MTP930B - Substained release lithium-containing tablets and method for their manufacture - Google Patents

Substained release lithium-containing tablets and method for their manufacture

Info

Publication number
MTP930B
MTP930B MT930A MTP930A MTP930B MT P930 B MTP930 B MT P930B MT 930 A MT930 A MT 930A MT P930 A MTP930 A MT P930A MT P930 B MTP930 B MT P930B
Authority
MT
Malta
Prior art keywords
tablets
granulate
lithium carbonate
sustained release
manufacture
Prior art date
Application number
MT930A
Inventor
David John Tzigger
Original Assignee
Delandale Labs Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delandale Labs Ltd filed Critical Delandale Labs Ltd
Publication of MTP930B publication Critical patent/MTP930B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The release pattern of sustained release lithium carbonate tablets is improved by using a particular form of lithium carbonate material. This should have acicular crystals with a substantially monomodal particle size distribution in which the curve showing volume percentages of particles of different sizes shows a peak at a particle diameter of between 10 and 25 mu m. Moreover not more than 20% by volume of the material should have a particular diameter above 30 mu m. A preferred sustained release agent is a mixture of glyceryl mono-di- and tri-esters of straight chain saturated fatty acids. The tablets may be made by a moist granulation technique, followed by screening to ensure a granulate of appropriate grain sizes, after which the granulate is compacted into tablets.
MT930A 1982-04-30 1983-04-18 Substained release lithium-containing tablets and method for their manufacture MTP930B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8212636 1982-04-30

Publications (1)

Publication Number Publication Date
MTP930B true MTP930B (en) 1984-04-10

Family

ID=10530100

Family Applications (1)

Application Number Title Priority Date Filing Date
MT930A MTP930B (en) 1982-04-30 1983-04-18 Substained release lithium-containing tablets and method for their manufacture

Country Status (14)

Country Link
EP (1) EP0093538B1 (en)
AT (1) ATE15760T1 (en)
AU (1) AU551212B2 (en)
CA (1) CA1200502A (en)
CY (1) CY1356A (en)
DE (1) DE3360873D1 (en)
EG (1) EG17257A (en)
GB (1) GB2119247B (en)
GR (1) GR78843B (en)
IL (1) IL68482A (en)
MT (1) MTP930B (en)
NZ (1) NZ203959A (en)
PT (1) PT76567B (en)
ZA (1) ZA832799B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8730011D0 (en) * 1987-12-23 1988-02-03 Smithkline Dauelsberg Pharmaceutical compositions
GB8809421D0 (en) * 1988-04-21 1988-05-25 Fordonal Sa Antacid compositions with prolonged gastric residence time
GB9018839D0 (en) * 1990-08-29 1990-10-10 Newton John M Slow release compositions
FR2740342B1 (en) * 1995-10-26 1997-12-19 Oreal USE OF LANTHANIDE, MANGANESE, LITHIUM, TIN, ZINC OR YTTRIUM SALT, COBALT, BARIUM, STRONTIUM IN PHARMACEUTICAL COMPOSITIONS
GB9806462D0 (en) * 1998-03-26 1998-05-27 Glaxo Group Ltd Improved compositions for inhalation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1209093A (en) * 1968-07-16 1970-10-14 Delandale Lab Ltd Pharmaceutical preparation
GB1450536A (en) * 1972-11-27 1976-09-22 Delandale Lab Ltd Method of making tablets
GB2016922B (en) * 1978-02-17 1982-08-18 Delandale Lab Ltd Sustained release lithium carbonate tables

Also Published As

Publication number Publication date
GB2119247B (en) 1985-08-07
GR78843B (en) 1984-10-02
GB2119247A (en) 1983-11-16
NZ203959A (en) 1985-10-11
CY1356A (en) 1987-08-07
ZA832799B (en) 1984-01-25
EP0093538A1 (en) 1983-11-09
PT76567A (en) 1983-05-01
AU551212B2 (en) 1986-04-17
IL68482A (en) 1986-12-31
PT76567B (en) 1985-12-10
AU1387983A (en) 1983-11-03
CA1200502A (en) 1986-02-11
IL68482A0 (en) 1983-07-31
EG17257A (en) 1991-03-30
GB8310535D0 (en) 1983-05-25
DE3360873D1 (en) 1985-10-31
EP0093538B1 (en) 1985-09-25
ATE15760T1 (en) 1985-10-15

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