MX2007007917A - Sintesis del peptido t-20 utilizando fragmentos peptidicos intermediarios. - Google Patents
Sintesis del peptido t-20 utilizando fragmentos peptidicos intermediarios.Info
- Publication number
- MX2007007917A MX2007007917A MX2007007917A MX2007007917A MX2007007917A MX 2007007917 A MX2007007917 A MX 2007007917A MX 2007007917 A MX2007007917 A MX 2007007917A MX 2007007917 A MX2007007917 A MX 2007007917A MX 2007007917 A MX2007007917 A MX 2007007917A
- Authority
- MX
- Mexico
- Prior art keywords
- peptide
- seq
- resin
- synthesis
- sup
- Prior art date
Links
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- 239000012047 saturated solution Substances 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M sodium bicarbonate Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 238000003746 solid phase reaction Methods 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 238000010530 solution phase reaction Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- ZFEAMMNVDPDEGE-LGRGJMMZSA-N tifuvirtide Chemical compound C([C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(C)=O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)C1=CC=C(O)C=C1 ZFEAMMNVDPDEGE-LGRGJMMZSA-N 0.000 description 1
- JBWKIWSBJXDJDT-UHFFFAOYSA-N triphenylmethyl chloride Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(Cl)C1=CC=CC=C1 JBWKIWSBJXDJDT-UHFFFAOYSA-N 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 125000005500 uronium group Chemical group 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
- C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
- C07K14/16—HIV-1 ; HIV-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- AIDS & HIV (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64091104P | 2004-12-30 | 2004-12-30 | |
| PCT/EP2005/013853 WO2006069728A1 (en) | 2004-12-30 | 2005-12-22 | Synthesis of peptide t-20 using peptide intermediate fragments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007007917A true MX2007007917A (es) | 2007-08-14 |
Family
ID=36025222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007007917A MX2007007917A (es) | 2004-12-30 | 2005-12-22 | Sintesis del peptido t-20 utilizando fragmentos peptidicos intermediarios. |
Country Status (12)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050261475A1 (en) * | 2004-02-13 | 2005-11-24 | Harvard Medical School | Solid-phase capture-release-tag methods for phosphoproteomic analyses |
| ES2329270T3 (es) * | 2004-12-30 | 2009-11-24 | F. Hoffmann-La Roche Ag | Sintesis del peptido t-1249 utilizando fragmentos intermediarios del ipeptido. |
| JP5473925B2 (ja) * | 2007-10-27 | 2014-04-16 | コーデン ファーマ コロラド インコーポレイテッド | 固相および溶液相の組み合わせ技法を使用するインスリン分泌性ペプチドの合成 |
| CA2707132A1 (en) * | 2007-12-11 | 2009-06-18 | F. Hoffmann-La Roche Ag | Insulinotropic peptide synthesis using solid and solution phase combination techniques |
| CN110372781B (zh) * | 2019-07-29 | 2021-11-16 | 深圳佳肽生物科技有限公司 | 恩夫韦肽的制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100358209B1 (ko) * | 1992-07-20 | 2003-01-24 | 듀크 유니버시티 | Hiv복제를저해하는조성물 |
| US6281335B1 (en) * | 1993-10-08 | 2001-08-28 | Coulter Corporation | Hybridoma and anti-KC-4 humanized monoclonal antibody |
| US6479055B1 (en) * | 1993-06-07 | 2002-11-12 | Trimeris, Inc. | Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission |
| US5464933A (en) * | 1993-06-07 | 1995-11-07 | Duke University | Synthetic peptide inhibitors of HIV transmission |
| US5817758A (en) * | 1995-06-07 | 1998-10-06 | Terrapin Technologies, Inc. | P-nitrobenzyl side-chain protection for solid-phase synthesis |
| NZ507083A (en) * | 1998-03-23 | 2003-10-31 | Trimeris Inc | Methods and compositions for peptide synthesis, in particular T-20 (DP-178) and T-20-like peptides |
| US6281331B1 (en) * | 1998-03-23 | 2001-08-28 | Trimeris, Inc. | Methods and compositions for peptide synthesis |
| US6469136B1 (en) * | 1999-07-07 | 2002-10-22 | Trimeris, Inc. | Methods and composition for peptide synthesis |
| US20040209999A1 (en) * | 2002-08-16 | 2004-10-21 | Bohling James Charles | Method of manufacturing polypeptides, including T-20 and T-1249, at commercial scale, and polypeptide compositions related thereto |
| AU2004200485A1 (en) * | 2003-02-25 | 2004-09-09 | Rohm And Haas Company | Method of manufacturing T-20 and T-1249 peptides at commercial scale, and T-20 and T-1249 compositions related thereto |
| ES2329270T3 (es) * | 2004-12-30 | 2009-11-24 | F. Hoffmann-La Roche Ag | Sintesis del peptido t-1249 utilizando fragmentos intermediarios del ipeptido. |
-
2005
- 2005-12-22 JP JP2007548732A patent/JP4886702B2/ja not_active Expired - Fee Related
- 2005-12-22 ES ES05824259T patent/ES2332418T3/es not_active Expired - Lifetime
- 2005-12-22 MX MX2007007917A patent/MX2007007917A/es not_active Application Discontinuation
- 2005-12-22 AT AT05824259T patent/ATE445636T1/de active
- 2005-12-22 EP EP05824259A patent/EP1833843B1/en not_active Expired - Lifetime
- 2005-12-22 CN CN2005800488423A patent/CN101133077B/zh not_active Expired - Fee Related
- 2005-12-22 KR KR1020077017404A patent/KR101243013B1/ko not_active Expired - Fee Related
- 2005-12-22 CA CA2592438A patent/CA2592438C/en not_active Expired - Fee Related
- 2005-12-22 DE DE602005017188T patent/DE602005017188D1/de not_active Expired - Lifetime
- 2005-12-22 WO PCT/EP2005/013853 patent/WO2006069728A1/en not_active Ceased
- 2005-12-30 US US11/322,323 patent/US20060276624A1/en not_active Abandoned
-
2007
- 2007-06-20 IL IL184080A patent/IL184080A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1833843A1 (en) | 2007-09-19 |
| CN101133077A (zh) | 2008-02-27 |
| JP2008526698A (ja) | 2008-07-24 |
| KR20070103400A (ko) | 2007-10-23 |
| CA2592438C (en) | 2013-09-03 |
| DE602005017188D1 (de) | 2009-11-26 |
| US20060276624A1 (en) | 2006-12-07 |
| WO2006069728A1 (en) | 2006-07-06 |
| IL184080A (en) | 2010-12-30 |
| ES2332418T3 (es) | 2010-02-04 |
| ATE445636T1 (de) | 2009-10-15 |
| IL184080A0 (en) | 2007-10-31 |
| CA2592438A1 (en) | 2006-07-06 |
| CN101133077B (zh) | 2012-09-05 |
| KR101243013B1 (ko) | 2013-03-14 |
| JP4886702B2 (ja) | 2012-02-29 |
| EP1833843B1 (en) | 2009-10-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |