MX2011013325A - 2-(lh-pirazol-4-ilamino)-pirimidina como inhibidores de cinasa. - Google Patents

2-(lh-pirazol-4-ilamino)-pirimidina como inhibidores de cinasa.

Info

Publication number
MX2011013325A
MX2011013325A MX2011013325A MX2011013325A MX2011013325A MX 2011013325 A MX2011013325 A MX 2011013325A MX 2011013325 A MX2011013325 A MX 2011013325A MX 2011013325 A MX2011013325 A MX 2011013325A MX 2011013325 A MX2011013325 A MX 2011013325A
Authority
MX
Mexico
Prior art keywords
sup
ylamino
pyrazol
pyrimidine
kinase inhibitors
Prior art date
Application number
MX2011013325A
Other languages
English (en)
Spanish (es)
Inventor
Michael R Michaelides
Michael L Curtin
Robin R Frey
Howard Robin Heyman
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX2011013325A publication Critical patent/MX2011013325A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MX2011013325A 2009-06-10 2010-06-08 2-(lh-pirazol-4-ilamino)-pirimidina como inhibidores de cinasa. MX2011013325A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18575809P 2009-06-10 2009-06-10
PCT/US2010/037801 WO2010144468A1 (en) 2009-06-10 2010-06-08 2- ( lh-pyrazol-4 -ylamino ) -pyrimidine as kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2011013325A true MX2011013325A (es) 2012-04-30

Family

ID=42333314

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011013325A MX2011013325A (es) 2009-06-10 2010-06-08 2-(lh-pirazol-4-ilamino)-pirimidina como inhibidores de cinasa.

Country Status (7)

Country Link
US (1) US8426408B2 (enExample)
EP (1) EP2440548A1 (enExample)
JP (1) JP2012529522A (enExample)
CN (1) CN102498110A (enExample)
CA (1) CA2764983A1 (enExample)
MX (1) MX2011013325A (enExample)
WO (1) WO2010144468A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011260323A1 (en) 2010-06-04 2012-11-15 F. Hoffmann-La Roche Ag Aminopyrimidine derivatives as LRRK2 modulators
DK2638031T3 (en) * 2010-11-10 2017-12-11 Genentech Inc PYRAZOLAMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS
EP4328223A3 (en) 2011-04-22 2024-11-06 Signal Pharmaceuticals, LLC Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith
MX363118B (es) * 2012-05-03 2019-03-11 Genentech Inc Derivados de pirazol aminopirimidina como moduladores de cinasa 2 de repeticion rica en leucina (lrrk2).
CA2907726A1 (en) * 2013-03-22 2014-09-25 Millennium Pharmaceuticals, Inc. Combination of catalytic mtorc1/2 inhibitors and selective inhibitors of aurora a kinase
WO2015025197A1 (en) 2013-08-22 2015-02-26 Jubilant Biosys Limited Substituted pyrimidine compounds, compositions and medicinal applications thereof
WO2015039613A1 (zh) * 2013-09-18 2015-03-26 北京韩美药品有限公司 抑制btk和/或jak3激酶活性的化合物
NZ715903A (en) 2014-01-30 2017-06-30 Signal Pharm Llc Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
CN104926794B (zh) * 2014-03-17 2017-12-05 广东东阳光药业有限公司 取代的杂芳基化合物及其组合物和用途
JP6517318B2 (ja) * 2014-03-28 2019-05-22 キャリター・サイエンシーズ・リミテッド・ライアビリティ・カンパニーＣａｌｉｔｏｒ Ｓｃｉｅｎｃｅｓ， Ｌｌｃ 置換されたヘテロアリール化合物および使用方法
US10059689B2 (en) 2014-10-14 2018-08-28 Calitor Sciences, Llc Substituted heteroaryl compounds and methods of use
JP6903577B2 (ja) 2014-12-16 2021-07-14 シグナル ファーマシューティカルズ，エルエルシー 皮膚におけるｃ−Ｊｕｎ Ｎ末端キナーゼの阻害の測定方法
CN107108524A (zh) 2014-12-16 2017-08-29 西格诺药品有限公司 2‑(叔丁基氨基)‑4‑((1r,3r,4r)‑3‑羟基‑4‑甲基环己基氨基)‑嘧啶‑5‑甲酰胺的配制物
US20180022710A1 (en) 2015-01-29 2018-01-25 Signal Pharmaceuticals, Llc Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
WO2017019487A1 (en) 2015-07-24 2017-02-02 Celgene Corporation Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein
EP3347097B1 (en) 2015-09-11 2021-02-24 Sunshine Lake Pharma Co., Ltd. Substituted aminopyrimidine derivatives as modulators of the kinases jak, flt3 and aurora
EP3349579A4 (en) * 2015-09-17 2019-03-20 Sunshine Lake Pharma Co., Ltd. SUBSTITUTED HETEROARYL COMPOUNDS AND METHOD FOR USE
CN106588885B (zh) * 2016-11-10 2019-03-19 浙江大学 2-取代芳环-嘧啶类衍生物及制备和应用
WO2019099311A1 (en) 2017-11-19 2019-05-23 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use
CN110862376A (zh) * 2019-10-24 2020-03-06 嘉兴特科罗生物科技有限公司 一种小分子化合物
TW202237119A (zh) 2020-12-10 2022-10-01 美商住友製藥腫瘤公司 Ａｌｋ﹘５抑制劑和彼之用途
CN118546132A (zh) * 2023-02-27 2024-08-27 科辉智药(深圳)新药研究中心有限公司 亚砜酰亚胺化合物及其作为lrrk2蛋白激酶抑制剂的应用
CN118440052B (zh) * 2024-07-05 2024-10-11 四川大学 一种化合物及其在制备tyk2激酶抑制剂中的用途

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374301A (en) * 1990-07-26 1994-12-20 Zeneca Limited Inks suitable for use in ink jet printing
GB9303912D0 (en) 1993-02-26 1993-04-14 Zeneca Ltd Inks
JP3880076B2 (ja) 1994-02-25 2007-02-14 キヤノン株式会社 インク、インクジェット記録方法、記録ユニット、インクカートリッジ及びインクジェット記録装置
JPH08113744A (ja) 1994-08-25 1996-05-07 Canon Inc インク、これを用いたインクジェット記録方法及びかかるインクを備えた記録機器
US6117996A (en) * 1995-09-20 2000-09-12 Novo Nordisk A/S Triazine based ligands and use thereof
GB9519197D0 (en) 1995-09-20 1995-11-22 Affinity Chromatography Ltd Novel affinity ligands and their use
JP3106966B2 (ja) * 1996-07-17 2000-11-06 富士ゼロックス株式会社 インクジェット記録用インク及びインクジェット記録方法
JPH1060338A (ja) * 1996-08-21 1998-03-03 Fuji Xerox Co Ltd インクジェット記録用インク及びインクジェット記録方法
US5980623A (en) * 1997-01-29 1999-11-09 Fuji Xerox Co., Ltd. Ink set for ink jet recording and ink jet recording method
JP3829419B2 (ja) 1997-07-09 2006-10-04 三菱化学株式会社 カラー画像の形成方法
EP1058549A4 (en) * 1998-12-23 2003-11-12 Bristol Myers Squibb Pharma Co FACTOR Xa OR THROMBIN INHIBITORS
US7141581B2 (en) * 1999-07-02 2006-11-28 Agouron Pharmaceuticals, Inc. Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
TWI262914B (en) * 1999-07-02 2006-10-01 Agouron Pharma Compounds and pharmaceutical compositions for inhibiting protein kinases
RU2395500C2 (ru) * 2003-08-15 2010-07-27 Новартис Аг 2,4-пиримидиндиамины, применяемые в лечении неопластических болезней, воспалительных и иммунных расстройств
WO2005118544A2 (en) 2004-05-18 2005-12-15 Rigel Pharmaceuticals, Inc. Cycloalkyl substituted pyrimidinediamine compounds and their uses
CA2585934C (en) * 2004-10-29 2013-09-10 Abbott Laboratories Novel pyrazolopyridine urea kinase inhibitors
GB2420559B (en) 2004-11-15 2008-08-06 Rigel Pharmaceuticals Inc Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses
RU2007122485A (ru) * 2004-11-17 2008-12-27 Мийкана Терапьютикс Ингибиторы киназы
US8211929B2 (en) * 2004-12-30 2012-07-03 Exelixis, Inc. Pyrimidine derivatives as kinase modulators and method of use
US20090234117A1 (en) 2005-05-27 2009-09-17 Toshihiko Kashiwagi Pyrazolopyrimidine Derivative
CA2608367C (en) 2005-06-08 2014-08-19 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
CA2611734A1 (en) 2005-06-10 2006-12-14 Prometic Biosciences Limited Triazines as protein binding ligands
US20070032514A1 (en) 2005-07-01 2007-02-08 Zahn Stephan K 2,4-diamino-pyrimidines as aurora inhibitors
WO2008147831A1 (en) * 2007-05-23 2008-12-04 Smithkline Beecham Corporation Anthranilamides

Also Published As

Publication number Publication date
US8426408B2 (en) 2013-04-23
CA2764983A1 (en) 2010-12-16
EP2440548A1 (en) 2012-04-18
CN102498110A (zh) 2012-06-13
WO2010144468A1 (en) 2010-12-16
JP2012529522A (ja) 2012-11-22
US20100317680A1 (en) 2010-12-16

Similar Documents

Publication Publication Date Title
MX2011013325A (es) 2-(lh-pirazol-4-ilamino)-pirimidina como inhibidores de cinasa.
MX2012013197A (es) Inhibidores de indazol de cinasa.
MX2012000711A (es) Inhibidores de pirrolopirazina de cinasas.
MX2011012631A (es) Inhibidores de actividad de cinasa tipo pirimidina.
MX2011012629A (es) Inhibidores de actividad de cinasa tipo pirimidina.
MX2012000709A (es) Inhibidores de pirrolopiridina de cinasas.
MX336726B (es) Compuestos heterociclicos y su uso como inhibidores de la glucogeno sintasa quinasa-3.
MX2013001361A (es) 4-(1h-indol-3-il) - pirimidina como inhibidores de alk.
MX2011012632A (es) Inhibidores de actividad de cinasa tipo pirimidina.
MX2013009873A (es) Inhibidores triciclicos de cinasas.
MX2010003366A (es) Derivados de piperidina y piperazina para el tratamiento de tumores.
WO2010002655A3 (en) Pyrimidine derivatives as kinase inhibitors
IL220155B (en) History of 2, 4-(phenyl-amine-)di-converted pyrimidines for use as kinase inhibitors
MY148634A (en) Pyridazinone derivatives
MX2010002336A (es) Derivados de 2-bifenil-amino-4-amino-pirimidina como inhibidores de cinasa.
MX2008005398A (es) Derivados de 4-(3-amino-pirazol)-pirimidina para uso como inhibidores de tirosina cinasa en el tratamiento de cancer.
MX2009013077A (es) Derivados dde benzoxazolona.
UA101057C2 (en) Pyrimidine derivatives as kinase inhibitors
NZ711376A (en) Heteroaryl compounds and uses thereof
MY149512A (en) Pyrazolylaminopyridine derivatives useful as kinase inhibitors
EA201101341A1 (ru) Соединения, ингибирующие киназы, и фармацевтическая композиция на их основе
EA201001687A1 (ru) Производные имидазопиридина в качестве ингибиторов активиноподобной рецепторной киназы ( alk-4 или alk-5 )
MY150778A (en) Fused heterocyclic compound
MX2009004140A (es) Compuestos heterociclicos y su uso como inhibidores de la glucogeno sintasa quinasa 3.
HK1223917A1 (zh) 作为dyrk激酶抑制剂的2，3-二氢苯并呋喃-5-基化合物

Legal Events

Date Code Title Description
GB Transfer or rights

Owner name: ABBVIE INC.

FG Grant or registration