MEP38508A - Benzofuran derivatives, their preparation and use - Google Patents

Benzofuran derivatives, their preparation and use

Info

Publication number
MEP38508A
MEP38508A MEP-385/08A MEP38508A MEP38508A ME P38508 A MEP38508 A ME P38508A ME P38508 A MEP38508 A ME P38508A ME P38508 A MEP38508 A ME P38508A
Authority
ME
Montenegro
Prior art keywords
alkyl
benzofuran derivatives
preparation
alkenyl
aryl
Prior art date
Application number
MEP-385/08A
Other languages
English (en)
Croatian (hr)
Inventor
Kim Andersen
Mario Rottlaender
Klaus Peter Boegesoe
Henrik Pedersen
Thomas Ruhland
Robert Dancer
Original Assignee
Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck As filed Critical Lundbeck As
Publication of MEP38508A publication Critical patent/MEP38508A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Ovaj pronalazak se odnosi na derivate benzofurana koji imaju opštu formulu (I). A je odobren od (1), (2), (3), (4) u kojima je Z O ili S; s je O ili 1; q je O ili 1; R4 je vodonik, C1-6 alkil, C 2-6 -alkenil, C 2-4 alkenil, C1-6 - alkil-aril, ili C1-6 alkil-O-aril; D je grupa koja daje razmak odabrana od C1-6 alkiln i C 2-6 alkenilen i C 2-6 alkenilen račvastog ilči ravnog lanca; njihove enantiomere, i farmaceutski prihvatljivu adicionu so kisjeline istih. Jedinjenja se snažno vezuju za 5-HTIA receptor.
MEP-385/08A 1998-12-08 1999-12-03 Benzofuran derivatives, their preparation and use MEP38508A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11136098P 1998-12-08 1998-12-08
DKPA199801631 1998-12-09
PCT/DK1999/000676 WO2000034263A1 (en) 1998-12-08 1999-12-03 Benzofuran derivatives, their preparation and use

Publications (1)

Publication Number Publication Date
MEP38508A true MEP38508A (en) 2011-02-10

Family

ID=43768792

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-385/08A MEP38508A (en) 1998-12-08 1999-12-03 Benzofuran derivatives, their preparation and use

Country Status (18)

Country Link
EP (1) EP1137644B9 (bs)
JP (1) JP2002531556A (bs)
AR (1) AR021509A1 (bs)
AT (1) ATE249451T1 (bs)
AU (1) AU759248B2 (bs)
CA (1) CA2353618A1 (bs)
CZ (1) CZ20012041A3 (bs)
DE (1) DE69911243T2 (bs)
DK (1) DK1137644T3 (bs)
ES (1) ES2204175T3 (bs)
HU (1) HUP0104510A3 (bs)
IL (1) IL143082A (bs)
ME (1) MEP38508A (bs)
PT (1) PT1137644E (bs)
RS (1) RS50065B (bs)
SE (1) SE1137644T5 (bs)
SI (1) SI1137644T1 (bs)
WO (1) WO2000034263A1 (bs)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR021155A1 (es) 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
EA008372B1 (ru) * 2000-07-07 2007-04-27 Х.Лундбекк А/С Применение эсциталопрама для лечения расстройства, связанного с социальной тревогой
EA008373B1 (ru) * 2000-07-07 2007-04-27 Х. Лундбекк А/С Применение эсциталопрама для лечения расстройства, связанного с посттравматическим стрессом
KR20030015889A (ko) * 2000-07-21 2003-02-25 하. 룬트벡 아크티에 셀스카브 신규한 화합물 및 글라이신 전달 억제제로서의 이들의 용도
WO2002020493A2 (en) * 2000-09-06 2002-03-14 Chugai Seiyaku Kabushiki Kaisha A traceless solid-phase synthesis of 2-imidazolones
US7235569B2 (en) 2003-05-02 2007-06-26 Wyeth Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use
US7276603B2 (en) 2003-05-02 2007-10-02 Wyeth Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
JP6064062B2 (ja) 2013-03-15 2017-01-18 ファイザー・インク Ａｍｐｋを活性化させるインダゾール化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (bs) * 1965-03-18
GB1173312A (en) * 1966-03-17 1969-12-10 Kefalas As Heterocyclic Compounds
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
WO1995018118A1 (en) * 1993-12-28 1995-07-06 The Upjohn Company Heterocyclic compounds for the treatment of cns and cardiovascular disorders
IL114026A (en) * 1994-06-08 1999-06-20 Lundbeck & Co As H 4-aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzo thiophenemethyl) piperidines tetrahydropyridines or piperazines and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CZ20012041A3 (cs) 2001-10-17
AR021509A1 (es) 2002-07-24
EP1137644B1 (en) 2003-09-10
EP1137644A1 (en) 2001-10-04
PT1137644E (pt) 2004-01-30
SE1137644T3 (bs) 2003-12-02
HUP0104510A3 (en) 2003-01-28
SI1137644T1 (en) 2003-12-31
CA2353618A1 (en) 2000-06-15
DK1137644T3 (da) 2003-12-08
RS50065B (sr) 2009-01-22
WO2000034263A1 (en) 2000-06-15
AU1503600A (en) 2000-06-26
DE69911243T2 (de) 2004-07-15
AU759248B2 (en) 2003-04-10
EP1137644B9 (en) 2004-03-17
ES2204175T3 (es) 2004-04-16
SE1137644T5 (bs) 2004-05-11
IL143082A0 (en) 2002-04-21
DE69911243D1 (de) 2003-10-16
HUP0104510A2 (hu) 2002-04-29
JP2002531556A (ja) 2002-09-24
ATE249451T1 (de) 2003-09-15
IL143082A (en) 2004-06-20
YU38401A (sh) 2005-06-10

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