MX2009005447A - Derivados de 2,5-dihidro-3h-pirazolo[4,3-c]piridazin-3-ona sustituidos, su preparacion y uso de los mismos como ligandos de los receptores cb1 de canabinoides. - Google Patents
Derivados de 2,5-dihidro-3h-pirazolo[4,3-c]piridazin-3-ona sustituidos, su preparacion y uso de los mismos como ligandos de los receptores cb1 de canabinoides.Info
- Publication number
- MX2009005447A MX2009005447A MX2009005447A MX2009005447A MX2009005447A MX 2009005447 A MX2009005447 A MX 2009005447A MX 2009005447 A MX2009005447 A MX 2009005447A MX 2009005447 A MX2009005447 A MX 2009005447A MX 2009005447 A MX2009005447 A MX 2009005447A
- Authority
- MX
- Mexico
- Prior art keywords
- substituted
- preparation
- dfflydro
- pyridazin
- pyrazolo
- Prior art date
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- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
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- Obesity (AREA)
- Hematology (AREA)
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- Immunology (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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Abstract
La presente invención tiene por objeto compuestos que responden a la fórmula (I), en la cual: -R1 representa: un alquilo (C1-C12) no sustituido o sustituido; un radical carbocíclico no aromático en (C3-C12) no sustituido o sustituido; un fenilo no sustituido o sustituido; un bencilo no sustituido o sustituido; un fenetilo no sustituido o sustituido; un benzhidrilo; un benzhidrilmetilo; un radical heterocíclico aromático; - R2 representa un fenilo no sustituido o sustituido; - R3 representa un fenilo no sustituido o sustituido; - R4 representa un átomo de hidrógeno, un alquilo (C1-C4), un alcoxi (C1-C4), un hidroxi; -Alk representa un alquilo (C1-C4) no sustituido o sustituido. La invención también se refiere a un procedimiento para la preparación y aplicación de ellos en terapéutica, como ligandos de los receptores CB1 de los canabinoides localizados al nivel central y/o periférico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0610371A FR2909090B1 (fr) | 2006-11-23 | 2006-11-23 | Derives de 2,5-dihydro-3h-pyrazolo[4,3-c]pyridazin-3-one substitues,leur preparation et leur application en therapeutique. |
PCT/FR2007/001889 WO2008068424A2 (fr) | 2006-11-23 | 2007-11-19 | Derives de 2, 5-dihydro-3h-pyrazolo [4, 3-c] pyridazin-3-one substitues, leur preparation et leur utilisation comme ligands des recepteurs cb1 des cannabinoides |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009005447A true MX2009005447A (es) | 2009-08-07 |
Family
ID=38229329
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009005447A MX2009005447A (es) | 2006-11-23 | 2007-11-19 | Derivados de 2,5-dihidro-3h-pirazolo[4,3-c]piridazin-3-ona sustituidos, su preparacion y uso de los mismos como ligandos de los receptores cb1 de canabinoides. |
Country Status (20)
Country | Link |
---|---|
US (1) | US7915258B2 (es) |
EP (1) | EP2094706B1 (es) |
JP (1) | JP2010510297A (es) |
KR (1) | KR20090092774A (es) |
CN (1) | CN101541802A (es) |
AR (1) | AR063898A1 (es) |
AT (1) | ATE494290T1 (es) |
AU (1) | AU2007330652A1 (es) |
BR (1) | BRPI0719291A2 (es) |
CA (1) | CA2668196A1 (es) |
CL (1) | CL2007003346A1 (es) |
DE (1) | DE602007011815D1 (es) |
FR (1) | FR2909090B1 (es) |
IL (1) | IL198523A0 (es) |
MX (1) | MX2009005447A (es) |
PE (1) | PE20081496A1 (es) |
RU (1) | RU2009123841A (es) |
TW (1) | TW200836739A (es) |
UY (1) | UY30742A1 (es) |
WO (1) | WO2008068424A2 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200920372A (en) * | 2007-07-13 | 2009-05-16 | Genelabs Tech Inc | Anti-viral compounds, compositions, and methods of use |
US8293744B2 (en) | 2009-04-20 | 2012-10-23 | Merck Sharp & Dohme Corp. | Heterocyclic fused cinnoline M1 receptor positive allosteric modulators |
JP5800813B2 (ja) * | 2010-08-04 | 2015-10-28 | 武田薬品工業株式会社 | 複素環化合物 |
EA026393B1 (ru) | 2012-05-22 | 2017-04-28 | Дженентек, Инк. | N-замещенные бензамиды и их применение в лечении боли |
CA2923075C (en) | 2013-09-12 | 2022-07-26 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
DK3030549T3 (da) * | 2013-09-12 | 2019-05-13 | Janssen Biopharma Inc | Pyridazinonforbindelser og anvendelser deraf |
WO2015099107A1 (ja) | 2013-12-26 | 2015-07-02 | 塩野義製薬株式会社 | 含窒素6員環誘導体およびそれらを含有する医薬組成物 |
US10208045B2 (en) | 2015-03-11 | 2019-02-19 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
WO2016171249A1 (ja) | 2015-04-24 | 2016-10-27 | 塩野義製薬株式会社 | 6員複素環誘導体およびそれらを含有する医薬組成物 |
CA3039458A1 (en) | 2016-10-17 | 2018-04-26 | Shionogi & Co., Ltd. | Bicyclic nitrogen-containing heterocyclic derivatives and pharmaceutical composition comprising the same |
TW202321229A (zh) | 2021-08-18 | 2023-06-01 | 美商富曼西公司 | 殺真菌的取代的雜環化合物 |
CN118546389B (zh) * | 2024-07-29 | 2024-10-15 | 陕西理工大学 | 哒嗪氢键骨架荧光传感材料及其制备方法和应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4345934A (en) | 1977-03-10 | 1982-08-24 | Rohm And Haas Company | Method of producing hybrid cereal grain seeds by application of 1-aryl-1,4-dihydro-4-oxo(thio)-pyridazines |
FR2713225B1 (fr) | 1993-12-02 | 1996-03-01 | Sanofi Sa | N-pipéridino-3-pyrazolecarboxamide substitué. |
FR2692575B1 (fr) | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
US6005103A (en) | 1993-11-19 | 1999-12-21 | Warner-Lambert Company | Pyrone derivatives as protease inhibitors and antiviral agents |
US5808082A (en) * | 1996-05-08 | 1998-09-15 | Merck & Co., Inc. | Method of preparing phosphodiesterase IV inhibitors |
FR2789079B3 (fr) | 1999-02-01 | 2001-03-02 | Sanofi Synthelabo | Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant |
WO2004072029A2 (en) * | 2003-02-06 | 2004-08-26 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridazines useful as inhibitors of protein kinases |
US7232823B2 (en) * | 2003-06-09 | 2007-06-19 | Pfizer, Inc. | Cannabinoid receptor ligands and uses thereof |
WO2005061504A1 (en) * | 2003-12-16 | 2005-07-07 | Pfizer Products Inc. | Bicyclic pyridazinone cannabinoid receptor ligands and uses thereof |
AR068480A1 (es) * | 2007-09-20 | 2009-11-18 | Glaxo Group Ltd | Compuesto de 4-heteroaril-piperidinil-n-substituido su uso para la preparacion de un medicamento util para el tratamiento de una afeccion en el que seria beneficioso el agonismo de un receptor muscarinico m1 y composicion farmaceutica que lo comprende |
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2006
- 2006-11-23 FR FR0610371A patent/FR2909090B1/fr not_active Expired - Fee Related
-
2007
- 2007-11-19 AU AU2007330652A patent/AU2007330652A1/en not_active Abandoned
- 2007-11-19 BR BRPI0719291-6A patent/BRPI0719291A2/pt not_active Application Discontinuation
- 2007-11-19 WO PCT/FR2007/001889 patent/WO2008068424A2/fr active Application Filing
- 2007-11-19 CN CNA2007800431890A patent/CN101541802A/zh active Pending
- 2007-11-19 DE DE602007011815T patent/DE602007011815D1/de active Active
- 2007-11-19 MX MX2009005447A patent/MX2009005447A/es not_active Application Discontinuation
- 2007-11-19 CA CA002668196A patent/CA2668196A1/fr not_active Abandoned
- 2007-11-19 JP JP2009537670A patent/JP2010510297A/ja not_active Withdrawn
- 2007-11-19 AT AT07870295T patent/ATE494290T1/de not_active IP Right Cessation
- 2007-11-19 RU RU2009123841/04A patent/RU2009123841A/ru not_active Application Discontinuation
- 2007-11-19 KR KR1020097010476A patent/KR20090092774A/ko not_active Application Discontinuation
- 2007-11-19 EP EP07870295A patent/EP2094706B1/fr active Active
- 2007-11-20 PE PE2007001610A patent/PE20081496A1/es not_active Application Discontinuation
- 2007-11-20 TW TW096143951A patent/TW200836739A/zh unknown
- 2007-11-22 AR ARP070105186A patent/AR063898A1/es unknown
- 2007-11-22 CL CL200703346A patent/CL2007003346A1/es unknown
- 2007-11-23 UY UY30742A patent/UY30742A1/es not_active Application Discontinuation
-
2009
- 2009-05-03 IL IL198523A patent/IL198523A0/en unknown
- 2009-05-19 US US12/468,294 patent/US7915258B2/en not_active Expired - Fee Related
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ATE494290T1 (de) | 2011-01-15 |
AU2007330652A1 (en) | 2008-06-12 |
WO2008068424A3 (fr) | 2008-07-24 |
US7915258B2 (en) | 2011-03-29 |
KR20090092774A (ko) | 2009-09-01 |
WO2008068424A8 (fr) | 2009-07-02 |
RU2009123841A (ru) | 2010-12-27 |
PE20081496A1 (es) | 2009-01-04 |
FR2909090B1 (fr) | 2009-01-09 |
IL198523A0 (en) | 2010-02-17 |
BRPI0719291A2 (pt) | 2014-02-25 |
TW200836739A (en) | 2008-09-16 |
EP2094706B1 (fr) | 2011-01-05 |
CA2668196A1 (fr) | 2008-06-12 |
US20090281107A1 (en) | 2009-11-12 |
FR2909090A1 (fr) | 2008-05-30 |
CN101541802A (zh) | 2009-09-23 |
CL2007003346A1 (es) | 2008-07-04 |
AR063898A1 (es) | 2009-02-25 |
EP2094706A2 (fr) | 2009-09-02 |
JP2010510297A (ja) | 2010-04-02 |
DE602007011815D1 (de) | 2011-02-17 |
UY30742A1 (es) | 2008-07-03 |
WO2008068424A2 (fr) | 2008-06-12 |
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