MX2009010081A - Metodos y composiciones relacionadas con los ribointerruptores (riboswitches) que controlan el corte y empalme (splicing) alternativo. - Google Patents

Metodos y composiciones relacionadas con los ribointerruptores (riboswitches) que controlan el corte y empalme (splicing) alternativo.

Info

Publication number
MX2009010081A
MX2009010081A MX2009010081A MX2009010081A MX2009010081A MX 2009010081 A MX2009010081 A MX 2009010081A MX 2009010081 A MX2009010081 A MX 2009010081A MX 2009010081 A MX2009010081 A MX 2009010081A MX 2009010081 A MX2009010081 A MX 2009010081A
Authority
MX
Mexico
Prior art keywords
riboswitches
methods
alternative splicing
compositions related
control alternative
Prior art date
Application number
MX2009010081A
Other languages
English (en)
Inventor
Andreas Wachter
Ronald R Breaker
Narasimhan Sudarsan
Ming Tatt Cheah
Original Assignee
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yale filed Critical Univ Yale
Publication of MX2009010081A publication Critical patent/MX2009010081A/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3519—Fusion with another nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/33—Alteration of splicing

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describen los métodos y composiciones relacionadas con los riboswitches (ribointerruptores) que controlan el splicing (corte y empalme) alternativo.
MX2009010081A 2007-03-22 2008-03-22 Metodos y composiciones relacionadas con los ribointerruptores (riboswitches) que controlan el corte y empalme (splicing) alternativo. MX2009010081A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91943307P 2007-03-22 2007-03-22
PCT/US2008/058045 WO2008116220A2 (en) 2007-03-22 2008-03-22 Methods and compositions related to riboswitches that control alternative splicing

Publications (1)

Publication Number Publication Date
MX2009010081A true MX2009010081A (es) 2010-01-20

Family

ID=39766802

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009010081A MX2009010081A (es) 2007-03-22 2008-03-22 Metodos y composiciones relacionadas con los ribointerruptores (riboswitches) que controlan el corte y empalme (splicing) alternativo.

Country Status (9)

Country Link
US (1) US20100184810A1 (es)
EP (2) EP2471925A1 (es)
JP (1) JP2010521977A (es)
KR (1) KR20100015757A (es)
CN (1) CN101801185A (es)
AU (1) AU2008227458A1 (es)
CA (1) CA2681634A1 (es)
MX (1) MX2009010081A (es)
WO (1) WO2008116220A2 (es)

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EP2061799A4 (en) * 2006-09-11 2010-12-22 Univ Yale METHOD AND COMPOSITIONS FOR USE OF LYSIN RIBOSWITCHES
CN101688251A (zh) * 2007-05-29 2010-03-31 耶鲁大学 与控制可变剪接和rna加工的核糖开关有关的方法和组合物
AU2008266684A1 (en) * 2007-05-29 2008-12-24 Yale University Riboswitches and methods and compositions for use of and with riboswitches
US8926065B2 (en) 2009-08-14 2015-01-06 Advanced Liquid Logic, Inc. Droplet actuator devices and methods
EP2614150A1 (en) 2010-09-07 2013-07-17 Yeda Research and Development Co. Ltd. Thiamine pyrophosphate (tpp) riboswitch mutants producing vitamin b1 enriched food and feed crops
AU2016215454B2 (en) 2015-02-02 2022-05-19 Meiragtx Uk Ii Limited Regulation of gene expression by aptamer-mediated modulation of alternative splicing
GB201506507D0 (en) * 2015-04-16 2015-06-03 Univ Wageningen Riboswitch inducible gene expression
GB201506440D0 (en) * 2015-04-16 2015-06-03 Univ Wageningen Riboswitch-controlled screening and selection of desired biocatalysts
FI3494229T3 (fi) 2016-08-03 2024-01-29 Meiragtx Uk Ii Ltd Suuren suorituskyvyn solupohjainen seulonta aptameereille
WO2020160338A1 (en) * 2019-01-30 2020-08-06 Applied Stemcell, Inc. Controllable genome editing system
CN110184326B (zh) * 2019-05-13 2022-07-01 华侨大学 一种tpp核糖开关序列引物和肠道菌群分类方法
CN110438012B (zh) * 2019-08-05 2021-10-26 四川大学 一种产花青素的萨氏曲霉h-1及其应用
WO2024020578A2 (en) * 2022-07-22 2024-01-25 The Regents Of The University Of California Systems and methods for engineering cell-type specificity in mrna

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Also Published As

Publication number Publication date
EP2471925A1 (en) 2012-07-04
JP2010521977A (ja) 2010-07-01
WO2008116220A3 (en) 2008-11-20
WO2008116220A2 (en) 2008-09-25
CN101801185A (zh) 2010-08-11
EP2139319A2 (en) 2010-01-06
AU2008227458A8 (en) 2009-11-05
EP2139319A4 (en) 2011-02-23
US20100184810A1 (en) 2010-07-22
KR20100015757A (ko) 2010-02-12
AU2008227458A1 (en) 2008-09-25
CA2681634A1 (en) 2008-09-25

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