YU38401A - Derivati benzofurana, njihova izrada i upotreba - Google Patents
Derivati benzofurana, njihova izrada i upotrebaInfo
- Publication number
- YU38401A YU38401A YU38401A YU38401A YU38401A YU 38401 A YU38401 A YU 38401A YU 38401 A YU38401 A YU 38401A YU 38401 A YU38401 A YU 38401A YU 38401 A YU38401 A YU 38401A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- alkyl
- benzofuran derivatives
- preparation
- aryl
- alkynylene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Ovaj pronalazak se odnosi na derivate benzofurana koji imaju opštu formulu (I). A je odabran od (1), (2), (3), (4) u kojima je Z O ili S; s je 0 ili 1; q je 0 ili 1; R4 je vodonik, C1-6alkil, C2-6alkenil, C2-4alkinil, C1-6alkil-aril, ili C1-6alkil-O-aril; D je grupa koja daje razmak odabrana od C1-6alkilen i C2-6alkenilen račvastog ili ravnog lanca; njihove enantiomere, i farmaceutski prihvatljivu adicionu so kiseline istih. Jedinjenja se snažno vezuju za 5-HT1A receptor.[The present invention relates to benzofuran derivatives having general Formula (I). A is selected from (1), (2), (3), (4) wherein: Z is O or S; s is 0 or 1; q is 0 or 1; R4 is hydrogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C1-6-alkyl-Aryl, or C1-6-alkyl-O-Aryl; D is a spacer group selected from branched or straight chain C1-6-alkylene, C2-6-alkenylene and C2-6-alkynylene; its enantiomers, and pharmaceutically acceptable acid addition salt thereof. The compounds are potently binding to the 5-HT1A receptor.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11136098P | 1998-12-08 | 1998-12-08 | |
| DKPA199801631 | 1998-12-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU38401A true YU38401A (sh) | 2005-06-10 |
| RS50065B RS50065B (sr) | 2009-01-22 |
Family
ID=43768792
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1137644B9 (sh) |
| JP (1) | JP2002531556A (sh) |
| AR (1) | AR021509A1 (sh) |
| AT (1) | ATE249451T1 (sh) |
| AU (1) | AU759248B2 (sh) |
| CA (1) | CA2353618A1 (sh) |
| CZ (1) | CZ20012041A3 (sh) |
| DE (1) | DE69911243T2 (sh) |
| DK (1) | DK1137644T3 (sh) |
| ES (1) | ES2204175T3 (sh) |
| HU (1) | HUP0104510A3 (sh) |
| IL (1) | IL143082A (sh) |
| ME (1) | MEP38508A (sh) |
| PT (1) | PT1137644E (sh) |
| RS (1) | RS50065B (sh) |
| SE (1) | SE1137644T5 (sh) |
| SI (1) | SI1137644T1 (sh) |
| WO (1) | WO2000034263A1 (sh) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR021155A1 (es) * | 1999-07-08 | 2002-06-12 | Lundbeck & Co As H | Tratamiento de desordenes neuroticos |
| EA008372B1 (ru) * | 2000-07-07 | 2007-04-27 | Х.Лундбекк А/С | Применение эсциталопрама для лечения расстройства, связанного с социальной тревогой |
| EA008373B1 (ru) * | 2000-07-07 | 2007-04-27 | Х. Лундбекк А/С | Применение эсциталопрама для лечения расстройства, связанного с посттравматическим стрессом |
| JP2004504393A (ja) | 2000-07-21 | 2004-02-12 | ハー・ルンドベック・アクチエゼルスカベット | 新規化合物及びそのグリシントランスポート阻害剤としての使用方法 |
| AU2001288605A1 (en) * | 2000-09-06 | 2002-03-22 | Chugai Seiyaku Kabushiki Kaisha | A traceless solid-phase synthesis of 2-imidazolones |
| US7276603B2 (en) | 2003-05-02 | 2007-10-02 | Wyeth | Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use |
| US7235569B2 (en) | 2003-05-02 | 2007-06-26 | Wyeth | Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| CA2905242C (en) | 2013-03-15 | 2016-11-29 | Pfizer Inc. | Indole compounds that activate ampk |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1143702A (sh) * | 1965-03-18 | |||
| GB1173312A (en) * | 1966-03-17 | 1969-12-10 | Kefalas As | Heterocyclic Compounds |
| GB1526331A (en) * | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
| DK0737189T3 (da) * | 1993-12-28 | 2000-03-06 | Upjohn Co | Heterocycliske forbindelser til behandling af CNS-forstyrrelser og cardiovaskulære forstyrrelser |
| ZA954689B (en) * | 1994-06-08 | 1996-01-29 | Lundbeck & Co As H | 4-Aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) piperidines tetrahydropyridines or piperazines |
-
1999
- 1999-12-01 AR ARP990106110A patent/AR021509A1/es unknown
- 1999-12-03 AT AT99957263T patent/ATE249451T1/de not_active IP Right Cessation
- 1999-12-03 WO PCT/DK1999/000676 patent/WO2000034263A1/en active IP Right Grant
- 1999-12-03 AU AU15036/00A patent/AU759248B2/en not_active Ceased
- 1999-12-03 ES ES99957263T patent/ES2204175T3/es not_active Expired - Lifetime
- 1999-12-03 ME MEP-385/08A patent/MEP38508A/xx unknown
- 1999-12-03 HU HU0104510A patent/HUP0104510A3/hu unknown
- 1999-12-03 DK DK99957263T patent/DK1137644T3/da active
- 1999-12-03 SE SE99957263T patent/SE1137644T5/xx unknown
- 1999-12-03 CZ CZ20012041A patent/CZ20012041A3/cs unknown
- 1999-12-03 CA CA002353618A patent/CA2353618A1/en not_active Abandoned
- 1999-12-03 JP JP2000586710A patent/JP2002531556A/ja active Pending
- 1999-12-03 SI SI9930412T patent/SI1137644T1/xx unknown
- 1999-12-03 EP EP99957263A patent/EP1137644B9/en not_active Expired - Lifetime
- 1999-12-03 DE DE69911243T patent/DE69911243T2/de not_active Expired - Fee Related
- 1999-12-03 PT PT99957263T patent/PT1137644E/pt unknown
- 1999-12-03 IL IL14308299A patent/IL143082A/en not_active IP Right Cessation
- 1999-12-03 RS YUP-384/01A patent/RS50065B/sr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2204175T3 (es) | 2004-04-16 |
| EP1137644B1 (en) | 2003-09-10 |
| CZ20012041A3 (cs) | 2001-10-17 |
| AR021509A1 (es) | 2002-07-24 |
| DE69911243T2 (de) | 2004-07-15 |
| AU759248B2 (en) | 2003-04-10 |
| RS50065B (sr) | 2009-01-22 |
| IL143082A (en) | 2004-06-20 |
| CA2353618A1 (en) | 2000-06-15 |
| SE1137644T5 (sh) | 2004-05-11 |
| ATE249451T1 (de) | 2003-09-15 |
| PT1137644E (pt) | 2004-01-30 |
| DE69911243D1 (de) | 2003-10-16 |
| IL143082A0 (en) | 2002-04-21 |
| SI1137644T1 (en) | 2003-12-31 |
| HUP0104510A3 (en) | 2003-01-28 |
| AU1503600A (en) | 2000-06-26 |
| SE1137644T3 (sh) | 2003-12-02 |
| EP1137644B9 (en) | 2004-03-17 |
| JP2002531556A (ja) | 2002-09-24 |
| WO2000034263A1 (en) | 2000-06-15 |
| EP1137644A1 (en) | 2001-10-04 |
| HUP0104510A2 (hu) | 2002-04-29 |
| MEP38508A (en) | 2011-02-10 |
| DK1137644T3 (da) | 2003-12-08 |
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