MX2011013134A - Derivados de piridinil como inhibidores de la enzima nicotinamida fosforribosiltransferasa. - Google Patents

Derivados de piridinil como inhibidores de la enzima nicotinamida fosforribosiltransferasa.

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Publication number
MX2011013134A
MX2011013134A MX2011013134A MX2011013134A MX2011013134A MX 2011013134 A MX2011013134 A MX 2011013134A MX 2011013134 A MX2011013134 A MX 2011013134A MX 2011013134 A MX2011013134 A MX 2011013134A MX 2011013134 A MX2011013134 A MX 2011013134A
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Prior art keywords
sup
alkyl
inhibitors
nicotinamide phosphoribosyltransferase
heterocyclyl
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MX2011013134A
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English (en)
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Fredrik Bjoerkling
Mette Knak Christensen
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Publication of MX2011013134A publication Critical patent/MX2011013134A/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

La presente solicitud describe un compuesto de la fórmula (I) donde Q es piridilo opcionalmente sustituido; p es 0 a 6; Y es Fórmulas (i), (ii) y (iii); donde X es =0, =S y =N-CN, r es 1 a 12, R es -Z-A, Z es una unión simple, -S (=0)2-, >P=O, >C=O, C(=O)NH y C(=S)NH; y A es hidrógeno, alquilo C1 12, cicloalquilo C3 12, -[CH2CH2O]1-10 (alquilo C1-6), alquenilo C1-12, arilo, heterociclilo y heteroarilo; B es una unión simple, -NRN- , -S(=O)2- y -O-; donde RN se selecciona de hidr´geno, alquilo C1-12, cicloalquilo C3-12, -[CH2CH2O]1-10 (alquilo C1-6), alquelino C1-12, arilo, heterociclilo y heteroarilo; s es 0 a 6; y Cy es arilo, cicloalquilo, heterociclilo y heteroarilo. Los compuestos son útiles para su uso como un medicamento para el tratamiento de una enfermedad o afección provocada por un nivel elevado de nicotinamida fosforribosiltransferasa (NAMPRT).
MX2011013134A 2009-06-09 2010-06-09 Derivados de piridinil como inhibidores de la enzima nicotinamida fosforribosiltransferasa. MX2011013134A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18528109P 2009-06-09 2009-06-09
PCT/EP2010/058102 WO2010142735A1 (en) 2009-06-09 2010-06-09 Pyridinyl derivatives as inhibitors of enzyme nicotinamide phosphoribosyltransferase

Publications (1)

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MX2011013134A true MX2011013134A (es) 2012-03-16

Family

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MX2011013134A MX2011013134A (es) 2009-06-09 2010-06-09 Derivados de piridinil como inhibidores de la enzima nicotinamida fosforribosiltransferasa.

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US (1) US20120264755A1 (es)
EP (1) EP2440527A1 (es)
JP (1) JP5717730B2 (es)
CN (1) CN102639503B (es)
AU (1) AU2010257504B2 (es)
CA (1) CA2764694A1 (es)
MX (1) MX2011013134A (es)
RU (1) RU2012100261A (es)
WO (1) WO2010142735A1 (es)

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TW201216963A (en) 2010-09-03 2012-05-01 Forma Therapeutics Inc Novel compounds and compositions for the inhibition of NAMPT
JP6038792B2 (ja) 2010-09-03 2016-12-07 フォーマ ティーエム， エルエルシー． 癌などの疾患の治療のためのｎａｍｐｔ阻害剤としての４−｛［（ピリジン−３−イル−メチル）アミノカルボニル］アミノ｝ベンゼン−スルホン誘導体
JP5872027B2 (ja) 2011-05-09 2016-03-01 フォーマ ティーエム， エルエルシー． ニコチンアミドホスホリボシルトランスフェラーゼ（ｎａｍｐｔ）を阻害するためのピペリジン誘導体および組成物
MX366761B (es) 2012-11-13 2019-07-23 Array Biopharma Inc Compuestos bíciclicos de urea, tiourea, guanidina y cianoguanidina útiles para el tratamiento del dolor.
WO2014078895A1 (en) * 2012-11-21 2014-05-30 The University Of Sydney Omega-3 analogues
TW201625578A (zh) 2014-04-18 2016-07-16 千禧製藥公司 喹啉化合物及其用途
WO2016118565A1 (en) 2015-01-20 2016-07-28 Millennium Pharmaceuticals, Inc. Quinazoline and quinoline compounds and uses thereof
MA46660A (fr) * 2016-10-18 2019-08-28 Seattle Genetics Inc Administration ciblée d'inhibiteurs de la voie de récupération de nicotinamide adénine dinucléotide
CN110799217A (zh) * 2017-04-27 2020-02-14 西雅图基因公司 季铵化烟酰胺腺嘌呤二核苷酸补救途径抑制剂缀合物
CN109485646A (zh) * 2018-12-12 2019-03-19 中国药科大学 一种苯并噻唑醌类化合物及其制备方法和用途
JP7251337B2 (ja) 2019-06-14 2023-04-04 住友ゴム工業株式会社 シーラントタイヤの製造装置
CN115747298B (zh) * 2022-10-10 2023-10-27 浙江大学 昆虫烟酰胺酶抑制剂及鉴定方法及用于杀虫剂的用途

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US20120264755A1 (en) 2012-10-18
CN102639503B (zh) 2014-10-15
CA2764694A1 (en) 2010-12-16
AU2010257504A1 (en) 2012-02-02
RU2012100261A (ru) 2013-07-20
JP5717730B2 (ja) 2015-05-13
CN102639503A (zh) 2012-08-15
AU2010257504B2 (en) 2015-04-09
WO2010142735A1 (en) 2010-12-16
JP2012529467A (ja) 2012-11-22
EP2440527A1 (en) 2012-04-18

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