MX2012010829A - Formulaciones estabilizadas de compuesto para el sistema nervioso central. - Google Patents
Formulaciones estabilizadas de compuesto para el sistema nervioso central.Info
- Publication number
- MX2012010829A MX2012010829A MX2012010829A MX2012010829A MX2012010829A MX 2012010829 A MX2012010829 A MX 2012010829A MX 2012010829 A MX2012010829 A MX 2012010829A MX 2012010829 A MX2012010829 A MX 2012010829A MX 2012010829 A MX2012010829 A MX 2012010829A
- Authority
- MX
- Mexico
- Prior art keywords
- molindone
- formulation according
- acid
- formulation
- release
- Prior art date
Links
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- 238000009472 formulation Methods 0.000 title claims abstract description 135
- 150000001875 compounds Chemical class 0.000 title description 10
- KLPWJLBORRMFGK-UHFFFAOYSA-N Molindone Chemical compound O=C1C=2C(CC)=C(C)NC=2CCC1CN1CCOCC1 KLPWJLBORRMFGK-UHFFFAOYSA-N 0.000 claims abstract description 97
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- 238000000034 method Methods 0.000 claims abstract description 27
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 8
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- 239000005711 Benzoic acid Substances 0.000 claims description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 3
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- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims 1
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Landscapes
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28278710P | 2010-03-31 | 2010-03-31 | |
| PCT/US2011/030444 WO2011123497A1 (en) | 2010-03-31 | 2011-03-30 | Stabilized formulations of cns compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2012010829A true MX2012010829A (es) | 2012-11-12 |
Family
ID=44709952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012010829A MX2012010829A (es) | 2010-03-31 | 2011-03-30 | Formulaciones estabilizadas de compuesto para el sistema nervioso central. |
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| JP5783908B2 (ja) | 2008-12-19 | 2015-09-24 | スパーナス ファーマシューティカルズ インコーポレイテッド | 攻撃性を治療する方法 |
| EP3572074B1 (en) * | 2010-03-31 | 2021-01-06 | Supernus Pharmaceuticals, Inc. | Stabilized formulations of molindone |
| EP3524251A1 (en) * | 2012-11-13 | 2019-08-14 | Supernus Pharmaceuticals, Inc. | Method of treatment of aggression |
| CA3022339A1 (en) * | 2016-04-29 | 2017-11-02 | Supernus Pharmaceuticals, Inc. | Methods, system, and kit for monitoring, diagnosing, and treating impulsive aggression |
| US20180078516A1 (en) * | 2016-09-19 | 2018-03-22 | Innovazone Labs LLC | Pharmaceutical Composition of Ibuprofen Sodium for Oral Administration |
| WO2019014201A1 (en) * | 2017-07-10 | 2019-01-17 | Apicore Us Llc | MOLINDONE COMPOSITIONS WITH EXTENDED RELEASE |
| EP4212149A1 (en) | 2022-01-18 | 2023-07-19 | Rijksuniversiteit Groningen | Oral dosage forms of acid-labile salt and methods and uses related thereto |
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| US4148896A (en) * | 1978-02-22 | 1979-04-10 | E. I. Du Pont De Nemours And Company | Antidepressant combination |
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| US6489319B2 (en) | 1999-08-16 | 2002-12-03 | Revaax Pharmaceuticals, Llc | Neurotherapeutic use of carboxypeptidase inhibitors |
| HK1042427A1 (zh) * | 1999-09-30 | 2002-08-16 | Penwest Pharmaceuticals Co. | 用於高溶度药物的持续释放基质方法 |
| FR2814463B1 (fr) | 2000-09-22 | 2002-11-15 | Sanofi Synthelabo | Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine |
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| WO2004106298A1 (en) | 2003-05-30 | 2004-12-09 | Janssen Pharmaceutica N.V. | Indole derivatives with an improved antipsychotic activity |
| US7737133B2 (en) | 2003-09-03 | 2010-06-15 | Agi Therapeutics Ltd. | Formulations and methods of treating inflammatory bowel disease |
| JP2007529829A (ja) | 2004-03-18 | 2007-10-25 | ユニヴァースティ オブ ヴァージニア パテント ファウンデイション | 注意機能障害の確率的精神生理学評価のための方法、装置およびコンピュータ・プログラムプロダクト |
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| TW200612899A (en) | 2004-06-14 | 2006-05-01 | Janssen Pharmaceutica Nv | Novel tetracyclic tetrahydrofuran derivatives |
| US20090208579A1 (en) * | 2004-12-27 | 2009-08-20 | Eisai R & D Management Co., Ltd. | Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same |
| FR2891459B1 (fr) * | 2005-09-30 | 2007-12-28 | Flamel Technologies Sa | Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant |
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| NZ575171A (en) | 2006-08-31 | 2012-04-27 | Aptalis Pharmatech Inc | Drug delivery systems comprising solid solutions of weakly basic drugs |
| JP2008189616A (ja) | 2007-02-07 | 2008-08-21 | Mitsubishi Tanabe Pharma Corp | 注意欠陥多動性障害の治療薬 |
| GB2447949B (en) | 2007-03-29 | 2010-03-31 | Renasci Consultancy Ltd | A method for identifying a compound for treating a disorder or condition associated with dysfunction of monoamine neurotransmission |
| US8637080B2 (en) * | 2007-06-28 | 2014-01-28 | Osmotica Kereskedelmi és Szolgáltató, KFT | Rupturing controlled release device comprising a subcoat |
| JP5783908B2 (ja) | 2008-12-19 | 2015-09-24 | スパーナス ファーマシューティカルズ インコーポレイテッド | 攻撃性を治療する方法 |
| EP3572074B1 (en) | 2010-03-31 | 2021-01-06 | Supernus Pharmaceuticals, Inc. | Stabilized formulations of molindone |
| SE536078C2 (sv) | 2010-10-09 | 2013-04-30 | Core Link Ab | Anordning för bearbetning av hylsor |
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| EP2552423A4 (en) | 2015-05-27 |
| EP3572074B1 (en) | 2021-01-06 |
| ES2643497T3 (es) | 2017-11-23 |
| EP2552423B1 (en) | 2017-07-12 |
| CA2793222A1 (en) | 2011-10-06 |
| JP2018024680A (ja) | 2018-02-15 |
| JP6759426B2 (ja) | 2020-09-23 |
| CA2793222C (en) | 2018-01-23 |
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| US20210322429A1 (en) | 2021-10-21 |
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| US8748472B2 (en) | 2014-06-10 |
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| ES2852899T3 (es) | 2021-09-14 |
| JP6529416B2 (ja) | 2019-06-12 |
| JP2016041722A (ja) | 2016-03-31 |
| WO2011123497A1 (en) | 2011-10-06 |
| EP3269363B1 (en) | 2019-08-28 |
| JP2019189645A (ja) | 2019-10-31 |
| US11077114B2 (en) | 2021-08-03 |
| US20110244042A1 (en) | 2011-10-06 |
| AU2011235222B2 (en) | 2014-09-25 |
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