MX2012001200A - (aza)indolizinacarboxamidas ciclicas, su preparacion y su uso como agentes farmaceuticos. - Google Patents

(aza)indolizinacarboxamidas ciclicas, su preparacion y su uso como agentes farmaceuticos.

Info

Publication number
MX2012001200A
MX2012001200A MX2012001200A MX2012001200A MX2012001200A MX 2012001200 A MX2012001200 A MX 2012001200A MX 2012001200 A MX2012001200 A MX 2012001200A MX 2012001200 A MX2012001200 A MX 2012001200A MX 2012001200 A MX2012001200 A MX 2012001200A
Authority
MX
Mexico
Prior art keywords
sup
indolizinecarboxamides
cyclic
preparation
aza
Prior art date
Application number
MX2012001200A
Other languages
English (en)
Inventor
Hans Matter
Henning Steinhagen
Bodo Scheiper
Gary Mccort
Guillaume Begis
Pascale Goberville
Berangere Thiers
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX2012001200A publication Critical patent/MX2012001200A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a indolizinacarboxamidas y azaindolizinacarboxamidas cíclicas de la fórmula la e Ib, (ver fórmulas) en las que R, Ra, R10, R20, R30, R40, Y, n, p y q tienen los significados indicados en las reivindicaciones, que son valiosos compuestos farmacéuticos activos. Específicamente, inhiben la renina enzimática y modulan la actividad del sistema renina-angiotensina, y son útiles para el tratamiento de enfermedades tales como por ejemplo la hipertensión. Además, la invención se refiere a procedimientos para la preparación de los compuestos de las fórmulas la e Ib, a su uso y composiciones farmacéuticas que tos comprenden.
MX2012001200A 2009-07-29 2010-07-23 (aza)indolizinacarboxamidas ciclicas, su preparacion y su uso como agentes farmaceuticos. MX2012001200A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09290599 2009-07-29
PCT/EP2010/060679 WO2011012538A1 (en) 2009-07-29 2010-07-23 Cyclic (aza)indolizinecarboxamides, their preparation and their use as pharmaceuticals

Publications (1)

Publication Number Publication Date
MX2012001200A true MX2012001200A (es) 2012-03-26

Family

ID=41181399

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012001200A MX2012001200A (es) 2009-07-29 2010-07-23 (aza)indolizinacarboxamidas ciclicas, su preparacion y su uso como agentes farmaceuticos.

Country Status (20)

Country Link
US (1) US8415336B2 (es)
EP (1) EP2459557B1 (es)
JP (1) JP5740399B2 (es)
KR (1) KR20120052247A (es)
CN (1) CN102548993B (es)
AR (1) AR077428A1 (es)
AU (1) AU2010277736B2 (es)
BR (1) BR112012008140A2 (es)
CA (1) CA2766535A1 (es)
DK (1) DK2459557T3 (es)
ES (1) ES2431948T3 (es)
HK (1) HK1171739A1 (es)
IL (1) IL217614A (es)
MX (1) MX2012001200A (es)
MY (1) MY153103A (es)
PT (1) PT2459557E (es)
RU (1) RU2539574C2 (es)
SG (1) SG178149A1 (es)
TW (1) TWI469982B (es)
WO (1) WO2011012538A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR077428A1 (es) 2009-07-29 2011-08-24 Sanofi Aventis (aza) indolizinacarboxamidas ciclicas su preparacion y su uso como agentes farmaceuticos
WO2013149940A1 (en) 2012-04-02 2013-10-10 Basf Se Acrylamide compounds for combating invertebrate pests
ES2616026T3 (es) 2013-03-11 2017-06-09 Bristol-Myers Squibb Company Pirrolopiridazinas como inhibidores de canales de iones potasio
GEP20186938B (en) * 2014-06-17 2018-12-25 Chiesi Farma Spa Indolizine derivatives as phoshoinositide 3-kinases inhibitors
US10233186B2 (en) 2016-04-15 2019-03-19 Blueprint Medicines Corporation Inhibitors of activin receptor-like kinase
CN111566102B (zh) 2017-10-18 2023-09-08 缆图药品公司 作为激活素受体样激酶抑制剂的取代的吡咯并吡啶

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5278161A (en) * 1990-06-28 1994-01-11 Hoffmann-La Roche Inc. Amino acid derivatives useful as renin inhibitors
AU5432696A (en) 1995-04-07 1996-10-23 Pharmacopeia, Inc. Carbonyl-piperazinyl and piperidinil compounds which inhibit farnesyl protein transferase
EP1085021A4 (en) 1998-05-21 2003-01-08 Shionogi & Co DERIVATIVES OF PYRROLO 1,2-B] PYRIDAZINE, WITH INHIBITOR EFFECT ON SPLA 2?
MXPA04002323A (es) * 2001-09-13 2005-04-08 Synta Pharmaceuticals Corp 1-GLIOXILILAMIDA-INDOLIZINAS PARA EL TRATAMIENTO DEL CáNCER.
US20040116462A1 (en) 2002-12-12 2004-06-17 Mitsunori Ono Indolizine compounds
TW200300681A (en) * 2001-11-12 2003-06-16 Ono Pharmaceutical Co Carboxylic acid derivative compound and medicament containing same as active ingredient
US6900208B2 (en) * 2002-03-28 2005-05-31 Bristol Myers Squibb Company Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders
US7030112B2 (en) * 2003-03-25 2006-04-18 Bristol-Myers Squibb Company Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders
FR2857966A1 (fr) * 2003-07-24 2005-01-28 Aventis Pharma Sa Produits aryl-heteroaromatiques, compositions les contenant et utilisation
US20060270656A1 (en) 2003-09-09 2006-11-30 Eli Lilly And Company Substituted piperazines of azepines, oxazepines and thiazepines
TW200529860A (en) 2003-12-22 2005-09-16 Astrazeneca Ab Nicotinic acetylcholine receptor ligands
EP1977741A3 (en) * 2004-03-17 2009-10-14 Novartis AG Use of renin inhibitors in therapy
WO2005090304A1 (en) * 2004-03-19 2005-09-29 Speedel Experimenta Ag Organic compounds
CN1934083A (zh) * 2004-03-19 2007-03-21 斯皮德尔实验股份公司 作为肾素抑制剂用于治疗高血压的5－氨基－4－羟基－7－(1h－吲哚基甲基)－8－甲基壬酰胺衍生物
GB0512944D0 (en) * 2005-06-24 2005-08-03 Argenta Discovery Ltd Indolizine compounds
AU2006322707B2 (en) 2005-12-07 2011-09-15 Sumitomo Chemical Company, Limited Pyridazine compound and use thereof
KR20100121610A (ko) * 2008-01-31 2010-11-18 사노피-아벤티스 사이클릭 인돌―３―카복스아미드, 이들의 제조방법 및 약제로서의 이들의 용도
EP2240482B1 (en) * 2008-01-31 2013-07-17 Sanofi Cyclic azaindole-3-carboxamides, their preparation and their use as pharmaceuticals
AR077428A1 (es) 2009-07-29 2011-08-24 Sanofi Aventis (aza) indolizinacarboxamidas ciclicas su preparacion y su uso como agentes farmaceuticos

Also Published As

Publication number Publication date
RU2539574C2 (ru) 2015-01-20
CN102548993B (zh) 2014-12-10
AR077428A1 (es) 2011-08-24
AU2010277736B2 (en) 2015-04-02
EP2459557A1 (en) 2012-06-06
ES2431948T3 (es) 2013-11-28
BR112012008140A2 (pt) 2016-09-13
DK2459557T3 (da) 2013-12-16
JP2013500300A (ja) 2013-01-07
TW201116527A (en) 2011-05-16
JP5740399B2 (ja) 2015-06-24
RU2012107484A (ru) 2013-09-10
KR20120052247A (ko) 2012-05-23
IL217614A (en) 2015-06-30
WO2011012538A1 (en) 2011-02-03
CN102548993A (zh) 2012-07-04
EP2459557B1 (en) 2013-09-18
HK1171739A1 (en) 2013-04-05
SG178149A1 (en) 2012-03-29
CA2766535A1 (en) 2011-02-03
AU2010277736A1 (en) 2012-02-16
US8415336B2 (en) 2013-04-09
US20120232081A1 (en) 2012-09-13
TWI469982B (zh) 2015-01-21
MY153103A (en) 2014-12-31
PT2459557E (pt) 2013-11-04

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