2014004383 A MX 2014004383A MX 2014004383 A MX2014004383 A MX 2014004383A MX 2014004383 A MX2014004383 A MX 2014004383A MX 2014004383 A MX2014004383 A MX 2014004383A
- Authority
- MX
- Mexico
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- brimonidine
- oxymetazoline
- composition
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 26
- 230000009885 systemic effect Effects 0.000 title claims abstract description 15
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 title claims description 20
- 206010016825 Flushing Diseases 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 claims abstract description 54
- 230000001815 facial effect Effects 0.000 claims abstract description 31
- 239000000695 adrenergic alpha-agonist Substances 0.000 claims abstract description 12
- OFHCOWSQAMBJIW-AVJTYSNKSA-N alfacalcidol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C OFHCOWSQAMBJIW-AVJTYSNKSA-N 0.000 claims abstract description 5
- 150000003839 salts Chemical class 0.000 claims description 65
- WYWIFABBXFUGLM-UHFFFAOYSA-N oxymetazoline Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C)=C1CC1=NCCN1 WYWIFABBXFUGLM-UHFFFAOYSA-N 0.000 claims description 45
- 150000001875 compounds Chemical class 0.000 claims description 40
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- 229960003679 brimonidine Drugs 0.000 claims description 23
- 229960001528 oxymetazoline Drugs 0.000 claims description 22
- -1 nefazoline Chemical compound 0.000 claims description 20
- BYJAVTDNIXVSPW-UHFFFAOYSA-N tetryzoline Chemical compound N1CCN=C1C1C2=CC=CC=C2CCC1 BYJAVTDNIXVSPW-UHFFFAOYSA-N 0.000 claims description 18
- 229940123333 Phosphodiesterase 5 inhibitor Drugs 0.000 claims description 17
- HUCJFAOMUPXHDK-UHFFFAOYSA-N Xylometazoline Chemical compound CC1=CC(C(C)(C)C)=CC(C)=C1CC1=NCCN1 HUCJFAOMUPXHDK-UHFFFAOYSA-N 0.000 claims description 10
- PTKSEFOSCHHMPD-SNVBAGLBSA-N 2-amino-n-[(2s)-2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide Chemical compound COC1=CC=C(OC)C([C@H](O)CNC(=O)CN)=C1 PTKSEFOSCHHMPD-SNVBAGLBSA-N 0.000 claims description 9
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- WJAJPNHVVFWKKL-UHFFFAOYSA-N Methoxamine Chemical compound COC1=CC=C(OC)C(C(O)C(C)N)=C1 WJAJPNHVVFWKKL-UHFFFAOYSA-N 0.000 claims description 9
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Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
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- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
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- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161548844P | 2011-10-19 | 2011-10-19 | |
| PCT/IB2012/002500 WO2013057579A2 (en) | 2011-10-19 | 2012-10-12 | Method of reducing facial flushing associated with systemic use of phosphodiesterase type 5 inhibitors |
Publications (1)
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| MX2014004383A true MX2014004383A (es) | 2014-11-12 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014004383A MX2014004383A (es) | 2011-10-19 | 2012-10-12 | Metodo para reducir el enrojecimiento facial asociado con el uso sistemico de inhibidores de fosfodiesterasa tipo 5. |
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| Country | Link |
|---|---|
| US (1) | US9744168B2 (enExample) |
| EP (1) | EP2768502A2 (enExample) |
| JP (1) | JP2014530846A (enExample) |
| KR (1) | KR20140091543A (enExample) |
| CN (1) | CN103889417A (enExample) |
| AU (1) | AU2012324543B2 (enExample) |
| BR (1) | BR112014009210A2 (enExample) |
| CA (1) | CA2850273A1 (enExample) |
| IL (1) | IL231820A0 (enExample) |
| MX (1) | MX2014004383A (enExample) |
| PH (1) | PH12014500783A1 (enExample) |
| RU (1) | RU2014119879A (enExample) |
| WO (1) | WO2013057579A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120076738A1 (en) * | 2010-09-28 | 2012-03-29 | Michael Graeber | Combination treatment for dermatological conditions |
| WO2015191917A1 (en) * | 2014-06-11 | 2015-12-17 | Allergan, Inc. | Stabilized oxymetazoline formulations and their uses |
| KR20190071720A (ko) | 2016-10-07 | 2019-06-24 | 마이크레오스 휴먼 헬스 비.브이. | 주사의 혈관수축성 및 항균성 병용 치료 |
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| DE2436882A1 (de) | 1974-07-29 | 1976-02-19 | Schering Ag | Neue oxyphenylbutazon-derivate und ihre herstellung |
| DE2632678C2 (de) | 1976-07-16 | 1986-02-27 | Schering AG, 1000 Berlin und 4709 Bergkamen | 6α-Fluor-12α-Halogen-Kortikoide und Verfahren zu ihrer Herstellung |
| NZ185295A (en) | 1976-10-04 | 1980-04-28 | Schering Ag | 9-chloroprednisolone derivatives and pharmaceutical compositions |
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2012
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- 2012-10-12 MX MX2014004383A patent/MX2014004383A/es unknown
- 2012-10-12 AU AU2012324543A patent/AU2012324543B2/en not_active Expired - Fee Related
- 2012-10-12 KR KR1020147011912A patent/KR20140091543A/ko not_active Withdrawn
- 2012-10-12 JP JP2014536349A patent/JP2014530846A/ja active Pending
- 2012-10-12 CN CN201280051534.6A patent/CN103889417A/zh active Pending
- 2012-10-12 BR BR112014009210A patent/BR112014009210A2/pt not_active IP Right Cessation
- 2012-10-12 EP EP12821025.9A patent/EP2768502A2/en not_active Withdrawn
- 2012-10-12 PH PH1/2014/500783A patent/PH12014500783A1/en unknown
- 2012-10-12 CA CA2850273A patent/CA2850273A1/en not_active Abandoned
- 2012-10-12 US US14/344,099 patent/US9744168B2/en not_active Expired - Fee Related
- 2012-10-12 WO PCT/IB2012/002500 patent/WO2013057579A2/en not_active Ceased
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2014
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| PH12014500783A1 (en) | 2014-05-12 |
| WO2013057579A2 (en) | 2013-04-25 |
| US9744168B2 (en) | 2017-08-29 |
| AU2012324543B2 (en) | 2017-08-10 |
| IL231820A0 (en) | 2014-05-28 |
| BR112014009210A2 (pt) | 2017-04-18 |
| RU2014119879A (ru) | 2015-11-27 |
| AU2012324543A1 (en) | 2014-05-01 |
| CA2850273A1 (en) | 2013-04-25 |
| CN103889417A (zh) | 2014-06-25 |
| EP2768502A2 (en) | 2014-08-27 |
| JP2014530846A (ja) | 2014-11-20 |
| KR20140091543A (ko) | 2014-07-21 |
| WO2013057579A3 (en) | 2013-07-04 |
| US20140343067A1 (en) | 2014-11-20 |
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