MX2007006646A - Metodos para administrar inhibidores de dihidropirimidina deshidrogenasa en combinacion con 5-fluorouracilo y profarmacos de 5-fluorouracilo. - Google Patents
Metodos para administrar inhibidores de dihidropirimidina deshidrogenasa en combinacion con 5-fluorouracilo y profarmacos de 5-fluorouracilo.Info
- Publication number
- MX2007006646A MX2007006646A MX2007006646A MX2007006646A MX2007006646A MX 2007006646 A MX2007006646 A MX 2007006646A MX 2007006646 A MX2007006646 A MX 2007006646A MX 2007006646 A MX2007006646 A MX 2007006646A MX 2007006646 A MX2007006646 A MX 2007006646A
- Authority
- MX
- Mexico
- Prior art keywords
- administrable
- eniluracil
- prodrug
- dose
- dpd
- Prior art date
Links
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
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| US63303404P | 2004-12-03 | 2004-12-03 | |
| PCT/US2005/043706 WO2006060697A1 (en) | 2004-12-03 | 2005-12-05 | Methods for administering dpd inhibitors in combination with 5-fu and 5-fu prodrugs |
Publications (1)
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| MX2007006646A true MX2007006646A (es) | 2007-11-16 |
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| MX2007006646A MX2007006646A (es) | 2004-12-03 | 2005-12-05 | Metodos para administrar inhibidores de dihidropirimidina deshidrogenasa en combinacion con 5-fluorouracilo y profarmacos de 5-fluorouracilo. |
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| CN101068549A (zh) * | 2004-12-03 | 2007-11-07 | 阿迪赫里克斯技术公司 | 与5－fu和5－fu前药组合施用dpd抑制剂的方法 |
| WO2009100367A2 (en) * | 2008-02-06 | 2009-08-13 | Adherex Technologies Inc. | Compositions comprising topical dpd inhibitors and methods of using same in the treatment of hand-foot syndrome |
| WO2009118712A2 (en) * | 2008-03-27 | 2009-10-01 | Ecole Polytechnique Federale De Lausanne (Epfl) | Novel dihydroxypyrrolidine derivatives as anti-cancer agents |
| JP5863047B2 (ja) * | 2009-07-17 | 2016-02-16 | ミリアド ジェネティクス， インコーポレイテッド | ５−ｆｕをアッセイする方法 |
| AU2010306698B2 (en) * | 2009-10-14 | 2016-05-26 | Adherex Technologies, Inc. | Treating neurotoxicity associated with combinations of 5 - FU or its prodrugs and DPD inhibitors |
| WO2014089004A1 (en) * | 2012-12-04 | 2014-06-12 | Adherex Technologies, Inc. | Methods for treating 5-fluorouracil prodrug non-responsive cancer patients |
| CN106692173A (zh) * | 2015-11-18 | 2017-05-24 | 北京诺普德医药科技有限公司 | 一种抗肿瘤复方组合物及其应用 |
| CN106619689B (zh) * | 2016-12-30 | 2018-05-01 | 陈晓华 | 一种用于治疗癌症的药物组合物、试剂盒及其应用 |
| WO2020125550A1 (zh) * | 2018-12-19 | 2020-06-25 | 广州君赫生物科技有限公司 | 化合物在治疗与saicar累积相关的疾病的用途 |
| CN109655606A (zh) * | 2019-01-11 | 2019-04-19 | 华东师范大学 | 一种利用3d类器官评价药物肠毒性的检测方法 |
| WO2023283921A1 (zh) * | 2021-07-16 | 2023-01-19 | 北京深蓝泰医药科技有限公司 | Dpd抑制剂及其药物组合物和用途 |
| JP2025538758A (ja) * | 2022-12-06 | 2025-11-28 | エリオン・オンコロジー・インコーポレイテッド | がんを治療するためのエニルウラシル及びカペシタビンの併用 |
| TW202517270A (zh) * | 2023-07-13 | 2025-05-01 | 美商普羅塞沙製藥公司 | 癌症治療個人化方法 |
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| GB8629892D0 (en) | 1986-12-15 | 1987-01-28 | Wellcome Found | Antiviral compounds |
| US5157114A (en) | 1988-08-19 | 1992-10-20 | Burroughs Wellcome Co. | 2',3'-dideoxy-3'-fluoro-5-ethyngluridine |
| WO1992001452A1 (en) | 1990-07-19 | 1992-02-06 | The Wellcome Foundation Limited | Enzyme inactivators |
| GB9020930D0 (en) * | 1990-09-26 | 1990-11-07 | Wellcome Found | Pharmaceutical combinations |
| IT1255522B (it) * | 1992-09-24 | 1995-11-09 | Ubaldo Conte | Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita' |
| US5476855A (en) | 1993-11-02 | 1995-12-19 | Mahmoud H. el Kouni | Enzyme inhibitors, their synthesis and methods for use |
| NZ330360A (en) | 1997-06-02 | 1999-03-29 | Hoffmann La Roche | 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents |
| US6716452B1 (en) * | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US20040028687A1 (en) | 2002-01-15 | 2004-02-12 | Waelti Ernst Rudolf | Methods and compositions for the targeted delivery of therapeutic substances to specific cells and tissues |
| CN101068549A (zh) * | 2004-12-03 | 2007-11-07 | 阿迪赫里克斯技术公司 | 与5－fu和5－fu前药组合施用dpd抑制剂的方法 |
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- 2005-12-05 KR KR1020077013028A patent/KR20070098798A/ko not_active Ceased
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- 2012-11-27 US US13/686,240 patent/US20130184232A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005311730B2 (en) | 2011-11-17 |
| JP2012229273A (ja) | 2012-11-22 |
| CN102441170A (zh) | 2012-05-09 |
| US20060148753A1 (en) | 2006-07-06 |
| WO2006060697A9 (en) | 2006-09-21 |
| JP2008521930A (ja) | 2008-06-26 |
| CA2587514A1 (en) | 2006-06-08 |
| NZ555176A (en) | 2010-03-26 |
| US8318756B2 (en) | 2012-11-27 |
| AU2005311730A1 (en) | 2006-06-08 |
| WO2006060697A1 (en) | 2006-06-08 |
| CN101068549A (zh) | 2007-11-07 |
| EP1827443A1 (en) | 2007-09-05 |
| KR20070098798A (ko) | 2007-10-05 |
| US20130184232A1 (en) | 2013-07-18 |
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