MX2009013678A - Metodo para preparar enlazadores hidrolizables a base de fmoc. - Google Patents

Metodo para preparar enlazadores hidrolizables a base de fmoc.

Info

Publication number
MX2009013678A
MX2009013678A MX2009013678A MX2009013678A MX2009013678A MX 2009013678 A MX2009013678 A MX 2009013678A MX 2009013678 A MX2009013678 A MX 2009013678A MX 2009013678 A MX2009013678 A MX 2009013678A MX 2009013678 A MX2009013678 A MX 2009013678A
Authority
MX
Mexico
Prior art keywords
fmoc
hydrolysable linkers
preparing fmoc
based hydrolysable
preparing
Prior art date
Application number
MX2009013678A
Other languages
English (en)
Inventor
Peter Turecek
Juergen Siekmann
Christian Noe
Gerhard Stoiber
Original Assignee
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int filed Critical Baxter Int
Publication of MX2009013678A publication Critical patent/MX2009013678A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Se proporciona un procedimiento novedoso para la producción de compuestos a base de Fmoc (9H-fluoren-9-ilmetoxicarbornilo), en donde un grupo protector para el grupo 9-hidroximetilo del sistema de anillo de fluoreno es utilizado Estos compuestos son útiles para la modificación de fármacos de proteína y péptido.
MX2009013678A 2007-06-26 2008-06-25 Metodo para preparar enlazadores hidrolizables a base de fmoc. MX2009013678A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93712507P 2007-06-26 2007-06-26
PCT/EP2008/005164 WO2009000523A1 (en) 2007-06-26 2008-06-25 Method for preparing fmoc-based hydrolysable linkers

Publications (1)

Publication Number Publication Date
MX2009013678A true MX2009013678A (es) 2010-03-08

Family

ID=39810152

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009013678A MX2009013678A (es) 2007-06-26 2008-06-25 Metodo para preparar enlazadores hidrolizables a base de fmoc.

Country Status (18)

Country Link
US (2) US7714147B2 (es)
EP (1) EP2170821B1 (es)
JP (1) JP5612467B2 (es)
KR (1) KR101667431B1 (es)
CN (1) CN101754951B (es)
AR (1) AR067173A1 (es)
AU (1) AU2008267361B2 (es)
BR (1) BRPI0813319A2 (es)
CA (1) CA2690553C (es)
DK (1) DK2170821T3 (es)
ES (1) ES2617737T3 (es)
HK (1) HK1143365A1 (es)
MX (1) MX2009013678A (es)
NZ (1) NZ582670A (es)
PL (1) PL2170821T3 (es)
PT (1) PT2170821T (es)
TW (1) TWI434845B (es)
WO (1) WO2009000523A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103933575B (zh) * 2013-01-23 2017-09-29 上海新理念生物医药科技有限公司 一种三齿型连接子及其应用
CN104030962B (zh) * 2014-06-19 2016-03-30 常州吉恩药业有限公司 一种生产芴甲氧羰酰琥珀酰亚胺并联产n,n′-二琥珀酰亚胺基碳酸酯的方法
CN106267225B (zh) 2015-05-29 2020-03-06 上海新理念生物医药科技有限公司 三马来酰亚胺型连接子及其应用
TW201833127A (zh) * 2017-02-27 2018-09-16 日商積水醫療股份有限公司 新穎四環式保護劑
CN113710692A (zh) * 2019-02-11 2021-11-26 Opko生物科学有限公司 长效glp-2类似物
CN116253667A (zh) * 2022-12-27 2023-06-13 煤炭科学研究总院有限公司 一种聚集诱导发光材料及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6259259A (ja) * 1985-09-09 1987-03-14 Suntory Ltd エキノカンジン合成中間体及びその製造法
JP2000505473A (ja) * 1996-02-27 2000-05-09 イーライ・リリー・アンド・カンパニー 医薬化合物
US6214966B1 (en) * 1996-09-26 2001-04-10 Shearwater Corporation Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
JP4162840B2 (ja) * 1999-08-20 2008-10-08 セケラ インコーポレイテッド 新規ａ−５００３５９誘導体
US7122189B2 (en) * 2002-08-13 2006-10-17 Enzon, Inc. Releasable polymeric conjugates based on aliphatic biodegradable linkers
GB0227555D0 (en) * 2002-11-26 2002-12-31 Syngenta Ltd Fungicides
CA2843439A1 (en) * 2003-04-08 2004-10-21 Yeda Research And Development Co. Ltd Reversible pegylated drugs
PT2279758E (pt) 2005-06-16 2015-05-27 Nektar Therapeutics Conjugados possuindo uma ligação degradável e reagentes poliméricos úteis na preparação de tais conjugados

Also Published As

Publication number Publication date
CN101754951A (zh) 2010-06-23
CA2690553C (en) 2016-11-08
JP5612467B2 (ja) 2014-10-22
CA2690553A1 (en) 2008-12-31
NZ582670A (en) 2012-05-25
BRPI0813319A2 (pt) 2014-12-23
JP2010531317A (ja) 2010-09-24
WO2009000523A1 (en) 2008-12-31
KR101667431B1 (ko) 2016-10-18
AU2008267361B2 (en) 2012-01-19
HK1143365A1 (en) 2010-12-31
US8871949B2 (en) 2014-10-28
AR067173A1 (es) 2009-09-30
EP2170821B1 (en) 2016-11-30
ES2617737T3 (es) 2017-06-19
US7714147B2 (en) 2010-05-11
PT2170821T (pt) 2017-03-07
TW200906819A (en) 2009-02-16
AU2008267361A1 (en) 2008-12-31
CN101754951B (zh) 2013-06-12
EP2170821A1 (en) 2010-04-07
US20090005574A1 (en) 2009-01-01
TWI434845B (zh) 2014-04-21
KR20100040301A (ko) 2010-04-19
US20100197940A1 (en) 2010-08-05
DK2170821T3 (en) 2017-03-06
PL2170821T3 (pl) 2017-07-31

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