AU2005311730B2 - Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs - Google Patents

Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs Download PDF

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Publication number
AU2005311730B2
AU2005311730B2 AU2005311730A AU2005311730A AU2005311730B2 AU 2005311730 B2 AU2005311730 B2 AU 2005311730B2 AU 2005311730 A AU2005311730 A AU 2005311730A AU 2005311730 A AU2005311730 A AU 2005311730A AU 2005311730 B2 AU2005311730 B2 AU 2005311730B2
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AU
Australia
Prior art keywords
eniluracil
administered
prodrug
dose
dpd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005311730A
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English (en)
Other versions
AU2005311730A1 (en
Inventor
Brian Huber
Donald William Kufe
William Paul Peters
Tom Spector
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fennec Pharmaceuticals Inc
Original Assignee
Adherex Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adherex Technologies Inc filed Critical Adherex Technologies Inc
Publication of AU2005311730A1 publication Critical patent/AU2005311730A1/en
Application granted granted Critical
Publication of AU2005311730B2 publication Critical patent/AU2005311730B2/en
Priority to AU2012200856A priority Critical patent/AU2012200856B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2005311730A 2004-12-03 2005-12-05 Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs Ceased AU2005311730B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2012200856A AU2012200856B2 (en) 2004-12-03 2012-02-14 Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63303404P 2004-12-03 2004-12-03
US60/633,034 2004-12-03
PCT/US2005/043706 WO2006060697A1 (en) 2004-12-03 2005-12-05 Methods for administering dpd inhibitors in combination with 5-fu and 5-fu prodrugs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2012200856A Division AU2012200856B2 (en) 2004-12-03 2012-02-14 Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs

Publications (2)

Publication Number Publication Date
AU2005311730A1 AU2005311730A1 (en) 2006-06-08
AU2005311730B2 true AU2005311730B2 (en) 2011-11-17

Family

ID=36087538

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005311730A Ceased AU2005311730B2 (en) 2004-12-03 2005-12-05 Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs

Country Status (10)

Country Link
US (2) US8318756B2 (enExample)
EP (1) EP1827443A1 (enExample)
JP (2) JP2008521930A (enExample)
KR (1) KR20070098798A (enExample)
CN (2) CN101068549A (enExample)
AU (1) AU2005311730B2 (enExample)
CA (1) CA2587514A1 (enExample)
MX (1) MX2007006646A (enExample)
NZ (1) NZ555176A (enExample)
WO (1) WO2006060697A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101068549A (zh) * 2004-12-03 2007-11-07 阿迪赫里克斯技术公司 与5－fu和5－fu前药组合施用dpd抑制剂的方法
WO2009100367A2 (en) * 2008-02-06 2009-08-13 Adherex Technologies Inc. Compositions comprising topical dpd inhibitors and methods of using same in the treatment of hand-foot syndrome
WO2009118712A2 (en) * 2008-03-27 2009-10-01 Ecole Polytechnique Federale De Lausanne (Epfl) Novel dihydroxypyrrolidine derivatives as anti-cancer agents
JP5863047B2 (ja) * 2009-07-17 2016-02-16 ミリアド ジェネティクス， インコーポレイテッド ５−ｆｕをアッセイする方法
AU2010306698B2 (en) * 2009-10-14 2016-05-26 Adherex Technologies, Inc. Treating neurotoxicity associated with combinations of 5 - FU or its prodrugs and DPD inhibitors
WO2014089004A1 (en) * 2012-12-04 2014-06-12 Adherex Technologies, Inc. Methods for treating 5-fluorouracil prodrug non-responsive cancer patients
CN106692173A (zh) * 2015-11-18 2017-05-24 北京诺普德医药科技有限公司 一种抗肿瘤复方组合物及其应用
CN106619689B (zh) * 2016-12-30 2018-05-01 陈晓华 一种用于治疗癌症的药物组合物、试剂盒及其应用
WO2020125550A1 (zh) * 2018-12-19 2020-06-25 广州君赫生物科技有限公司 化合物在治疗与saicar累积相关的疾病的用途
CN109655606A (zh) * 2019-01-11 2019-04-19 华东师范大学 一种利用3d类器官评价药物肠毒性的检测方法
WO2023283921A1 (zh) * 2021-07-16 2023-01-19 北京深蓝泰医药科技有限公司 Dpd抑制剂及其药物组合物和用途
JP2025538758A (ja) * 2022-12-06 2025-11-28 エリオン・オンコロジー・インコーポレイテッド がんを治療するためのエニルウラシル及びカペシタビンの併用
TW202517270A (zh) * 2023-07-13 2025-05-01 美商普羅塞沙製藥公司 癌症治療個人化方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817664A (en) * 1990-09-26 1998-10-06 Glaxo Wellcome Inc. Uracil reductase inactivators

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8629892D0 (en) 1986-12-15 1987-01-28 Wellcome Found Antiviral compounds
US5157114A (en) 1988-08-19 1992-10-20 Burroughs Wellcome Co. 2',3'-dideoxy-3'-fluoro-5-ethyngluridine
WO1992001452A1 (en) 1990-07-19 1992-02-06 The Wellcome Foundation Limited Enzyme inactivators
IT1255522B (it) * 1992-09-24 1995-11-09 Ubaldo Conte Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita'
US5476855A (en) 1993-11-02 1995-12-19 Mahmoud H. el Kouni Enzyme inhibitors, their synthesis and methods for use
NZ330360A (en) 1997-06-02 1999-03-29 Hoffmann La Roche 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents
US6716452B1 (en) * 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US20040028687A1 (en) 2002-01-15 2004-02-12 Waelti Ernst Rudolf Methods and compositions for the targeted delivery of therapeutic substances to specific cells and tissues
CN101068549A (zh) * 2004-12-03 2007-11-07 阿迪赫里克斯技术公司 与5－fu和5－fu前药组合施用dpd抑制剂的方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817664A (en) * 1990-09-26 1998-10-06 Glaxo Wellcome Inc. Uracil reductase inactivators

Also Published As

Publication number Publication date
JP2012229273A (ja) 2012-11-22
CN102441170A (zh) 2012-05-09
US20060148753A1 (en) 2006-07-06
WO2006060697A9 (en) 2006-09-21
JP2008521930A (ja) 2008-06-26
MX2007006646A (es) 2007-11-16
CA2587514A1 (en) 2006-06-08
NZ555176A (en) 2010-03-26
US8318756B2 (en) 2012-11-27
AU2005311730A1 (en) 2006-06-08
WO2006060697A1 (en) 2006-06-08
CN101068549A (zh) 2007-11-07
EP1827443A1 (en) 2007-09-05
KR20070098798A (ko) 2007-10-05
US20130184232A1 (en) 2013-07-18

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired