MX2008012993A - Compuestos de acido ribonucleico inmunomodulador estabilizado para receptores tipo toll-7 y receptores tipo toll-8. - Google Patents

Compuestos de acido ribonucleico inmunomodulador estabilizado para receptores tipo toll-7 y receptores tipo toll-8.

Info

Publication number
MX2008012993A
MX2008012993A MX2008012993A MX2008012993A MX2008012993A MX 2008012993 A MX2008012993 A MX 2008012993A MX 2008012993 A MX2008012993 A MX 2008012993A MX 2008012993 A MX2008012993 A MX 2008012993A MX 2008012993 A MX2008012993 A MX 2008012993A
Authority
MX
Mexico
Prior art keywords
simra
rna
medicament
cells
linker
Prior art date
Application number
MX2008012993A
Other languages
English (en)
Spanish (es)
Inventor
Sudhir Agrawal
Yukui Li
Ekambar R Kandimalla
Tao Lan
Dong Yu
Daqing Wang
Mallikarjuna Reddy Putta
Original Assignee
Idera Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idera Pharmaceuticals Inc filed Critical Idera Pharmaceuticals Inc
Publication of MX2008012993A publication Critical patent/MX2008012993A/es

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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
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    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • AHUMAN NECESSITIES
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/04Antibacterial agents
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    • A61P31/12Antivirals
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/17Immunomodulatory nucleic acids
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/318Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/318Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3183Diol linkers, e.g. glycols or propanediols
    • CCHEMISTRY; METALLURGY
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3212'-O-R Modification
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/33Chemical structure of the base
    • C12N2310/336Modified G

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  • Tropical Medicine & Parasitology (AREA)
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MX2008012993A 2006-04-07 2007-04-06 Compuestos de acido ribonucleico inmunomodulador estabilizado para receptores tipo toll-7 y receptores tipo toll-8. MX2008012993A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US79046606P 2006-04-07 2006-04-07
US82783506P 2006-10-02 2006-10-02
US86392606P 2006-11-01 2006-11-01
PCT/US2007/008739 WO2007117686A2 (en) 2006-04-07 2007-04-06 Stabilized immune modulatory rna (simra) compounds for tlr7 and tlr8

Publications (1)

Publication Number Publication Date
MX2008012993A true MX2008012993A (es) 2008-12-18

Family

ID=38581687

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008012993A MX2008012993A (es) 2006-04-07 2007-04-06 Compuestos de acido ribonucleico inmunomodulador estabilizado para receptores tipo toll-7 y receptores tipo toll-8.

Country Status (10)

Country Link
US (3) US8106173B2 (OSRAM)
EP (1) EP2021008B1 (OSRAM)
JP (2) JP5761911B2 (OSRAM)
KR (2) KR101221589B1 (OSRAM)
CN (1) CN101460178B (OSRAM)
AU (1) AU2007235231B2 (OSRAM)
CA (1) CA2648585C (OSRAM)
ES (1) ES2564303T3 (OSRAM)
MX (1) MX2008012993A (OSRAM)
WO (1) WO2007117686A2 (OSRAM)

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