CA2587514A1 - Methods for administering dpd inhibitors in combination with 5-fu and 5-fu prodrugs - Google Patents
Methods for administering dpd inhibitors in combination with 5-fu and 5-fu prodrugs Download PDFInfo
- Publication number
- CA2587514A1 CA2587514A1 CA002587514A CA2587514A CA2587514A1 CA 2587514 A1 CA2587514 A1 CA 2587514A1 CA 002587514 A CA002587514 A CA 002587514A CA 2587514 A CA2587514 A CA 2587514A CA 2587514 A1 CA2587514 A1 CA 2587514A1
- Authority
- CA
- Canada
- Prior art keywords
- administered
- eniluracil
- prodrug
- dose
- dpd inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63303404P | 2004-12-03 | 2004-12-03 | |
| US60/633,034 | 2004-12-03 | ||
| PCT/US2005/043706 WO2006060697A1 (en) | 2004-12-03 | 2005-12-05 | Methods for administering dpd inhibitors in combination with 5-fu and 5-fu prodrugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2587514A1 true CA2587514A1 (en) | 2006-06-08 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002587514A Abandoned CA2587514A1 (en) | 2004-12-03 | 2005-12-05 | Methods for administering dpd inhibitors in combination with 5-fu and 5-fu prodrugs |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8318756B2 (enExample) |
| EP (1) | EP1827443A1 (enExample) |
| JP (2) | JP2008521930A (enExample) |
| KR (1) | KR20070098798A (enExample) |
| CN (2) | CN101068549A (enExample) |
| AU (1) | AU2005311730B2 (enExample) |
| CA (1) | CA2587514A1 (enExample) |
| MX (1) | MX2007006646A (enExample) |
| NZ (1) | NZ555176A (enExample) |
| WO (1) | WO2006060697A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101068549A (zh) * | 2004-12-03 | 2007-11-07 | 阿迪赫里克斯技术公司 | 与5－fu和5－fu前药组合施用dpd抑制剂的方法 |
| WO2009100367A2 (en) * | 2008-02-06 | 2009-08-13 | Adherex Technologies Inc. | Compositions comprising topical dpd inhibitors and methods of using same in the treatment of hand-foot syndrome |
| WO2009118712A2 (en) * | 2008-03-27 | 2009-10-01 | Ecole Polytechnique Federale De Lausanne (Epfl) | Novel dihydroxypyrrolidine derivatives as anti-cancer agents |
| JP5863047B2 (ja) * | 2009-07-17 | 2016-02-16 | ミリアド ジェネティクス， インコーポレイテッド | ５−ｆｕをアッセイする方法 |
| AU2010306698B2 (en) * | 2009-10-14 | 2016-05-26 | Adherex Technologies, Inc. | Treating neurotoxicity associated with combinations of 5 - FU or its prodrugs and DPD inhibitors |
| WO2014089004A1 (en) * | 2012-12-04 | 2014-06-12 | Adherex Technologies, Inc. | Methods for treating 5-fluorouracil prodrug non-responsive cancer patients |
| CN106692173A (zh) * | 2015-11-18 | 2017-05-24 | 北京诺普德医药科技有限公司 | 一种抗肿瘤复方组合物及其应用 |
| CN106619689B (zh) * | 2016-12-30 | 2018-05-01 | 陈晓华 | 一种用于治疗癌症的药物组合物、试剂盒及其应用 |
| WO2020125550A1 (zh) * | 2018-12-19 | 2020-06-25 | 广州君赫生物科技有限公司 | 化合物在治疗与saicar累积相关的疾病的用途 |
| CN109655606A (zh) * | 2019-01-11 | 2019-04-19 | 华东师范大学 | 一种利用3d类器官评价药物肠毒性的检测方法 |
| WO2023283921A1 (zh) * | 2021-07-16 | 2023-01-19 | 北京深蓝泰医药科技有限公司 | Dpd抑制剂及其药物组合物和用途 |
| JP2025538758A (ja) * | 2022-12-06 | 2025-11-28 | エリオン・オンコロジー・インコーポレイテッド | がんを治療するためのエニルウラシル及びカペシタビンの併用 |
| TW202517270A (zh) * | 2023-07-13 | 2025-05-01 | 美商普羅塞沙製藥公司 | 癌症治療個人化方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB8629892D0 (en) | 1986-12-15 | 1987-01-28 | Wellcome Found | Antiviral compounds |
| US5157114A (en) | 1988-08-19 | 1992-10-20 | Burroughs Wellcome Co. | 2',3'-dideoxy-3'-fluoro-5-ethyngluridine |
| WO1992001452A1 (en) | 1990-07-19 | 1992-02-06 | The Wellcome Foundation Limited | Enzyme inactivators |
| GB9020930D0 (en) * | 1990-09-26 | 1990-11-07 | Wellcome Found | Pharmaceutical combinations |
| IT1255522B (it) * | 1992-09-24 | 1995-11-09 | Ubaldo Conte | Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita' |
| US5476855A (en) | 1993-11-02 | 1995-12-19 | Mahmoud H. el Kouni | Enzyme inhibitors, their synthesis and methods for use |
| NZ330360A (en) | 1997-06-02 | 1999-03-29 | Hoffmann La Roche | 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents |
| US6716452B1 (en) * | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US20040028687A1 (en) | 2002-01-15 | 2004-02-12 | Waelti Ernst Rudolf | Methods and compositions for the targeted delivery of therapeutic substances to specific cells and tissues |
| CN101068549A (zh) * | 2004-12-03 | 2007-11-07 | 阿迪赫里克斯技术公司 | 与5－fu和5－fu前药组合施用dpd抑制剂的方法 |
-
2005
- 2005-12-05 CN CNA2005800414059A patent/CN101068549A/zh active Pending
- 2005-12-05 CN CN2011104284155A patent/CN102441170A/zh active Pending
- 2005-12-05 JP JP2007544558A patent/JP2008521930A/ja active Pending
- 2005-12-05 US US11/294,643 patent/US8318756B2/en active Active
- 2005-12-05 EP EP05852819A patent/EP1827443A1/en not_active Withdrawn
- 2005-12-05 KR KR1020077013028A patent/KR20070098798A/ko not_active Ceased
- 2005-12-05 WO PCT/US2005/043706 patent/WO2006060697A1/en not_active Ceased
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2012
- 2012-08-27 JP JP2012186899A patent/JP2012229273A/ja active Pending
- 2012-11-27 US US13/686,240 patent/US20130184232A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005311730B2 (en) | 2011-11-17 |
| JP2012229273A (ja) | 2012-11-22 |
| CN102441170A (zh) | 2012-05-09 |
| US20060148753A1 (en) | 2006-07-06 |
| WO2006060697A9 (en) | 2006-09-21 |
| JP2008521930A (ja) | 2008-06-26 |
| MX2007006646A (es) | 2007-11-16 |
| NZ555176A (en) | 2010-03-26 |
| US8318756B2 (en) | 2012-11-27 |
| AU2005311730A1 (en) | 2006-06-08 |
| WO2006060697A1 (en) | 2006-06-08 |
| CN101068549A (zh) | 2007-11-07 |
| EP1827443A1 (en) | 2007-09-05 |
| KR20070098798A (ko) | 2007-10-05 |
| US20130184232A1 (en) | 2013-07-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20150622 |