MX2009005023A - Nuevas amidas que actuan sobre los receptores de adenosina. - Google Patents

Nuevas amidas que actuan sobre los receptores de adenosina.

Info

Publication number
MX2009005023A
MX2009005023A MX2009005023A MX2009005023A MX2009005023A MX 2009005023 A MX2009005023 A MX 2009005023A MX 2009005023 A MX2009005023 A MX 2009005023A MX 2009005023 A MX2009005023 A MX 2009005023A MX 2009005023 A MX2009005023 A MX 2009005023A
Authority
MX
Mexico
Prior art keywords
amino
adenosine receptors
carbon atoms
compounds
groups selected
Prior art date
Application number
MX2009005023A
Other languages
English (en)
Inventor
Torbjoern Lundstedt
Arne Boman
Elisabeth Seifert
Per Lek
Original Assignee
Acure Pharma Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acure Pharma Ab filed Critical Acure Pharma Ab
Publication of MX2009005023A publication Critical patent/MX2009005023A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a compuestos de fórmula (I) en la cual R3 a R8 son independientemente seleccionados a partir de hidrógeno, halógeno, trihaloalquilo, alquilo que tiene 1, 2, 3, 4 ó 5 átomos de carbono, grupos donadores de electrón seleccionados de alcoxi que tiene 1, 2, 3, 4 ó 5 átomos de carbono, trihaloalcoxi, hidroxi o amino, grupos aceptores de electrón seleccionados de ciano, sulfónico, nitro o amida; R1 es un grupo fenilo, bencilo, o ciclohexilo opcionalmente sustituido; R2 se selecciona de grupos amino, amino sustituido o guanidino, Z es una cadena de hidrocarburo C1-5 saturada o insaturada y sales de los mismos. También se describen un proceso para su preparación y composiciones que los contienen. Los compuestos son ya sea agonistas o antagonistas de un receptor de adenosina específico o un número de receptores de adenosina y que tienen utilidad para el tratamiento de inflamación, condiciones artríticas, artritis reumatoide, osteoartritis, trastornos mentales o para inducir regeneración de nerviosa central.
MX2009005023A 2006-11-15 2007-11-09 Nuevas amidas que actuan sobre los receptores de adenosina. MX2009005023A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0622826.6A GB0622826D0 (en) 2006-11-15 2006-11-15 Novel amides acting on the adenosine receptors
PCT/EP2007/009721 WO2008058679A2 (en) 2006-11-15 2007-11-09 Novel amides acting on the adenosine receptors

Publications (1)

Publication Number Publication Date
MX2009005023A true MX2009005023A (es) 2009-05-20

Family

ID=37605369

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005023A MX2009005023A (es) 2006-11-15 2007-11-09 Nuevas amidas que actuan sobre los receptores de adenosina.

Country Status (12)

Country Link
US (1) US8227502B2 (es)
EP (1) EP2099815B1 (es)
JP (1) JP5536456B2 (es)
KR (1) KR20090091166A (es)
AU (1) AU2007321460B2 (es)
CA (1) CA2669162C (es)
ES (1) ES2389271T3 (es)
GB (1) GB0622826D0 (es)
IL (1) IL198618A (es)
MX (1) MX2009005023A (es)
NZ (1) NZ576781A (es)
WO (1) WO2008058679A2 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0019357D0 (en) * 2000-08-07 2000-09-27 Melacure Therapeutics Ab Novel phenyl guanidines

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5007067A (en) 1989-09-29 1991-04-09 At&T Bell Laboratories Diversity coding for transparent self-healing communications networks
DE10110747A1 (de) * 2001-03-07 2002-09-12 Bayer Ag Substituierte 2,6-Diamino-3,5-dicyano-4-aryl-pyridine und ihre Verwendung
RU2334742C2 (ru) * 2003-01-13 2008-09-27 Ф.Хоффманн-Ля Рош Аг Производные бензоксазола и фармацевтическая композиция, обладающая свойствами лигандов рецептора аденозина
SI1633355T1 (sl) * 2003-05-30 2008-08-31 Hoffmann La Roche Derivati benzotiazola in njihova uporaba pri zdravljenju bolezni, povezanih z receptorjem a2a adenozina
US7217702B2 (en) * 2004-04-02 2007-05-15 Adenosine Therapeutics, Llc Selective antagonists of A2A adenosine receptors
EP1778712B1 (en) * 2004-08-02 2013-01-30 University Of Virginia Patent Foundation 2-propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
US7576069B2 (en) 2004-08-02 2009-08-18 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having A2A agonist activity
WO2006091896A2 (en) 2005-02-25 2006-08-31 Adenosine Therapeutics, Llc Pyridyl substituted xanthines
US7579348B2 (en) 2005-02-25 2009-08-25 Pgxhealth, Llc Derivatives of 8-substituted xanthines
US7598379B2 (en) * 2005-02-25 2009-10-06 Pgx Health, Llc Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines
WO2006091898A2 (en) 2005-02-25 2006-08-31 Adenosine Therapeutics, Llc Pyrazolyl substituted xanthines

Also Published As

Publication number Publication date
CA2669162C (en) 2015-02-10
JP5536456B2 (ja) 2014-07-02
JP2010509383A (ja) 2010-03-25
EP2099815B1 (en) 2012-06-20
IL198618A0 (en) 2010-02-17
WO2008058679A2 (en) 2008-05-22
US20100098629A1 (en) 2010-04-22
EP2099815A2 (en) 2009-09-16
GB0622826D0 (en) 2006-12-27
ES2389271T3 (es) 2012-10-24
IL198618A (en) 2013-07-31
AU2007321460A1 (en) 2008-05-22
CA2669162A1 (en) 2008-05-22
AU2007321460B2 (en) 2012-05-03
US8227502B2 (en) 2012-07-24
NZ576781A (en) 2012-02-24
WO2008058679A3 (en) 2008-07-10
KR20090091166A (ko) 2009-08-26

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