MX2009005398A - Metodos para el tratamiento de enfermedades inflamatorias cronicas usando antagonista de gm-csf. - Google Patents
Metodos para el tratamiento de enfermedades inflamatorias cronicas usando antagonista de gm-csf.Info
- Publication number
- MX2009005398A MX2009005398A MX2009005398A MX2009005398A MX2009005398A MX 2009005398 A MX2009005398 A MX 2009005398A MX 2009005398 A MX2009005398 A MX 2009005398A MX 2009005398 A MX2009005398 A MX 2009005398A MX 2009005398 A MX2009005398 A MX 2009005398A
- Authority
- MX
- Mexico
- Prior art keywords
- chronic inflammatory
- methods
- inflammatory diseases
- treating chronic
- csf antagonist
- Prior art date
Links
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 title abstract 4
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 title abstract 4
- 239000005557 antagonist Substances 0.000 title abstract 4
- 208000037976 chronic inflammation Diseases 0.000 title abstract 2
- 208000037893 chronic inflammatory disorder Diseases 0.000 title abstract 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 abstract 1
- 230000003432 anti-folate effect Effects 0.000 abstract 1
- 229940127074 antifolate Drugs 0.000 abstract 1
- 239000004052 folic acid antagonist Substances 0.000 abstract 1
- 229960000485 methotrexate Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Genetics & Genomics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86078006P | 2006-11-21 | 2006-11-21 | |
| US90274207P | 2007-02-21 | 2007-02-21 | |
| PCT/US2007/085402 WO2008064321A2 (en) | 2006-11-21 | 2007-11-21 | Methods of treating chronic inflammatory diseases using a gm-csf antagonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009005398A true MX2009005398A (es) | 2009-08-20 |
Family
ID=39386167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009005398A MX2009005398A (es) | 2006-11-21 | 2007-11-21 | Metodos para el tratamiento de enfermedades inflamatorias cronicas usando antagonista de gm-csf. |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20080206241A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2101780B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5410293B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101517251B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN101605547A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2007323541B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0719109A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2670288C (cg-RX-API-DMAC7.html) |
| EA (1) | EA200900709A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2432173T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL198829A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2009005398A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ598345A (cg-RX-API-DMAC7.html) |
| SG (1) | SG176503A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008064321A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2101780B1 (en) | 2006-11-21 | 2013-10-09 | Kalobios Pharmaceuticals, Inc. | Methods of treating chronic inflammatory diseases using a gm-csf antagonist |
| US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
| US8680019B2 (en) * | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
| JP5781762B2 (ja) * | 2007-08-10 | 2015-09-24 | プロテリックス、インク | ユニバーサルiii型フィブロネクチン結合ドメインのライブラリ |
| TW200918553A (en) | 2007-09-18 | 2009-05-01 | Amgen Inc | Human GM-CSF antigen binding proteins |
| NZ586027A (en) | 2007-11-13 | 2012-01-12 | Evec Inc | Monoclonal antibodies that bind to human granulocyte macrophage colony stimulating factor and medical compositions comprising same |
| WO2009091905A1 (en) * | 2008-01-15 | 2009-07-23 | Kalobios Pharmaceuticals, Inc. | Methods of treating bone-loss disorders using a gm-csf antagonist |
| US8075885B2 (en) * | 2008-04-07 | 2011-12-13 | Kalobios Pharmaceuticals, Inc. | Methods of treating heart failure using an anti-GM-CSF antibody |
| BRPI0911902A2 (pt) | 2008-04-28 | 2015-10-13 | Kalobios Pharmaceuticals Inc | anticorpos para fator estimulador de colônia granulocítica-macrofágica |
| AU2015224416B2 (en) * | 2008-12-22 | 2017-04-20 | The University Of Melbourne | Osteoarthritis treatment |
| KR101761324B1 (ko) | 2008-12-22 | 2017-07-25 | 더 유니버시티 오브 멜버른 | 통증 치료 |
| CN106397591A (zh) | 2008-12-22 | 2017-02-15 | 墨尔本大学 | 骨关节炎治疗 |
| WO2010093814A1 (en) * | 2009-02-11 | 2010-08-19 | Kalobios Pharmaceuticals, Inc. | Methods of treating dementia using a gm-csf antagonist |
| CA2759506A1 (en) * | 2009-04-23 | 2010-10-28 | Theraclone Sciences, Inc. | Granulocyte-macrophage colony-stimulating factor (gm-csf) neutralizing antibodies |
| CN102439039A (zh) * | 2009-05-05 | 2012-05-02 | 莫佛塞斯公司 | 多发性硬化的治疗 |
| AU2012280267B2 (en) * | 2011-07-06 | 2016-04-21 | Morphosys Ag | Therapeutic combinations of anti-cd20 and anti-gm-csf antibodies and uses thereof |
| EP2897977A1 (en) * | 2012-09-20 | 2015-07-29 | MorphoSys AG | Treatment for rheumatoid arthritis |
| KR20210021153A (ko) * | 2012-09-20 | 2021-02-24 | 모르포시스 아게 | 류마티스 관절염에 대한 치료 |
| AR093297A1 (es) * | 2012-10-31 | 2015-05-27 | Amgen Res Munich Gmbh | Formulacion liquida que comprende un compuesto neutralizante de gm-csf |
| KR20240090993A (ko) * | 2013-08-30 | 2024-06-21 | 다케다 야쿠힌 고교 가부시키가이샤 | 류마티스성 관절염의 치료에서 또는 진통제로서 사용하기 위한 gm-csf 중화 항체 |
| JP6360696B2 (ja) * | 2014-03-18 | 2018-07-18 | 日本光電工業株式会社 | 血液検査装置および血液検査方法 |
| US20170260276A1 (en) * | 2014-05-19 | 2017-09-14 | Medimmune Limited | Treatment for rheumatoid arthritis |
| WO2018031967A1 (en) * | 2016-08-12 | 2018-02-15 | L.E.A.F. Holdings Group Llc | Polyglutamated antifolates and uses thereof |
| CN109219616B (zh) | 2016-09-19 | 2022-10-21 | 天境生物科技(杭州)有限公司 | Gm-csf抗体及其用途 |
| US11130805B2 (en) | 2017-10-02 | 2021-09-28 | Humanigen, Inc. | Methods of treating CART-T cell therapy-induced neuroinflammation using a GM-CSF antagonist |
| US10927168B2 (en) | 2017-10-02 | 2021-02-23 | Humanicen, Inc. | Method of reducing tumor relapse rate in immunotherapy by administration of lenzilumab |
| EP3691663A4 (en) | 2017-10-02 | 2021-08-18 | Humanigen, Inc. | METHODS OF TREATMENT OF TOXICITY ASSOCIATED WITH IMMUNOTHERAPIES USING A GM-CSF ANTAGONIST |
| US10899831B2 (en) | 2017-10-02 | 2021-01-26 | Humanigen, Inc. | Method of reducing the level of non-GM-CSF cytokines/chemokines in immunotherapy-related toxicity |
| BR112021008263A2 (pt) * | 2018-10-31 | 2021-08-10 | Humanigen, Inc. | materiais e métodos para tratamento de câncer |
| BR112022017891A2 (pt) * | 2020-03-08 | 2022-11-01 | Humanigen Inc | Métodos para tratar a infecção por coronavírus e lesão pulmonar induzida por inflamação resultante |
| EP4255483A4 (en) * | 2020-12-04 | 2025-07-09 | CSL Innovation Pty Ltd | METHODS OF TREATMENT OF INFLAMMATORY SKIN CONDITIONS |
| WO2022192093A1 (en) * | 2021-03-08 | 2022-09-15 | Humanigen, Inc. | Methods for treating coronavirus infection and resulting inflammation-induced lung injury |
| WO2023138499A1 (zh) * | 2022-01-20 | 2023-07-27 | 舒泰神(北京)生物制药股份有限公司 | 一种特异性地识别粒细胞-巨噬细胞集落刺激因子受体的抗体制剂及其应用 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
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-
2007
- 2007-11-21 EP EP07868831.4A patent/EP2101780B1/en not_active Revoked
- 2007-11-21 AU AU2007323541A patent/AU2007323541B2/en not_active Ceased
- 2007-11-21 KR KR1020097012906A patent/KR101517251B1/ko not_active Expired - Fee Related
- 2007-11-21 SG SG2011085834A patent/SG176503A1/en unknown
- 2007-11-21 EP EP11182971A patent/EP2402013A1/en not_active Withdrawn
- 2007-11-21 BR BRPI0719109-0A2A patent/BRPI0719109A2/pt not_active IP Right Cessation
- 2007-11-21 NZ NZ598345A patent/NZ598345A/xx not_active IP Right Cessation
- 2007-11-21 CN CNA2007800495322A patent/CN101605547A/zh active Pending
- 2007-11-21 WO PCT/US2007/085402 patent/WO2008064321A2/en not_active Ceased
- 2007-11-21 CN CN201510674256.5A patent/CN105435223A/zh active Pending
- 2007-11-21 CA CA2670288A patent/CA2670288C/en not_active Expired - Fee Related
- 2007-11-21 EA EA200900709A patent/EA200900709A1/ru unknown
- 2007-11-21 JP JP2009538506A patent/JP5410293B2/ja not_active Expired - Fee Related
- 2007-11-21 ES ES07868831T patent/ES2432173T3/es active Active
- 2007-11-21 US US11/944,162 patent/US20080206241A1/en not_active Abandoned
- 2007-11-21 MX MX2009005398A patent/MX2009005398A/es active IP Right Grant
-
2009
- 2009-05-19 IL IL198829A patent/IL198829A0/en unknown
-
2015
- 2015-05-14 US US14/712,627 patent/US20150246121A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20080206241A1 (en) | 2008-08-28 |
| EP2101780A2 (en) | 2009-09-23 |
| AU2007323541B2 (en) | 2012-01-19 |
| EA200900709A1 (ru) | 2009-12-30 |
| IL198829A0 (en) | 2010-02-17 |
| WO2008064321A3 (en) | 2008-10-02 |
| JP2010510323A (ja) | 2010-04-02 |
| US20150246121A1 (en) | 2015-09-03 |
| KR20090110827A (ko) | 2009-10-22 |
| NZ598345A (en) | 2013-09-27 |
| EP2402013A1 (en) | 2012-01-04 |
| AU2007323541A1 (en) | 2008-05-29 |
| CA2670288C (en) | 2015-10-27 |
| KR101517251B1 (ko) | 2015-05-07 |
| CN105435223A (zh) | 2016-03-30 |
| ES2432173T3 (es) | 2013-12-02 |
| EP2101780B1 (en) | 2013-10-09 |
| CN101605547A (zh) | 2009-12-16 |
| BRPI0719109A2 (pt) | 2013-12-10 |
| WO2008064321A2 (en) | 2008-05-29 |
| JP5410293B2 (ja) | 2014-02-05 |
| SG176503A1 (en) | 2011-12-29 |
| CA2670288A1 (en) | 2008-05-29 |
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