MX2009002236A - Formulaciones de dosis oral de liberacion controlada que comrpenden un nucleo y una o mas capas de barrera. - Google Patents
Formulaciones de dosis oral de liberacion controlada que comrpenden un nucleo y una o mas capas de barrera.Info
- Publication number
- MX2009002236A MX2009002236A MX2009002236A MX2009002236A MX2009002236A MX 2009002236 A MX2009002236 A MX 2009002236A MX 2009002236 A MX2009002236 A MX 2009002236A MX 2009002236 A MX2009002236 A MX 2009002236A MX 2009002236 A MX2009002236 A MX 2009002236A
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- MX
- Mexico
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- A61P9/12—Antihypertensives
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Urology & Nephrology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| Application Number | Priority Date | Filing Date | Title |
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| US82404306P | 2006-08-30 | 2006-08-30 | |
| US82405406P | 2006-08-30 | 2006-08-30 | |
| PCT/EP2007/007549 WO2008025535A1 (en) | 2006-08-30 | 2007-08-29 | Controlled release oral dosage formulations comprising a core and one or more barrier layers |
Publications (1)
| Publication Number | Publication Date |
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| MX2009002236A true MX2009002236A (es) | 2009-03-13 |
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| MX2009002236A MX2009002236A (es) | 2006-08-30 | 2007-08-29 | Formulaciones de dosis oral de liberacion controlada que comrpenden un nucleo y una o mas capas de barrera. |
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| MX2009002235A MX2009002235A (es) | 2006-08-30 | 2007-08-29 | Formulaciones de dosis oral, solidas, de liberacion controlada que comprenden nisoldipina. |
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| JP (3) | JP2010501607A (enExample) |
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| ES (1) | ES2547226T5 (enExample) |
| MX (2) | MX2009002235A (enExample) |
| WO (2) | WO2008025535A1 (enExample) |
| ZA (1) | ZA200901688B (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
| DK2049123T4 (en) | 2006-08-03 | 2016-11-28 | Horizon Pharma Ag | LATE discharge-glucocorticoid treatment of rheumatoid ILLNESS |
| MX2009002235A (es) | 2006-08-30 | 2009-03-13 | Jagotec Ag | Formulaciones de dosis oral, solidas, de liberacion controlada que comprenden nisoldipina. |
| WO2009012791A1 (en) * | 2007-07-23 | 2009-01-29 | Pharmathen S.A. | Pharmaceutical composition containing dihydropyridine calcium channel antagonist and method for the preparation thereof |
| BRPI0815387B8 (pt) * | 2007-08-13 | 2021-05-25 | Abuse Deterrent Pharmaceutical Llc | composição farmacêutica, método para fazer uma composição farmacêutica e uso da composição farmacêutica |
| CN102026627B (zh) | 2008-03-11 | 2016-10-26 | 武田药品工业株式会社 | 口腔崩解固体制剂 |
| US20110207718A1 (en) | 2008-08-06 | 2011-08-25 | Gosforth Centre (Holdings) Pty Ltd. | Compositions and methods for treating psychiatric disorders |
| EP2331094A4 (en) * | 2008-08-29 | 2011-10-26 | Uab Research Foundation | NOVEL AGENT AGAINST ARTHHYTHMIA |
| KR20100069170A (ko) * | 2008-12-16 | 2010-06-24 | 삼일제약주식회사 | 라시디핀 함유 과립 및 이를 포함하는 약학 조성물 |
| CA2749646A1 (en) * | 2009-01-26 | 2010-07-29 | Nitec Pharma Ag | Delayed-release glucocorticoid treatment of asthma |
| US20100247646A1 (en) * | 2009-03-26 | 2010-09-30 | Ranbaxy Laboratories Limited | Extended release tablets of nisoldipine |
| US20100260842A1 (en) * | 2009-04-06 | 2010-10-14 | Rashmi Nair | Pseudoephedrine pharmaceutical formulations |
| US20100285125A1 (en) * | 2009-05-07 | 2010-11-11 | Padma Venkitachalam Devarajan | Delivery system for poorly soluble drugs |
| US12478503B2 (en) | 2009-05-18 | 2025-11-25 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
| CA2979355C (en) | 2009-05-18 | 2023-02-21 | Dose Medical Corporation | Drug eluting ocular implant |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| CA2767576C (en) | 2009-07-08 | 2020-03-10 | Charleston Laboratories Inc. | Pharmaceutical compositions comprising an antiemetic and an opioid analgesic |
| BR112012013487A2 (pt) | 2009-12-02 | 2017-10-03 | Adamas Pharmaceuticals Inc | Composições de amantadina e métodos de uso |
| US20110217373A1 (en) * | 2010-01-29 | 2011-09-08 | Kumaravel Vivek | Extended release pharmaceutical compositions of guanfacine hydrochloride |
| CA2788732C (en) * | 2010-03-31 | 2017-08-15 | Yumio Kudou | Easily dosable solid preparation |
| CN103327979A (zh) * | 2010-11-22 | 2013-09-25 | 葛兰素史密斯克莱知识产权（第2号）有限公司 | 治疗癌症的方法 |
| EP2654715B1 (en) | 2010-11-24 | 2017-01-25 | Dose Medical Corporation | Drug eluting ocular implant |
| US8808740B2 (en) | 2010-12-22 | 2014-08-19 | Purdue Pharma L.P. | Encased tamper resistant controlled release dosage forms |
| PH12013501345A1 (en) | 2010-12-23 | 2022-10-24 | Purdue Pharma Lp | Tamper resistant solid oral dosage forms |
| US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
| GB201111712D0 (en) | 2011-07-08 | 2011-08-24 | Gosforth Ct Holdings Pty Ltd | Pharmaceutical compositions |
| CN107049979B (zh) | 2011-09-30 | 2020-08-14 | 持田制药株式会社 | 易服用性固体制剂 |
| CN113842362A (zh) | 2012-11-14 | 2021-12-28 | 格雷斯公司 | 含有生物活性材料与无序无机氧化物的组合物 |
| PE20151301A1 (es) | 2013-02-05 | 2015-09-16 | Purdue Pharma Lp | Formulaciones farmaceuticas resistentes a la manipulacion indebida |
| US10751287B2 (en) | 2013-03-15 | 2020-08-25 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
| EP2976082A4 (en) | 2013-03-15 | 2016-05-11 | Inspirion Delivery Technologies Llc | MISS-INFANT COMPOSITIONS AND METHODS OF USE |
| US10154971B2 (en) | 2013-06-17 | 2018-12-18 | Adamas Pharma, Llc | Methods of administering amantadine |
| KR102170642B1 (ko) * | 2013-11-14 | 2020-10-27 | 코웨이 주식회사 | 기능성 제재 공급기 및 이를 포함하는 연수기 |
| EP3677229A1 (en) | 2014-05-29 | 2020-07-08 | Glaukos Corporation | Implants with controlled drug delivery features |
| US10729685B2 (en) | 2014-09-15 | 2020-08-04 | Ohemo Life Sciences Inc. | Orally administrable compositions and methods of deterring abuse by intranasal administration |
| WO2017040853A1 (en) | 2015-09-02 | 2017-03-09 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
| WO2017053885A1 (en) | 2015-09-25 | 2017-03-30 | Glaukos Corporation | Punctal implants with controlled drug delivery features and methods of using same |
| WO2017136745A1 (en) * | 2016-02-05 | 2017-08-10 | Entrega Inc. | Oral dosage form with drying agent for delivery of active agent |
| CA3055170A1 (en) | 2016-03-04 | 2017-09-08 | Charleston Laboratories, Inc. | Pharmaceutical compositions |
| CN115120405A (zh) | 2016-04-20 | 2022-09-30 | 多斯医学公司 | 生物可吸收眼部药物的递送装置 |
| CN109069475B (zh) | 2016-04-22 | 2022-01-28 | 受体控股公司 | 快速作用植物类医药化合物和营养补剂 |
| EA201892396A1 (ru) | 2016-12-02 | 2019-04-30 | Ресептор Лайф Сайенсиз, Инк. | Быстродействующие растительные лекарственные соединения и биологически активные добавки |
| WO2018230713A1 (ja) * | 2017-06-16 | 2018-12-20 | 学校法人同志社 | カスパーゼ阻害活性を有する化合物、これらの化合物を含む、角膜内皮の症状、障害または疾患を治療または予防するための医薬およびその応用 |
| WO2018230711A1 (ja) | 2017-06-16 | 2018-12-20 | 学校法人同志社 | ｍＴＯＲインヒビターを含む、眼の症状、障害または疾患を治療または予防するための医薬およびその応用 |
| MX2020002078A (es) | 2017-08-24 | 2020-09-21 | Adamas Pharma Llc | Composiciones de amantadina, preparaciones de estas y métodos de uso. |
| SG11202003153TA (en) * | 2017-10-25 | 2020-05-28 | Chiesi Farm Spa | Delayed release deferiprone tablets and methods of using the same |
| UY38480A (es) | 2018-11-19 | 2020-06-30 | Receptor Holdings Inc | Aminoácidos grasos n-acilados para reducir la variabilidad de absorción en composiciones a base de cannabinoides |
| IT201800011120A1 (it) * | 2018-12-14 | 2020-06-14 | Dpl Pharma S P A | Composizioni farmaceutiche orali solide per la somministrazione di mesalazina o suoi derivati |
| US20220331257A1 (en) * | 2019-03-01 | 2022-10-20 | Avadel Legacy Pharmaceuticals, Llc | Liquid pharmaceutical compositions with stable drug release profiles |
| EP4021428A4 (en) * | 2019-08-26 | 2023-09-20 | ISP Investments LLC | Mucoadhesive compositions and method of use thereof |
| EP4433034A1 (en) * | 2021-11-19 | 2024-09-25 | Sushma Paul BERLIA | Controlled release formulations of flavoxate and process for preparation thereof |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62120315A (ja) * | 1985-11-20 | 1987-06-01 | Shin Etsu Chem Co Ltd | 経口投与型徐放性錠剤の製造方法 |
| DE3636123A1 (de) * | 1986-10-23 | 1988-05-05 | Rentschler Arzneimittel | Arzneizubereitungen zur oralen verabreichung, die als einzeldosis 10 bis 240 mg dihydropyridin enthalten |
| US5015479A (en) * | 1987-02-02 | 1991-05-14 | Seamus Mulligan | Sustained release capsule or tablet formulation comprising a pharmaceutically acceptable dihydropyridine |
| US4968508A (en) * | 1987-02-27 | 1990-11-06 | Eli Lilly And Company | Sustained release matrix |
| DE3720757A1 (de) | 1987-06-24 | 1989-01-05 | Bayer Ag | Dhp-manteltablette |
| NO883326L (no) * | 1987-08-11 | 1989-02-13 | Bayer Ag | Dhp-retard-tilberedning. |
| DE3814532A1 (de) | 1988-04-29 | 1989-11-09 | Bayer Ag | Dhp-retard-zubereitung |
| IT1237904B (it) | 1989-12-14 | 1993-06-18 | Ubaldo Conte | Compresse a rilascio a velocita' controllata delle sostanze attive |
| US5209933A (en) * | 1990-01-10 | 1993-05-11 | Syntex (U.S.A.) Inc. | Long acting calcium channel blocker composition |
| IT1251153B (it) * | 1991-08-06 | 1995-05-04 | Vectorpharma Int | Composizioni farmaceutiche solide per somministrazione orale aventi proungata residenza gastrica |
| IL104192A (en) * | 1992-02-17 | 1998-01-04 | Siegfried Ag Pharma | Pharmaceutical dosage forms having prolonged release rate of zero order of the active ingredient |
| US6235313B1 (en) * | 1992-04-24 | 2001-05-22 | Brown University Research Foundation | Bioadhesive microspheres and their use as drug delivery and imaging systems |
| US6210714B1 (en) * | 1993-11-23 | 2001-04-03 | Euro-Celtique S.A. | Immediate release tablet cores of acetaminophen having sustained-release coating |
| IT1265240B1 (it) * | 1993-11-30 | 1996-10-31 | Ekita Investments Nv | Compressa farmaceutica a rilascio controllato, di forma lenticolare |
| GB9402203D0 (en) | 1994-02-04 | 1994-03-30 | Smithkline Beecham Plc | Pharmaceutical formulation |
| US6103263A (en) * | 1994-11-17 | 2000-08-15 | Andrx Pharmaceuticals, Inc. | Delayed pulse release hydrogel matrix tablet |
| JP2849047B2 (ja) * | 1994-12-19 | 1999-01-20 | 大正薬品工業株式会社 | ジクロフェナクナトリウム持続性製剤およびその製法 |
| US5534263A (en) * | 1995-02-24 | 1996-07-09 | Alza Corporation | Active agent dosage form comprising a matrix and at least two insoluble bands |
| US6083532A (en) * | 1995-03-01 | 2000-07-04 | Duramed Pharmaceuticals, Inc. | Sustained release formulation containing three different types of polymers and tablet formed therefrom |
| US5736159A (en) * | 1995-04-28 | 1998-04-07 | Andrx Pharmaceuticals, Inc. | Controlled release formulation for water insoluble drugs in which a passageway is formed in situ |
| US5900425A (en) * | 1995-05-02 | 1999-05-04 | Bayer Aktiengesellschaft | Pharmaceutical preparations having controlled release of active compound and processes for their preparation |
| US5783212A (en) | 1996-02-02 | 1998-07-21 | Temple University--of the Commonwealth System of Higher Education | Controlled release drug delivery system |
| IT1282576B1 (it) | 1996-02-06 | 1998-03-31 | Jagotec Ag | Compressa farmaceutica atta a cedere la sostanza attiva in tempi successivi e predeterminabili |
| IT1282650B1 (it) | 1996-02-19 | 1998-03-31 | Jagotec Ag | Compressa farmaceutica,caratterizzata da elevato aumento di volume a contatto con liquidi biologici |
| US6096339A (en) * | 1997-04-04 | 2000-08-01 | Alza Corporation | Dosage form, process of making and using same |
| US5955096A (en) | 1996-06-25 | 1999-09-21 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients |
| IT1289160B1 (it) * | 1997-01-08 | 1998-09-29 | Jagotec Ag | Compressa farmaceutica completamente rivestita per il rilascio controllato di principi attivi che presentano problemi di |
| US5922352A (en) * | 1997-01-31 | 1999-07-13 | Andrx Pharmaceuticals, Inc. | Once daily calcium channel blocker tablet having a delayed release core |
| IT1294760B1 (it) * | 1997-09-03 | 1999-04-12 | Jagotec Ag | Procedimento per la preparazione di compresse farmaceutiche in grado di cedere,secondo schemi predeterminabili, principi attivi poco |
| DK1146862T3 (da) | 1999-01-29 | 2003-07-21 | Disphar Int Bv | Farmaceutiske sammensætninger |
| DE19906290A1 (de) | 1999-02-15 | 2000-08-17 | Falk Pharma Gmbh | Arzneimittel zur Behandlung bzw. Prävention von Darmkrebs |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| AR030557A1 (es) * | 2000-04-14 | 2003-08-27 | Jagotec Ag | Una tableta en multicapa de liberacion controlada y metodo de tratamiento |
| US6866866B1 (en) * | 2000-11-03 | 2005-03-15 | Andrx Labs, Llc | Controlled release metformin compositions |
| DE10115216A1 (de) * | 2001-03-28 | 2002-10-10 | Bosch Gmbh Robert | Kraftstoffeinspritzventil für Brennkraftmaschinen |
| US20040198789A1 (en) * | 2003-02-28 | 2004-10-07 | Recordati Ireland Limited | Lercanidipine/ARB/diuretic therapeutic combinations |
| CA2520660C (en) | 2003-03-28 | 2013-08-20 | Sigmoid Biotechnologies Limited | Solid oral dosage form containing seamless microcapsules |
| JP2005132803A (ja) * | 2003-10-31 | 2005-05-26 | Ono Pharmaceut Co Ltd | 胃内滞留固形剤 |
| US20050209288A1 (en) | 2004-01-12 | 2005-09-22 | Grogan Donna R | Compositions comprising (S)-amlodipine malate and an angiotensin receptor blocker and methods of their use |
| US20080020018A1 (en) | 2004-09-27 | 2008-01-24 | Joey Moodley | Combination Products |
| MX2009002235A (es) | 2006-08-30 | 2009-03-13 | Jagotec Ag | Formulaciones de dosis oral, solidas, de liberacion controlada que comprenden nisoldipina. |
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- 2007-08-29 US US11/847,012 patent/US20080057123A1/en not_active Abandoned
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2009
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2014
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2015
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| ZA200901688B (en) | 2014-02-26 |
| US20080057123A1 (en) | 2008-03-06 |
| CA2662123A1 (en) | 2008-03-06 |
| AU2007291506A1 (en) | 2008-03-06 |
| KR101575679B1 (ko) | 2015-12-08 |
| CA2662122A1 (en) | 2008-03-06 |
| JP2010501607A (ja) | 2010-01-21 |
| JP2010501609A (ja) | 2010-01-21 |
| KR20090065520A (ko) | 2009-06-22 |
| US20160008288A1 (en) | 2016-01-14 |
| EP2063872B1 (en) | 2015-05-06 |
| JP2014114323A (ja) | 2014-06-26 |
| KR20090065519A (ko) | 2009-06-22 |
| WO2008025532A1 (en) | 2008-03-06 |
| AU2007291509A1 (en) | 2008-03-06 |
| CA2662123C (en) | 2015-12-01 |
| EP2063872A1 (en) | 2009-06-03 |
| JP5788547B2 (ja) | 2015-09-30 |
| ES2547226T5 (es) | 2020-06-12 |
| US9101544B2 (en) | 2015-08-11 |
| US9622980B2 (en) | 2017-04-18 |
| AU2007291509B2 (en) | 2013-05-02 |
| US20080063711A1 (en) | 2008-03-13 |
| WO2008025535A1 (en) | 2008-03-06 |
| ES2547226T3 (es) | 2015-10-02 |
| MX2009002235A (es) | 2009-03-13 |
| EP2063872B2 (en) | 2019-12-04 |
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