MX2007003014A - Proceso para la preparacion de derivados de '1,7-naftiridina 6,8-sustituida, mediante la reaccion del derivado de 8-halo-'1,7-naftidirina con un derivado de acido boronico organico, e intermediarios de este proceso. - Google Patents
Proceso para la preparacion de derivados de '1,7-naftiridina 6,8-sustituida, mediante la reaccion del derivado de 8-halo-'1,7-naftidirina con un derivado de acido boronico organico, e intermediarios de este proceso.Info
- Publication number
- MX2007003014A MX2007003014A MX2007003014A MX2007003014A MX2007003014A MX 2007003014 A MX2007003014 A MX 2007003014A MX 2007003014 A MX2007003014 A MX 2007003014A MX 2007003014 A MX2007003014 A MX 2007003014A MX 2007003014 A MX2007003014 A MX 2007003014A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- halo
- naphthpyridin
- alkoxy
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Un proceso para la preparacion de compuestos de la Formula (I) (Ver Formula I) en donde R1 es alquilo de 1 a 20 atomos de carbono opcionalmente sustituido por 1 o 2 de hidroxilo, cicloalquilo de 3 a 12 atomos de carbono, arilo de 6 a 12 atomos de carbono; alcoxilo de 1 a 7 atomos de carbono, tilo, tioalquilo de 1 a 7 atomos de carbono, o carboxilo; o R1 es cicloalquilo de 3 a 12 atomos de carbono opcionalmente sustituido por 1 o 2 de alquilo de 1 a 7 atomos de carbono, hidroxilo, alcoxilo de 1 a 7 atomos de carbono, tioalquilo de 1 a 7 atomos de carbono, carboxilo, o R1 es arilo de 6 a 12 atomos de carbono opcionalmente sustituido por 1, 2, 3, o 4 sustituyentes seleccionados a partir de alquilo de 1 a 7 atomos de carbono, halogeno, hidroxilo, alcoxilo de 1 a 7 atomos de carbono, tioalquilo de 1 a 7 atomos de carbono, y nitro, o R1 es heteroarilo opcionalmente por alquilo de 1 a 7 atomos de carbono, alcoxilo de 1 a 7 atomos de carbono, o halogeno; R2 y R3 son independientemente hidrogeno o alcoxilo de 1 a 20 atomos de carbono; R4 es arilo de 6 a 12 atomos de carbono opcionalmente sustituido por 1, 2, 3, o 4 sustituyentes seleccionados a partir de alquilo de 1 a 7 atomos de carbono, halogeno, hidroxilo, alcoxilo de 1 a 7 atomos de carbono, tioalquilo de 1 a 7 atomos de carbono, y nitro, o R4 es heteroarilo opcionalmente sustituido por alquilo de 1 a 7 atomos de carbono, alcoxilo de 1 a 7 atomos de carbono, o halogeno; y X es N o CH; o una sal de los mismos; cuyo proceso comprende acoplar los compuestos de la Formula (VI) en donde Y es cloro o bromo, en la presencia de un catalizador y una base, con un compuesto de la Formula (VII), y R6 y R7 son hidrogeno o alquilo de 1 a 7 atomos de carbono, o R6 y R7 combinados son alquileno de 2 a 3 atomos de carbono opcionalmente sustituido por 1 o 2 de alquilo de 1 a 4 atomos de carbono que, junto con los atomos de boro y oxigeno, forman un anillo de 5 o 6 miembros.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60957604P | 2004-09-14 | 2004-09-14 | |
| PCT/US2005/032909 WO2006031959A1 (en) | 2004-09-14 | 2005-09-12 | Process for the preparation of 6, 8-substituted `1, 7 naphthpyridin derivatives by reacting the 8-halo-`1, 7 naphthpyridin-derivate with an organic boronic acid derivatives and intermadiates of this process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007003014A true MX2007003014A (es) | 2007-05-10 |
Family
ID=35546849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007003014A MX2007003014A (es) | 2004-09-14 | 2005-09-12 | Proceso para la preparacion de derivados de '1,7-naftiridina 6,8-sustituida, mediante la reaccion del derivado de 8-halo-'1,7-naftidirina con un derivado de acido boronico organico, e intermediarios de este proceso. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20070293678A1 (es) |
| EP (1) | EP1791842A1 (es) |
| JP (1) | JP2008513371A (es) |
| KR (1) | KR20070053245A (es) |
| CN (1) | CN101018791A (es) |
| AU (1) | AU2005284826A1 (es) |
| BR (1) | BRPI0515307A (es) |
| CA (1) | CA2577171A1 (es) |
| MX (1) | MX2007003014A (es) |
| RU (1) | RU2007113915A (es) |
| WO (1) | WO2006031959A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009013286A1 (en) * | 2007-07-24 | 2009-01-29 | Novartis Ag | Organic compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1228090A (zh) * | 1996-06-20 | 1999-09-08 | 先灵公司 | 影响il－4和g－csf的二氮萘 |
| GB9622386D0 (en) * | 1996-10-28 | 1997-01-08 | Sandoz Ltd | Organic compounds |
| ATE404539T1 (de) * | 1997-10-02 | 2008-08-15 | Eisai R&D Man Co Ltd | Kondensierte pyridinderivate |
-
2005
- 2005-09-12 US US11/574,255 patent/US20070293678A1/en not_active Abandoned
- 2005-09-12 JP JP2007531474A patent/JP2008513371A/ja active Pending
- 2005-09-12 WO PCT/US2005/032909 patent/WO2006031959A1/en active Application Filing
- 2005-09-12 MX MX2007003014A patent/MX2007003014A/es not_active Application Discontinuation
- 2005-09-12 CN CNA2005800305047A patent/CN101018791A/zh active Pending
- 2005-09-12 BR BRPI0515307-7A patent/BRPI0515307A/pt not_active IP Right Cessation
- 2005-09-12 EP EP05805619A patent/EP1791842A1/en not_active Withdrawn
- 2005-09-12 KR KR1020077005778A patent/KR20070053245A/ko not_active Application Discontinuation
- 2005-09-12 AU AU2005284826A patent/AU2005284826A1/en not_active Abandoned
- 2005-09-12 RU RU2007113915/04A patent/RU2007113915A/ru not_active Application Discontinuation
- 2005-09-12 CA CA002577171A patent/CA2577171A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1791842A1 (en) | 2007-06-06 |
| BRPI0515307A (pt) | 2008-07-15 |
| AU2005284826A1 (en) | 2006-03-23 |
| RU2007113915A (ru) | 2008-10-27 |
| CN101018791A (zh) | 2007-08-15 |
| JP2008513371A (ja) | 2008-05-01 |
| WO2006031959A1 (en) | 2006-03-23 |
| KR20070053245A (ko) | 2007-05-23 |
| US20070293678A1 (en) | 2007-12-20 |
| CA2577171A1 (en) | 2006-03-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |