MX2009014055A - Metodo para producir alcoholes opticamente activos usando una dehidrogenasa azoarcus sp ebn1. - Google Patents

Metodo para producir alcoholes opticamente activos usando una dehidrogenasa azoarcus sp ebn1.

Info

Publication number
MX2009014055A
MX2009014055A MX2009014055A MX2009014055A MX2009014055A MX 2009014055 A MX2009014055 A MX 2009014055A MX 2009014055 A MX2009014055 A MX 2009014055A MX 2009014055 A MX2009014055 A MX 2009014055A MX 2009014055 A MX2009014055 A MX 2009014055A
Authority
MX
Mexico
Prior art keywords
sup
dehydrogenase
optically active
producing optically
ebn1
Prior art date
Application number
MX2009014055A
Other languages
English (en)
Inventor
Michael Breuer
Ralf Rabus
Johann Heider
Original Assignee
Basf Se
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Se filed Critical Basf Se
Publication of MX2009014055A publication Critical patent/MX2009014055A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un proceso para preparar alcoholes ?pticamente activos de la f?rmula la o Ib (ver f?rmulas) F?rmula la F?rmula Ib en la que R1,R2 son grupos alquilo, alquenilo, arilo, o alquilarilo, que a su vez pueden estar substituidos una o m?s veces por alquilo, hal?geno, SH, SR2, OH, OR2, NO2, CN, CO, COOR2, NR2R3 o NR2R3R4+X en donde R2, R3 y R4 son independientemente uno del otro H o un radical alquilo inferior o alcoxi inferior, y X es un contra ion, con la condici?n de que R1 no sea igual a R2, reduciendo la cetona correspondiente, en donde la reducci?n se lleva a cabo con una dehidrogenasa que tiene la secuencia de polip?ptido de SEC ID NO: 2 o NO: 4, o con una secuencia de polip?ptido en la que hasta 25% de los residuos de amino?cido se alteran mediante comparaci?n con SEC ID NO: 2 o NO: 4 mediante omisi?n, inserci?n, substituci?n o una combinaci?n de los mismos.
MX2009014055A 2007-06-20 2008-06-16 Metodo para producir alcoholes opticamente activos usando una dehidrogenasa azoarcus sp ebn1. MX2009014055A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07110670 2007-06-20
PCT/EP2008/057522 WO2008155302A1 (de) 2007-06-20 2008-06-16 Verfahren zur herstellung optisch aktiver alkohole unter verwendung einer azoarcus sp. ebn1 dehydrogenase

Publications (1)

Publication Number Publication Date
MX2009014055A true MX2009014055A (es) 2010-04-27

Family

ID=39846606

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009014055A MX2009014055A (es) 2007-06-20 2008-06-16 Metodo para producir alcoholes opticamente activos usando una dehidrogenasa azoarcus sp ebn1.

Country Status (9)

Country Link
US (1) US8338146B2 (es)
EP (1) EP2171074B1 (es)
JP (1) JP5503534B2 (es)
CN (1) CN101796192B (es)
AT (1) ATE535608T1 (es)
CA (1) CA2691799C (es)
ES (1) ES2377907T3 (es)
MX (1) MX2009014055A (es)
WO (1) WO2008155302A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8617854B2 (en) * 2008-09-17 2013-12-31 Basf Se Method for producing L-phenylephrine using an alcohol dehydrogenase of Aromatoleum aromaticum EBN1 (Azoarcus sp. EBN1)
AU2009348523B2 (en) 2009-06-22 2015-02-26 Sk Biopharmaceuticals Co., Ltd. Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester
WO2011009849A2 (en) * 2009-07-21 2011-01-27 Basf Se Method for preparing optically active hydroxy acid esters
US8404461B2 (en) 2009-10-15 2013-03-26 SK Biopharmaceutical Co. Ltd. Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester
EP2643467A1 (de) * 2010-11-24 2013-10-02 Basf Se Verfahren zur herstellung n-heterozyklischer optisch aktiver alkohole
US20120135476A1 (en) * 2010-11-24 2012-05-31 Basf Se Process for preparing n-heterocyclic optically active alcohols
US20130273619A1 (en) 2012-04-16 2013-10-17 Basf Se Process for the Preparation of (3E, 7E)-Homofarnesol
EP4092126A1 (en) 2021-03-29 2022-11-23 Instytut Katalizy I Fizykochemii Powierzchni Im.Jerzego Habera Polskiej Akademii Nauk A method of enzymatic reduction of the oxidized nicotinamide adenine dinucleotide and carboxylic acids

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4310702A (en) 1980-07-28 1982-01-12 Allied Corporation Selective monochlorination of ketones and aromatic alcohols
DE19511861A1 (de) 1995-03-31 1996-10-02 Basf Ag Verfahren zur Herstellung von a-Chloralkylarylketonen
DE19902229C2 (de) 1999-01-21 2000-11-02 Boehringer Ingelheim Pharma Verfahren zur Herstellung von L-Phenylephrinhydrochlorid
TW200305645A (en) * 2002-03-19 2003-11-01 Mitsubishi Chem Corp Novel carbonyl reductase, gene encoding the same and process for producing optically active alcohols using the same
DE102004022686A1 (de) 2004-05-05 2005-11-24 Basf Ag Verfahren zur Herstellung optisch aktiver Alkohole
DE102005010804A1 (de) * 2005-03-07 2006-09-14 Basf Ag Verfahren zur Herstellung optisch aktiver Alkohole
WO2007147897A1 (de) 2006-06-23 2007-12-27 Basf Se Verfahren zur herstellung von optisch aktiven 2-halogen-1-phenylethanol-derivaten und folgeprodukten davon
DE502007003046D1 (de) 2006-11-10 2010-04-15 Basf Se Verfahren zur herstellung von (4s)-3,4-dihydroxy-2,6,6-trimethyl-cyclohex-2-enon und derivaten davon unter verwendung der azoarcus phenylethanol dehydrogenase
US8617854B2 (en) * 2008-09-17 2013-12-31 Basf Se Method for producing L-phenylephrine using an alcohol dehydrogenase of Aromatoleum aromaticum EBN1 (Azoarcus sp. EBN1)
CN101503714A (zh) 2008-12-23 2009-08-12 广东工业大学 一种不对称合成(s)-2-氯-1-苯基乙醇衍生物的方法

Also Published As

Publication number Publication date
US8338146B2 (en) 2012-12-25
WO2008155302A1 (de) 2008-12-24
ES2377907T3 (es) 2012-04-03
CN101796192B (zh) 2014-01-15
ATE535608T1 (de) 2011-12-15
JP5503534B2 (ja) 2014-05-28
CN101796192A (zh) 2010-08-04
CA2691799A1 (en) 2008-12-24
JP2010530230A (ja) 2010-09-09
EP2171074B1 (de) 2011-11-30
EP2171074A1 (de) 2010-04-07
CA2691799C (en) 2016-06-07
US20100143991A1 (en) 2010-06-10

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