MX2013005989A - Tratamiento de obesidad utilizando administracion no diaria de 6-o-(4-dimetilaminoetoxi)cinamoil fumagilol. - Google Patents
Tratamiento de obesidad utilizando administracion no diaria de 6-o-(4-dimetilaminoetoxi)cinamoil fumagilol.Info
- Publication number
- MX2013005989A MX2013005989A MX2013005989A MX2013005989A MX2013005989A MX 2013005989 A MX2013005989 A MX 2013005989A MX 2013005989 A MX2013005989 A MX 2013005989A MX 2013005989 A MX2013005989 A MX 2013005989A MX 2013005989 A MX2013005989 A MX 2013005989A
- Authority
- MX
- Mexico
- Prior art keywords
- obesity
- daily administration
- dimethylaminoethoxy
- treatment
- cinnamoyl fumagillol
- Prior art date
Links
- 208000008589 Obesity Diseases 0.000 title abstract 2
- 235000020824 obesity Nutrition 0.000 title abstract 2
- CEVCTNCUIVEQOY-UHFFFAOYSA-N Fumagillol Natural products O1C(CC=C(C)C)C1(C)C1C(OC)C(O)CCC21CO2 CEVCTNCUIVEQOY-UHFFFAOYSA-N 0.000 title 1
- -1 cinnamoyl fumagillol Chemical compound 0.000 title 1
- 206010033307 Overweight Diseases 0.000 abstract 2
- 102100023174 Methionine aminopeptidase 2 Human genes 0.000 abstract 1
- 108090000192 Methionyl aminopeptidases Proteins 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41769210P | 2010-11-29 | 2010-11-29 | |
| US201161500662P | 2011-06-24 | 2011-06-24 | |
| PCT/US2011/062413 WO2012075020A1 (en) | 2010-11-29 | 2011-11-29 | Treatment of obesity using non-daily administration of 6 - 0 - (4 - dimethylaminoethoxy) cinnamoyl fumagillol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2013005989A true MX2013005989A (es) | 2013-08-21 |
Family
ID=45316099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013005989A MX2013005989A (es) | 2010-11-29 | 2011-11-29 | Tratamiento de obesidad utilizando administracion no diaria de 6-o-(4-dimetilaminoetoxi)cinamoil fumagilol. |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US9173865B2 (OSRAM) |
| EP (1) | EP2646016B1 (OSRAM) |
| JP (1) | JP2013543899A (OSRAM) |
| KR (1) | KR20140009273A (OSRAM) |
| CN (1) | CN103379905A (OSRAM) |
| AU (1) | AU2011336785A1 (OSRAM) |
| BR (1) | BR112013013411A2 (OSRAM) |
| CA (1) | CA2819251A1 (OSRAM) |
| MX (1) | MX2013005989A (OSRAM) |
| WO (1) | WO2012075020A1 (OSRAM) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2731020A1 (en) * | 2008-07-18 | 2010-01-21 | Zafgen, Inc. | Use of antiangiogenic fumagillins in the treatment of obesity |
| WO2010065883A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Method of treating an overweight or obese subject |
| WO2013055385A2 (en) | 2011-10-03 | 2013-04-18 | Zafgen Corporation | Methods of treating age related disorders |
| US20120004162A1 (en) | 2008-12-04 | 2012-01-05 | Vath James E | Methods of Treating an Overweight or Obese Subject |
| CA2777108A1 (en) | 2009-10-09 | 2011-04-14 | Zafgen Corporation | Sulphone compounds and methods of making and using same |
| US8815309B2 (en) | 2010-01-08 | 2014-08-26 | Zafgen, Inc. | Methods of treating a subject with benign prostate hyperplasia |
| BR112012016793A2 (pt) | 2010-01-08 | 2018-07-31 | Zafgen Corp | compostos tipo fumagilol e métodos de fazer e usar os mesmos |
| WO2011127304A2 (en) | 2010-04-07 | 2011-10-13 | Zafgen Corporation | Methods of treating an overweight subject |
| JP5913310B2 (ja) | 2010-07-22 | 2016-04-27 | ザフゲン,インコーポレイテッド | 三環式化合物ならびにその作製および使用方法 |
| WO2012075020A1 (en) | 2010-11-29 | 2012-06-07 | Zafgen Corporation | Treatment of obesity using non-daily administration of 6 - 0 - (4 - dimethylaminoethoxy) cinnamoyl fumagillol |
| BR112013018771A2 (pt) | 2011-01-26 | 2019-09-17 | Zafgen Inc | compostos de tetrazol e métodos para fazer e usar os mesmos |
| WO2012122264A1 (en) | 2011-03-08 | 2012-09-13 | Zafgen Corporation | Oxaspiro [2.5] octane derivatives and analogs |
| CA2835261C (en) | 2011-05-06 | 2019-06-04 | Zafgen, Inc. | Partially saturated tricyclic compounds and methods of making and using same |
| MX343688B (es) | 2011-05-06 | 2016-11-16 | Zafgen Inc | Compuestos tricíclicos de sulfonamida y pirazolo y métodos para su fabricación y uso. |
| US9187494B2 (en) | 2011-05-06 | 2015-11-17 | Zafgen, Inc. | Aryl-substituted tricyclic sulfonamides as methionyl aminopeptidase 2 modulators |
| US9359369B2 (en) | 2012-01-18 | 2016-06-07 | Zafgen, Inc. | Tricyclic sulfonamide compounds and methods of making and using same |
| WO2013169857A1 (en) | 2012-05-08 | 2013-11-14 | Zafgen, Inc. | Treating hypothalamic obesity with metap2 inhibitors |
| JP6177888B2 (ja) | 2012-05-09 | 2017-08-09 | ザフゲン,インコーポレイテッド | フマギロール型化合物ならびにその製造および使用方法 |
| CA2890344A1 (en) | 2012-11-05 | 2014-05-08 | Zafgen, Inc. | Tricyclic compounds for use in the treatment and/or control of obesity |
| JP2015536981A (ja) | 2012-11-05 | 2015-12-24 | ザフゲン,インコーポレイテッド | 三環式化合物ならびにその製造および使用方法 |
| MX362391B (es) | 2013-03-14 | 2019-01-15 | Zafgen Inc | Métodos de tratamiento de enfermedad renal y otros trastornos. |
| US9173956B2 (en) * | 2013-04-10 | 2015-11-03 | Syndevrx, Inc. | METAP2 inhibitors and methods of treating obesity |
| CN106432255A (zh) | 2015-08-11 | 2017-02-22 | 扎夫根公司 | 烟曲霉素醇螺环化合物和制备和使用其的方法 |
| AR105671A1 (es) | 2015-08-11 | 2017-10-25 | Zafgen Inc | Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso |
| US20190329042A1 (en) * | 2018-02-26 | 2019-10-31 | Daniel John DiLorenzo | Method, apparatus, surgical technique, and optimal stimulation parameters for noninvasive & minimally invasive autonomic vector neuromodulation for physiologic optimization and for the treatment of obesity, cardiac disease, pulmonary disorders, hypertension, and other conditions |
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| CA2741683C (en) | 2008-10-24 | 2016-03-22 | Wake Forest University | Platinum acridine anti-cancer compounds and methods thereof |
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| WO2010065883A2 (en) * | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Method of treating an overweight or obese subject |
| US20120010259A1 (en) | 2008-12-04 | 2012-01-12 | Vath James E | Methods of Treating an Overweight or Obese Subject |
| WO2010065879A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Methods of treating an overweight or obese subject |
| CA2777108A1 (en) | 2009-10-09 | 2011-04-14 | Zafgen Corporation | Sulphone compounds and methods of making and using same |
| US8815309B2 (en) | 2010-01-08 | 2014-08-26 | Zafgen, Inc. | Methods of treating a subject with benign prostate hyperplasia |
| BR112012016793A2 (pt) * | 2010-01-08 | 2018-07-31 | Zafgen Corp | compostos tipo fumagilol e métodos de fazer e usar os mesmos |
| WO2011088055A2 (en) | 2010-01-12 | 2011-07-21 | Zafgen Corporation | Methods and compositions for treating cardiovascular disorders |
| WO2011127304A2 (en) * | 2010-04-07 | 2011-10-13 | Zafgen Corporation | Methods of treating an overweight subject |
| WO2011150338A1 (en) | 2010-05-27 | 2011-12-01 | Zafgen Corporation | Methods of treating obesity |
| JP5913310B2 (ja) | 2010-07-22 | 2016-04-27 | ザフゲン,インコーポレイテッド | 三環式化合物ならびにその作製および使用方法 |
| JP5913333B2 (ja) | 2010-10-12 | 2016-04-27 | ザフゲン,インコーポレイテッド | スルホンアミド化合物、およびそれを製造し使用する方法 |
| PH12013500934A1 (en) | 2010-11-09 | 2022-10-24 | Zafgen Inc | Crystalline solids of a metap-2 inhibitor and methods of making and using same |
| WO2012064928A1 (en) | 2010-11-10 | 2012-05-18 | Zafgen Corporation | Methods and compositions for treating thyroid hormone related disorders |
| WO2012075020A1 (en) * | 2010-11-29 | 2012-06-07 | Zafgen Corporation | Treatment of obesity using non-daily administration of 6 - 0 - (4 - dimethylaminoethoxy) cinnamoyl fumagillol |
| WO2012074968A1 (en) | 2010-11-29 | 2012-06-07 | Zafgen Corporation | Methods of reducing risk of hepatobiliary dysfunction during rapid weight loss with metap-2 inhibitors |
| US20140011870A1 (en) | 2010-11-29 | 2014-01-09 | Zafgen, Inc. | Methods of Treating Obesity Using an Effective Dose of a METAP-2 Inhibitor |
| BR112013018771A2 (pt) | 2011-01-26 | 2019-09-17 | Zafgen Inc | compostos de tetrazol e métodos para fazer e usar os mesmos |
| MX343688B (es) | 2011-05-06 | 2016-11-16 | Zafgen Inc | Compuestos tricíclicos de sulfonamida y pirazolo y métodos para su fabricación y uso. |
| US9187494B2 (en) | 2011-05-06 | 2015-11-17 | Zafgen, Inc. | Aryl-substituted tricyclic sulfonamides as methionyl aminopeptidase 2 modulators |
| CA2835261C (en) | 2011-05-06 | 2019-06-04 | Zafgen, Inc. | Partially saturated tricyclic compounds and methods of making and using same |
| US9090640B2 (en) | 2011-09-02 | 2015-07-28 | Ulrich Bierbach | Targeted delivery and prodrug designs for platinum-acridine anti-cancer compounds and methods thereof |
-
2011
- 2011-11-29 WO PCT/US2011/062413 patent/WO2012075020A1/en not_active Ceased
- 2011-11-29 US US13/990,271 patent/US9173865B2/en not_active Expired - Fee Related
- 2011-11-29 JP JP2013541073A patent/JP2013543899A/ja active Pending
- 2011-11-29 AU AU2011336785A patent/AU2011336785A1/en not_active Abandoned
- 2011-11-29 CA CA2819251A patent/CA2819251A1/en not_active Abandoned
- 2011-11-29 EP EP11794331.6A patent/EP2646016B1/en active Active
- 2011-11-29 CN CN2011800646973A patent/CN103379905A/zh active Pending
- 2011-11-29 MX MX2013005989A patent/MX2013005989A/es active IP Right Grant
- 2011-11-29 BR BR112013013411A patent/BR112013013411A2/pt not_active IP Right Cessation
- 2011-11-29 KR KR1020137016894A patent/KR20140009273A/ko not_active Withdrawn
-
2013
- 2013-10-17 US US14/056,816 patent/US8980946B2/en not_active Expired - Fee Related
- 2013-10-17 US US14/056,829 patent/US9000035B2/en not_active Expired - Fee Related
-
2015
- 2015-04-02 US US14/677,498 patent/US20150209321A1/en not_active Abandoned
- 2015-09-17 US US14/856,929 patent/US20160243073A1/en not_active Abandoned
-
2017
- 2017-09-13 US US15/703,398 patent/US20180221328A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BR112013013411A2 (pt) | 2016-09-13 |
| US20160243073A1 (en) | 2016-08-25 |
| US20140045935A1 (en) | 2014-02-13 |
| CN103379905A (zh) | 2013-10-30 |
| WO2012075020A1 (en) | 2012-06-07 |
| US8980946B2 (en) | 2015-03-17 |
| US20180221328A1 (en) | 2018-08-09 |
| US20140045934A1 (en) | 2014-02-13 |
| US20150209321A1 (en) | 2015-07-30 |
| US20140051752A1 (en) | 2014-02-20 |
| US9173865B2 (en) | 2015-11-03 |
| JP2013543899A (ja) | 2013-12-09 |
| EP2646016B1 (en) | 2017-05-17 |
| KR20140009273A (ko) | 2014-01-22 |
| AU2011336785A1 (en) | 2013-06-20 |
| US9000035B2 (en) | 2015-04-07 |
| CA2819251A1 (en) | 2012-06-07 |
| EP2646016A1 (en) | 2013-10-09 |
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